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    Method for reducing hook effect in an immunoassay
    4.
    发明授权
    Method for reducing hook effect in an immunoassay 失效
    在免疫测定中减少钩效应的方法

    公开(公告)号：US06184042B2

    公开(公告)日：2001-02-06

    申请号：US08862062

    申请日：1997-05-22

    申请人： Ulrich Neumann ,  Helmut Lenz ,  Norbert Franken

    发明人： Ulrich Neumann ,  Helmut Lenz ,  Norbert Franken

    IPC分类号： G01N33543

    CPC分类号： C07K16/26 ,  G01N33/6857 ,  G01N33/76 ,  Y10S435/962

    摘要： In order to extend the measuring range and to reduce the Hook effect in an immunological method of determination of an antigen based on the principle of a sandwich assay it is preferable to use a method which is characterized in that the labelled detection molecule is an oligomer of a binding molecule selected from antibody or/and antibody fragment.

    摘要翻译： 为了延长测量范围，并且基于夹心测定原理，在抗原测定的免疫学方法中降低Hook效应，优选使用其特征在于标记的检测分子是 选自抗体或/和抗体片段的结合分子。

    Quantification schemes for quantifying nucleic acids
    5.
    发明授权
    Quantification schemes for quantifying nucleic acids 有权
    定量核酸定量方案

    公开(公告)号：US07920971B2

    公开(公告)日：2011-04-05

    申请号：US10571958

    申请日：2004-09-24

    申请人： Reiner Babiel ,  Norbert Franken ,  Hermann Leying ,  Judith Pinsl-Ober ,  Thomas Vess ,  Guenter Ziegler

    发明人： Reiner Babiel ,  Norbert Franken ,  Hermann Leying ,  Judith Pinsl-Ober ,  Thomas Vess ,  Guenter Ziegler

    IPC分类号： G01N33/48

    CPC分类号： C12Q1/6851 ,  C12Q2537/165

    摘要： Method and apparatus, including computer program products, implement techniques for quantifying a target nucleic acid (target) in a test sample. The techniques include providing a target and a defined initial amount of an internal control nucleic acid (control) different from the target; amplifying the target and control in a common amplification process; measuring a quantity indicating the amount of amplification product for the target and for the control in relation to a parameter representing the progress of the amplification; determining a characteristic value of the progress parameter for the target based on measurement results related to the amount of target amplification product; possibly determining a characteristic value of the progress parameter for the control based on measurement results related to the amount of control amplification product; and quantifying the original amount of target according to a predefined or selected quantification scheme using at least the characteristic value for the target.

    摘要翻译： 方法和装置，包括计算机程序产品，实现了在测试样品中定量目标核酸（靶标）的技术。 所述技术包括提供目标和定义的初始量的不同于目标的内部对照核酸（对照）; 在常见的扩增过程中放大靶和控制; 相对于表示放大进度的参数，测量指示靶的扩增产物量和对于控制的量的量; 基于与目标扩增产物量相关的测量结果，确定目标进度参数的特征值; 可能基于与控制扩增产物量相关的测量结果确定控制进度参数的特征值; 以及使用至少目标的特征值，根据预定义或选择的量化方案量化目标的原始量。

    Quantification schemes for quantifying nucleic acids
    6.
    发明申请
    Quantification schemes for quantifying nucleic acids 失效
    定量核酸定量方案

    公开(公告)号：US20060292571A1

    公开(公告)日：2006-12-28

    申请号：US10571958

    申请日：2004-09-14

    申请人： Reiner Babiel ,  Norbert Franken ,  Hermann Leying ,  Judith Pinsl-Ober ,  Thomas Vess ,  Guenter Ziegler

    发明人： Reiner Babiel ,  Norbert Franken ,  Hermann Leying ,  Judith Pinsl-Ober ,  Thomas Vess ,  Guenter Ziegler

    IPC分类号： C12Q1/68 ,  G06F19/00 ,  C12P19/34

    CPC分类号： C12Q1/6851 ,  C12Q2537/165

    摘要： Method and apparatus, including computer program products, implement techniques for quantifying a target nucleic acid (target) in a test sample. The techniques include providing a target and a defined initial amount of an internal control nucleic acid (control) different from the target; amplifying the target and control in a common amplification process; measuring a quantity indicating the amount of amplification product for the target and for the control in relation to a parameter representing the progress of the amplification; determining a characteristic value of the progress parameter for the target based on measurement results related to the amount of target amplification product; possibly determining a characteristic value of the progress parameter for the control based on measurement results related to the amount of control amplification product; and quantifying the original amount of target according to a predefined or selected quantification scheme using at least the characteristic value for the target.

    摘要翻译： 方法和装置，包括计算机程序产品，实现了在测试样品中定量目标核酸（靶标）的技术。 所述技术包括提供目标和定义的初始量的不同于目标的内部对照核酸（对照）; 在常见的扩增过程中放大靶和控制; 相对于表示放大进度的参数，测量指示靶的扩增产物量和对于控制的量的量; 基于与目标扩增产物量相关的测量结果，确定目标进度参数的特征值; 可能基于与控制扩增产物量相关的测量结果确定控制进度参数的特征值; 以及使用至少所述目标的特征值，根据预定义或选择的量化方案量化原始目标量。