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公开(公告)号:US20220241380A1
公开(公告)日:2022-08-04
申请号:US17549017
申请日:2021-12-13
申请人: OPKO BIOLOGICS LTD.
发明人: Fuad FARES , Udi Eyal FIMA
IPC分类号: A61K38/27 , C07K14/61 , C07K14/59 , A61K38/24 , C07K14/555 , C07K14/505 , A61K47/02 , A61K47/12 , G01N33/74
摘要: CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.
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公开(公告)号:US20180251510A9
公开(公告)日:2018-09-06
申请号:US14555353
申请日:2014-11-26
申请人: OPKO Biologics Ltd.
发明人: Fuad FARES , Udi Eyal Fima
IPC分类号: C07K14/59 , C07K14/505
CPC分类号: C07K14/59 , A61K38/00 , C07K14/505 , C07K14/555 , C07K14/605 , C07K14/61 , C07K2319/00 , C07K2319/02 , C07K2319/31
摘要: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
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公开(公告)号:US20160310576A1
公开(公告)日:2016-10-27
申请号:US15200813
申请日:2016-07-01
申请人: OPKO Biologics Ltd.
发明人: Fuad FARES , Udi Eyal Fima
CPC分类号: A61K38/27 , A61K38/24 , A61K47/02 , A61K47/12 , C07K14/505 , C07K14/555 , C07K14/59 , C07K14/61 , C07K2319/00 , C07K2319/31 , G01N33/74 , G01N2333/65 , G01N2800/52
摘要: CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.
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公开(公告)号:US20150152155A1
公开(公告)日:2015-06-04
申请号:US14550346
申请日:2014-11-21
申请人: OPKO BIOLOGICS LTD.
发明人: Fuad FARES , Udi Eyal Fima
IPC分类号: C07K14/505 , C07K14/59
CPC分类号: C07K14/555 , A61K38/19 , A61K47/64 , C07K14/505 , C07K14/59 , C07K14/61 , C07K2319/00 , C07K2319/31 , C07K2319/35 , C07K2319/91
摘要: A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
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公开(公告)号:US20180186852A1
公开(公告)日:2018-07-05
申请号:US15898384
申请日:2018-02-16
申请人: Opko Biologics Ltd.
发明人: Fuad FARES , Udi Eyal Fima
IPC分类号: C07K14/555 , C07K14/61 , C07K14/505 , C07K14/59 , A61K47/64 , A61K38/19
CPC分类号: C07K14/555 , A61K38/19 , A61K47/64 , C07K14/505 , C07K14/59 , C07K14/61 , C07K2319/00 , C07K2319/31 , C07K2319/35 , C07K2319/91
摘要: A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
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