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    TRAF family molecules, polynucleotides encoding them, and antibodies against them
    4.
    发明授权
    TRAF family molecules, polynucleotides encoding them, and antibodies against them 失效
    TRAF家族分子，编码它们的多核苷酸和针对它们的抗体

    公开(公告)号：US06426403B1

    公开(公告)日：2002-07-30

    申请号：US09138277

    申请日：1998-08-18

    申请人： Motomi Nakata ,  Hiroyasu Nakano ,  Hideo Yagita ,  Ko Okumura

    发明人： Motomi Nakata ,  Hiroyasu Nakano ,  Hideo Yagita ,  Ko Okumura

    IPC分类号： C07K1452

    CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K14/715 ,  C07K14/7151

    摘要： This invention relates to a TRAF family molecule, a polynucleotide encoding the molecules, an antibody against the molecules, and an antisense polynucleotide of the molecule. Employing an oligo-DNA primer capable of amplifying the most highly conserved region of a known TRAF family molecule, PCR was performed with the aid of cDNA derived from various cell strains and tissues as a template. Thus, the base sequence of the gene of an unknown TRAF family molecule and the amino acid sequence of the TRAF family molecule encoded by the gene were elucidated. An antibody against the molecule was also prepared. By utilizing the TRAF family molecules, genes thereof, and antibodies against the molecules, there are provided methods for elucidating the functions of the proteins and methods for elucidating the signal transduction system of the TNF-R family involving the molecules, as well as probes for research and diagosis, which suggest applications in therapeutic agents.

    摘要翻译： 本发明涉及TRAF家族分子，编码该分子的多核苷酸，针对该分子的抗体以及该分子的反义多核苷酸。 使用能够扩增已知TRAF家族分子的最高度保守区域的寡DNA引物，借助于源自各种细胞株和组织的cDNA作为模板进行PCR。 因此，阐明了未知TRAF家族分子的基因的碱基序列和由该基因编码的TRAF家族分子的氨基酸序列。 还制备了抗分子的抗体。 通过利用TRAF家族分子，其基因和针对分子的抗体，提供了阐明蛋白质功能的方法和阐明涉及分子的TNF-R家族的信号转导系统的方法，以及用于 研究和诊断，这表明在治疗药物中的应用。

    Humanized immunoglobulin reacting specifically with Fas ligand or active fragments thereof and region inducing apoptosis originating in Fas ligand
    5.
    发明授权
    Humanized immunoglobulin reacting specifically with Fas ligand or active fragments thereof and region inducing apoptosis originating in Fas ligand 有权
    与Fas配体或其活性片段特异性反应的人源化免疫球蛋白和诱导Fas配体凋亡的区域

    公开(公告)号：US06777540B1

    公开(公告)日：2004-08-17

    申请号：US09254180

    申请日：1999-04-15

    申请人： Ko Okumura ,  Motomi Nakata ,  Hirofumi Higuchi ,  Yoshitaka Ushio ,  Hiroaki Maeda ,  Yasuyuki Eda

    发明人： Ko Okumura ,  Motomi Nakata ,  Hirofumi Higuchi ,  Yoshitaka Ushio ,  Hiroaki Maeda ,  Yasuyuki Eda

    IPC分类号： C07K1600

    CPC分类号： C07K16/2875 ,  C07K14/70575 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2319/00

    摘要： Novel humanized immunoglobulins and active fragments thereof which are specifically reactive to Fas ligand are provided, and a site on Fas ligand which is important to inhibit apoptosis induced by the Fas-Fas ligand interaction against Fas-expressing cells is demonstrated. The novel humanized immunoglobulins and active fragments thereof which are specifically reactive to Fas ligand are prepared from hybridomas which produce monoclonal antibodies specifically reactive to Fas ligand, via recombinant DNA techniques. The humanized immunoglobulins can inhibit the physiological reactions between Fas ligand and Fas such as apoptosis. Further, identification of the site which is on Fas ligand and responsible for apoptosis induction allows creation of recombinant proteins or peptides which are specifically reactive to the amino acids within the site so as to inhibit apoptosis, and to find new therapeutic or diagnostic agents.

    摘要翻译： 提供了与Fas配体特异性反应的新型人源化免疫球蛋白及其活性片段，证明了Fas配体上对Fas-Fas配体与Fas表达细胞相互作用诱导的细胞凋亡重要的位点。 通过重组DNA技术从与Fas配体特异性反应的单克隆抗体的杂交瘤制备与Fas配体特异性反应的新型人源化免疫球蛋白及其活性片段。 人源化免疫球蛋白可以抑制Fas配体和Fas之间的生理反应，如细胞凋亡。 此外，鉴定在Fas配体上并负责细胞凋亡诱导的位点允许产生对位点内的氨基酸具有特异性反应性的重组蛋白质或肽，以便抑制细胞凋亡，并找到新的治疗剂或诊断剂。

    Drug for the treatment of rheumatoid arthritis
    6.
    发明授权
    Drug for the treatment of rheumatoid arthritis 失效
    用于治疗类风湿关节炎的药物

    公开(公告)号：US5855888A

    公开(公告)日：1999-01-05

    申请号：US727406

    申请日：1996-10-17

    申请人： Tadashi Nishida ,  Sachiko Miyake ,  Hideo Yagita ,  Ko Okumura

    发明人： Tadashi Nishida ,  Sachiko Miyake ,  Hideo Yagita ,  Ko Okumura

    IPC分类号： A61K38/00 ,  C07K16/28 ,  C12P21/08 ,  A61K39/395

    CPC分类号： C07K16/2845 ,  C07K16/2821 ,  C07K16/2839 ,  C07K16/2842 ,  C07K16/2875 ,  A61K38/00

    摘要： A drug for the treatment of rheumatoid arthritis, which comprises as an active ingredient a monoclonal antibody which recognizes specifically extracellular region of human VLA-2. Preferable drug for the treatment of rheumatoid arthritis comprises as an active ingredient a monoclonal antibody which recognizes specifically extracellular region of human VLA-2, .alpha. chain. The above drug for the treatment of rheumatoid arthritis can suppress swelling due to arthritis in rheumatoid arthritis with low toxicity and hence is useful for the treatment of rheumatoid arthritis.

    摘要翻译： PCT No.PCT / JP95 / 00527 Sec。 371日期1996年10月17日第 102（e）日期1996年10月17日PCT 1995年3月22日PCT公布。 第WO95 / 28961号公报 日期：1995年11月2日用于治疗类风湿性关节炎的药物，其包含识别人VLA-2特异性胞外区域的单克隆抗体作为活性成分。 用于治疗类风湿性关节炎的优选药物包括作为活性成分，其识别人VLA-2，α链的特异性细胞外区域的单克隆抗体。 用于治疗类风湿性关节炎的上述药物可以抑制由于类风湿性关节炎中的关节炎引起的低毒性的肿胀，因此可用于治疗类风湿性关节炎。