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公开(公告)号：US08138164B2
公开(公告)日：2012-03-20
申请号：US12446341
申请日：2007-10-19
IPC分类号： A61K31/675 , C07D498/14 , A61P31/14
CPC分类号： C07D498/18 , C07F9/6561
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
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公开(公告)号：US20100317623A1
公开(公告)日：2010-12-16
申请号：US12446341
申请日：2007-10-19
IPC分类号： A61K31/675 , C07D498/14 , A61P31/14
CPC分类号： C07D498/18 , C07F9/6561
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
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公开(公告)号：US20100298210A1
公开(公告)日：2010-11-25
申请号：US12446296
申请日：2007-10-19
申请人： Nigel J. Liverton , Vincenzo Summa , Joseph P. Vacca , Maria Emilia Di Francesco , Marco Pompei
发明人： Nigel J. Liverton , Vincenzo Summa , Joseph P. Vacca , Maria Emilia Di Francesco , Marco Pompei
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/0808
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use treating or preventing HCV infections.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS3蛋白酶抑制剂及其合成及其用于治疗或预防HCV感染的用途的式（I）的大环化合物。
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公开(公告)号：US08377873B2
公开(公告)日：2013-02-19
申请号：US12446296
申请日：2007-10-19
申请人： Nigel J. Liverton , Vincenzo Summa , Joseph P. Vacca , Maria Emilia Di Francesco , Marco Pompei
发明人： Nigel J. Liverton , Vincenzo Summa , Joseph P. Vacca , Maria Emilia Di Francesco , Marco Pompei
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/0808
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use treating or preventing HCV infections.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS3蛋白酶抑制剂及其合成及其用于治疗或预防HCV感染的用途的式（I）的大环化合物。
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公开(公告)号：US08309540B2
公开(公告)日：2012-11-13
申请号：US12446763
申请日：2007-10-22
IPC分类号： A61K31/33 , A61K31/47 , C07D201/16 , C07D223/00 , C07D267/02 , C07D273/00
CPC分类号： C07D498/18
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections. (I)
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS3蛋白酶抑制剂及其合成及其用于治疗或预防HCV感染的用途的式（I）的大环化合物。 （一世）
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公开(公告)号：US08278322B2
公开(公告)日：2012-10-02
申请号：US11989886
申请日：2006-07-28
申请人： M. Katharine Holloway , Nigel J. Liverton , John A. McCauley , Michael T. Rudd , Joseph P. Vacca , Steven W. Ludmerer , David B. Olsen
发明人： M. Katharine Holloway , Nigel J. Liverton , John A. McCauley , Michael T. Rudd , Joseph P. Vacca , Steven W. Ludmerer , David B. Olsen
IPC分类号： A61K31/44 , A61K31/519 , A61K31/33 , A61K38/12 , C07D225/00 , C07D267/22 , C07D245/00
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/0827
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS3蛋白酶抑制剂及其合成及其用于治疗或预防HCV感染的用途的式（I）的大环化合物。
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公开(公告)号：US08377874B2
公开(公告)日：2013-02-19
申请号：US12446789
申请日：2007-10-23
CPC分类号： C07K5/0802 , A61K38/00 , C07D519/00
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
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公开(公告)号：US07879797B2
公开(公告)日：2011-02-01
申请号：US11919783
申请日：2006-04-28
申请人： M. Katharine Holloway , Nigel J. Liverton , Steven W. Ludmerer , John A. McCauley , David Olsen , Michael T. Rudd , Joseph P. Vacca
发明人： M. Katharine Holloway , Nigel J. Liverton , Steven W. Ludmerer , John A. McCauley , David Olsen , Michael T. Rudd , Joseph P. Vacca
IPC分类号： A61K38/00
CPC分类号： C07K5/0808 , C07K5/0806 , C07K5/0812 , C07K5/0815 , C07K5/0821
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS3蛋白酶抑制剂及其合成及其用于治疗或预防HCV感染的用途的式（I）的大环化合物。
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公开(公告)号：US20100286185A1
公开(公告)日：2010-11-11
申请号：US12446789
申请日：2007-10-23
IPC分类号： A61K31/4745 , C07D498/22 , A61P31/12
CPC分类号： C07K5/0802 , A61K38/00 , C07D519/00
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
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公开(公告)号：US07470664B2
公开(公告)日：2008-12-30
申请号：US11484925
申请日：2006-07-12
申请人： M. Katharine Holloway , Nigel J. Liverton , Steven W. Ludmerer , John A. McCauley , David B. Olsen , Michael T. Rudd , Joseph P. Vacca , Charles J. McIntyre
发明人： M. Katharine Holloway , Nigel J. Liverton , Steven W. Ludmerer , John A. McCauley , David B. Olsen , Michael T. Rudd , Joseph P. Vacca , Charles J. McIntyre
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/0812 , C07K5/0827
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS3蛋白酶抑制剂及其合成及其用于治疗或预防HCV感染的用途的式（I）的大环化合物。
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