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公开(公告)号：US20090076259A1
公开(公告)日：2009-03-19
申请号：US11719601
申请日：2005-11-18
IPC分类号： C07H1/00
CPC分类号： A61K51/0491 , C07H1/00 , C07H13/04 , C07H13/10
摘要： The invention relates to an improved process for the fluoridation of sugar derivatives in which a controlled amount of water is present in the solvent.
摘要翻译： 本发明涉及在溶剂中存在受控量的水的糖衍生物的氟化的改进方法。
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公开(公告)号：US20080226552A1
公开(公告)日：2008-09-18
申请号：US12089726
申请日：2006-10-09
CPC分类号： A61K51/0448
摘要： The present invention provides an automated method for the preparation of 123I-labelled radiopharmaceutical compositions, together with disposable cassettes for use in the method. The use of an automated synthesizer apparatus in the preparation of 123I-labelled radiopharmaceuticals is also described. Also described is the use of cassettes of the present invention in the preparation of 123I-labelled radiopharmaceuticals.
摘要翻译： 本发明提供了一种用于制备“123”标记的放射性药物组合物的自动化方法，以及用于该方法的一次性盒。 还描述了使用自动化合成装置制备标签的放射性药物。 还描述了本发明的盒用于制备标签的123放射性药物。
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公开(公告)号：US09585976B2
公开(公告)日：2017-03-07
申请号：US12089726
申请日：2006-10-09
CPC分类号： A61K51/0448
摘要： The present invention provides an automated method for the preparation of 123I-labelled radiopharmaceutical compositions, together with disposable cassettes for use in the method. The use of an automated synthesizer apparatus in the preparation of 123I-labelled radiopharmaceuticals is also described. Also described is the use of cassettes of the present invention in the preparation of 123I-labelled radiopharmaceuticals.
摘要翻译： 本发明提供了一种用于制备123I标记的放射性药物组合物的自动化方法，以及用于该方法的一次性盒。 还描述了在制备123I标记的放射性药物中使用自动合成仪装置。 还描述了本发明的盒在制备123I标记的放射性药物中的用途。
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公开(公告)号：US20090155167A1
公开(公告)日：2009-06-18
申请号：US12089734
申请日：2006-10-09
申请人： Nigel Anthony Powell , Peter Stewart Weisner , Ian Anthony Sargeant , Torgrim Engell , John Henrik Johansen
发明人： Nigel Anthony Powell , Peter Stewart Weisner , Ian Anthony Sargeant , Torgrim Engell , John Henrik Johansen
CPC分类号： A61K51/0448 , A61K51/025 , G21H5/02
摘要： The present invention provides an automated method for the preparation of 99mTc radiopharmaceutical compositions, together with disposable cassettes for use in the method. The use of an automated synthesizer apparatus in the preparation of 99mTc radiopharmaceuticals is also described. Also described is the use of kits for the preparation of 99mTc radiopharmaceuticals in the method and disposable cassettes of the present invention.
摘要翻译： 本发明提供了一种用于制备99mTc放射性药物组合物的自动化方法，以及用于该方法的一次性盒。 还描述了在制备99mTc放射性药物中使用自动合成仪装置。 还描述了在本发明的方法和一次性盒中制备99mTc放射性药物的试剂盒的用途。
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公开(公告)号：US07767796B2
公开(公告)日：2010-08-03
申请号：US11572161
申请日：2005-07-19
IPC分类号： C07F13/00
CPC分类号： A61K51/0478 , A61K51/0497
摘要： The present invention provides tetra-amine chelator conjugates with biological targeting moieties, linked via a linker group and technetium complexes thereof as radiopharmaceuticals. The linker group is such that the chelator is mono-functionalized at the bridgehead position and provides both flexibility and a lack or aryl groups, to minimize lipophilicity and steric hulk. Protected versions of the chelators are provided which permit conjugation with a wide range of targeting molecules without interfering reactions with the amine nitrogens of the tetra-amine chelator. Syntheses of the functionalised chelators are described, together with bifunctional chelate precursors. Radiopharmaceutical compositions comprising the technetium metal complexes of the invention are described, together with non-radioactive kits for the preparation of such radiopharmaceuticals.
摘要翻译： 本发明提供四胺螯合剂与生物靶向部分，通过连接基团和其锝络合物作为放射性药物连接。 接头基团使得螯合剂在桥头位置被单官能化并且提供柔性和缺乏或芳基，以使亲脂性和空间巨大的最小化。 提供了螯合剂的保护形式，其允许与宽范围的靶向分子缀合，而不与四胺螯合剂的胺氮化物发生干扰反应。 描述了官能化螯合剂的合成以及双官能螯合物前体。 本发明描述了包含本发明的锝金属络合物的放射性药物组合物，以及用于制备这种放射性药物的非放射性试剂盒。
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公开(公告)号：US07431914B2
公开(公告)日：2008-10-07
申请号：US10559880
申请日：2004-11-23
申请人： Alan Cuthbertson , Magne Solbakken , Dagfinn Lovhaug , Philip Duncanson , Harry John Wadsworth , Anthony Eamon Storey , Nigel Anthony Powell
发明人： Alan Cuthbertson , Magne Solbakken , Dagfinn Lovhaug , Philip Duncanson , Harry John Wadsworth , Anthony Eamon Storey , Nigel Anthony Powell
IPC分类号： A61K51/00
CPC分类号： A61K51/0497
摘要： A contrast agent of formula I: V-L-R (I) where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linear or branched amino acid-comprising biomodifier or linker moiety, and R is a reporter moiety detectable in in vivo imaging of a human or animal body.
摘要翻译： 式I的造影剂：VLR（I）其中V是对血管紧张素II受体位点具有结合亲和力的有机基团，L是包含直链或支链氨基酸的生物改性剂或连接体部分，R是可检测的报道部分 人体或动物身体的体内成像。
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公开(公告)号：US20080131368A1
公开(公告)日：2008-06-05
申请号：US11572161
申请日：2005-07-19
IPC分类号： A61K51/08 , C07K7/06 , C07C271/10 , C07D403/08 , C07K5/062
CPC分类号： A61K51/0478 , A61K51/0497
摘要： The present invention provides tetra-amine chelator conjugates with biological targeting moieties, linked via a linker group and technetium complexes thereof as radiopharmaceuticals. The linker group is such that the chelator is mono-functionalised at the bridgehead position and provides both flexibility and a lack or aryl groups, to minimise lipophilicity and steric hulk. Protected versions of the chelators are provided which permit conjugation with a wide range of targeting molecules without interfering reactions with the amine nitrogens of the tetra-amine chelator. Syntheses of the functionalised chelators are described, together with bifunctional chelate precursors. Radiopharmaceutical compositions comprising the technetium metal complexes of the invention are described, together with non-radioactive kits for the preparation of such radiopharmaceuticals.
摘要翻译： 本发明提供四胺螯合剂与生物靶向部分，通过连接基团和其锝络合物作为放射性药物连接。 接头基团使得螯合剂在桥头位置单官能化并提供柔性和缺乏或芳基，以使亲脂性和空间巨噬最小化。 提供了螯合剂的保护形式，其允许与宽范围的靶向分子缀合，而不与四胺螯合剂的胺氮化物发生干扰反应。 描述了官能化螯合剂的合成以及双官能螯合物前体。 本发明描述了包含本发明的锝金属络合物的放射性药物组合物，以及用于制备这种放射性药物的非放射性试剂盒。
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