公开(公告)号：US07097999B2

公开(公告)日：2006-08-29

申请号：US10121693

申请日：2002-04-15

申请人： Nobuharu Tsujimoto ,  Tomoko Suzuki ,  Hisao Ito

发明人： Nobuharu Tsujimoto ,  Tomoko Suzuki ,  Hisao Ito

IPC分类号： C12P1/00 ,  C12P13/04

CPC分类号： C07K14/245 ,  C12P13/04 ,  C12P13/08 ,  C12P13/222

摘要： The present invention describes a method for producing a target substance by utilizing a microorganism comprising culturing the microorganism in a medium, allowing the target substance to accumulate, and collecting the target substance from the medium. Also the microorganism used in the present invention is a mutant strain whereby maltose assimilation is controlled by the interaction between IIAGlc protein of glucose PTS and MalK.

摘要翻译： 本发明描述了通过利用微生物来生产目标物质的方法，所述微生物包括在培养基中培养微生物，允许目标物质积聚，并从培养基中收集目标物质。 本发明中使用的微生物也是通过葡萄糖PTS和MalK的IIA蛋白质蛋白质之间的相互作用来控制麦芽糖同化的突变菌株。

公开(公告)号：US08497087B2

公开(公告)日：2013-07-30

申请号：US11275900

申请日：2006-02-02

申请人： Nobuharu Tsujimoto ,  Tomoko Suzuki ,  Hisao Ito

发明人： Nobuharu Tsujimoto ,  Tomoko Suzuki ,  Hisao Ito

IPC分类号： C12P1/00 ,  C12P13/04 ,  C12P13/22 ,  C12P13/08 ,  C12N1/21

CPC分类号： C07K14/245 ,  C12P13/04 ,  C12P13/08 ,  C12P13/222

摘要： A method for producing a target substance by utilizing a microorganism by culturing the microorganism in a medium to produce and accumulate the target substance in the medium and collecting the target substance from the culture is described. The microorganism is a mutant recombinant strain in which maltose assimilation is controlled by reducing or eliminating the interaction between IIAGlc protein of the glucose PTS and a protein involved in non-PTS uptake of maltose.

摘要翻译： 描述了通过在培养基中培养微生物来生产和积累目标物质并从培养物中收集目标物质的微生物生产目标物质的方法。 该微生物是通过减少或消除葡萄糖PTS的IIAGlc蛋白与参与非PTS摄取麦芽糖的蛋白质之间的相互作用来控制麦芽糖同化的突变重组菌株。

公开(公告)号：US20060205043A1

公开(公告)日：2006-09-14

申请号：US11275900

申请日：2006-02-02

申请人： Nobuharu Tsujimoto ,  Tomoko Suzuki ,  Hisao Ito

发明人： Nobuharu Tsujimoto ,  Tomoko Suzuki ,  Hisao Ito

IPC分类号： C12P13/04 ,  C12P13/22 ,  C12P13/08 ,  C12N1/21

CPC分类号： C07K14/245 ,  C12P13/04 ,  C12P13/08 ,  C12P13/222

摘要： A method for producing a target substance by utilizing a microorganism by culturing the microorganism in a medium to produce and accumulate the target substance in the medium and collecting the target substance from the culture is described. The microorganism is a mutant recombinant strain in which maltose assimilation is controlled by reducing or eliminating the interaction between IIAGlc protein of the glucose PTS and a protein involved in non-PTS uptake of maltose.

摘要翻译： 描述了通过在培养基中培养微生物来生产和积累目标物质并从培养物中收集目标物质的微生物生产目标物质的方法。 微生物是通过减少或消除葡萄糖PTS的IIA蛋白与参与非PTS摄取麦芽糖的蛋白质之间的相互作用来控制麦芽糖同化的突变重组菌株。

公开(公告)号：US20130052246A1

公开(公告)日：2013-02-28

申请号：US13696456

申请日：2010-08-12

申请人： Hisao Ito ,  Hideyuki Yamaki ,  Naoyuki Enomoto

发明人： Hisao Ito ,  Hideyuki Yamaki ,  Naoyuki Enomoto

IPC分类号： A61K8/19 ,  A61Q1/10 ,  A61K8/27 ,  A61Q1/06 ,  A61K8/29 ,  A61K8/02 ,  A61Q1/02

CPC分类号： A61K8/19 ,  A61K8/29 ,  A61K2800/412 ,  A61K2800/621 ,  A61K2800/623 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q1/10 ,  A61Q1/12

摘要： A cosmetic composition includes a boron nitride complex powder in which particles of metal oxide are attached to at least a part of the surface of a base material consisting of boron nitride. The metal oxide is preferably a combination of titanium dioxide, yellow iron oxide, red iron oxide and black iron oxide. Preferred compositions include liquid or powder foundation, lipstick, eye shadow, eye liner and mascara. The cosmetic composition including a cosmetic powder is capable of imparting smoothness to the touch, lively finish with fine texture and natural glow, and adhesion to the skin when applied to the skin.

摘要翻译： 化妆品组合物包括其中金属氧化物颗粒附着到由氮化硼组成的基材的表面的至少一部分上的氮化硼复合粉末。 金属氧化物优选为二氧化钛，黄色氧化铁，红色氧化铁和黑色氧化铁的组合。 优选的组合物包括液体或粉底，口红，眼影，眼线和睫毛膏。 包含化妆粉末的化妆品组合物能够赋予触感平滑感，以细纹理和自然发光而活泼地完成，以及当施用于皮肤时对皮肤的粘附。

公开(公告)号：US08278074B2

公开(公告)日：2012-10-02

申请号：US13047260

申请日：2011-03-14

申请人： Jun Nakamura ,  Seiko Hirano ,  Hisao Ito

发明人： Jun Nakamura ,  Seiko Hirano ,  Hisao Ito

IPC分类号： C12P13/14 ,  C12N1/20

CPC分类号： C12P13/14 ,  C07K14/34

摘要： A coryneform bacterium that is modified by using a yggB gene so that L-glutamic acid-producing ability is enhanced as compared to a non-modified strains is cultured in a medium to cause accumulation of L-glutamic acid in the medium or bacterial cells, and L-glutamic acid is collected from the medium or cells.

摘要翻译： 通过在培养基中培养通过使用yggB基因修饰的棒状细菌，使得与非修饰菌株相比增强L-谷氨酸生产能力，以在培养基或细菌细胞中引起L-谷氨酸的积累， 从培养基或细胞收集L-谷氨酸。

公开(公告)号：US08045765B2

公开(公告)日：2011-10-25

申请号：US11889999

申请日：2007-08-17

申请人： Kozo Baba ,  Hisao Ito ,  Akiyoshi Tafuku ,  Masatoshi Tohno ,  Taku Katagiri

发明人： Kozo Baba ,  Hisao Ito ,  Akiyoshi Tafuku ,  Masatoshi Tohno ,  Taku Katagiri

IPC分类号： G06K9/00

CPC分类号： G06K9/00248 ,  G06T7/74 ,  G06T2207/30201

摘要： For example, a plurality of elliptical candidate areas that become candidate areas of detecting objects are set in an image, characteristic values such as average values of luminance of the pixels inside and outside the set candidate areas are compared, and a candidate area whose difference of the characteristic values is determined to be the maximum is detected as the area of the detecting object. In addition, central moment of the detecting object is calculated, and the inclination of the detecting object in the image is detected based on the calculated central moment. Further, two specific points such as eyes of the driver included in the detecting object are detected, and the inclination of the detecting object in the image determined by the detected two points is detected.

摘要翻译： 例如，将成为检测对象的候补区域的多个椭圆候选区域设定为图像，比较设定候选区域内外的像素的亮度的平均值等特征值， 将特征值确定为最大值被检测为检测对象的区域。 此外，计算检测对象的中心矩，并且基于计算出的中心时刻来检测图像中的检测对象的倾斜度。 此外，检测包括在检测对象中的驱动器的眼睛的两个特定点，并且检测由检测到的两个点确定的图像中的检测对象的倾斜度。

公开(公告)号：US07991202B2

公开(公告)日：2011-08-02

申请号：US11889994

申请日：2007-08-17

申请人： Hisao Ito ,  Kozo Baba ,  Akiyoshi Tafuku ,  Masatoshi Tohno ,  Taku Katagiri

发明人： Hisao Ito ,  Kozo Baba ,  Akiyoshi Tafuku ,  Masatoshi Tohno ,  Taku Katagiri

IPC分类号： G06K9/00

CPC分类号： G06K9/00234 ,  G06T7/73 ,  G06T2207/30201

摘要： There are provided an image processing method, and an image processing system, an image processing device, and a computer program product capable of detecting a position of a fringe portion of a detecting object such as an outline of a face of a driver with high precision, even when a variation of illuminance occurs locally in a system using, for example, an on-vehicle camera mounted on a vehicle for imaging the face of the driver. Luminance of pixels arranged in a first direction such as a horizontal direction of an image is subjected to quadric differential, and data based on a quadratic differentiation result is accumulated in a second direction such as a vertical direction, and based on an accumulated result, a position in the first direction of the detecting object in the image is detected.

摘要翻译： 提供了一种图像处理方法，以及能够以高精度检测驾驶员的面部轮廓的检测对象的边缘部分的位置的图像处理系统，图像处理装置和计算机程序产品 即使在使用例如安装在车辆上的用于对驾驶员的脸进行成像的车载摄像机的系统中本发明的照度变化也是如此。 排列在图像的水平方向等第一方向上的像素的亮度经受二次微分，并且基于二次微分结果的数据在诸如垂直方向的第二方向上累积，并且基于累积结果， 检测图像中检测对象的第一方向的位置。

公开(公告)号：US07867735B2

公开(公告)日：2011-01-11

申请号：US12034101

申请日：2008-02-20

申请人： Seiko Hirano ,  Jun Nakamura ,  Hisao Ito

发明人： Seiko Hirano ,  Jun Nakamura ,  Hisao Ito

IPC分类号： C12P21/00 ,  C12N1/20

CPC分类号： C12P13/14 ,  C07K14/34

摘要： A method for producing L-glutamic acid by culturing a coryneform bacterium which has L-glutamic acid producing ability and which has been modified so that expression of the fasR gene is enhanced in a medium to produce and accumulate L-glutamic acid in the medium or cells, and collecting L-glutamic acid from the medium or cells.

摘要翻译： 通过培养具有L-谷氨酸生产能力的棒状细菌生产L-谷氨酸的方法，其已被修饰以使培养基中的fasR基因的表达增强以产生和积累L-谷氨酸，或者 细胞，并从培养基或细胞中收集L-谷氨酸。

公开(公告)号：US07785845B2

公开(公告)日：2010-08-31

申请号：US11844559

申请日：2007-08-24

申请人： Yoshihiko Hara ,  Hiroshi Izui ,  Hisao Ito

发明人： Yoshihiko Hara ,  Hiroshi Izui ,  Hisao Ito

IPC分类号： C12P13/14 ,  C12N1/20

CPC分类号： C12P13/14 ,  C07K14/34

摘要： L-Glutamic acid is produced by culturing a microorganism in which an expression of L-glutamic acid-export gene, a yhfK gene, is enhanced or overexpressed, in a medium to produce and cause accumulation of L-glutamic acid in the medium, and collecting L-glutamic acid from the medium.

摘要翻译： 通过培养在培养基中培养L-谷氨酸输出基因yhfK基因，yhfK基因的表达增强或过表达的微生物产生并引起培养基中L-谷氨酸的积累而产生L-谷氨酸，以及 从培养基中收集L-谷氨酸。

公开(公告)号：US20090263874A1

公开(公告)日：2009-10-22

申请号：US11624080

申请日：2007-01-17

申请人： Mika Moriya ,  Hiroshi Izui ,  Eiji Ono ,  Kazuhiko Matsui ,  Hisao Ito ,  Yoshihiko Hara

发明人： Mika Moriya ,  Hiroshi Izui ,  Eiji Ono ,  Kazuhiko Matsui ,  Hisao Ito ,  Yoshihiko Hara

IPC分类号： C12P13/14

CPC分类号： C12N9/0016 ,  C12N9/88 ,  C12P13/14 ,  C12R1/01 ,  C12R1/425 ,  Y10S435/822 ,  Y10S435/88

摘要： L-Glutamic acid is produced by culturing in a liquid culture medium a microorganism belonging to the genus Enterobacter or Serratia and having an ability to produce L-glutamic acid, which increases in an activity of enzyme catalyzing a reaction for L-glutamic acid biosynthesis or which decreases in or is deficient in an activity of an enzyme catalyzing a reaction branching from a pathway for L-glutamic acid biosynthesis and producing a compound other than L-glutamic acid, and collecting produced L-glutamic acid from the culture medium.

摘要翻译： L-谷氨酸通过在液体培养基中培养属于肠杆菌属或沙雷氏菌属的具有生产L-谷氨酸能力的微生物产生，其增加了催化L-谷氨酸生物合成的反应的酶的活性，或 其催化从L-谷氨酸生物合成途径分支的反应的酶的活性降低或缺乏，并产生除L-谷氨酸以外的化合物，并从培养基中收集L-谷氨酸。