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    Pharmaceutical composition
    5.
    发明授权
    Pharmaceutical composition 失效
    药物组成

    公开(公告)号：US4983605A

    公开(公告)日：1991-01-08

    申请号：US110284

    申请日：1987-10-20

    申请人： Nobuo Kondo ,  Masahiro Kikuchi ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kazumasa Yokoyama ,  Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi

    发明人： Nobuo Kondo ,  Masahiro Kikuchi ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kazumasa Yokoyama ,  Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi

    IPC分类号： A61K9/14 ,  A61K9/19 ,  A61K31/44 ,  A61K31/50 ,  A61K31/505 ,  A61K47/14 ,  A61K47/26

    CPC分类号： A61K31/505 ,  A61K31/44 ,  A61K31/50 ,  A61K9/145 ,  A61K9/146 ,  A61K9/19 ,  A61K47/14 ,  A61K47/26 ,  Y10S514/961 ,  Y10S514/964

    摘要： A pharmaceutical composition comprising a benzoyl urea compound (A) selected from the group consisting of a benzoyl urea compound (I) having the formula: ##STR1## wherein X is a halogen atom, a nitro group or a trifluoromethyl group, provided that when Y is a nitro group, X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is a .dbd.CH-- group or a nitrogen atom, and a benzoyl urea compound (II) having the formula: ##STR2## wherein each of X.sub.1 and X.sub.2 is a hydrogen atom, a halogen atom or a nitro group, provided that when Y is a nitro group, X.sub.1 is a hydrogen atom, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, and Z is a hydrogen atom, a halogen atom or a trifluoromethyl group, as an active ingredient; a nonionic surfactant as a dispersant; and at least one member selected from the group consisting of a saccharide, a saccharide alcohol, silicic anhydride and a nonionic surfactant, as a disintegrator.

    摘要翻译： 提供一种药物组合物，其包含选自具有下式的苯甲酰脲化合物（I）的苯甲酰脲化合物（A）：其中X为卤素原子，硝基或三氟甲基，其提供 当Y为硝基时，X为卤原子或硝基，Y为氢原子，卤原子，硝基或三氟甲基，Z1为卤原子或三氟甲基，Z2为氢 原子或卤素原子，A为= CH-基或氮原子，和具有下式的苯甲酰脲化合物（II）：其中X1和X2各自为氢原子，卤素 原子或硝基，条件是当Y为硝基时，X 1为氢原子，Y为氢原子，卤素原子，硝基或三氟甲基，Z为氢原子，卤素原子或 三氟甲基作为活性成分; 作为分散剂的非离子表面活性剂; 和选自糖，糖醇，硅酸酐和非离子表面活性剂的至少一种作为崩解剂。

    N-benzoyl urea compounds, antitumorous compositions containing them
    8.
    发明授权
    N-benzoyl urea compounds, antitumorous compositions containing them 失效
    N-苯甲酰脲化合物，含有它们的抗肿瘤组合物

    公开(公告)号：US4863924A

    公开(公告)日：1989-09-05

    申请号：US939025

    申请日：1986-12-08

    申请人： Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi ,  Hiroshi Okada

    发明人： Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi ,  Hiroshi Okada

    IPC分类号： C07D213/64 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61K31/50 ,  A61K31/505 ,  A61P35/00 ,  C07D213/643 ,  C07D237/14 ,  C07D239/34

    CPC分类号： C07D213/643 ,  C07D237/14 ,  C07D239/34

    摘要： An N-benzoyl urea compound having the formula: ##STR1## wherein X is a hydrogen atom, a halogen atom or a nitro group, n is an integer of from 1 to 3, and Q is ##STR2## wherein Y.sub.1 is an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Y.sub.2 is a hydrogen atom, a halogen atom, a nitro group, an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Z is a hydrogen atom, a halogen atom, a trifluoromethyl group or a nitro group, and each of A and B is .dbd.CH-- or a nitrogen atom, provided that one of A and B is .dbd.CH-- and the other is a nitrogen atom, with the provisos (1) that when Q is ##STR3## where when X is a hydrogen atom and Y.sub.1 is an alkyl group, Z is not a hydrogen atom, a halogen atom nor a trifluoromethyl group, and (2) that when Q is ##STR4## wherein A is a nitrogen atom and Y.sub.1 is a trifluoromethyl group, Y.sub.2 is other than a hydrogen atom.

    摘要翻译： 具有下式的N-苯甲酰脲化合物：其中X是氢原子，卤素原子或硝基，n是1至3的整数，Q是＆lt; IMAGE＆gt; 其中Y1是未取代或取代的烷基，或其烷基部分被未取代或取代的烷氧基或烷氧基羰基，Y2是氢原子，卤素原子，硝基，未取代或取代的烷基或烷氧基 或其烷基部分为未取代或取代的烷氧基羰基，Z为氢原子，卤素原子，三氟甲基或硝基，A和B各自为= CH-或氮原子，条件是A和 B是= CH-，另一个是氮原子，条件是（1）当Q是 + TR 时，当X是氢原子且Y1是烷基时，Z是 不是氢原子，卤素原子或三氟甲基，和（2）当Q是氮时，其中A是氮原子，Y 1是三氟甲基 堆，Y2不是氢原子。

    N-benzoyl-N'-pyridazinyloxyphenyl urea compounds, and antitumorous compositions containing them, and process for their preparation
    9.
    发明授权
    N-benzoyl-N'-pyridazinyloxyphenyl urea compounds, and antitumorous compositions containing them, and process for their preparation 失效
    N-苯甲酰基-N'-哒嗪氧基苯基脲化合物和含有它们的抗肿瘤组合物及其制备方法

    公开(公告)号：US4845093A

    公开(公告)日：1989-07-04

    申请号：US111080

    申请日：1987-10-19

    申请人： Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi ,  hiroshi Okada

    发明人： Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi ,  hiroshi Okada

    IPC分类号： A61K31/50 ,  A61P35/00 ,  C07D237/14

    CPC分类号： C07D237/14 ,  A61K31/50

    摘要： An N-benzoyl-N'-pyridazinyloxyphenyl urea compound having the formula: ##STR1## wherein each of X.sub.1 and X.sub.2 is a hydrogen atom, a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom or a methyl group which may be substituted by fluorine, and Z is a hydrogen atom, a halogen atom or a trifluoromethyl group, provided that when X.sub.1 is a hydrogen atom and X.sub.2 is a hydrogen atom or a halogen atom, Y is a methyl group which may be substituted by fluorine and/or Z is a hydrogen atom or a trifluoromethyl group. The compound is useful as an active ingredient for an antitumorous composition.

    摘要翻译： 具有下式的N-苯甲酰基-N'-哒嗪氧基苯基脲化合物：其中X1和X2各自为氢原子，卤素原子或硝基，Y为氢原子，卤素原子或 可以被氟取代的甲基，Z是氢原子，卤素原子或三氟甲基，条件是当X1为氢原子，X2为氢原子或卤素原子时，Y为甲基， 可以被氟取代，和/或Z是氢原子或三氟甲基。 该化合物可用作抗肿瘤组合物的活性成分。