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9 条记录 (耗时 0.066 秒)

    System and method for stimulation and/or enhancement of myocardial angiogenesis
    3.
    发明授权
    System and method for stimulation and/or enhancement of myocardial angiogenesis 失效
    用于刺激和/或增强心肌血管发生的系统和方法

    公开(公告)号：US06755821B1

    公开(公告)日：2004-06-29

    申请号：US09457490

    申请日：1999-12-08

    申请人： Stephen M. Fry

    发明人： Stephen M. Fry

    IPC分类号： A61B1900

    CPC分类号： A61N7/00 ,  A61B17/22022 ,  A61B18/26 ,  A61B2017/00247 ,  A61B2018/00392

    摘要： Shock-waves are applied using a combination lithotripsy probe/balloon system, comprising a needle and cannular balloon which can be inserted through the skin at a point between the ribs into the cavity beneath the chest wall and overlying the heart. Alternatively, the shock-wave can be administered extracorporally or via a catheter. A fluid injector is connected to the balloon, allowing it to be inflated with saline or other appropriate fluid to fill the space (for transmission of shock waves and/or to displace tissue—such as lung) and contact the surface of the heart. A shock-wave (acoustic) generator is used to generate shock-waves through the lithotripsy probe, through the fluid and into the myocardial tissue. The fluid provides a uniform medium for transmission of the acoustic energy, allowing precise focus and direction of the shock-wave to induce repeatable cavitation events, producing small fissures which are created by the cavitation bubbles. In this case, channels would not be ‘drilled’ into the heart muscle, minimizing trauma to the tissue while still creating conditions that will stimulate increased expression of angiogenic growth factors.

    摘要翻译： 使用组合碎石探针/气囊系统施加冲击波，其包括针和球囊，其可以在肋之间的点处插入通过皮肤进入胸壁下方的空腔并且覆盖心脏。 或者，冲击波可以在体外或通过导管施用。 流体注射器连接到球囊，允许其用盐水或其他适当的流体充气以填充空间（用于传递冲击波和/或置换组织，例如肺）并接触心脏的表面。 使用冲击波（声学）发生器通过碎石探针，通过流体并进入心肌组织产生冲击波。 流体提供用于传播声能的均匀介质，允许冲击波的精确聚焦和方向引起可重复的空化事件，产生由空化气泡产生的小裂缝。 在这种情况下，通道不会被“钻入心脏肌肉”，从而最小化对组织的创伤，同时仍然产生刺激血管生成生长因子表达增加的条件。

    Multi-line ammonia laser utilizing intra-molecular energy transfer via a buffer gas
    4.
    发明授权
    Multi-line ammonia laser utilizing intra-molecular energy transfer via a buffer gas 失效
    利用通过缓冲气体进行分子内能量转移的多线氨激光

    公开(公告)号：US4196403A

    公开(公告)日：1980-04-01

    申请号：US826788

    申请日：1977-08-22

    申请人： Stephen M. Fry

    发明人： Stephen M. Fry

    IPC分类号： H01S3/223 ,  H01S3/00

    CPC分类号： H01S3/223

    摘要： The disclosed laser employs a working gas comprising ammonia and a buffer gas which is chemically non-reactive with ammonia. A pumping laser beam at a wavelength of 9.2 .mu.m, provided by a carbon dioxide laser tuner to the R(30) transition of the 001-020 band, irradiates the working gas to excite ammonia molecules from the symmetric ground state to the anti-symmetric .nu..sub.2 =1 vibrational manifold. Collisions with buffer gas molecules cause the excited ammonia molecules to undergo intra-molecular energy transfer to a plurality of energy levels in the symmetric .nu..sub.2 =1 vibrational manifold. Laser oscillation is achieved simultaneously on a plurality of .nu..sub.2 =1 to ground transitions in the wavelength range extending from about 9.3 .mu.m to about 13.8 .mu.m.

    摘要翻译： 所公开的激光器使用包含氨和与氨无化学反应的缓冲气体的工作气体。 由二氧化碳激光调谐器向001-020波段的R（30）跃迁提供的波长为9.2μm的泵浦激光束照射工作气体，以将氨分子从对称基态激发到抗 - 对称nu 2 = 1振动歧管。 与缓冲气体分子的碰撞导致激发的氨分子在对称的nu 2 = 1振动歧管中经受分子内能量转移到多个能级。 在从约9.3μm至约13.8μm的波长范围内的多个nu 2 = 1至接地跃迁上同时实现激光振荡。

    Method of controlling laser energy removal of plaque to prevent vessel wall damage
    5.
    发明授权
    Method of controlling laser energy removal of plaque to prevent vessel wall damage 失效
    控制斑块激光能量去除以防止血管壁损伤的方法

    公开(公告)号：US4791926A

    公开(公告)日：1988-12-20

    申请号：US119167

    申请日：1987-11-10

    申请人： Stephen M. Fry

    发明人： Stephen M. Fry

    IPC分类号： A61B18/20 ,  A61B18/24 ,  A61B17/36

    CPC分类号： A61B18/20 ,  A61B18/245 ,  A61B2018/00636

    摘要： A method of controlling laser energy removal of plaque or other obstructions from a vessel of the cardiovascular system includes advancing a laser delivery catheter to a position in proximity with a targeted lesion, placing a laser energy sensor device in a monitoring position adapted to sense laser energy from the catheter that passes beyond the lesion, and controlling the laser energy according to the output of the sensor. An intraoperative approach places the sensor external to the vessel, while a percutaneous approach places the sensor within the vessel utilizing an additional sensor fiber on the catheter that extends beyond the lesion to the monitoring position. Each fiber in a multifiber laser delivery bundle may be controlled according to sensor output for precision aiming and improved laser control.

    摘要翻译： 控制从心血管系统的容器移除斑块或其他障碍物的激光能量消除的方法包括将激光输送导管推进到与目标病变附近的位置，将激光能量传感器装置放置在适于感测激光能量的监视位置 从导管穿过病变，并根据传感器的输出控制激光能量。 手术中的方法将传感器放置在血管外部，而经皮方法将传感器放置在血管内，利用导管上的额外的传感器纤维延伸超过病变至监测位置。 可以根据传感器输出来控制多光纤激光传输束中的每个光纤，以实现精确瞄准和改进的激光控制。

    Ammonia laser with simultaneous transitions from substrates of different K-values
    6.
    发明授权
    Ammonia laser with simultaneous transitions from substrates of different K-values 失效
    氨激光器同时从不同K值的衬底转变

    公开(公告)号：US4322693A

    公开(公告)日：1982-03-30

    申请号：US826787

    申请日：1977-08-22

    申请人： Stephen M. Fry

    发明人： Stephen M. Fry

    IPC分类号： H01S3/094 ,  H01S3/223

    CPC分类号： H01S3/094 ,  H01S3/223

    摘要： A multi-line NH.sub.3 laser is disclosed pumped by a multi-longitudinal mode and multi-transverse mode laser beam from a high-pressure CO.sub.2 laser operating on the R(30) 9.2 .mu.m transition. The resulting comb of pumping wavelengths simultaneously pumps several close-lying sR(5,K) transitions in ammonia from the symmetric ground state to the antisymmetric .nu..sub.2 =1 state, providing simultaneous lasing on a plurality of sP(7,K) transitions of different K-values. A plurality of sP(5,K) ammonia laser lines originating in the .nu..sub.2 =1 antisymmetric band and terminating in the depleted lower pump levels are also generated.

    摘要翻译： 公开了一种多线NH3激光器，其通过在R（30）9.2μm过渡上操作的高压CO 2激光器的多纵模和多横模激光束来泵浦。 所产生的泵浦波长的梳状物同时将氨中的几个靠近的sR（5，K）跃迁从对称基态转换成反对称nu 2 = 1状态，在多个sP（7，K）跃迁上提供同时激光 不同的K值。 还产生了源于nu 2 = 1反对称带并终止于耗尽的较低泵水平的多个sP（5，K）氨激光线。

    Device for adjusting laser system pulse forming network voltage on replacement of power supply or receiver transmitter unit
    7.
    发明授权
    Device for adjusting laser system pulse forming network voltage on replacement of power supply or receiver transmitter unit 失效
    用于在更换电源或接收器发射器单元时调整激光系统脉冲形成网络电压的装置

    公开(公告)号：US3986117A

    公开(公告)日：1976-10-12

    申请号：US631797

    申请日：1975-11-13

    申请人： Stephen M. Fry ,  Himeo B. Masuda

    发明人： Stephen M. Fry ,  Himeo B. Masuda

    IPC分类号： G01R19/165 ,  G01S7/40 ,  G01R19/16

    CPC分类号： G01R19/1659 ,  G01S7/4008

    摘要： A test device is used in combination with two selectable resistors to indte when the pulse forming network voltage of a tank laser range finder system is properly adjusted. The test device utilizes a precision temperature compensated current source, an operational amplifier, and a comparator and a lamp driver circuit, electrically coupled intermediate a pulse forming network power supply and a receiver transmitter unit, to indicate overvoltage, undervoltage and null conditions.

    摘要翻译： 测试装置与两个可选择的电阻组合使用，以指示罐式激光测距仪系统的脉冲形成网络电压何时被适当调整。 测试装置利用精密温度补偿电流源，运算放大器以及比较器和灯驱动器电路，电耦合中间脉冲形成网络电源和接收器发射器单元，以指示过电压，欠压和空值条件。

    Vascular image co-registration
    8.
    发明授权
    Vascular image co-registration 有权
    血管图像共同注册

    公开(公告)号：US07930014B2

    公开(公告)日：2011-04-19

    申请号：US11329609

    申请日：2006-01-11

    申请人： R. Scott Huennekens ,  Stephen M. Fry ,  Blair D. Walker ,  Jon D. Klingensmith ,  Nancy Perry Pool ,  Vincent J. Burgess ,  William R. Kanz

    发明人： R. Scott Huennekens ,  Stephen M. Fry ,  Blair D. Walker ,  Jon D. Klingensmith ,  Nancy Perry Pool ,  Vincent J. Burgess ,  William R. Kanz

    IPC分类号： A61B5/05

    CPC分类号： A61B5/06 ,  A61B5/0215 ,  A61B6/12 ,  A61B6/4441 ,  A61B6/4494 ,  A61B6/463 ,  A61B6/487 ,  A61B6/504 ,  A61B6/5247 ,  A61B8/12 ,  A61B8/4494 ,  A61B8/463 ,  A61B8/543

    摘要： A system and method for providing a vascular image are disclosed wherein a single composite display simultaneously provides a first view of a patient including an angiogram image and a second view including an intravascular image rendered from information provided by an imaging probe mounted on a distal end of a flexible elongate member. A cursor, having a position derived from image information provided by a radiopaque marker proximate the imaging probe, is displayed within the angiogram image to correlate the position of the imaging probe to a presently displayed intravascular image and thus provide an easily discernable identification of a position within a patient corresponding to a currently displayed intravascular image. The resulting composite display simultaneously provides: an intravascular image that includes information about a vessel that is not available from an angiogram and a current location within a vessel of a source of intravascular image data from which the intravascular image is rendered.

    摘要翻译： 公开了一种用于提供血管图像的系统和方法，其中单个复合显示器同时提供包括血管造影图像的患者的第一视图和第二视图，所述第二视图包括由安装在所述血管图像的远端上的成像探针提供的信息所呈现的血管内图像 柔性细长构件。 具有从靠近成像探针的不透射线标记提供的图像信息导出的位置的光标显示在血管造影图像内，以将成像探针的位置与当前显示的血管内图像相关联，并且因此提供容易辨别的位置识别 在对应于当前显示的血管内图像的患者内。 所得到的复合显示器同时提供：血管内图像，其包括关于从血管造影图不可用的血管的信息和血管内图像来源的血管内图像数据来源的血管内的当前位置。

    Mode locked laser range finder
    9.
    发明授权
    Mode locked laser range finder 失效
    模式锁定激光测距仪

    公开(公告)号：US4097148A

    公开(公告)日：1978-06-27

    申请号：US744531

    申请日：1976-11-24

    申请人： Stephen M. Fry

    发明人： Stephen M. Fry

    IPC分类号： G01S17/10 ,  G01C3/08 ,  G01P3/36

    CPC分类号： G01S17/105

    摘要： A laser range finder utilizing a mode locked laser for measuring target range with a high degree of accuracy and simplicity by measuring the time of flight of a transmitted pulse utilizing the pulses in the laser cavity for clocking a range counter. The laser consists of mirrors with at least one being semi-reflective, an amplifying medium and a suitable method of mode locking. A switch is provided outside of the cavity for transmitting a gated train of ultra short pulses or a single pulse to a target. The return signal is processed, detected and sent to an electronic circuit which uses the detected signal to stop a counter at the proper range count. The pulses inside the cavity are detected after they pass through one of the mirrors to provide the range counting pulses as well as to energize the switch outside of the cavity at the proper switching time. Thus, the laser ranger in accordance with the invention does not require a separate oscillator and utilizes the oscillating pulse in the laser cavity to perform that function and provide extremely high range resolution.

    摘要翻译： 一种激光测距仪，利用模式锁定激光器以高精度和简单的方式测量目标范围，通过利用激光腔中的脉冲测量发射脉冲的时间来计时范围计数器。 激光由具有至少一个半反射镜，放大介质和适合的模式锁定方法的镜子组成。 在腔外设置有一个开关，用于将超短脉冲或单个脉冲的门控发送到目标。 返回信号被处理，检测并发送到使用检测信号的电子电路以适当的范围计数停止计数器。 腔内的脉冲在它们通过一个反射镜之后被检测以提供范围计数脉冲，并且在恰当的切换时间对腔的外部通电。 因此，根据本发明的激光测距仪不需要单独的振荡器并且利用激光腔中的振荡脉冲来执行该功能并提供极高的分辨率。