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公开(公告)号：US07432343B2
公开(公告)日：2008-10-07
申请号：US11585030
申请日：2006-10-23
CPC分类号： C07K16/18 , C07K14/4702 , G01N33/574 , G01N33/57407 , G01N33/57415 , G01N33/57484 , G01N33/57496 , G01N33/6863 , G01N2333/4703 , G01N2500/00
摘要： The present invention provides nucleic acids. Polypeptides, antibodies and cells related to MAIL (Molecule possessing Ankyrin repeats Induced by LPS; or IκB-ζ), a novel member of the IκB family, expressed in LPS stimulated monocytes and uses thereof. The isolated nucleic acids, polypeptides, antibodies and cells of the invention can be used in detection assays, screening methods and drug discovery assays.
摘要翻译： 本发明提供核酸。 与LPS相关的多肽，抗体和细胞（由LPS诱导的锚蛋白重复的分子;或IkappaB-zeta），IkappaB家族的新成员，以LPS刺激的单核细胞及其用途表达。 本发明的分离的核酸，多肽，抗体和细胞可用于检测测定，筛选方法和药物发现测定。
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公开(公告)号：US20070099252A1
公开(公告)日：2007-05-03
申请号：US11585030
申请日：2006-10-23
申请人： Ameesha Batheja , George Ho , Michael D'Andrea , David Uhlinger
发明人： Ameesha Batheja , George Ho , Michael D'Andrea , David Uhlinger
IPC分类号： G01N33/574 , C07K16/30
CPC分类号： C07K16/18 , C07K14/4702 , G01N33/574 , G01N33/57407 , G01N33/57415 , G01N33/57484 , G01N33/57496 , G01N33/6863 , G01N2333/4703 , G01N2500/00
摘要： The present invention provides nucleic acids. Polypeptides, antibodies and cells related to MAIL (Molecule possessing Ankyrin repeats Induced by LPS; or IκB-ζ), a novel member of the IκB family, expressed in LPS stimulated monocytes and uses thereof. The isolated nucleic acids, polypeptides, antibodies and cells of the invention can be used in detection assays, screening methods and drug discovery assays.
摘要翻译： 本发明提供核酸。 与LPS相关的多肽，抗体和细胞（由LPS诱导的锚蛋白重复的分子;或IkappaB-zeta），IkappaB家族的新成员，以LPS刺激的单核细胞及其用途表达。 本发明的分离的核酸，多肽，抗体和细胞可用于检测测定，筛选方法和药物发现测定。
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公开(公告)号：US20100003712A1
公开(公告)日：2010-01-07
申请号：US12474413
申请日：2009-05-29
IPC分类号： C12Q1/02 , C07K14/715
CPC分类号： C12Q1/37 , G01N33/6869 , G01N2333/9648 , G01N2500/10
摘要： A biomarker that correlates to treatment with drugs that inhibit chymase is disclosed. This biomarker has been shown to have utility in assessing response to chymase inhibitor compounds. The immunoreactivity or levels of the biomarker is increased upon treatment with chymase inhibitor compounds, thus indicating that this biomarker is involved in chymase activity.
摘要翻译： 公开了与用抑制胃促胰酶的药物治疗相关的生物标志物。 该生物标志物已被证明可用于评估对胃促胰酶抑制剂化合物的反应。 在用糜酶抑制剂化合物治疗时，生物标志物的免疫反应性或水平增加，因此表明该生物标志物参与糜酶活性。
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公开(公告)号：US20070166779A1
公开(公告)日：2007-07-19
申请号：US11652753
申请日：2007-01-12
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , G01N2333/811
摘要： It is now discovered that human chymase cleaves human SLPI at a specific site and that this cleavage can be used as an indicator of chymase activity. The present invention provides methods of diagnosing a chymase-associated disease or evaluating the efficiency of a treatment of a chymase-associated disease in a human subject by measuring SLPI processing, as well as other related methods and compositions.
摘要翻译： 现在发现人糜酶在特定位点切割人SLPI，并且该切割可以用作糜酶活性的指示剂。 本发明提供了通过测量SLPI处理以及其它相关方法和组合物来诊断糜酶相关疾病或通过测量人受试者中糜酶相关疾病的治疗效率的方法。
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公开(公告)号：US06994993B2
公开(公告)日：2006-02-07
申请号：US09875456
申请日：2001-06-06
申请人： Ning Qin , Ellen Codd , Michael D'Andrea
发明人： Ning Qin , Ellen Codd , Michael D'Andrea
IPC分类号： C12N15/12
CPC分类号： C07K16/2803 , C07K14/705 , C07K2319/00 , C12N2799/021 , C12N2799/026
摘要： DNAs encoding human voltage gated sodium channel β1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
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6.发明申请公开(公告)号：US20050227297A1
公开(公告)日：2005-10-13
申请号：US11100656
申请日：2005-04-07
申请人： Michael D'Andrea
发明人： Michael D'Andrea
IPC分类号： G01N33/53 , G01N33/554 , G01N33/567 , G01N33/569 , G01N33/68
CPC分类号： G01N33/6887 , G01N33/68 , G01N2333/78 , G01N2333/96486
摘要： Pretreating a tissue sample with an effective amount of collagenase results in increased immunodetection of collagen and enhanced preservation of tissue morphology. Such an improved method for immunodetection of collagen can be used in immunohistochemical studies of formalin-fixed, paraffin-embedded tissue sections.
摘要翻译： 用有效量的胶原酶预处理组织样品导致增加的胶原免疫检测和增强组织形态的保存。 这种改进的胶原免疫检测方法可用于福尔马林固定的石蜡包埋组织切片的免疫组织化学研究。
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公开(公告)号：US08147178B2
公开(公告)日：2012-04-03
申请号：US12342972
申请日：2008-12-23
申请人： Marcus Joseph Ottaviano , Robert John Parks , John Lawrence Noon , Mark Michael D'Andrea , Thomas Michael Regan , Aaron Todd Williams
发明人： Marcus Joseph Ottaviano , Robert John Parks , John Lawrence Noon , Mark Michael D'Andrea , Thomas Michael Regan , Aaron Todd Williams
IPC分类号： F01D3/04
CPC分类号： F02C7/18 , F01D3/04 , F01D9/045 , F02C3/08 , F02C6/08 , F04D29/444 , F05D2250/324 , F05D2260/15
摘要： A gas turbine engine centrifugal compressor axial forward thrust apparatus bleeds impeller tip aft bleed flow from between an annular centrifugal compressor impeller of a high pressure rotor and a diffuser directly downstream of the impeller. The apparatus then uses the aft bleed flow to pressurize an annular cavity extending radially between an inner combustor casing and the rotor and extending axially between forward and aft thrust balance seals. Forward and aft thrust balance lands are in sealing engagement with the forward and aft thrust balance seals on the high pressure rotor respectively. An annular stator plenum in fluid communication with the annular cavity is bounded in part by a forward end wall having conical diffusion holes therethrough which may be axially or circumferentially or axially and circumferentially angled. The forward thrust balance seal may be on an aft conical arm of the impeller.
摘要翻译： 燃气涡轮发动机离心式压缩机轴向前推推力装置使叶轮尖端从高压转子的环形离心式压缩机叶轮与直接在叶轮下游的扩散器之间流出。 然后，该装置使用尾部流出流对在内部燃烧器壳体和转子之间径向延伸并在前后推力平衡密封件之间轴向延伸的环形空腔加压。 前后推力平衡台分别与高压转子上的前后推力平衡密封件密封接合。 与环形空腔流体连通的环形定子增压室部分地由具有锥形扩散孔的前端壁限定，其可以在轴向或周向或轴向和周向上成角度。 前推力平衡密封件可以在叶轮的后圆锥形臂上。
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公开(公告)号：US20100158668A1
公开(公告)日：2010-06-24
申请号：US12342972
申请日：2008-12-23
申请人： Marcus Joseph Ottaviano , Robert John Parks , John Lawrence Noon , Mark Michael D'Andrea , Thomas Michael Regan , Aaron Todd Williams
发明人： Marcus Joseph Ottaviano , Robert John Parks , John Lawrence Noon , Mark Michael D'Andrea , Thomas Michael Regan , Aaron Todd Williams
IPC分类号： F01D3/04
CPC分类号： F02C7/18 , F01D3/04 , F01D9/045 , F02C3/08 , F02C6/08 , F04D29/444 , F05D2250/324 , F05D2260/15
摘要： A gas turbine engine centrifugal compressor axial forward thrust apparatus bleeds impeller tip aft bleed flow from between an annular centrifugal compressor impeller of a high pressure rotor and a diffuser directly downstream of the impeller. The apparatus then uses the aft bleed flow to pressurize an annular cavity extending radially between an inner combustor casing and the rotor and extending axially between forward and aft thrust balance seals. Forward and aft thrust balance lands are in sealing engagement with the forward and aft thrust balance seals on the high pressure rotor respectively. An annular stator plenum in fluid communication with the annular cavity is bounded in part by a forward end wall having conical diffusion holes therethrough which may be axially or circumferentially or axially and circumferentially angled. The forward thrust balance seal may be on an aft conical arm of the impeller.
摘要翻译： 燃气涡轮发动机离心式压缩机轴向前推推力装置使叶轮尖端从高压转子的环形离心式压缩机叶轮与直接在叶轮下游的扩散器之间流出。 然后，该装置使用尾部流出流对在内部燃烧器壳体和转子之间径向延伸并在前后推力平衡密封件之间轴向延伸的环形空腔加压。 前后推力平衡台分别与高压转子上的前后推力平衡密封件密封接合。 与环形空腔流体连通的环形定子增压室部分地由具有锥形扩散孔的前端壁限定，所述锥形扩散孔可沿轴向或周向或轴向和周向成角度。 前推力平衡密封件可以在叶轮的后圆锥形臂上。
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公开(公告)号：US07063953B2
公开(公告)日：2006-06-20
申请号：US10401916
申请日：2003-03-28
申请人： Ning Qin , Ellen Codd , Michael D'Andrea
发明人： Ning Qin , Ellen Codd , Michael D'Andrea
IPC分类号： G01N33/567
CPC分类号： C07K16/2803 , C07K14/705 , C07K2319/00 , C12N2799/021 , C12N2799/026
摘要： DNAs encoding human voltage gated sodium channel β1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
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公开(公告)号：US20060269996A1
公开(公告)日：2006-11-30
申请号：US11370490
申请日：2006-03-08
申请人： Ning Qin , Ellen Codd , Michael D'andrea
发明人： Ning Qin , Ellen Codd , Michael D'andrea
IPC分类号： C12P21/06 , C07H21/04 , C07K16/28 , C07K14/705
CPC分类号： C07K16/2803 , C07K14/705 , C07K2319/00 , C12N2799/021 , C12N2799/026
摘要： DNAs encoding human voltage gated sodium channel β1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
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