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公开(公告)号：US08742116B2
公开(公告)日：2014-06-03
申请号：US12487479
申请日：2009-06-18
申请人： Oliver Plettenburg , Armin Hofmeister , Katrin Lorenz , Joachim Brendel , Matthias Löhn , John Weston
发明人： Oliver Plettenburg , Armin Hofmeister , Katrin Lorenz , Joachim Brendel , Matthias Löhn , John Weston
IPC分类号： A61K31/445 , C07D211/32
CPC分类号： C07D217/24 , C07D401/12
摘要： The invention relates to 6-substituted isoquinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代的异喹诺酮衍生物和含有这些化合物的组合物。
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公开(公告)号：US20120316152A1
公开(公告)日：2012-12-13
申请号：US13586468
申请日：2012-08-15
IPC分类号： A61K31/4725 , A61P9/12 , A61P27/06 , A61P9/00 , A61P9/04 , A61P9/10 , A61P1/16 , A61P13/12 , A61P11/06 , A61P11/00 , A61P7/02 , A61P25/00 , A61P29/00 , A61P25/28 , A61P15/00 , A61P5/00 , A61P3/10 , A61P3/00 , A61P31/04 , A61P31/00 , A61P35/00 , A61P19/08 , A61P37/00 , A61K31/55
CPC分类号： C07D401/12 , C07D401/14
摘要： A method for the treatment or prevention in a mammal of a disease associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase comprising administering to the mammal in need thereof at least one compound of the formula (I)
摘要翻译： 一种用于治疗或预防哺乳动物与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化相关疾病的方法，其包括向有需要的哺乳动物施用至少一种式（I）化合物，
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公开(公告)号：US08796458B2
公开(公告)日：2014-08-05
申请号：US13161003
申请日：2011-06-15
申请人： Oliver Plettenburg , Armin Hofmeister , Dieter Kadereit , Joachim Brendel , Matthias Loehn , Jean-Michel Altenburger
发明人： Oliver Plettenburg , Armin Hofmeister , Dieter Kadereit , Joachim Brendel , Matthias Loehn , Jean-Michel Altenburger
IPC分类号： C07D217/22 , A61K31/545 , C07D217/24
CPC分类号： C07D217/24 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The invention relates to 6-cyclohexylamine-substituted isoquinolone derivatives of the formula (I) or isoquinoline derivatives of the formula (I′) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及式（I）的6-环己胺取代的异喹啉酮衍生物或式（I'）的异喹啉衍生物，其用于治疗和/或预防与Rho-激酶和/或Rho-激酶介导的磷酸化相关的疾病 的肌球蛋白轻链磷酸酶，以及含有这些化合物的组合物。
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公开(公告)号：US08461144B2
公开(公告)日：2013-06-11
申请号：US13586468
申请日：2012-08-15
IPC分类号： A61K31/397
CPC分类号： C07D401/12 , C07D401/14
摘要： A method for the treatment or prevention in a mammal of a disease associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase comprising administering to the mammal in need thereof at least one compound of the formula (I).
摘要翻译： 一种用于治疗或预防哺乳动物与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化相关疾病的方法，包括向有需要的哺乳动物施用至少一种式（I）的化合物。
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5.发明授权Substituted isoquinoline and isoquinolinone derivatives as inhibitors of Rho-kinase 有权取代的异喹啉和异喹啉酮衍生物作为Rho激酶的抑制剂公开(公告)号：US08278294B2
公开(公告)日：2012-10-02
申请号：US12487403
申请日：2009-06-18
IPC分类号： A61K31/397
CPC分类号： C07D401/12 , C07D401/14
摘要： The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异诺酮酮衍生物， 化合物。
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公开(公告)号：US20090093518A1
公开(公告)日：2009-04-09
申请号：US12019866
申请日：2008-01-25
IPC分类号： A61K31/4725 , A61P25/00 , A61P11/00 , A61P9/00 , A61P3/00 , A61P35/00 , C07D401/12 , C07D401/14
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要： The invention relates to 6-piperidinyl-substituted isoquinolone derivatives of the formula (I) or isoquinoline derivatives of the formula (I′) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及式（I）的6-哌啶基取代的异喹啉酮衍生物或式（I'）的异喹啉衍生物，其用于治疗和/或预防与Rho-激酶和/或Rho-激酶介导的磷酸化相关的疾病 的肌球蛋白轻链磷酸酶，以及含有这些化合物的组合物。
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公开(公告)号：US08609691B2
公开(公告)日：2013-12-17
申请号：US12019799
申请日：2008-01-25
申请人： Oliver Plettenburg , Armin Hofmeister , Dieter Kadereit , Joachim Brendel , Matthias Loehn , Jean-Michel Altenburger
发明人： Oliver Plettenburg , Armin Hofmeister , Dieter Kadereit , Joachim Brendel , Matthias Loehn , Jean-Michel Altenburger
IPC分类号： C07D217/24 , A61K31/472
CPC分类号： C07D217/24 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The invention relates to 6-cyclohexylamine-substituted isoquinolone derivatives of the formula (I) or isoquinoline derivatives of the formula (I′) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及式（I）的6-环己胺取代的异喹啉酮衍生物或式（I'）的异喹啉衍生物，其用于治疗和/或预防与Rho-激酶和/或Rho-激酶介导的磷酸化相关的疾病 的肌球蛋白轻链磷酸酶，以及含有这些化合物的组合物。
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公开(公告)号：US08188117B2
公开(公告)日：2012-05-29
申请号：US12019866
申请日：2008-01-25
IPC分类号： C07D401/12 , A61K31/4725
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要： The invention relates to 6-piperidinyl-substituted isoquinolone derivatives of the formula (I) or isoquinoline derivatives of the formula (I′) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及式（I）的6-哌啶基取代的异喹啉酮衍生物或式（I'）的异喹啉衍生物，其用于治疗和/或预防与Rho-激酶和/或Rho-激酶介导的磷酸化相关的疾病 的肌球蛋白轻链磷酸酶，以及含有这些化合物的组合物。
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![Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them](/abs-image/US/2015/09/08/US09127001B2/abs.jpg.150x150.jpg)
9.发明授权Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them 有权取代的4,5,6,7-四氢-1H-吡唑并[4,3-c]吡啶，它们作为药物的用途，以及包含它们的药物制剂公开(公告)号：US09127001B2
公开(公告)日：2015-09-08
申请号：US14342744
申请日：2011-09-16
申请人： Laurent Bialy , Katrin Lorenz , Klaus Wirth , Klaus Steinmeyer , Gerhard Hessler , Josef Pernerstorfer , Joachim Brendel
发明人： Laurent Bialy , Katrin Lorenz , Klaus Wirth , Klaus Steinmeyer , Gerhard Hessler , Josef Pernerstorfer , Joachim Brendel
IPC分类号： C07D513/02 , C07D471/04 , C07D471/18
CPC分类号： C07D471/04 , C07D471/18
摘要： The invention relates to substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines of formula (I), their use as medicament, and pharmaceutical preparations comprising them. The compounds of formula (I) act on the TASK-1 potassium channel. The compounds are particularly suitable for the treatment or prevention of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.
摘要翻译： 本发明涉及式（I）的取代的4,5,6,7-四氢-1H-吡唑并[4,3-c]吡啶，它们作为药物的用途，以及包含它们的药物制剂。 式（I）化合物作用于TASK-1钾通道。 该化合物特别适用于治疗或预防房性心律失常，例如房颤（AF）或心房扑动。
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10.发明授权Combination of phenylcarboxamides with blockers of the IKr channel and their use for the treatment of atrial arrhythmias 有权苯卡巴胺与IKr通道阻滞剂的组合及其用于治疗房性心律失常的用途公开(公告)号：US08106099B2
公开(公告)日：2012-01-31
申请号：US10796894
申请日：2004-03-09
申请人： Joachim Brendel , Klaus Wirth , Heinz Goegelein , Maurits Allessie , Yuri Blaauw
发明人： Joachim Brendel , Klaus Wirth , Heinz Goegelein , Maurits Allessie , Yuri Blaauw
CPC分类号： A61K45/06 , A61K31/165 , A61K31/18 , A61K31/44 , A61K2300/00
摘要： The invention relates to the combination of one or more IKr channel blockers and of one or more Kv1.5 blockers, in particular phenyl-carboxamides of the formula Ia or Ib or pharmaceutically tolerable salts thereof, and the use of the combination for the treatment of atrial arrhythmias.
摘要翻译： 本发明涉及一种或多种IKr通道阻滞剂和一种或多种Kv1.5阻断剂，特别是式Ia或Ib的苯基 - 甲酰胺或其药学上可耐受的盐的组合，以及该组合用于治疗 房性心律失常。
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