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公开(公告)号:US20100099695A1
公开(公告)日:2010-04-22
申请号:US12447342
申请日:2007-10-23
申请人: Nigel J. Liverton , Vincenzo Summa , Maria Emilia Di Francesco , Marco Ferrara , Kevin F. Gilbert , Steven Harper , John A. McCauley , Charles A. McIntyre , Alessia Petrocchi , Marco Pompei , Joseph J. Romano , Michael T. Rudd , John W. Butcher , M. Katharine Holloway
发明人: Nigel J. Liverton , Vincenzo Summa , Maria Emilia Di Francesco , Marco Ferrara , Kevin F. Gilbert , Steven Harper , John A. McCauley , Charles A. McIntyre , Alessia Petrocchi , Marco Pompei , Joseph J. Romano , Michael T. Rudd , John W. Butcher , M. Katharine Holloway
IPC分类号: A61K31/439 , C07D513/18 , C07D513/08 , A61K31/407 , A61K31/4748 , A61P31/12
CPC分类号: C07D498/22 , A61K31/407 , A61K31/4192 , A61K31/437 , A61K31/439 , A61K38/00 , A61K45/06 , C07D498/08 , C07D498/18 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/0812
摘要: The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
摘要翻译: 本发明涉及可用作丙型肝炎病毒(HCV)NS3蛋白酶抑制剂及其合成及其用于治疗或预防HCV感染的用途的式(I)的大环化合物。
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公开(公告)号:US08927569B2
公开(公告)日:2015-01-06
申请号:US12668987
申请日:2008-07-17
申请人: Steven Harper , Vincenzo Summa , Nigel J. Liverton , John A. McCauley , John W. Butcher , Marcello Di Filippo , Maria Emilia Di Francesco , Marco Ferrara , Joseph J. Romano , Michael T. Rudd
发明人: Steven Harper , Vincenzo Summa , Nigel J. Liverton , John A. McCauley , John W. Butcher , Marcello Di Filippo , Maria Emilia Di Francesco , Marco Ferrara , Joseph J. Romano , Michael T. Rudd
IPC分类号: A61K31/44 , A61K31/33 , C07D245/00 , C07D225/04 , C07D295/00 , C07K5/087 , C07K5/083
CPC分类号: C07K5/0812 , C07K5/0808
摘要: A class of macrocyclic compounds of formula (I), wherein R1, R3, R4, Ra, Rb, A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. Formula (I):
摘要翻译: 一类式(I)的大环化合物,其中R1,R3,R4,Ra,Rb,A,Z,Y,X,M,W,n和m如本文所定义,其可用作病毒蛋白酶的抑制剂, 特别是丙型肝炎病毒(HCV)NS3蛋白酶。 还提供了用于合成和使用这种用于治疗或预防HCV感染的大环化合物的方法5。 式(I):
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公开(公告)号:US20100183551A1
公开(公告)日:2010-07-22
申请号:US12668987
申请日:2008-07-17
申请人: Steven Harper , Vincenzo Summa , Nigel J. Liverton , John A. McCauley , John W. Butcher , Marcello Di Filippo , Maria Emilia Di Francesco , Marco Ferrara , Joseph J. Romano , Michael T. Rudd
发明人: Steven Harper , Vincenzo Summa , Nigel J. Liverton , John A. McCauley , John W. Butcher , Marcello Di Filippo , Maria Emilia Di Francesco , Marco Ferrara , Joseph J. Romano , Michael T. Rudd
CPC分类号: C07K5/0812 , C07K5/0808
摘要: A class of macrocyclic compounds of formula (I), wherein R1, R3, R4, Ra, Rb, A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. Formula (I):
摘要翻译: 一类式(I)的大环化合物,其中R1,R3,R4,Ra,Rb,A,Z,Y,X,M,W,n和m如本文所定义,其可用作病毒蛋白酶的抑制剂, 特别是丙型肝炎病毒(HCV)NS3蛋白酶。 还提供了用于合成和使用这种用于治疗或预防HCV感染的大环化合物的方法5。 式(I):
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公开(公告)号:US20130178413A1
公开(公告)日:2013-07-11
申请号:US13825245
申请日:2011-09-16
申请人: John A. McCauley , Nigel J. Liverton , Michael T. Rudd , Kevin F. Gilbert , Marco Ferrara , Vincenzo Summa , Benedetta Crescenzi
发明人: John A. McCauley , Nigel J. Liverton , Michael T. Rudd , Kevin F. Gilbert , Marco Ferrara , Vincenzo Summa , Benedetta Crescenzi
CPC分类号: A61K38/07 , A61K45/06 , C07D498/18 , C07K5/101 , C07K5/1016
摘要: The present invention relates to macrocyclic compounds of formula I that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
摘要翻译: 本发明涉及可用作丙型肝炎病毒(HCV)NS3蛋白酶抑制剂及其合成及其用于治疗或预防HCV感染的用途的式I的大环化合物。
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公开(公告)号:US20100298210A1
公开(公告)日:2010-11-25
申请号:US12446296
申请日:2007-10-19
申请人: Nigel J. Liverton , Vincenzo Summa , Joseph P. Vacca , Maria Emilia Di Francesco , Marco Pompei
发明人: Nigel J. Liverton , Vincenzo Summa , Joseph P. Vacca , Maria Emilia Di Francesco , Marco Pompei
CPC分类号: C07K5/0812 , A61K38/00 , C07K5/0808
摘要: The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use treating or preventing HCV infections.
摘要翻译: 本发明涉及可用作丙型肝炎病毒(HCV)NS3蛋白酶抑制剂及其合成及其用于治疗或预防HCV感染的用途的式(I)的大环化合物。
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公开(公告)号:US08377873B2
公开(公告)日:2013-02-19
申请号:US12446296
申请日:2007-10-19
申请人: Nigel J. Liverton , Vincenzo Summa , Joseph P. Vacca , Maria Emilia Di Francesco , Marco Pompei
发明人: Nigel J. Liverton , Vincenzo Summa , Joseph P. Vacca , Maria Emilia Di Francesco , Marco Pompei
CPC分类号: C07K5/0812 , A61K38/00 , C07K5/0808
摘要: The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use treating or preventing HCV infections.
摘要翻译: 本发明涉及可用作丙型肝炎病毒(HCV)NS3蛋白酶抑制剂及其合成及其用于治疗或预防HCV感染的用途的式(I)的大环化合物。
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7.
公开(公告)号:US07973040B2
公开(公告)日:2011-07-05
申请号:US12504955
申请日:2009-07-17
IPC分类号: C07D498/08 , A61K31/40 , A61P31/22
CPC分类号: C07K5/0808
摘要: The present invention relates to macrocyclic a compound of formula (I) and its use as inhibitors of the hepatitis C virus (HCV) NS3 protease, and in treating or preventing HCV infections.
摘要翻译: 本发明涉及大环式(I)化合物及其作为丙型肝炎病毒(HCV)NS3蛋白酶抑制剂的用途,用于治疗或预防HCV感染。
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8.
公开(公告)号:US20100029666A1
公开(公告)日:2010-02-04
申请号:US12504955
申请日:2009-07-17
IPC分类号: A61K31/4985 , C07D498/18 , A61P31/12
CPC分类号: C07K5/0808
摘要: The present invention relates to macrocyclic a compound of formula (I) and its use as inhibitors of the hepatitis C virus (HCV) NS3 protease, and in treating or preventing HCV infections.
摘要翻译: 本发明涉及大环式(I)化合物及其作为丙型肝炎病毒(HCV)NS3蛋白酶抑制剂的用途,用于治疗或预防HCV感染。
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公开(公告)号:US08080654B2
公开(公告)日:2011-12-20
申请号:US13112281
申请日:2011-05-20
IPC分类号: C07D498/08
CPC分类号: C07K5/0808
摘要: The present invention relates to macrocyclic a compound of formula (I) and its use as inhibitors of the hepatitis C virus (HCV) NS3 protease, and in treating or preventing HCV infections.
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10.
公开(公告)号:US20110224134A1
公开(公告)日:2011-09-15
申请号:US13112281
申请日:2011-05-20
CPC分类号: C07K5/0808
摘要: The present invention relates to macrocyclic a compound of formula (I) and its use as inhibitors of the hepatitis C virus (HCV) NS3 protease, and in treating or preventing HCV infections.
摘要翻译: 本发明涉及大环式(I)化合物及其作为丙型肝炎病毒(HCV)NS3蛋白酶抑制剂的用途,以及治疗或预防HCV感染。
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