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公开(公告)号：US10746978B2
公开(公告)日：2020-08-18
申请号：US15872149
申请日：2018-01-16
Applicant: OLYMPUS CORPORATION
Inventor： Brendan Brinkman , Yoshihiro Shimada , Daisuke Nishiwaki
Abstract: An immersion liquid holder 2 is an immersion liquid holder that is used for an observation device 10 for observing sample S by using an immersion method, and includes a supporting member 2b configured to support an absorption member 3 that has absorbed an immersion liquid and a connection unit 2c configured to relatively fix the absorption member 3 that has absorbed the immersion liquid with respect to an optical system, which is an optical system included in the observation device 10, and to fix the absorption member 3 on an optical path of the optical system 1, by fixing the supporting member 2b to the observation device 10.
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公开(公告)号：US10684457B2
公开(公告)日：2020-06-16
申请号：US15871368
申请日：2018-01-15
Applicant: OLYMPUS CORPORATION
Inventor： Masahito Dohi , Yoshihiro Shimada
Abstract: A microscope apparatus 10 includes a detection optical system 12 that captures light from a sample S and an illumination optical system 11 that radiates an illumination light onto the sample S. The illumination optical system 11 includes a cylindrical lens 5 that has a power in a first-axis direction and does not have a power in a second-axis direction that is perpendicular to the first-axis direction, a cylindrical lens 6 that has a power in the second-axis direction and does not have a power in the first-axis direction, and a scanner 4 that scans the illumination light in a width direction. The illumination optical system 11 is configured such that the first-axis direction is the width direction described above, and the cylindrical lenses 5 and 6 are arranged posterior to the scanner 4.
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公开(公告)号：US20180224648A1
公开(公告)日：2018-08-09
申请号：US15821605
申请日：2017-11-22
Applicant: OLYMPUS CORPORATION
Inventor： Yoshihiro Shimada
CPC classification number: G02B21/26 , G02B21/0032 , G02B21/0076 , G02B21/06 , G02B21/24 , G02B21/33 , G02B21/36 , G02B21/367
Abstract: A microscope device 100 includes: a sample container holder 7 that is capable of housing a plurality of sample containers 9 and that is supported so as to be attachable, each of the sample containers 9 housing a sample S and a first immersion medium and including a transparent section that transmits light; an illumination optical system 1 that emits illumination light to the sample S via the transparent section; a detection optical system 2 that detects light from the sample S via the transparent section; and a movement mechanism 16 that relatively moves the sample container holder 7, the detection optical system 2, and the illumination optical system 1 in a gravity direction. The sample container holder 7 houses the plurality of sample containers S in the gravity direction.
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公开(公告)号：US10754135B2
公开(公告)日：2020-08-25
申请号：US15629467
申请日：2017-06-21
Applicant: OLYMPUS CORPORATION
Inventor： Yoshihiro Shimada , Yujin Arai
Abstract: A light sheet microscope includes an objective, an illumination optical system, a first adjustor, a second adjustor and a controller. The illumination optical system irradiates sample with a light sheet from a direction that is different from an optical axis direction of the objective. The first adjustor adjusts a relative position between a light sheet plane on which the light sheet is formed and the objective in an optical axis direction of the objective. The second adjustor adjusts a relative position between the light sheet plane and the sample in an optical axis direction of the objective. The controller controls the first adjustor on the basis of light that is from the light sheet plane and that is detected via the objective when a relative position between the light sheet plane and the sample is changed by the second adjustor.
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5.发明授权公开(公告)号：US10895728B2
公开(公告)日：2021-01-19
申请号：US16186303
申请日：2018-11-09
Applicant: OLYMPUS CORPORATION
Inventor： Yoshihiro Shimada , Kazuhito Goda
Abstract: Provided is a sample observation method including: bringing a gel-like transparent sample that encloses an observation target into contact with a transparent flat surface section of a substrate; and collecting light from the observation target by means of an objective lens via the substrate, in a state in which a pressing force is made to act in a direction in which the sample and the flat surface section relatively approach each other, until the contact area between the sample and the flat surface section comes to have a size allowing an effective light flux for the objective lens of a microscope to pass therethrough.
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Patent Agency Ranking
公开(公告)号：US10509215B2
公开(公告)日：2019-12-17
申请号：US15436738
申请日：2017-02-17
Applicant: OLYMPUS CORPORATION
Inventor： Yoshihiro Shimada , Yujin Arai
Abstract: The present invention provides a light-field microscope including: an illumination optical system that radiates excitation light onto a sample; and a detection optical system including an objective lens that collects fluorescence generated in the sample as a result of the sample being irradiated with the excitation light by the illumination optical system, an image-acquisition element that acquires an image of the fluorescence collected by the objective lens, and a microlens array disposed between the image-acquisition element and the objective lens. The illumination optical system radiates a beam of the excitation light having a predetermined width in the optical-axis direction of the objective lens so as to include the focal plane of the objective lens onto the sample in a direction substantially perpendicular to the optical axis.
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公开(公告)号：US10168520B2
公开(公告)日：2019-01-01
申请号：US15161997
申请日：2016-05-23
Applicant: OLYMPUS CORPORATION
Inventor： Hisao Kitagawa , Yoshihiro Shimada , Kosuke Takagi
Abstract: Provided is a microscope system including a motor-driven stage on which is mounted a culture vessel containing one or more cell clusters, each including cells having a target molecule labeled with a fluorescent or luminescent chemical; a low-magnification-image acquiring unit that acquires low-magnification images of the cell clusters in the culture vessel mounted on the stage; a detecting unit that detects the position of each cell cluster in the culture vessel by analyzing the acquired low-magnification images; and a high-magnification-image acquiring unit that, after the detected position is aligned with the optical axis of an objective lens, acquires slice images of fluorescence or luminescence emitted from the cells forming the cell cluster at a higher magnification than the low-magnification-image acquiring unit at intervals along the optical axis while the stage and/or the lens is moved to change stepwise the distance between the lens and the cell cluster.
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公开(公告)号：US10859807B2
公开(公告)日：2020-12-08
申请号：US16196773
申请日：2018-11-20
Applicant: OLYMPUS CORPORATION
Inventor： Yoshihiro Shimada
Abstract: An inverted microscope includes a stage supporting a bottom member; an immersion objective disposed facing vertically upward such that a distal end thereof faces a bottom face of the bottom member; an alignment unit moving the stage or the immersion objective in an optical-axis direction of the immersion objective; a liquid injecting unit injecting liquid between the bottom face and the distal end; and a controller controlling the liquid injecting unit, in a state where the bottom face and the distal end are disposed with a gap therebetween, to inject the liquid onto the distal end to form a droplet, and controlling the alignment unit to bring the bottom member and the immersion objective closer to each other to bring the droplet into contact with the bottom face, thereby forming a liquid column, and moving the stage and the immersion objective relative to each other while maintaining the liquid column.
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公开(公告)号：US10310248B2
公开(公告)日：2019-06-04
申请号：US15678854
申请日：2017-08-16
Applicant: OLYMPUS CORPORATION
Inventor： Brendan Brinkman , Yoshihiro Shimada
IPC: G02B23/00 , G02B21/33 , G01N21/03 , G01N21/64 , G02B21/08 , G02B21/16 , G02B21/22 , G02B21/26 , G02B21/34 , G02B21/36 , G02B21/00
Abstract: Provided is a microscope including: a chamber storing a solution in which a cuvette accommodating a solution together with a sample is immersed and that has an index of refraction identical to that of the solution; an immersion objective lens being placed outside the chamber and collecting light from the sample; a camera acquiring an image of the light collected by the lens; a targeting section moving the lens in a direction along a detection light axis thereof; and a movable stage supporting the cuvette in the chamber so as to be movable in at least a direction along the detection light axis. Each of the cuvette and the chamber has a transparent section that can transmit light coming from the sample. The lens is placed so as to face the transparent section of the cuvette with the transparent section of the chamber interposed therebetween.
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公开(公告)号：US10288861B2
公开(公告)日：2019-05-14
申请号：US15655382
申请日：2017-07-20
Applicant: OLYMPUS CORPORATION
Inventor： Yoshihiro Shimada
Abstract: A light sheet microscope includes an objective, an illumination optical system, a correction device, an image pickup device, a first adjustor, a second adjustor and a controller. The controller performs a first focus process and a spherical aberration correction process. The first focus process is a process in which the first adjustor is controlled on the basis of light that is from the light sheet plane and that is detected via the objective so that the light sheet plane and a focal plane become closer when a relative position between the light sheet plane and a sample has been changed. The spherical aberration correction process is a process in which the correction device is controlled so that an evaluation value of the image obtained by the image pickup device becomes greater when the first adjustor has changed the relative position between the light sheet plane and the objective.
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