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公开(公告)号：US20230092895A1
公开(公告)日：2023-03-23
申请号：US17753320
申请日：2019-08-30
发明人： Vipin Suri , Michael Joseph Briskin , Brian Dolinski , Kutlu Goksu Elpek , Tucker Ezell , Scott Francis Heller , Mara Christine Inniss , Tariq A. Kassum , Nicole Kosmider , Abhishek Kulkarni , Meghan Langley , Dan Jun Li , Michelle Lynn Ols , Benjamin J. Primack , Celeste Richardson , Steven Mark Shamah , James Storer , Dexue Sun , Vijaya Balakrishnan , Andrew R.M. Bradbury , Michael Frank Erasmus , Fortunato Ferrara
IPC分类号： C12N9/06 , C07K16/28 , C07K14/54 , C07K14/715 , C07K14/725 , A61K35/17
摘要： The present invention provides biocircuit systems, effector modules and compositions for cancer immunotherapy. Methods for inducing anti-cancer immune responses in a subject are also provided.
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公开(公告)号：US20230074330A1
公开(公告)日：2023-03-09
申请号：US17649592
申请日：2022-02-01
发明人： Vipin Suri , Byron Delabarre , Michael N. Gladstone , Celeste Richardson , Brian Dolinski , Abhishek Kulkarni , Mara Christine Inniss , Dexue Sun , Dan Jun Li , Grace Y. Olinger , Scott Francis Heller
IPC分类号： A61K38/46 , A61P35/00 , A61K31/4985 , A61K35/17 , A61K38/17 , A61K38/20 , A61K39/395 , C07K14/54 , C07K14/725 , C07K14/705 , C07K14/715 , C07K16/28 , C12N9/16
摘要： The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.
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公开(公告)号：US11666642B2
公开(公告)日：2023-06-06
申请号：US17649592
申请日：2022-02-01
发明人： Vipin Suri , Byron Delabarre , Michael N. Gladstone , Celeste Richardson , Brian Dolinski , Abhishek Kulkarni , Mara Christine Inniss , Dexue Sun , Dan Jun Li , Grace Y. Olinger , Scott Francis Heller
IPC分类号： A61K38/46 , A61P35/00 , A61K31/4985 , A61K35/17 , A61K38/17 , A61K38/20 , A61K39/395 , C07K14/54 , C07K14/725 , C07K14/705 , C07K14/715 , C07K16/28 , C12N9/16 , A61K39/00 , A61P37/04 , C07K19/00
CPC分类号： A61K38/465 , A61K31/4985 , A61K35/17 , A61K38/177 , A61K38/1774 , A61K38/1793 , A61K38/2086 , A61K39/3955 , A61P35/00 , C07K14/5443 , C07K14/7051 , C07K14/70517 , C07K14/70578 , C07K14/7155 , C07K16/2803 , C12N9/16 , C12Y301/04035 , A61K2039/505 , C07K2317/53 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/33
摘要： The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.
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公开(公告)号：US11629340B2
公开(公告)日：2023-04-18
申请号：US16558224
申请日：2019-09-02
发明人： Vipin Suri , Dan Jun Li , Dexue Sun , Byron Delabarre , Vijaya Balakrishnan , Brian Dolinski , Mara Christine Inniss , Grace Y. Olinger
IPC分类号： C12N15/85 , C07K14/54 , A61K35/17 , C12N9/06 , C07K14/715 , C07K14/705
摘要： The present invention is related to compositions and methods for the regulated and controlled expression of proteins.
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公开(公告)号：US12104178B2
公开(公告)日：2024-10-01
申请号：US17646212
申请日：2021-12-28
发明人： Vipin Suri , Dan Jun Li , Dexue Sun , Byron Delabarre , Vijaya Balakrishnan , Brian Dolinski , Mara Christine Inniss , Grace Y. Olinger
IPC分类号： A61K35/17 , C07K14/54 , C07K14/705 , C07K14/715 , C12N9/06 , C12N15/85 , C12N15/86
CPC分类号： C12N9/003 , A61K35/17 , C07K14/5434 , C07K14/5443 , C07K14/70503 , C07K14/7155 , C12N15/85 , C12Y105/01003 , C07K2319/30 , C07K2319/33
摘要： The present invention is related to compositions and methods for the regulated and controlled expression of proteins.
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公开(公告)号：US20230056856A1
公开(公告)日：2023-02-23
申请号：US17791091
申请日：2021-01-08
摘要： The present disclosure provides compositions and methods related to transcription factor systems. Such systems provide for modular and tunable protein expression driven by regulated transcriptional activity.
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公开(公告)号：US20230026259A1
公开(公告)日：2023-01-26
申请号：US17436892
申请日：2020-03-06
发明人： Vipin SURI , Celeste RICHARDSON , Brian DOLINSKI , Abhishek KULKARNI , Mara Christine Inniss , Dexue SUN , Elizabeth Jane WEISMAN , Grace Y. Olinger , Scott Francis HELLER , Jennifer Leah GORI , Michelle Lynn OLS , Kutlu Goksu ELPEK , Tucker Read EZELL , Michael SCHEBESTA , Michelle Lois FLEURY , Dhruv Kam SETHI
IPC分类号： C12N9/88 , A61K39/00 , C07K14/705
摘要： The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities. In particular, the present application is directed to fusion proteins comprising a fragment of human human carbonic anhydrase 2 and a chimeric antigen receptor (CAR). The activity of the destabilizing domain can be regulated by externally administered agents.
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公开(公告)号：US20220348937A1
公开(公告)日：2022-11-03
申请号：US17753505
申请日：2020-09-04
摘要： The present disclosure is related to compositions and methods for the regulated and controlled expression of proteins.
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公开(公告)号：US11241485B2
公开(公告)日：2022-02-08
申请号：US16621593
申请日：2018-06-12
发明人： Vipin Suri , Byron Delabarre , Michael N. Gladstone , Celeste Richardson , Brian Dolinski , Abhishek Kulkarni , Mara Christine Inniss , Dexue Sun , Dan Jun Li , Grace Y. Olinger , Scott Francis Heller
IPC分类号： A61K38/46 , A61P35/00 , A61K31/4985 , A61K35/17 , A61K38/17 , A61K38/20 , A61K39/395 , C07K14/54 , C07K14/725 , C07K14/705 , C07K14/715 , C07K16/28 , C12N9/16 , A61K39/00 , A61P37/04 , C07K19/00
摘要： The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.
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