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公开(公告)号：US07063953B2
公开(公告)日：2006-06-20
申请号：US10401916
申请日：2003-03-28
申请人： Ning Qin , Ellen Codd , Michael D'Andrea
发明人： Ning Qin , Ellen Codd , Michael D'Andrea
IPC分类号： G01N33/567
CPC分类号： C07K16/2803 , C07K14/705 , C07K2319/00 , C12N2799/021 , C12N2799/026
摘要： DNAs encoding human voltage gated sodium channel β1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
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公开(公告)号：US06994993B2
公开(公告)日：2006-02-07
申请号：US09875456
申请日：2001-06-06
申请人： Ning Qin , Ellen Codd , Michael D'Andrea
发明人： Ning Qin , Ellen Codd , Michael D'Andrea
IPC分类号： C12N15/12
CPC分类号： C07K16/2803 , C07K14/705 , C07K2319/00 , C12N2799/021 , C12N2799/026
摘要： DNAs encoding human voltage gated sodium channel β1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
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公开(公告)号：US20060269996A1
公开(公告)日：2006-11-30
申请号：US11370490
申请日：2006-03-08
申请人： Ning Qin , Ellen Codd , Michael D'andrea
发明人： Ning Qin , Ellen Codd , Michael D'andrea
IPC分类号： C12P21/06 , C07H21/04 , C07K16/28 , C07K14/705
CPC分类号： C07K16/2803 , C07K14/705 , C07K2319/00 , C12N2799/021 , C12N2799/026
摘要： DNAs encoding human voltage gated sodium channel β1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
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公开(公告)号：US07408036B2
公开(公告)日：2008-08-05
申请号：US11370490
申请日：2006-03-08
申请人： Ning Qin , Ellen Codd , Michael D'Andrea
发明人： Ning Qin , Ellen Codd , Michael D'Andrea
IPC分类号： C07K14/705
CPC分类号： C07K16/2803 , C07K14/705 , C07K2319/00 , C12N2799/021 , C12N2799/026
摘要： DNAs encoding human voltage gated sodium channel β1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译： 编码人电压门控钠通道β1A亚基的DNA已被克隆和表征。 重组蛋白能够形成生物活性蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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公开(公告)号：US07820792B2
公开(公告)日：2010-10-26
申请号：US12408407
申请日：2009-03-20
申请人： Ning Qin , Ellen Codd
发明人： Ning Qin , Ellen Codd
CPC分类号： C07K16/28 , C07K14/705 , C07K2317/34
摘要： The present invention provides nucleic acid and polypeptide sequences describing an isoform of the α2δ-4 subunit of a voltage gated calcium channel. The nucleic acids described herein can be used to produce functional α2δ-4 protein. The calcium channel α2δ-4 protein may be isolated for the purposes of binding experiments or may be used in cells to form a functional calcium channel complex.
摘要翻译： 本发明提供描述电压门控钙通道的α2δ-4亚基的同种型的核酸和多肽序列。 本文所述的核酸可用于产生功能性α2δ-4蛋白。 钙通道α2δ-4蛋白可以分离用于结合实验的目的或可用于细胞以形成功能性钙通道复合物。
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公开(公告)号：US20070166789A1
公开(公告)日：2007-07-19
申请号：US11651705
申请日：2007-01-10
申请人： Ning Qin , Ellen Codd , Christopher Flores , Sui-Po Zhang
发明人： Ning Qin , Ellen Codd , Christopher Flores , Sui-Po Zhang
CPC分类号： C12N9/0083 , A61K38/00
摘要： The present invention provides nucleic acid and polypeptide sequences describing a novel isozyme of the cyclooxygenase enzyme, herein named as human cyclooxygenase-3. The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays, gene therapy, and screening assays.
摘要翻译： 本发明提供描述环氧合酶的新型同工酶的核酸和多肽序列，这里命名为人环加氧酶-3。 本发明的分离的核酸或多肽分子可用于检测测定，基因治疗和筛选测定。
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公开(公告)号：US20090259022A1
公开(公告)日：2009-10-15
申请号：US12408407
申请日：2009-03-20
申请人： Ning Qin , Ellen Codd
发明人： Ning Qin , Ellen Codd
IPC分类号： C07K14/435
CPC分类号： C07K16/28 , C07K14/705 , C07K2317/34
摘要： The present invention provides nucleic acid and polypeptide sequences describing an isoform of the α2δ-4 subunit of a voltage gated calcium channel. The nucleic acids described herein can be used to produce functional α2δ-4 protein. The calcium channel α2δ-4 protein may be isolated for the purposes of binding experiments or may be used in cells to form a functional calcium channel complex.
摘要翻译： 本发明提供描述电压门控钙通道的α2dta-4亚基的同种型的核酸和多肽序列。 本文所述的核酸可用于产生功能性α2delta-4蛋白。 钙通道α2delta-4蛋白可以分离用于结合实验的目的，或者可以用于细胞中以形成功能性钙通道复合物。
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公开(公告)号：US07524643B2
公开(公告)日：2009-04-28
申请号：US09833222
申请日：2001-04-11
申请人： Ning Qin , Ellen Codd
发明人： Ning Qin , Ellen Codd
CPC分类号： C07K16/28 , C07K14/705 , C07K2317/34
摘要： The present invention provides nucleic acid and polypeptide sequences describing an isoform of the α2δ-4 subunit of a voltage gated calcium channel. The nucleic acids described herein can be used to produce functional α2δ-4 protein. The calcium channel α2δ-4 protein may be isolated for the purposes of binding experiments or may be used in cells to form a functional calcium channel complex.
摘要翻译： 本发明提供描述电压门控钙通道的α2dta-4亚基的同种型的核酸和多肽序列。 本文所述的核酸可用于产生功能性α2delta-4蛋白。 钙通道α2delta-4蛋白可以分离用于结合实验的目的，或者可以用于细胞中以形成功能性钙通道复合物。
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公开(公告)号：US07157248B2
公开(公告)日：2007-01-02
申请号：US10119624
申请日：2002-04-10
申请人： Ning Qin , Ellen Codd
发明人： Ning Qin , Ellen Codd
CPC分类号： C07K16/28 , C07K14/705 , C07K2317/34
摘要： The present invention provides nucleic acid and polypeptide sequences describing a novel isoform of the α2δ subunit of a voltage gated calcium channel, herein named as α2δ-4. The isolated nucleic acid or polypeptide molecule of the invention can be used in diagnosing and treating a disease or disorder associated with a defective α2δ-4 subunit, such as seizure-related syndromes, anxiety, multiple sclerosis, and the like.
摘要翻译： 本发明提供描述电压门控钙通道的α2delta亚基的新型同工型的核酸和多肽序列，这里命名为α2δ-4。 本发明的分离的核酸或多肽分子可用于诊断和治疗与有缺陷的α2δ-4亚基相关的疾病或病症，例如发作相关综合征，焦虑症，多发性硬化症等。
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公开(公告)号：US09123166B2
公开(公告)日：2015-09-01
申请号：US13358077
申请日：2012-01-25
申请人： Shahrokh Shahpar , Ning Qin , Yibin Wang , Greg Carnie
发明人： Shahrokh Shahpar , Ning Qin , Yibin Wang , Greg Carnie
CPC分类号： G06T17/20
摘要： A method of connecting three-dimensional structured meshes to form a conformal mesh, for solutions of flow problems, including: forming an interface by overlaying surfaces of two structured meshes; defining an interface set of mesh points in the interface; merging mesh points in the interface set that are within a predetermined distance of each other and projecting mesh points of one mesh in the interface that are within a predetermined distance of a line of the other mesh; generating an interface layer in the form of an unstructured mesh; and inserting a node at the center of each hexahedra, and producing an unstructured layer of cells between the two structured meshes by joining the nodes to the mesh points of the interface layer.
摘要翻译： 一种连接三维结构网格以形成共形网格的方法，用于解决流动问题，包括：通过覆盖两个结构化网格的表面形成界面; 定义接口中的网格点的接口集; 将界面集合中的网格点合并在彼此的预定距离内，并且在界面中的一个网格的网格点在另一个网格的线的预定距离内预定的距离; 生成非结构化网格形式的界面层; 并在每个六面体的中心插入节点，并通过将节点连接到界面层的网格点，在两个结构化网格之间产生非结构化的单元格层。
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