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公开(公告)号：US20240124512A1
公开(公告)日：2024-04-18
申请号：US18476763
申请日：2023-09-28
发明人： Xiaohui DU , John EKSTEROWICZ , Valeria R. FANTIN , Daqing SUN , Qiuping YE , Jared MOORE , Tatiana ZAVOROTINSKAYA , Brian R. BLANK , Yosup REW , Kejia WU , Liusheng ZHU , Johnny PHAM , Hiroyuki KAWAI
摘要： Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
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公开(公告)号：US20210122730A1
公开(公告)日：2021-04-29
申请号：US16604543
申请日：2018-04-10
发明人： Xiaohui DU , John EKSTEROWICZ , Valeria R. FANTIN , Yosup REW , Daqing SUN , Qiuping YE , Haiying ZHOU , Hiroyuki KAWAI , Jared MOORE , Johnny PHAM , Kejia WU , Liusheng ZHU , Dennis YAMASHITA
IPC分类号： C07D401/12 , C07D417/12 , C07D401/14 , C07D417/14 , C07D405/14 , A61K31/4439 , A61K31/4545 , A61K31/444 , A61K31/427 , A61K31/337 , A61K31/404 , A61K31/58 , A61K31/473 , A61K31/277 , A61K31/567 , A61K31/4164 , A61K31/167 , A61K31/496 , A61K31/18 , A61K31/4166 , A61K45/06 , A61K35/17 , A61K39/00 , A61K39/395
摘要： Described herein are glucocorticoid receptor modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
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公开(公告)号：US20200347090A1
公开(公告)日：2020-11-05
申请号：US16760380
申请日：2018-11-02
发明人： Xiaohui DU , John EKSTEROWICZ , Valeria R. FANTIN , Erica L. JACKSON , Daqing SUN , Qiuping YE , Jared MOORE , Tatiana ZAVOROTINSKAYA
IPC分类号： C07H19/23
摘要： Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
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公开(公告)号：US20200291058A1
公开(公告)日：2020-09-17
申请号：US16889624
申请日：2020-06-01
发明人： Daqing SUN , Lawrence R. McGEE , Xiaohui DU , Liusheng ZHU , Xuelei YAN , Yosup REW , John EKSTEROWICZ , Julio C. MEDINA , Valeria R. FANTIN , Haiying ZHOU , Minna Delarae BALBAS
摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
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公开(公告)号：US20230096870A1
公开(公告)日：2023-03-30
申请号：US17887777
申请日：2022-08-15
发明人： Daqing SUN , Lawrence R. McGEE , Xiaohui DU , Liusheng ZHU , Xuelei YAN , Yosup REW , John EKSTEROWICZ , Julio C. MEDINA , Valeria R. FANTIN , Haiying ZHOU , Minna Delarae BALBAS
摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
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公开(公告)号：US20220331343A1
公开(公告)日：2022-10-20
申请号：US17626731
申请日：2020-07-15
发明人： Xiaohui DU , John EKSTEROWICZ , Valeria R. FANTIN , Daqing SUN , Qiuping YE , Jared MOORE , Tatiana ZAVOROTINSKAYA , Brian R. BLANK , Hiroyuki KAWAI , Chien-Hung YEH , Yosup REW , Kejia WU , Johnny PHAM
IPC分类号： A61K31/675 , C07F9/6561 , A61P35/00 , A61K45/06
摘要： Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
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公开(公告)号：US20210395295A1
公开(公告)日：2021-12-23
申请号：US17404493
申请日：2021-08-17
发明人： Daqing SUN , Lawrence R. McGEE , Xiaohui DU , Liusheng ZHU , Xuelei YAN , Yosup REW , John EKSTEROWICZ , Julio C. MEDINA , Haiying ZHOU , Minna Delarae BALBAS , Valeria R. FANTIN
摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
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8.发明申请公开(公告)号：US20210147472A1
公开(公告)日：2021-05-20
申请号：US17045413
申请日：2019-04-11
发明人： Valeria R. FANTIN , Qiuping YE , Belinda DE LEON , Daqing SUN , Sunil V. MHASKAR
摘要： The present invention relates generally to formulations and methods for treating cancer. Provided herein are formulations comprising substituted steroidal derivatives. The subject formulations are useful for the treatment of cancer.
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公开(公告)号：US20220220147A1
公开(公告)日：2022-07-14
申请号：US17697318
申请日：2022-03-17
发明人： Xiaohui DU , John EKSTEROWICZ , Valeria R. FANTIN , Daqing SUN , Qiuping YE , Jared MOORE , Tatiana ZAVOROTINSKAYA , Brian R. BLANK , Yosup REW , Kejia WU , Liusheng ZHU , Johnny PHAM , Hiroyuki KAWAI
IPC分类号： C07H19/23
摘要： Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
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公开(公告)号：US20220079924A1
公开(公告)日：2022-03-17
申请号：US17283700
申请日：2019-10-09
发明人： Xiaohui DU , John EKSTEROWICZ , Valeria R. FANTIN , Yosup REW , Daqing SUN , Qiuping YE , Haiying ZHOU , Hiroyuki KAWAI , Jared MOORE , Johnny PHAM , Kejia WU , Liusheng ZHU
IPC分类号： A61K31/427 , C07D417/14 , C07D401/14 , A61K31/4439 , A61K31/277 , A61K31/58 , A61K31/496 , A61K31/573 , A61K31/167 , A61K31/404 , A61K31/473 , A61K31/4166 , A61K33/243 , A61K31/282 , A61K31/337 , A61K31/7068 , A61K31/704 , A61K31/4745 , A61K31/519 , A61K35/17
摘要： Described herein are glucocorticoid receptor modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
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