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公开(公告)号：US10060862B2
公开(公告)日：2018-08-28
申请号：US15479657
申请日：2017-04-05
申请人： Yongtao Cui , Yue Ma , Zhixun Shen
发明人： Yongtao Cui , Yue Ma , Zhixun Shen
CPC分类号： G01N22/00 , G01N27/02 , G01Q10/045 , G01Q20/04 , G01Q60/30
摘要： A microwave impedance microscope including a tuning fork having a high-aspect ratio etched metal tip electrode extending transversely to one tine of the fork and having a high aspect ratio to thereby reduce parasitic capacitance. The metal tip may be electrochemically etched from a wire, then bonded to the tine. The fork is slightly inclined from the surface of the sample and the tip electrode projects transversely to the fork. A microwave signal is impressed on the tip. Microwave circuitry receives microwave signals reflected from the sample back into the tip and demodulates the reflected signal according to the impressed signal. Further circuitry further demodulates the reflected signal according to the lower-frequency signal causing the fork to oscillate at its mechanically resonant frequency. A multi-wavelength matching circuit interposed between the microwave circuitry and the probe includes a coaxial cable of length half a fundamental microwave wavelength.
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公开(公告)号：US09593808B1
公开(公告)日：2017-03-14
申请号：US13706450
申请日：2012-12-06
申请人： Angelo Gaitas
发明人： Angelo Gaitas
IPC分类号： G01N33/551 , F17D3/00 , G01N33/543
CPC分类号： F17D3/00 , B01L3/021 , B01L3/0217 , B01L3/502715 , B01L3/502761 , B01L7/52 , B01L2200/141 , B01L2200/16 , B01L2300/1827 , B01L2400/0484 , B01L2400/0487 , G01N33/54366 , G01N2021/6482 , G01Q20/04 , G01Q30/14 , G01Q60/02 , G01Q60/42 , G01Q60/44 , G01Q70/06 , G01Q70/14
摘要： A polymeric micro-arm apparatus and method to use the same. The apparatus comprises of an elongated hollow polymeric structure with a distal end and a proximal end, an opening near the distal end, a main body attached to the polymeric structure means to move the polymeric structure, means to generate fluid flow through the opening, means to measure a flowrate of the fluid flow through the opening; and an element embedded in the polymeric structure, wherein the element is configured to detect when the polymeric structure contacts an object and measures the force that the object exerts upon the polymeric structure.
摘要翻译： 一种聚合物微型臂装置及其使用方法。 该装置包括具有远端和近端的细长中空聚合物结构，靠近远端的开口，连接到聚合物结构装置以移动聚合物结构的主体，以产生流过该开口的流体流动装置 以测量通过所述开口的流体流量的流量; 以及嵌入在所述聚合物结构中的元件，其中所述元件被配置为检测所述聚合物结构何时接触物体并测量所述物体施加在所述聚合物结构上的力。
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公开(公告)号：US20150362525A1
公开(公告)日：2015-12-17
申请号：US14762261
申请日：2014-01-16
申请人： ELIONIX INC.
发明人： Hironao AMEMIYA , Hayato KOBAYASHI , Takahisa KATO
CPC分类号： G01Q60/38 , G01N2203/0286 , G01Q10/00 , G01Q20/04
摘要： The present invention provides a method and an apparatus for measuring a force (which will be referred to as surface force) acting between two material surfaces. A surface force measuring method includes moving an object (1) toward a probe (4) until the probe (4) is adsorbed to the object (1), then applying a load from an electromagnetic-force generator (20) to a supporting member (6) in a direction as to separate the probe (4) from the object (1) while gradually increasing an electric current supplied to the electromagnetic-force generator (20), obtaining a value of the electric current supplied to the electromagnetic-force generator (20) when the probe (4) is separated from the object (1), and converting the value of the electric current into a surface force acting between the probe (4) and the object (1).
摘要翻译： 本发明提供一种用于测量作用在两个材料表面之间的力（将被称为表面力）的方法和装置。 表面力测量方法包括将物体（1）朝向探针（4）移动直到探针（4）被吸附到物体（1），然后将负载从电磁力发生器（20）施加到支撑构件 （6）沿着使探针（4）与物体（1）分离的方向，同时逐渐增加供应到电磁力发生器（20）的电流，获得提供给电磁力的电流值 发生器（20），当探头（4）与物体（1）分离时，将电流值转换成作用在探头（4）和物体（1）之间的表面力。
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公开(公告)号：US20150323347A1
公开(公告)日：2015-11-12
申请号：US14697038
申请日：2015-04-27
发明人： Hwansoo SUH , Insu JEON , Jhinhwan LEE
IPC分类号： G01D5/14
摘要： A piezoelectric actuator and a method of measuring a motion by using the piezoelectric actuator are provided. The piezoelectric actuator includes: a movable member that is disposed to face the fixed member; a piezoelectric element that is disposed between the fixed member and the movable member, and configured to operate in a shear mode based on input voltages applied to the piezoelectric element and move the movable member relative to the fixed member; and a position sensor that is disposed between the piezoelectric element and the movable member, and configured to measure a motion of the movable member.
摘要翻译： 提供了压电致动器和通过使用压电致动器测量运动的方法。 压电致动器包括：可移动构件，其被设置成面对固定构件; 压电元件，其设置在所述固定构件和所述可动构件之间，并且被配置为基于施加到所述压电元件的输入电压以剪切模式操作并相对于所述固定构件移动所述可动构件; 以及位置传感器，其设置在所述压电元件和所述可动构件之间，并且被配置为测量所述可动构件的运动。
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5.发明授权AFM-coupled microscale radiofrequency probe for magnetic resonance imaging and spectroscopy 有权用于磁共振成像和光谱的AFM耦合微型射频探头公开(公告)号：US08884608B2
公开(公告)日：2014-11-11
申请号：US14351055
申请日：2012-10-10
CPC分类号： G01R33/4808 , G01N24/08 , G01Q20/04 , G01Q30/02 , G01Q60/08 , G01Q60/52 , G01Q70/16 , G01R33/341 , G01R33/46
摘要： The present disclosure is discloses the development of a new device, system, and method that combines advantages of magnetic resonance and atomic force microscopy technologies, and the utility of the new device, system, and method for a wide range of biomedical and clinical researchers. According to one aspect of the present disclosure, a device for micro-scale spectroscopy is disclosed. The micro-scale spectroscopy device includes a beam having a distal end, a proximal end, a top surface and a bottom surface, where the beam is attached to an anchor at the proximal end and further includes a tip extending substantially perpendicular from the bottom surface at or near the distal end, and a coil having at least one turn mounted to the top surface of the beam at or near the distal end opposite the tip, where the coil is capable of both transmitting and sensing electromagnetic radiation.
摘要翻译： 本公开公开了一种结合磁共振和原子力显微技术的优点的新器件，系统和方法的开发，以及用于广泛的生物医学和临床研究者的新器件，系统和方法的实用性。 根据本公开的一个方面，公开了一种用于微尺度光谱的装置。 微型光谱装置包括具有远端，近端，顶表面和底表面的光束，其中光束附接到近端处的锚固件，并且还包括从底表面基本垂直延伸的尖端 在远端处或附近，以及具有至少一个匝的线圈，其安装到梁的顶表面处，或者与尖端相对的远端附近，其中线圈能够传输和感测电磁辐射。
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公开(公告)号：US20140250553A1
公开(公告)日：2014-09-04
申请号：US14342758
申请日：2012-08-21
申请人： Dominik Ziegler , Paul Ashby
发明人： Dominik Ziegler , Paul Ashby
IPC分类号： G01Q70/08
摘要： The embodiments described herein provide a sensor. In an exemplary embodiment, the sensor includes (1) a resonator, (2) a probe attached to the resonator, and (3) an encasement that encases the resonator, where the encasement includes an opening through which the probe can protrude and where the dimensions of the encasement are on the same order as the dimensions of the resonator.
摘要翻译： 这里描述的实施例提供了一种传感器。 在一个示例性实施例中，传感器包括（1）谐振器，（2）附接到谐振器的探头，以及（3）包围谐振器的外壳，其中所述外壳包括探针可以突出的开口， 外壳的尺寸与谐振器的尺寸相同。
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7.发明申请公开(公告)号：US20140047585A1
公开(公告)日：2014-02-13
申请号：US13570666
申请日：2012-08-09
申请人： Jens Hofrichter , Felix Holzner , folkert Horst , Philip Paul
发明人： Jens Hofrichter , Felix Holzner , folkert Horst , Philip Paul
IPC分类号： G01Q70/08
摘要： An apparatus and method directed to a scanning probe microscopy cantilever. The apparatus includes body and an electromagnetic sensor having a detectable electromagnetic property varying upon deformation of the body. The method includes scanning the surface of a material with the cantilever, such that the body of the cantilever undergoes deformations and detecting the electromagnetic property varying upon deformation of the body of the cantilever.
摘要翻译： 一种针对扫描探针显微镜悬臂的装置和方法。 该装置包括主体和电磁传感器，该电磁传感器具有在身体变形时变化的可检测的电磁特性。 该方法包括用悬臂扫描材料的表面，使得悬臂的主体经历变形并检测在悬臂体的变形时变化的电磁特性。
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公开(公告)号：US08394625B2
公开(公告)日：2013-03-12
申请号：US13099351
申请日：2011-05-02
申请人： Angelo Gaitas , Amar Basu
发明人： Angelo Gaitas , Amar Basu
CPC分类号： F17D3/00 , B01L3/021 , B01L3/0217 , B01L3/502715 , B01L3/502761 , B01L7/52 , B01L2200/141 , B01L2200/16 , B01L2300/1827 , B01L2400/0484 , B01L2400/0487 , G01N33/54366 , G01N2021/6482 , G01Q20/04 , G01Q30/14 , G01Q60/02 , G01Q60/42 , G01Q60/44 , G01Q70/06 , G01Q70/14
摘要： This invention generally relates to an integrated ‘lab-on-a-Pipette’™ which will provide sample-to-answer single cell genetic diagnosis for preimplantation genetic diagnosis (PGD) and other forms of single cell analysis (SCA). SCA is a quickly growing field with substantial impact in prenatal testing, cancer biopsies, diabetes, stem cell research, and our overall understanding of heterogeneity in biology. However, single cell genetic analysis is challenging, inaccurate, and in many cases impossible, due to the small amount of sample (5 pg), and difficulties in handling small sample volumes (50-100 pL). The ‘lab-on-a-pipette’ device integrates a microaspiration tip with microfluidic analysis components to conduct in-situ, real-time single cell genetic diagnosis in a single device. The microaspiration tip extracts and encapsulate a cell into an ultra-low volume plug (˜300 pL).
摘要翻译： 本发明一般涉及一种集成的实验室移液器，其将提供用于植入前遗传诊断（PGD）和其它形式的单细胞分析（SCA）的样本 - 答复单细胞遗传诊断。 SCA是一个快速增长的领域，对产前检测，癌症活检，糖尿病，干细胞研究以及我们对生物学异质性的整体理解产生重大影响。 然而，单细胞遗传分析是挑战性的，不准确的，并且在许多情况下由于少量样品（5pg）和处理小样本体积（50-100μL）的困难在许多情况下是不可能的。 实验室吸管装置将微型吸头和微流体分析组件集成在单一设备中进行原位实时单细胞遗传诊断。 微量吸头提取并将细胞封装到超低容量塞（〜300 pL）中。
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公开(公告)号：US08393011B2
公开(公告)日：2013-03-05
申请号：US12465625
申请日：2009-05-13
IPC分类号： G01Q70/14
摘要： A device comprising at least one cantilever comprising at least one piezoresistor is described, where the cantilevers comprise silicon nitride or silicon carbide and the piezoresistors comprise doped silicon. Methods for making and using such a device are also provided.
摘要翻译： 描述了包括至少一个包括至少一个压敏电阻的悬臂的装置，其中悬臂包括氮化硅或碳化硅，并且压电电阻包括掺杂的硅。 还提供了制造和使用这种装置的方法。
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公开(公告)号：US08261368B2
公开(公告)日：2012-09-04
申请号：US12465621
申请日：2009-05-13
申请人： John Edward Bussan , Michael R. Nelson , Joseph S. Fragala , Albert K. Henning , Jeffrey R. Rendlen
发明人： John Edward Bussan , Michael R. Nelson , Joseph S. Fragala , Albert K. Henning , Jeffrey R. Rendlen
摘要： Devices for performing nanofabrication are provided which provide small volume reaction space and high reaction versatility. A device may include a reaction chamber adapted for nanoscale modification of a substrate and vacuum conditions; a scanning probe tip assembly enclosed within the reaction chamber; a first port coupled to the reaction chamber for delivering a gas; a second port coupled to the reaction chamber for applying a vacuum; and a substrate assembly insertedly mounted to the reaction chamber. The reaction chamber may include a body having one or more flexible walls and one or more supports to prevent the reaction chamber from collapsing under a vacuum. The device may further include an electrical conduit for coupling the tips of the scanning probe tip assembly to electrical components outside the reaction chamber. Also provided are apparatuses incorporating the devices and methods of using the devices and apparatuses.
摘要翻译： 提供用于进行纳米制造的装置，其提供小体积的反应空间和高反应多功能性。 装置可以包括适于对基底进行纳米尺寸改性的反应室和真空条件; 包围在反应室内的扫描探针头组件; 耦合到所述反应室的用于输送气体的第一端口; 耦合到所述反应室的第二端口，用于施加真空; 以及插入安装到反应室的基板组件。 反应室可以包括具有一个或多个柔性壁和一个或多个支撑物的主体，以防止反应室在真空下塌缩。 该装置还可以包括用于将扫描探针头组件的尖端耦合到反应室外部的电气部件的电导管。 还提供了结合装置的装置和使用装置和装置的方法。
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