公开(公告)号：US09810896B2

公开(公告)日：2017-11-07

申请号：US14552043

申请日：2014-11-24

Applicant: OLYMPUS CORPORATION

Inventor： Daisuke Nishiwaki

IPC: G02B21/36 ,  G02B21/06 ,  G02B21/16 ,  G02B21/22 ,  H04N13/02

CPC classification number: G02B21/367 ,  G02B21/06 ,  G02B21/16 ,  G02B21/22 ,  G02B21/36 ,  H04N13/211 ,  H04N13/221 ,  H04N13/229 ,  H04N13/239

Abstract: A microscope device includes an illumination optical system that illuminates a specimen with a light sheet, and a stereo image capturing device that captures images of the specimen in a plurality of different directions in which a resolution based on a triangulation method in a Z direction orthogonal to a direction of one or a plurality of light sheets formed on the specimen by the illumination optical system is less than a thickness in the Z direction of light sheet illumination that comprises the one or the plurality of light sheets.

公开(公告)号：US08912510B2

公开(公告)日：2014-12-16

申请号：US13744750

申请日：2013-01-18

Applicant: Olympus Corporation

Inventor： Daisuke Nishiwaki

IPC: F21V9/16 ,  G01N21/64

CPC classification number: G01N21/64 ,  G01N21/6458

Abstract: Fluorescence observation apparatus includes laser scanning fluorescence observation unit and wide field fluorescence observation unit. The former unit includes: lasers; scanning unit that scans sample by laser light; and detector that detects fluorescence from the sample excited by the laser light. The latter unit includes: light source to planar-illuminate the sample; excitation filters that are selectively arranged on light path from the light source, and that correspond to the lasers, respectively; and two-dimensional detector that detects fluorescence from the sample excited by light that has passed through excitation filter arranged on light path from the light source. Each of the excitation filters has optical property in which center wavelength of transmissive band is approximately the same as oscillation wavelength of corresponding laser and bandwidth of transmissive band is approximately the same as tolerance width of oscillation wavelength of corresponding laser.

Abstract translation: 荧光观察装置包括激光扫描荧光观察单元和宽场荧光观察单元。 前一单位包括：激光; 用激光扫描样品的扫描单元; 以及检测由激光激发的样品的荧光的检测器。 后者单元包括：光源平面照射样品; 激励滤光器，其选择性地布置在来自光源的光路上，并且分别对应于激光器; 以及二维检测器，其检测来自已经通过布置在光源的光路上的激发滤光器的光激发的样品的荧光。 每个激发滤光器具有光学性质，其中透射带的中心波长与相应激光器的振荡波长大致相同，并且透射带的带宽与相应激光器的振荡波长的容许宽度大致相同。

公开(公告)号：US09069167B2

公开(公告)日：2015-06-30

申请号：US14056765

申请日：2013-10-17

Applicant: OLYMPUS CORPORATION

Inventor： Daisuke Nishiwaki

IPC: G02B21/06 ,  G02B26/08

CPC classification number: G02B21/06 ,  G02B26/0833

Abstract: A illumination apparatus for microscope comprises a light source, a spatial modulation section, a first illumination optical system, a second illumination optical system, and the spatial modulation section includes a spatial modulation element which is of reflecting type, and a polarizing element, and the first illumination optical system is disposed in an optical path from the light source up to the spatial modulation element, and the second illumination optical system is disposed in an optical path from the spatial modulation element up to a specimen position, and a position of the spatial modulation element is conjugate with the specimen position. Moreover, a microscope comprises a illumination apparatus, a main-body section, an observation unit, and a control unit, and the illumination apparatus for microscope is to be used as the illumination apparatus.

Abstract translation: 显微镜照明装置包括光源，空间调制部，第一照明光学系统，第二照明光学系统，空间调制部包括反射型的空间调制元件和偏振元件， 第一照明光学系统设置在从光源到空间调制元件的光路中，并且第二照明光学系统设置在从空间调制元件到样本位置的光路中，并且空间 调制元素与样品位置共轭。 此外，显微镜包括照明装置，主体部，观察单元和控制单元，并且用于显微镜的照明装置将用作照明装置。

公开(公告)号：US10746978B2

公开(公告)日：2020-08-18

申请号：US15872149

申请日：2018-01-16

Applicant: OLYMPUS CORPORATION

Inventor： Brendan Brinkman ,  Yoshihiro Shimada ,  Daisuke Nishiwaki

IPC: G02B21/33 ,  G02B21/24 ,  G01N21/64

Abstract: An immersion liquid holder 2 is an immersion liquid holder that is used for an observation device 10 for observing sample S by using an immersion method, and includes a supporting member 2b configured to support an absorption member 3 that has absorbed an immersion liquid and a connection unit 2c configured to relatively fix the absorption member 3 that has absorbed the immersion liquid with respect to an optical system, which is an optical system included in the observation device 10, and to fix the absorption member 3 on an optical path of the optical system 1, by fixing the supporting member 2b to the observation device 10.

公开(公告)号：US09411142B2

公开(公告)日：2016-08-09

申请号：US14180189

申请日：2014-02-13

Applicant: OLYMPUS CORPORATION

Inventor： Yoshihiro Ue ,  Daisuke Nishiwaki

IPC: G02B21/00

CPC classification number: G02B21/008 ,  G02B21/0072

Abstract: A microscope system includes: an objective; a correction apparatus which corrects a spherical aberration; a controller which obtains a plurality of combinations of a relative position of the objective to a sample and an optimum value, which is a set value of the correction apparatus in a state in which a spherical aberration caused in accordance with the relative position has been corrected, calculates a function expressing the relationship between the relative position and the optimum value on the basis of the obtained plurality of combinations by interpolation, and calculates the optimum value according to an observation target surface of the sample, on the basis of the function and the relative position which is determined from the observation target surface; and a correction apparatus driving apparatus which drives the correction apparatus in accordance with the optimum value, which is calculated by the controller.

Abstract translation: 显微镜系统包括：目标; 校正球面像差的校正装置; 获取目标与样本的相对位置和最佳值的多个组合的控制器，该最佳值是在根据相对位置引起的球面像差已被校正的状态下校正装置的设定值 基于所获得的多个组合，通过插值来计算表示相对位置与最佳值之间的关系的函数，并且根据该函数和该样本计算出根据样本的观察目标表面的最佳值 从观察目标表面确定的相对位置; 以及根据由控制器计算的最佳值驱动校正装置的校正装置驱动装置。

公开(公告)号：US09383567B2

公开(公告)日：2016-07-05

申请号：US14329388

申请日：2014-07-11

Applicant: OLYMPUS CORPORATION

Inventor： Yoshihiro Ue ,  Tetsuya Tajima ,  Daisuke Nishiwaki ,  Kaori Higuchi

IPC: G02B21/06 ,  G02B21/24 ,  G02B7/14

CPC classification number: G02B21/06 ,  G02B7/14 ,  G02B21/0088 ,  G02B21/248

Abstract: A microscope system includes: a main body portion having an optical system for forming an image from at least observation light from a specimen; an objective lens unit having an objective lens for taking in the observation light and having a base portion with an approximately belt shape for holding the objective lens on one end; and a unit attachment portion that is held by the main body portion and is configured to detachably attach the base portion at a position where at least an optical axis of the objective lens coincides with an optical path of the observation light.

Abstract translation: 显微镜系统包括：主体部分，具有用于至少从样本观察光形成图像的光学系统; 物镜单元，具有用于摄取观察光的物镜，具有用于将物镜保持在一端的大致带状的基部; 以及由所述主体部保持并且被构造成将所述基部可拆卸地附接到所述物镜的至少光轴与所述观察光的光路重合的位置的单元附接部。