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1.发明申请Glucopyranose derivatives and medicaments for preventing and/or treating HIV infection diseases comprising the same as an active ingredient 审中-公开吡喃葡萄糖衍生物和用于预防和/或治疗HIV感染疾病的药物，其包含其作为活性成分公开(公告)号：US20040072767A1
公开(公告)日：2004-04-15
申请号：US10668290
申请日：2003-09-24
IPC分类号： A61K031/7008 , A61K031/255
CPC分类号： A61K31/7024 , A61K31/7008 , C07C305/20 , C07C2601/14 , C07D309/14 , C07H13/04
摘要： The present invention relates to a medicament for preventing and/or treating HIV infectious diseases comprising a compound of formula (J) as active ingredient and glucopyranose derivative of formula (W) or non-toxic salts thereof (the symbols in the formula are as described in the specification). A glucopyranose derivative of formulae (J) or (W) or a non-toxic salt thereof is useful as a medicament for preventing and/or treating HIV infectious disease (AIDS). 1
摘要翻译： 本发明涉及用于预防和/或治疗HIV感染性疾病的药物，其包含作为活性成分的式（J）化合物和式（W）的吡喃葡萄糖衍生物或其无毒盐（式中的符号如上所述 在规范中）。 式（J）或（W）的吡喃葡萄糖衍生物或其无毒盐可用作预防和/或治疗HIV感染性疾病（AIDS）的药物。
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公开(公告)号：US20040241804A1
公开(公告)日：2004-12-02
申请号：US10885101
申请日：2004-07-07
IPC分类号： C07H021/04 , C07K014/47
摘要： The present invention discloses a new human polypeptide, and fragments and homologues of the polypeptide, cDNAs encoding the polypeptides, and pharmaceutical uses for the polypeptides. The polypeptides of the present invention possess hematopoiesis regulating activity, tissue generation/regeneration activity, activin/inhibin activity, chemotactic/chemokinetic activity, hemostatic and thrombolytic activity, and receptor/ligand activity, and are therefore expected to be useful for the prevention and/or treatment of various diseases.
摘要翻译： 本发明公开了一种新的人多肽，多肽的片段和同系物，编码多肽的cDNA以及多肽的药物用途。 本发明的多肽具有造血调节活性，组织产生/再生活性，激活素/抑制素活性，趋化性/动力学活性，止血和溶栓活性以及受体/配体活性，因此预期可用于预防和/ 或治疗各种疾病。
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公开(公告)号：US20030232411A1
公开(公告)日：2003-12-18
申请号：US10404438
申请日：2003-04-02
IPC分类号： C12P021/02 , C12N005/06 , C07K014/47 , C07K016/18 , C07H021/04
CPC分类号： C07K14/705 , A61K38/00 , C07K14/4703
摘要： Novel polypeptides produced by a human adult brain tissue, a cell line derived therefrom, a cell line derived from human bone marrow and a human umbilical cord venous endothelial cell line; a process for producing these polypeptides; cDNAs encoding the polypeptides; fragments hybridizable selectively with the cDNA sequences; replication or expression plasmids having the cDNAs integrated thereinto; host cells transformed by the plasmids; antibodies against the above polypeptides; and medicinal compositions containing the peptides or the antibodies.
摘要翻译： 由人成人脑组织产生的新型多肽，源自其的细胞系，源自人骨髓的细胞系和人脐带静脉内皮细胞系; 一种生产这些多肽的方法; 编码多肽的cDNA; 片段可与cDNA序列选择性杂交; 具有整合cDNA的复制或表达质粒; 由质粒转化的宿主细胞; 针对上述多肽的抗体; 以及含有肽或抗体的药物组合物。
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公开(公告)号：US20030008356A1
公开(公告)日：2003-01-09
申请号：US10201964
申请日：2002-07-25
IPC分类号： C07H021/04 , C12N009/64 , C12P021/02 , C12N005/06
摘要： A new human polypeptide, a cDNA encoding the same and a pharmaceutical use of it. The polypeptides of the present invention possess hematopolesis regulating activity, tissue generation/regeneration activity, activin/inhibin activity, chemotactic/chemokinetic activity, hemostatic and thrombolytic activity, and receptor/ligand activity, therefore, they are expected to be useful for prevention and/or treatment of various diseases.
摘要翻译： 新的人多肽，编码它的cDNA及其药学用途。 本发明的多肽具有造血调节活性，组织产生/再生活性，激活素/抑制素活性，趋化性/动力学活性，止血和溶栓活性以及受体/配体活性，因此预期它们可用于预防和/ 或治疗各种疾病。
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公开(公告)号：US20040142423A1
公开(公告)日：2004-07-22
申请号：US10774378
申请日：2004-02-10
发明人： Hideaki Tada , Mikio Konishi , Daikichi Fukushima
IPC分类号： C07H021/04 , C07K014/705 , C07K016/28
CPC分类号： C07K14/70578 , A61K38/00
摘要： Polypeptide produced from human stromal cell line, the process for the preparation of the polypeptide, DNA encoding the polypeptide, vector carrying the DNA, host cell transformed by the vector, antibody of the polypeptide, and pharmaceutical composition containing the polypeptide or the antibody.
摘要翻译： 由人类基质细胞系产生的多肽，制备多肽的方法，编码多肽的DNA，携带DNA的载体，载体转化的宿主细胞，多肽的抗体和含多肽或抗体的药物组合物。
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6.发明申请Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient 失效羧酸衍生物和含有该衍生物作为活性成分的药物组合物公开(公告)号：US20040087636A1
公开(公告)日：2004-05-06
申请号：US10464459
申请日：2003-06-19
IPC分类号： C07D413/02 , A61K031/422
CPC分类号： C07D413/04 , C07D263/32 , C07D493/08
摘要： A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) 1 (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from, risk factors of diabetes or syndrome X.
摘要翻译： 含有式（I）的羧酸衍生物（其中所有符号如说明书中所定义），其无毒性酸或其水合物作为活性成分的过氧化物酶体增殖物激活受体调节剂。 由于具有调节PPAR的作用，式（I）化合物可用作降血糖剂，降血脂药，用于代谢紊乱（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症）的疾病的预防和/或补救措施 等），高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂和用于缓解危险因素的药物 的糖尿病或综合症。
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7.发明申请公开(公告)号：US20040038285A1
公开(公告)日：2004-02-26
申请号：US10657103
申请日：2003-09-09
IPC分类号： C12Q001/68 , C07H021/04 , C07K014/47
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/47 , C12N9/6421
摘要： Structure A novel human polypeptide, the method for prepareation thereof, a cDNA encoding the polypeptide; a fragment selectively hybridizing with the sequence of the cDNA, a replication or expression plasmid containing the cDNA integrated thereinto, a host cell transformed with plasmid, an antibody against the polypeptide and a pharmaceutical composition containing the polypeptide or the antibody. Effect The polypeptides of the present invention possess hematopoiesis regulating activity, tissue generation/regeneration activity, activin/inhibin activity, chemotactic/chemokinetic activity, hemostatic and thrombolytic activity, and receptor/ligand activity, therefore, they are expected to be useful for prevention and/or treatment of various diseases.
摘要翻译： 结构一种新的人多肽，其制备方法，编码多肽的cDNA; 与cDNA序列选择性杂交的片段，其中整合了cDNA的复制或表达质粒，用质粒转化的宿主细胞，针对多肽的抗体和含有多肽或抗体的药物组合物。 效果本发明的多肽具有造血调节活性，组织产生/再生活性，激活素/抑制素活性，趋化性/动力学活性，止血和溶栓活性以及受体/配体活性，因此，它们 预计可用于预防和/或治疗各种疾病。
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8.发明申请Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient 失效羧酸衍生物和含有衍生物作为活性成分的药物组合物公开(公告)号：US20030225145A1
公开(公告)日：2003-12-04
申请号：US10428096
申请日：2003-05-02
IPC分类号： C07D417/02 , C07D413/02 , C07D49/02 , C07D45/02 , A61K031/427 , A61K031/422 , A61K031/4178
CPC分类号： C07D413/06 , C07D413/14 , C07D417/06
摘要： A peroxisome proliferator activated receptor regulator containing a compound of formula (I) 1 (wherein all symbols are as defined in the specification), or a salt thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or syndrome X.
摘要翻译： 含有式（I）化合物（其中所有符号如说明书中所定义）的过氧化物酶体增殖物激活受体调节剂或其盐作为活性成分。 由于具有调节PPAR的作用，式（I）化合物可用作降血糖剂，降血脂药，用于代谢紊乱（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症）的疾病的预防和/或补救措施 等），高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂和用于缓解危险因素的药物 糖尿病或综合症。
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公开(公告)号：US20030165981A1
公开(公告)日：2003-09-04
申请号：US10414378
申请日：2003-04-16
IPC分类号： C12Q001/68 , C07H021/04 , C12P021/02 , C12N005/06 , C07K014/47
摘要： A new polypeptide prepared from human library by the SST method and a process for preparation of it; a cDNA encoding the polypeptide; a fragment selectively hybridizing with the sequence of the cDNA; a replication or expression plasmid containing the cDNA integrated thereinto; a host cell transformed with plasmid; an antibody against the polypeptide; and a pharmaceutical composition containing the polypeptide or the antibody.
摘要翻译： 通过SST方法从人类文库制备的新多肽及其制备方法; 编码该多肽的cDNA; 选择性地与cDNA序列杂交的片段; 包含其中整合的cDNA的复制或表达质粒; 用质粒转化的宿主细胞; 抗多肽的抗体; 和含有多肽或抗体的药物组合物。
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10.发明申请Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient 失效羧酸衍生物和含有该衍生物作为活性成分的药物组合物公开(公告)号：US20030153579A1
公开(公告)日：2003-08-14
申请号：US10251805
申请日：2002-09-23
IPC分类号： A61K031/497 , A61K031/445 , A61K031/277 , A61K031/192
CPC分类号： C07D213/30 , A61K31/00 , C07C59/66 , C07C59/68 , C07C59/72 , C07C323/52 , C07D213/65 , C07D263/32 , C07D263/34 , C07D263/48 , C07D277/24 , C07D317/54 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/10
摘要： A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) 1 (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diseases or syndrome X.
摘要翻译： 含有式（I）的羧酸衍生物（其中所有符号如说明书中所定义），其无毒性酸或其水合物作为活性成分的过氧化物酶体增殖物激活受体调节剂。 由于具有调节PPAR的作用，式（I）化合物可用作降血糖剂，降血脂药，用于代谢紊乱（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症）的疾病的预防和/或补救措施 等），高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂和用于缓解危险因素的药物 疾病或综合征X.
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