公开(公告)号：US5454793A

公开(公告)日：1995-10-03

申请号：US108638

申请日：1993-08-30

Applicant: Gustav Levander ,  Olle Ljungquist

Inventor： Gustav Levander ,  Olle Ljungquist

IPC: A61M5/24 ,  A61M5/315 ,  A61M5/00

CPC classification number: A61M5/31591 ,  A61M5/24 ,  A61M5/31551 ,  A61M5/3158

Abstract: A medicine dispensing device including a slotted housing, a front end, a rear end, at least one threaded portion in the vicinity of the rear end, a dosage ampoule fitting in the vicinity of the front end and a discharge conduit for connection with a discharge ampoule. A hollow screw-threaded device receives the ampoule therein. The screw-threaded device is received by the rear end of the housing. The screw-threaded device includes an exterior surface provided with a threaded surface engaging the at least one threaded portion for securing the ampoule within the housing. A medicine discharge and metering device for metering and discharging the contents of the ampoule is received within the screw-threaded device and is movable in a direction of a longitudinal axis thereof. Subsequent to administering a dosage from the ampoule, the medicine discharge and metering device enables the ampoule to move rearwardly in a direction of a longitudinal axis of the housing to an extent sufficient to release the ampoule from engagement with the ampoule fitting. The ampoule, the screw-threaded device, and the discharge and metering device are thereby permitted to swing outwardly through the slotted housing, whereby the screw-threaded device is disengaged from the at least one threaded portion, thereby enabling the screw-threaded device and the discharging and metering device to move rearwardly and to return to a starting position within the housing where the screw-threaded device can receive a new ampoule through the housing.

Abstract translation: PCT No.PCT / SE93 / 00015 Sec。 371日期：1993年8月30日 102（e）日期1993年8月30日PCT提交1993年1月14日PCT公布。 第WO93 / 14799号公报 日期：1993年8月5日。一种药物分配装置，包括开槽壳体，前端，后端，后端附近的至少一个螺纹部分，在前端附近的剂量安瓿配件 排放管道，用于与排放安瓿连接。 中空的螺纹装置在其中容纳安瓿。 螺纹装置由壳体的后端容纳。 所述螺纹装置包括外表面，所述外表面具有与所述至少一个螺纹部分接合的螺纹表面，用于将所述安瓿固定在所述壳体内。 用于计量和排出安瓿内容物的药物排放和计量装置被容纳在螺纹装置内并可在其纵向轴线的方向上移动。 在从安瓿中施用剂量之后，药物排出和计量装置使得安瓿能够沿着壳体的纵向轴线的方向向后移动到足以释放安瓿与安瓿配件接合的程度。 因此，安瓿，螺纹装置以及排出和计量装置允许通过开槽壳体向外摆动，由此螺纹装置从至少一个螺纹部分脱离，从而使螺纹装置和 排放和计量装置向后移动并返回到壳体内的起始位置，螺纹装置可以通过壳体接收新的安瓿。

公开(公告)号：US5394907A

公开(公告)日：1995-03-07

申请号：US952829

申请日：1992-11-30

Applicant: Birger Hjertman ,  Gustav Levander ,  Olle Ljungquist

Inventor： Birger Hjertman ,  Gustav Levander ,  Olle Ljungquist

IPC: A61J1/00 ,  A61J1/10 ,  A61J1/20 ,  B65B61/24 ,  B65D33/00 ,  B65D81/32 ,  B65D83/00 ,  A61J1/12 ,  B65B9/12

CPC classification number: A61J1/2093 ,  A61J1/00 ,  B65B61/24 ,  B65D81/3266 ,  A61J1/2034

Abstract: Device and method for dosing a liquid product from a tubular container are provided. The container includes a plurality of doses of the liquid product and a plate for pinching the container together locally such that it is divided into a plurality of separate liquid chambers containing a desired dose.

Abstract translation: PCT No.PCT / SE91 / 00425 Sec。 371日期：1992年11月30日 102（e）日期1992年11月30日PCT提交1991年6月12日PCT公布。 出版物WO92 / 01434 日期：1992年2月6日。提供了从管状容器计量液体产品的设备和方法。 容器包括多个剂量的液体产品和用于将容器局部夹持在一起的板，使得其被分成包含期望剂量的多个单独的液体室。

公开(公告)号：US06708847B2

公开(公告)日：2004-03-23

申请号：US10185975

申请日：2002-06-27

Applicant: Olle Ljungquist

Inventor： Olle Ljungquist

IPC: B67D552

CPC classification number: A61B17/00491 ,  A61B2017/00495 ,  B05C17/00553 ,  B05C17/0109 ,  B05C17/0136

Abstract: A dispenser comprising at least two parallel, hollow cylinders for supplying different mutually reactive components to a mixing device located downstream of the cylinders. The dispenser comprises a respective first piston moveable in each of the cylinders and displaceable by a piston rod connected to the respective piston. A component for actuating the pistons rods to perform a forward stroke of the pistons in their respective cylinders for dispensing an amount of the reactive components to the mixing device comprises at least one rotatable member biased in a rotational direction by a torsion spring, and at least one flexible string attached to the rotatable member and to an element connected to the piston rods. A manually operable brake member is arranged to normally act on the rotatable member to hold it still, but, when deactivated, adapted to release the rotatable member thereby causing the pistons to dispense the reactive components to the mixing device.

Abstract translation: 一种分配器，包括至少两个平行的中空圆柱体，用于向位于气缸下游的混合装置提供不同的相互反应的部件。 分配器包括可在每个气缸中移动的相应的第一活塞，并且可由连接到相应活塞的活塞杆移动。 用于致动活塞杆以在其各自的气缸中执行活塞的向前冲程的部件用于将一定量的反作用部件分配到混合装置包括至少一个可旋转构件，其通过扭转弹簧沿旋转方向偏置，并且至少 连接到可旋转构件的一个柔性绳和连接到活塞杆的元件。 一个可手动操作的制动器构件被布置成通常作用在可旋转构件上以保持其静止，但是当被停用时，适于释放可旋转构件，从而使活塞将反应组分分配到混合装置。

公开(公告)号：US5545144A

公开(公告)日：1996-08-13

申请号：US232109

申请日：1994-09-26

Applicant: Linda Fryklund ,  Birger Hjertman ,  Marie-Louise Gustavsson ,  Jacob Kaluski ,  Gustav Levander ,  Olle Ljungquist ,  Anders Strom ,  Jonas Virding

Inventor： Linda Fryklund ,  Birger Hjertman ,  Marie-Louise Gustavsson ,  Jacob Kaluski ,  Gustav Levander ,  Olle Ljungquist ,  Anders Strom ,  Jonas Virding

IPC: A61M5/315 ,  A61M5/142 ,  A61M5/24 ,  A61M5/31 ,  A61M5/00

CPC classification number: A61M5/31548 ,  A61M5/31578 ,  A61M5/24 ,  A61M5/31525 ,  A61M5/3155 ,  A61M5/31595

Abstract: A liquid preparation of a pharmaceutically active agent having a defined composation is repeatedly dosed from a multi-dose container having a defined volume. The amount dosed is selected as 1/N of the volume of the multi-dose container, N being an integer having a value of 2 or higher.A device for dosing a liquid preparation comprises a holder (1) for a multi-dose container (2), which has a movable rear wall (5) acting as a piston for expelling the liquid preparation (6) from the container, and a piston rod (7), which is provided with releasable blocking means (11, 14, 19, 22), such that the movement of the piston rod is limited to a preset length (35) corresponding to an expelled volume of 1/N of the volume of said multi-dose container, N being an integer having a value of 2 or higher.A preferred embodiment of the device is as an injection device for repeated parenteral injections from an injection cartridge.

Abstract translation: PCT No.PCT / SE92 / 00654 Sec。 371日期：1994年9月26日 102（e）日期1994年9月26日PCT提交1992年9月23日PCT公布。 公开号WO93 / 08854 日期1993年5月13日具有确定的组合物的药物活性剂的液体制剂从具有确定体积的多剂量容器重复给药。 选定剂量为多剂量容器体积的1 / N，N为2以上的整数。 一种用于计量液体制剂的装置包括用于多剂量容器（2）的保持器（1），其具有用作将液体制剂（6）从容器排出的活塞的活动后壁（5），以及 活塞杆（7）设置有可释放的阻塞装置（11,14,19,22），使得活塞杆的移动被限制到对应于1 / N的排出体积的预设长度（35） 所述多剂量容器的体积，N为2以上的整数。 该装置的优选实施例是用于从注射筒重复胃肠外注射的注射装置。

公开(公告)号：US5817055A

公开(公告)日：1998-10-06

申请号：US477607

申请日：1995-06-07

Applicant: Olle Ljungquist

Inventor： Olle Ljungquist

IPC: A61M5/24 ,  A61M37/00

CPC classification number: A61M5/2448

Abstract: An injection cartridge of the dual-chamber type, which comprises a cylindrical cartridge barrel having a front chamber for a solid product and a rear chamber for a liquid product. The chambers are sealingly separated by a displaceable piston of a resilient material, and have an openable bypass connection for liquid from the rear chamber to the front chamber and a resilient sealing closure of the front end of the front chamber.

Abstract translation: 一种双室型注射筒，其包括具有用于固体产品的前室和用于液体产品的后室的圆柱形筒管。 这些室被弹性材料的可移动活塞密封地分开，并且具有用于从后室到前室的液体的可开启的旁路连接器，以及前室的前端的弹性密封件。

公开(公告)号：US5435076A

公开(公告)日：1995-07-25

申请号：US142408

申请日：1993-11-24

Applicant: Birger Hjertman ,  Gustav Levander ,  Olle Ljungquist

Inventor： Birger Hjertman ,  Gustav Levander ,  Olle Ljungquist

IPC: A61J1/05 ,  A61M5/28 ,  A61M5/31 ,  A61M5/315 ,  F26B5/06

CPC classification number: A61M5/284 ,  F26B5/06 ,  A61M2005/3123 ,  A61M2205/6045 ,  A61M5/31586

Abstract: A device for an injection apparatus, including a dual-chamber injection cartridge. The cartridge includes a front end, a rear end, a front opening in the vicinity of a front end of the cartridge, a front chamber located in the vicinity of the front opening and including a drug freeze-dried in the front chamber, a rear chamber including a liquid component, a movable wall separating the front chamber and the rear chamber, a bypass for transferring the liquid component between the front chamber and the rear chamber, and a rear piston. The cartridge is slidably arranged within a cylindrical sleeve substantially the same length as the cartridge. A stopper is located in the vicinity of the front opening of the cartridge. The stopper is directed rearwardly coaxially with the cartridge, wherein as the sleeve is displaced rearwardly after the freeze-drying of the drug, the stopper enters the front opening of the cartridge to sealingly close the cartridge. An actuator for actuating the rear piston may be attached in the vicinity of the rear end of the cartridge.

Abstract translation: PCT No.PCT / SE93 / 00336 Sec。 371日期：1993年11月24日 102（e）1993年11月24日PCT 1993年4月16日PCT公布。 公开号WO93 / 20869 日期：1993年10月28日。一种用于注射装置的装置，包括双室注射筒。 所述盒包括前端，后端，所述盒的前端附近的前开口，位于所述前开口附近的前室，并且包括在所述前室中冻干的药物，后端 包括液体部件的腔室，分隔前腔室和后腔室的可动壁，用于在前腔室和后腔室之间传送液体部件的旁路和后活塞。 墨盒可滑动地布置在与墨盒基本相同长度的圆柱形套筒内。 止动器位于盒的前开口附近。 止动器与药筒同轴向后引导，其中当药物冷冻干燥后套筒向后移位时，止动器进入药筒的前开口以密封封闭药筒。 用于致动后活塞的致动器可以附接在盒的后端附近。

公开(公告)号：US06773414B2

公开(公告)日：2004-08-10

申请号：US10047322

申请日：2002-01-14

Applicant: Olle Ljungquist

Inventor： Olle Ljungquist

IPC: A61M3700

CPC classification number: A61B17/00491 ,  A61B17/0057 ,  A61B2017/00495 ,  B01F5/0082 ,  B01F13/0023

Abstract: A device for dispensing at least two mutually reactive components, such as fibrinogen and thrombin, comprising a supplier (12A, 12B) having a primary channel for supplying a respective one of said at least two reactive components to a dispenser (14) having secondary channels (18A, 18B) for separately discharging said components at a distal end orifice thereof opening into a target area for external intimate mixing of the respective reactive components outside a distal tip end of said dispenser (14). A distributor (38, 40) is interposed between said supplier and said dispenser for multiplying the number of the respective primary channels with at least a factor 2. Adjacent ones of said secondary channels (18A, 18B) are adjoined to primary channels (32, 34) intended for supply of reactive components of different kind.

Abstract translation: 用于分配至少两个相互反应的组分（例如纤维蛋白原和凝血酶）的装置，包括具有用于将所述至少两个反应性组分中的相应一个供应至所述至少两个反应组分中的相应一个的主要通道的供应器（12A，12B），其具有辅助通道 （18A，18B），用于在其远端孔口处分开排出所述部件，所述远端孔口开口到目标区域中，用于在所述分配器（14）的远侧末端之外的各个反应组件的外部紧密混合。 在所述供应商和所述分配器之间插入分配器（38,40），用于将相应主要通道的数量乘以至少因子2.相邻的所述次级通道（18A，18B）与主通道（32， 34）旨在供应不同类型的反应性组分。

公开(公告)号：US06331173B1

公开(公告)日：2001-12-18

申请号：US09294552

申请日：1999-04-20

Applicant: Olle Ljungquist

Inventor： Olle Ljungquist

IPC: A61M500

CPC classification number: A61M5/284 ,  A61M5/31586

Abstract: A multi-chamber ampoule comprises a container having at least one movable partition therein, the movable partition being adapted to sealingly isolate at least two substances to be mixed with each other, a seal or plunger movably disposed in the container, a holder connected to the container, and a screw actuator engageable with the seal or plunger for displacing the same in the container. The screw actuator has a male thread, and the holder includes a female thread engageable with the screw actuator male thread. The screw actuator is provided with a bore therethrough for slidably receiving a dispensing rod.

Abstract translation: 多室安瓿包括其中具有至少一个活动隔板的容器，所述可移动隔板适于将至少两种彼此混合的物质密封隔离，可移动地设置在所述容器中的密封件或柱塞，连接到所述容器的保持器 容器和可与密封件或柱塞接合的螺杆致动器，用于将容器移动到容器中。 螺杆致动器具有阳螺纹，并且保持器包括可与螺杆致动器公螺纹接合的阴螺纹。 螺杆致动器设置有穿过其中的孔，用于可滑动地容纳分配杆。

公开(公告)号：US5925019A

公开(公告)日：1999-07-20

申请号：US13

申请日：1998-04-27

Applicant: Olle Ljungquist

Inventor： Olle Ljungquist

IPC: A61M5/178 ,  A61M5/24 ,  A61M5/28 ,  A61M5/31 ,  A61M5/315 ,  A61M5/00

CPC classification number: A61M5/315 ,  A61M5/284 ,  A61M2005/3132 ,  A61M5/31505

Abstract: A device for displacing a plunger (35), movably disposed in a container (23), e.g. a medical multi-chamber ampoule, which has at least one movable partition (29), sealingly isolating at least two substances to be mixed with each other, comprises a holder means (6) for releasable connection to the container (23), a screw actuator (4) engageable with the plunger (37) for displacing it in the container (23), the holder means (6) further having a female thread, engageable with the corresponding male thread of the screw actuator. The female thread is divided into at least two parts, which are movable between a first position, in which the parts of the female thread are not engageable with the screw actuator, and a second position, in which the parts of the female thread are engageable with the actuator. The bolder means (8) has actuating means for moving the female read parts between said first and second positions.

Abstract translation: PCT No.PCT / SE96 / 01042 Sec。 371日期：1998年4月27日 102（e）日期1998年4月27日PCT提交1996年8月22日PCT公布。 公开号WO97 / 07844 日期1997年3月6日用于移动可移动地设置在容器（23）中的柱塞（35）的装置，例如 具有至少一个活动隔板（29）的医用多室安瓿，其密封地隔离至少两个彼此混合的物质，包括用于可释放地连接到容器（23）的保持器装置（6），螺钉 致动器（4）可与柱塞（37）接合，用于将其移动到容器（23）中，保持器装置（6）还具有可与螺旋致动器的相应外螺纹接合的内螺纹。 内螺纹被分成至少两个部分，其可在第一位置和第二位置之间移动，在第一位置，内螺纹的部分不能与螺钉致动器接合，第二位置，内螺纹的部分可接合 与致动器。 较大的装置（8）具有用于在所述第一和第二位置之间移动所述母读取部分的致动装置。

公开(公告)号：US5743890A

公开(公告)日：1998-04-28

申请号：US898239

申请日：1997-07-22

Applicant: Birger Hjertman ,  Olle Ljungquist

Inventor： Birger Hjertman ,  Olle Ljungquist

IPC: A61M5/315

CPC classification number: A61M5/31511 ,  A61M5/31525 ,  A61M5/31556

Abstract: A piston (11) to be used in displacing a liquid inside a cylindrical chamber, such as in an injection cartridge of the dual-chamber type, has at least one of its end surfaces (12) shaped convex such that said end surface or surfaces (12) are essentially planar when the piston has been arranged inside the barrel of said cartridge. Preferably both pistons in the cartridge have such a shape, their planar surfaces facing each other.

Abstract translation: 用于移动圆柱形室内的液体的活塞（11），例如在双室型的注射筒中，其中的至少一个端面（12）成形为凸形，使得所述端面或表面 （12）当活塞已经布置在所述筒的筒内时基本上是平面的。 盒中的两个活塞优选具有这样的形状，它们的平面彼此面对。