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公开(公告)号：US20090239832A1
公开(公告)日：2009-09-24
申请号：US12476717
申请日：2009-06-02
IPC分类号： A61K31/60 , C07C229/00 , A61K31/27 , A61P29/00
CPC分类号： C07C235/42 , C07C235/12 , C07C271/22 , C07C271/54 , C07C2601/14
摘要： The present invention relates to nitrooxyderivatives or salts thereof having the following general formula (I): R—NR1c—(K)k0—(B)b0—(C)c0—NO2 (I) wherein c0, b0 and k0 are 0 or 1; R is the radical of an analgesic drug for chronic pain, for instance neurophatic pain; R1c is H or alkyl with from 1 to 5 carbon atoms; B is such that its precursor is selected from amino acids, hydroxy acids, polyalcohol, compounds; C is a bivalent radical containing an aliphatic, heterocyclic or aromatic radical.
摘要翻译： 本发明涉及具有以下通式（I）的硝基氧基衍生物或其盐：<？in-line-formula description =“In-line Formulas”end =“lead”？> R-NR1c-（K）k0-（ B）b0-（C）c0-NO2（I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中c0，b0和k0为0或1; R是用于慢性疼痛的镇痛药的基础，例如神经性疼痛; R 1c是H或具有1至5个碳原子的烷基; B的前体选自氨基酸，羟基酸，多元醇，化合物; C是含有脂族，杂环或芳族基团的二价基团。
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2.发明申请Nitoroxy derivatives of losartan, valsatan, candesartan, telmisartan, eprosartan and olmesartan as angiotensin-II receptor blockers for the treatment of cardiovascular diseases 审中-公开氯沙坦，缬沙坦，坎地沙坦，替米沙坦，依普罗沙坦和奥美沙坦的N-硝基衍生物作为血管紧张素-II受体阻断剂治疗心血管疾病公开(公告)号：US20060276523A1
公开(公告)日：2006-12-07
申请号：US10566292
申请日：2004-07-20
IPC分类号： A61K31/4184 , A61K31/4178 , C07D409/02 , C07D403/02 , A61K31/60
CPC分类号： C07D257/04 , C07D235/20 , C07D403/10 , C07D409/06
摘要： Angiotensin II receptor blocker nitroderivatives of formula (I): R—(Y—ONO2)s (I) having wider pharmacological activity and enhanced tolerability. They can be employed for treating cardiovascular, renal and chronic liver diseases and inflammatory processes.
摘要翻译： 式（I）的血管紧张素II受体阻断剂硝基衍生物：<？in-line-formula description =“In-line Formulas”end =“lead”？> R-（Y-ONO 2 （I）<？in-line-formula description =“具有更广泛的药理活性和增强的耐受性的”在线公式“end =”tail“？> 它们可用于治疗心血管，肾脏和慢性肝脏疾病和炎症过程。
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公开(公告)号：US20060270608A1
公开(公告)日：2006-11-30
申请号：US10537439
申请日：2003-12-03
IPC分类号： A61K38/04 , C07D233/61 , C07C237/02 , A61K31/21
CPC分类号： C07C235/42 , C07C235/12 , C07C271/22 , C07C271/54 , C07C2601/14
摘要： The present invention relates to nitrooxyderivatives or salts thereof having the following general formula (I): R—NR1c—(K)k0—(B)b0—(C)c0—NO2 (I) wherein c0, b0 and k0 are 0 or 1; R is the radical of an analgesic drug for chronic pain, for instance neurophatic pain; R1c is H or alkyl with from 1 to 5 carbon atoms; B is such that its precursor is selected from amino acids, hydroxy acids, polyalcohol, compounds; C is a bivalent radical containing an aliphatic, heterocyclic or aromatic radical.
摘要翻译： 本发明涉及具有以下通式（I）的硝基氧基衍生物或其盐：<？in-line-formula description =“In-line formula”end =“lead”？> R-NR 1c - （K）k0 - （B）b0 - （C）C0 - NO2（I） <？in-line-formula description =“In-line formula”end =“tail”？>其中c0，b0和k0为0或1; R是用于慢性疼痛的镇痛药的基础，例如神经性疼痛; R 1c是H或具有1至5个碳原子的烷基; B的前体选自氨基酸，羟基酸，多元醇，化合物; C是含有脂族，杂环或芳族基团的二价基团。
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公开(公告)号：US20050004100A1
公开(公告)日：2005-01-06
申请号：US10869038
申请日：2004-06-17
IPC分类号： A61K38/00 , A61P9/12 , C07D207/16 , C07K5/02 , C07K5/062 , A61K31/5513 , A61K31/21 , A61K31/401 , A61K31/55
CPC分类号： C07K5/0222 , A61K38/00 , C07D207/16 , C07K5/06026 , C07K5/06086 , C07K5/06139 , C07K5/06165
摘要： ACE inhibitor nitroderivatives of formula (I): A-(X1—ONO2)s (I) having wider pharmacological activity and enhanced tolerability. They can be employed for treating cardiovascular and renal diseases and inflammatory processes.
摘要翻译： 式（I）的ACE抑制剂硝基衍生物：具有更宽的药理活性和增强的耐受性的A-（X1-ONO2）s（I）。 它们可用于治疗心血管和肾脏疾病和炎症过程。
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公开(公告)号：US07858665B2
公开(公告)日：2010-12-28
申请号：US12476717
申请日：2009-06-02
IPC分类号： A61K31/16 , A61K31/166 , C07C229/04 , C07C229/28
CPC分类号： C07C235/42 , C07C235/12 , C07C271/22 , C07C271/54 , C07C2601/14
摘要： The present invention relates to nitrooxyderivatives or salts thereof having the following general formula (I): R—NR1c—(K)k0—(B)b0—(C)c0—NO2 (I) wherein c0, b0 and k0 are 0 or 1; R is the radical of an analgesic drug for chronic pain, for instance neurophatic pain; R1c is H or alkyl with from 1 to 5 carbon atoms; B is such that its precursor is selected from amino acids, hydroxy acids, polyalcohol, compounds; C is a bivalent radical containing an aliphatic, heterocyclic or aromatic radical.
摘要翻译： 本发明涉及具有以下通式（I）的硝基氧基衍生物或其盐：R-NR1c-（K）k0-（B）b0-（C）c0-NO2（I）其中c0，b0和k0为0或 1; R是用于慢性疼痛的止痛药的基础，例如神经性疼痛; R 1c是H或具有1至5个碳原子的烷基; B的前体选自氨基酸，羟基酸，多元醇，化合物; C是含有脂族，杂环或芳族基团的二价基团。
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公开(公告)号：US07217733B2
公开(公告)日：2007-05-15
申请号：US10869038
申请日：2004-06-17
IPC分类号： A61K31/40 , C07D207/00
CPC分类号： C07K5/0222 , A61K38/00 , C07D207/16 , C07K5/06026 , C07K5/06086 , C07K5/06139 , C07K5/06165
摘要： ACE inhibitor nitroderivatives of formula (I): A—(X1—ONO2)s (I) having wider pharmacological activity and enhanced tolerability. They can be employed for treating cardiovascular and renal diseases and inflammatory processes.
摘要翻译： ACE抑制剂式（I）的硝基衍生物：<？in-line-formula description =“In-line Formulas”end =“lead”→A-（X 1 -ONO 2） （I）<？在线公式描述=具有更宽的药理活性和增强的耐受性的“在线公式”end =“尾”？>。 它们可用于治疗心血管和肾脏疾病和炎症过程。
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公开(公告)号：US07169805B2
公开(公告)日：2007-01-30
申请号：US10849560
申请日：2004-05-20
IPC分类号： A61K31/401 , C07D207/08 , A61K31/5377 , A61K31/454 , C07D401/12 , C07D413/12
CPC分类号： C07D207/16
摘要： Captopril nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment or prophylaxis of cardiovascular, inflammatory and renal diseases.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的卡托普利硝基衍生物。 它们可用于治疗或预防心血管，炎症和肾脏疾病。
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公开(公告)号：US20080058392A1
公开(公告)日：2008-03-06
申请号：US11841628
申请日：2007-08-20
IPC分类号： A61K31/192 , A61K31/433 , A61P27/06 , C07C229/06
CPC分类号： C07C405/0016
摘要： Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素硝基衍生物。 可用于治疗青光眼和高眼压症。
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公开(公告)号：US07199141B2
公开(公告)日：2007-04-03
申请号：US10480805
申请日：2002-05-10
申请人： Piero Del Soldato , Ennio Ongini
发明人： Piero Del Soldato , Ennio Ongini
IPC分类号： A61K31/44 , C07C229/00
CPC分类号： A61K31/4184 , A61K31/21 , A61K31/425 , A61K31/55 , A61K31/60 , A61K31/7024 , C07C203/04 , C07C291/02
摘要： Nitro-oxyderivative compounds or salts thereof having the following general formula (I): A—(B)b0—(C)c0—NO2 wherein: c0 is an integer and is 0 or 1, b0 is an integer and is 0 or 1, A=R—T1—, wherein R is the radical of an analgesic drug for the chronic pain, in particular for the neuropathic pain; B is such that its precursor is selected from anminoacids, hydroxyacids, polyalcohols, compounds containing at least one acid function; C is a bivalent radical containing an aliphatic, heterocyclic or aromatic radical.
摘要翻译： 具有以下通式（I）的硝基氧化衍生化合物或其盐：A-（B）b0 - （C）C 0 -NO 2 2 / >其中：c0为整数，为0或1，b0为整数，为0或1，A = RT 1 - ，其中R为慢性疼痛镇痛药物的基团， 特别是神经性疼痛; B使其前体选自氨肟酸，羟基酸，多元醇，含有至少一个酸官能团的化合物; C是含有脂族，杂环或芳族基团的二价基团。
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公开(公告)号：US20070060586A1
公开(公告)日：2007-03-15
申请号：US10581450
申请日：2004-12-01
IPC分类号： A61K31/5377 , A61K31/4704 , A61K31/405 , A61K31/34 , A61K31/21
CPC分类号： C07D285/10
摘要： The present invention relates to β-adrenergic blockers nitrooxyderivatives of general formula (I): A-(Y—ONO2)s and enantiomers and diastereoisomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them and their use for the treatment of hypertension, cardiovascular diseases, glaucoma, migraine headache and vascular diseases.
摘要翻译： 本发明涉及通式（I）的β-肾上腺素能阻断剂硝基氧基衍生物：其对映异构体和非对映异构体及其药学上可接受的盐， 含有它们的药物组合物及其用于治疗高血压，心血管疾病，青光眼，偏头痛和血管疾病的用途。
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