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    LONG ACTING BETA-2-AGONISTS AND THEIR USE AS MEDICAMENTS
    5.
    发明申请
    LONG ACTING BETA-2-AGONISTS AND THEIR USE AS MEDICAMENTS 有权

    公开(公告)号：US20080194550A1

    公开(公告)日：2008-08-14

    申请号：US12101462

    申请日：2008-04-11

    申请人： Thierry BOUYSSOU ,  Ingo KONETZKI ,  Philipp LUSTENBERGER ,  Juergen MACK ,  Andreas SCHNAPP ,  Dieter WIEDENMAYER ,  Christoph HOENKE ,  Klaus RUDOLF

    发明人： Thierry BOUYSSOU ,  Ingo KONETZKI ,  Philipp LUSTENBERGER ,  Juergen MACK ,  Andreas SCHNAPP ,  Dieter WIEDENMAYER ,  Christoph HOENKE ,  Klaus RUDOLF

    IPC分类号： A61K31/5415 ,  A61P11/00

    CPC分类号： C07D265/36 ,  C07D413/12

    摘要： A compound of formula 1′ wherein: V is —CH2—, —NH—, or —O—; Ra and Rb are each independently hydrogen, C1-4-alkyl, or halogen-C1-4-alkyl, or Ra and Rb together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R1 and R1′ are each independently hydrogen, C1-6-alkyl, C3-6-cycloalkyl, halogen-C1-6-alkyl, halogen-C3-6-cycloalkyl, or C1-6-alkylene-C3-6-cycloalkyl, or R1 and R1′ together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R2, R2′, R2″, and R2′″ are each independently hydrogen, C1-6-alkyl, halogen-C1-6-alkylene, OH, HO—C1-6-alkylene, —O—C1-6-alkyl, C6-10-aryl, C6-10-aryl-C1-4-alkylene, C6-10-aryl-C1-6-alkylene-O, COOH, COOC1-6-alkyl, O—C1-6-alkylene-COOH, O—C1-6-alkylene-COOC1-6-alkyl, NHSO2—C1-6-alkyl, CN, NH2, NH—C1-6-alkyl, N(C1-6-alkyl)2, NO2, S—C1-6-alkyl, SO2—C1-6-alkyl, SO—C1-6-alkyl, O(CO)C1-6-alkyl, COC1-6-alkyl, NHCOC1-6-alkyl, or halogen; and n is 0, 1, or 2, or an optical isomer thereof, or a corresponding acid addition salt thereof with a pharmacologically acceptable acid, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.