公开(公告)号：US08784867B2

公开(公告)日：2014-07-22

申请号：US13716496

申请日：2012-12-17

Applicant: Novartis AG

Inventor： Newton T. Samuel ,  Nirupama Kenkare ,  Peter D. Lackey ,  Jessie Chen

IPC: A61K9/00 ,  G02B1/04 ,  A61K31/355 ,  C07C403/24 ,  A61F9/00 ,  C09B61/00

CPC classification number: A61K9/0051 ,  A61F9/0017 ,  A61K31/355 ,  C07C403/24 ,  C09B61/00 ,  G02B1/043

Abstract: The instant invention pertains to a method for producing contact lenses with improved oxidative stability of Carotenoids in the contact lens. The method of the invention involves adding a vitamin E material into a contact lens in an amount sufficient to reduce oxidative degradation of Carotenoids in the lens by at least about 30% in comparison with an identical contact lens without the vitamin E material.

Abstract translation: 本发明涉及一种具有改善隐形眼镜中类胡萝卜素的氧化稳定性的隐形眼镜的方法。 本发明的方法涉及将隐形眼镜中的维生素E添加到相对于没有维生素E材料的相同隐形眼镜相比，其量足以减少透镜中类胡萝卜素的氧化降解至少约30％。

公开(公告)号：US09261626B2

公开(公告)日：2016-02-16

申请号：US13706737

申请日：2012-12-06

Applicant: Novartis AG

Inventor： Newton T. Samuel ,  Nirupama Kenkare

IPC: G02B1/04

CPC classification number: G02B1/043

Abstract: The invention is related to a disposable contact lens comprising a top coating which is made of a hydrophilic polymeric material including dangling hydrophilic polymer chains covalently linked to the hydrophilic polymeric material through oligo-caprolactone linkages susceptible to enzymatic degradation in the eyes. The top coating is stable to lens processing/storage and confers lubricity to the lens. However, it slowly is degraded during the lens wear due to the action of enzymes (e.g., Lipase) in tear film. The loss in lubricity will be experienced as a drop in comfort for the lens wearer and thereby serves as the built-in compliance features of the disposable contact lens.

Abstract translation: 本发明涉及一次性隐形眼镜，其包括由亲水性聚合材料制成的顶部涂层，其包括通过易于在眼睛中酶促降解的低聚己内酯键与亲水性聚合物材料共价连接的悬浮的亲水性聚合物链。 顶部涂层对透镜加工/储存稳定，并赋予透镜润滑性。 然而，由于在泪液膜中的酶（例如脂肪酶）的作用，它在镜片佩戴期间缓慢地降解。 润滑性的损失将作为镜片佩戴者的舒适度降低，从而用作一次性隐形眼镜的内置柔顺特征。

公开(公告)号：US20130178518A1

公开(公告)日：2013-07-11

申请号：US13716496

申请日：2012-12-17

Applicant: Novartis AG

Inventor： Newton T. Samuel ,  Nirupama Kenkare ,  Peter D. Lackey ,  Jessie Chen

IPC: A61K9/00

CPC classification number: A61K9/0051 ,  A61F9/0017 ,  A61K31/355 ,  C07C403/24 ,  C09B61/00 ,  G02B1/043

Abstract: The instant invention pertains to a method for producing contact lenses with improved oxidative stability of Carotenoids in the contact lens. The method of the invention involves adding a vitamine E material into a contact lens in an amount sufficient to reduce oxidative degradation of Carotenoids in the lens by at least about 30% in comparison with an identical contact lens without the vitamin E material.

Abstract translation: 本发明涉及一种具有改善隐形眼镜中类胡萝卜素的氧化稳定性的隐形眼镜的方法。 本发明的方法包括将维生素E材料添加到隐形眼镜中，其量足以与不含维生素E的相同隐形眼镜相比减少眼镜中类胡萝卜素的氧化降解至少约30％。

公开(公告)号：US20130148077A1

公开(公告)日：2013-06-13

申请号：US13706737

申请日：2012-12-06

Applicant: Novartis AG

Inventor： Newton T. Samuel ,  Nirupama Kenkare

IPC: G02B1/04

CPC classification number: G02B1/043

Abstract: The invention is related to a disposable contact lens comprising a top coating which is made of a hydrophilic polymeric material including dangling hydrophilic polymer chains covalently linked to the hydrophilic polymeric material through oligo-caprolactone linkages susceptible to enzymatic degradation in the eyes. The top coating is stable to lens processing/storage and confers lubricity to the lens. However, it slowly is degraded during the lens wear due to the action of enzymes (e.g., Lipase) in tear film. The loss in lubricity will be experienced as a drop in comfort for the lens wearer and thereby serves as the built-in compliance features of the disposable contact lens.

Abstract translation: 本发明涉及一次性隐形眼镜，其包括由亲水性聚合材料制成的顶部涂层，其包括通过易于在眼睛中酶促降解的低聚己内酯键与亲水性聚合物材料共价连接的悬浮的亲水性聚合物链。 顶部涂层对透镜加工/储存稳定，并赋予透镜润滑性。 然而，由于在泪液膜中的酶（例如脂肪酶）的作用，它在镜片佩戴期间缓慢地降解。 润滑性的损失将作为镜片佩戴者的舒适度降低，从而用作一次性隐形眼镜的内置柔顺特征。