公开(公告)号：US20090048116A1

公开(公告)日：2009-02-19

申请号：US12162253

申请日：2007-01-26

申请人： Nobuyuki Miyajima ,  Akira Horinouchi ,  Kenji Takami ,  Ryota Ise

发明人： Nobuyuki Miyajima ,  Akira Horinouchi ,  Kenji Takami ,  Ryota Ise

IPC分类号： C40B30/00 ,  C40B40/08

CPC分类号： C12Q1/6876 ,  C07K14/47 ,  C12Q2600/158

摘要： The present invention provides a tool for analysis of expression of Macaca fascicularis gene.The present invention provides a Macaca fascicularis gene expression analysis tool containing a set of nucleic acids containing base sequences the same or substantially the same as two or more base sequences selected from the group consisting of the base sequences shown by SEQ ID NOs: 1-14, or partial sequences thereof, and a method of analyzing the expression of Macaca fascicularis gene, including measuring a gene transcription product in a Macaca fascicularis sample using the tool.

摘要翻译： 本发明提供了用于分析猕猴猕猴的基因表达的工具。 本发明提供了一种含有一组含有与SEQ ID NO：1-14所示的碱基序列相同或基本上相同的两个或多个碱基序列的碱基序列的核酸的猕猴属绦虫基因表达分析工具 或其部分序列，以及分析猕猴猕猴碱基因表达的方法，包括使用该工具测定猕猴属绦虫样品中的基因转录产物。

公开(公告)号：US08138123B2

公开(公告)日：2012-03-20

申请号：US12162253

申请日：2007-01-26

申请人： Nobuyuki Miyajima ,  Akira Horinouchi ,  Kenji Takami ,  Ryota Ise

发明人： Nobuyuki Miyajima ,  Akira Horinouchi ,  Kenji Takami ,  Ryota Ise

IPC分类号： C40B40/06 ,  C40B60/10 ,  C40B60/12 ,  C07H21/02

CPC分类号： C12Q1/6876 ,  C07K14/47 ,  C12Q2600/158

摘要： The present invention provides a tool for analysis of expression of Macaca fascicularis gene expression analysis tool containing a set of nucleic acids containing base sequences the same or substantially the same as two or more base sequences selected from the group consisting of the base sequences shown by SEQ ID NOs:1-14, or partial sequences thereof, and a method of analyzing the expression of Macaca fascicularis gene, including measuring a gene transcription product in a Macaca fascicularis sample using the tool.

摘要翻译： 本发明提供了一种用于分析猕猴猕猴基因表达分析工具的表达的工具，其包含一组核酸，所述核酸含有与两个或更多个碱基序列相同或基本上相同的碱基序列，所述碱基序列选自SEQ ID NO： ID NO：1-14或其部分序列，以及分析猕猴猕猴的基因表达的方法，包括使用该工具测定猕猴属绦虫样品中的基因转录产物。

公开(公告)号：US08535880B2

公开(公告)日：2013-09-17

申请号：US12447446

申请日：2007-10-26

申请人： Saku Miyamoto ,  Kenji Takami ,  Akira Horinouchi

发明人： Saku Miyamoto ,  Kenji Takami ,  Akira Horinouchi

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6876 ,  C12Q1/6881 ,  C12Q2600/158 ,  G06F19/20

摘要： The present invention provides a method of extracting an organ- or tissue-specific highly expressed gene, including: (1) a step for measuring expression level of a specified gene group for each organ or tissue in 2 or more individuals, (2) a step for acquiring (a) a minimum value of expression levels in a particular organ or tissue in all individuals, and (b) a maximum value of expression levels in other organs and tissues in all individuals, for each gene, and (3) a step for extracting the gene as a gene highly expressed specifically in the particular organ or tissue if the above-described (a)/(b) ratio is larger than 1. By the present invention, truly organ- or tissue-specific genes are extracted.

公开(公告)号：US20090311701A1

公开(公告)日：2009-12-17

申请号：US12447446

申请日：2007-10-26

申请人： Saku Miyamoto ,  Kenji Takami ,  Akira Horinouchi

发明人： Saku Miyamoto ,  Kenji Takami ,  Akira Horinouchi

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6876 ,  C12Q1/6881 ,  C12Q2600/158 ,  G06F19/20

摘要： The present invention provides a method of extracting an organ- or tissue-specific highly expressed gene, including:(1) a step for measuring expression level of a specified gene group for each organ or tissue in 2 or more individuals, (2) a step for acquiring (a) a minimum value of expression levels in a particular organ or tissue in all individuals, and (b) a maximum value of expression levels in other organs and tissues in all individuals, for each gene, and (3) a step for extracting the gene as a gene highly expressed specifically in the particular organ or tissue if the above-described (a)/(b) ratio is larger than 1. By the present invention, truly organ- or tissue-specific genes are extracted.

摘要翻译： 本发明提供一种提取器官或组织特异性高表达基因的方法，包括：（1）测定2个以上个体中各器官或组织的特定基因组的表达水平的步骤，（2） 获得（a）所有个体的特定器官或组织中表达水平的最小值的步骤，和（b）每个基因的所有个体的其他器官和组织中的表达水平的最大值，和（3）a 如果上述（a）/（b）比大于1，则将该基因提取为特异性高度表达于特定器官或组织的基因的步骤。通过本发明，提取真正的器官或组织特异性基因 。

公开(公告)号：US07399638B2

公开(公告)日：2008-07-15

申请号：US10584366

申请日：2004-12-24

申请人： Akira Horinouchi ,  Ikuo Mori ,  Mika Murabayashi

发明人： Akira Horinouchi ,  Ikuo Mori ,  Mika Murabayashi

IPC分类号： G01N33/92 ,  G01N33/48

CPC分类号： G01N33/92 ,  G01N33/5038 ,  G01N2800/044

摘要： The present invention provides a prediction method for lipidosis caused by a compound, which includes detecting (a) phenylacetylglycine and/or phenylacetylglutamine, or an optionally chosen metabolic intermediate in the metabolic pathway from phenylalanine to phenylacetylglycine or phenylacetylglutamine, and (b) hippuric acid or an optionally chosen metabolic intermediate in the metabolic pathway from phenylalanine to hippuric acid, in a sample collected from a mammal receiving the compound or a mammalian cell or tissue culture exposed to the compound, and predicting the compound's potential for inducing lipidosis with the quantitative ratio of the two as the index. The present invention also provides a diagnostic method for lipidosis and diseases related thereto, including detecting (a) and (b) above in a sample collected from a mammal, and making a diagnosis with the quantitative ratio of the two as the index.

摘要翻译： 本发明提供了一种由化合物引起的脂质沉积的预测方法，其包括检测（a）苯乙酰甘氨酸和/或苯乙酰谷氨酰胺或代谢途径中任选选择的代谢中间体，所述代谢途径由苯丙氨酸至苯乙酰甘氨酸或苯乙酰谷氨酰胺，以及（b）马尿酸或 在从接受化合物的哺乳动物或哺乳动物细胞或暴露于该化合物的组织培养物收集的样品中的从苯丙氨酸到马尿酸的代谢途径中的任选选择的代谢中间体，并且以化合物的定量比例预测化合物诱导脂质沉积的潜力 两者为指标。 本发明还提供了一种用于脂质沉积及其相关疾病的诊断方法，包括从哺乳动物收集的样品中检测（a）和（b），并以两者的定量比作为指标进行诊断。

公开(公告)号：US20070166829A1

公开(公告)日：2007-07-19

申请号：US10584366

申请日：2004-12-24

申请人： Akira Horinouchi ,  Ikuo Mori ,  Mika Murabayashi

发明人： Akira Horinouchi ,  Ikuo Mori ,  Mika Murabayashi

IPC分类号： G01N33/00

CPC分类号： G01N33/92 ,  G01N33/5038 ,  G01N2800/044

摘要： The present invention provides a prediction method for lipidosis caused by a compound, which comprises detecting (a) phenylacetylglycine and/or phenylacetylglutamine, or an optionally chosen metabolic intermediate in the metabolic pathway from phenylalanine to phenylacetylglycine or phenylacetylglutamine, and (b) hippuric acid or an optionally chosen metabolic intermediate in the metabolic pathway from phenylalanine to hippuric acid, in a sample collected from a mammal receiving the compound or a mammalian cell or tissue culture exposed to the compound, and predicting the compound's potential for inducing lipidosis with the quantitative ratio of the two as the index. The present invention also provides a diagnostic method for lipidosis and diseases related thereto, comprising detecting (a) and (b) above in a sample collected from a mammal, and making a diagnosis with the quantitative ratio of the two as the index.

摘要翻译： 本发明提供了一种由化合物引起的脂质沉积的预测方法，其包括检测（a）苯乙酰甘氨酸和/或苯乙酰谷氨酰胺或代谢途径中从苯丙氨酸至苯乙酰甘氨酸或苯乙酰谷氨酰胺的任选选择的代谢中间体，和（b）马尿酸或 在从接受化合物的哺乳动物或哺乳动物细胞或暴露于该化合物的组织培养物收集的样品中的从苯丙氨酸到马尿酸的代谢途径中的任选选择的代谢中间体，并且以化合物的定量比例预测化合物诱导脂质沉积的潜力 两者为指标。 本发明还提供了一种脂质沉积及其相关疾病的诊断方法，其特征在于，在从哺乳动物收集的样本中检测上述（a）和（b），并以两者的定量比作为指标进行诊断。