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8 条记录 (耗时 0.012 秒)

    Antigen-specific IgM detection
    1.
    发明授权
    Antigen-specific IgM detection 有权
    抗原特异性IgM检测

    公开(公告)号：US06489129B1

    公开(公告)日：2002-12-03

    申请号：US09319084

    申请日：1999-11-15

    申请人： Elke Faatz ,  Urban Schmitt ,  Beatus Ofenloch-Hahnle

    发明人： Elke Faatz ,  Urban Schmitt ,  Beatus Ofenloch-Hahnle

    IPC分类号： G01N3353

    CPC分类号： G01N33/6854 ,  G01N33/56988 ,  Y10S435/962 ,  Y10S436/825

    摘要： The invention concerns a method for the determination of antigen-specific antibodies of the immunoglobulin M class in the presence of immunoglobulins of the G class and/or rheumatoid factors in body fluids by incubation with at least two different receptors R1 and R2 and optionally additional receptors wherein an essential component of R2 is a binding partner in a polymeric form and interference by IgG antibodies of the same antigen specificity is reduced by binding partners in a monomeric form; a reagent for determining an antigen-specific antibody of the immunoglobulin M class, as well as the use of binding partners in a monomeric form to reduce interference by IgG antibodies in the determination of antigen-specific IgM antibodies.

    摘要翻译： 本发明涉及通过与至少两种不同的受体R1和R2以及任选的另外的受体一起温育来测定在体液中G类和/或类风湿因子的免疫球蛋白存在下免疫球蛋白M级的抗原特异性抗体的方法 其中R2的必需组分是聚合形式的结合伴侣，并且具有相同抗原特异性的IgG抗体的干扰通过单体形式的结合配偶体降低; 用于测定免疫球蛋白M类的抗原特异性抗体的试剂，以及以单体形式的结合伴侣的用途，以减少IgG抗体在抗原特异性IgM抗体测定中的干扰。

    Ligand trap useful in immunoassays of biotin or free biotin containing samples and improved immunoassays using these ligand traps
    8.
    发明授权
    Ligand trap useful in immunoassays of biotin or free biotin containing samples and improved immunoassays using these ligand traps 失效
    LIGAND TRAP有用的免疫力免疫生物素或免费生物素样品和改进的免疫力使用这些配对TRAPS

    公开(公告)号：US5212063A

    公开(公告)日：1993-05-18

    申请号：US521121

    申请日：1990-05-09

    申请人： Beatus Ofenloch-Hahnle ,  Michael Berger ,  Arno Deger

    发明人： Beatus Ofenloch-Hahnle ,  Michael Berger ,  Arno Deger

    IPC分类号： G01N33/531 ,  G01N33/538 ,  G01N33/543 ,  G01N33/544 ,  G01N33/546 ,  G01N33/548 ,  G01N33/573

    CPC分类号： G01N33/54306 ,  G01N33/538 ,  G01N33/54313 ,  G01N33/54393 ,  Y10S435/962 ,  Y10T436/25125

    摘要： The present invention provides a process for the detection of analytes in body fluids containing free biotin by immunoassay with the use of biotin conjugates for the labelling, immobilization or complexing of immunological reagents, wherein the biotin present in free form is removed from the immunological reaction by incubating the sample solution with polymer particles consisting of a core and a covering which, as core, contain a polymer which has a plurality of binding sites for biotin and, as covering, at least one layer of protein, peptide, carbohydrate or co-polymer of carbohydrate and amino acids, the layer thickness of the covering being so adjusted that the coating is permeable for the free biotin but not for the biotin conjugate.

    摘要翻译： 本发明提供了一种通过免疫测定法检测含有游离生物素的体液中的分析物的方法，其中使用生物素偶联物进行免疫试剂的标记，固定或络合，其中以游离形式存在的生物素通过免疫反应从免疫反应中除去 将样品溶液与由核心和覆盖物组成的聚合物颗粒孵育，所述聚合物颗粒作为核心，其包含聚合物，所述聚合物具有多个用于生物素的结合位点，并且覆盖至少一层蛋白质，肽，碳水化合物或共聚物 的碳水化合物和氨基酸，覆盖层的层厚度被调节，使得涂层对于游离生物素是可渗透的，而不是生物素缀合物。