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8 条记录 (耗时 0.034 秒)

    Method and device for dosing a liquid preparation
    1.
    发明授权
    Method and device for dosing a liquid preparation 失效
    用于给药液体制剂的方法和装置

    公开(公告)号：US5545144A

    公开(公告)日：1996-08-13

    申请号：US232109

    申请日：1994-09-26

    申请人： Linda Fryklund ,  Birger Hjertman ,  Marie-Louise Gustavsson ,  Jacob Kaluski ,  Gustav Levander ,  Olle Ljungquist ,  Anders Strom ,  Jonas Virding

    发明人： Linda Fryklund ,  Birger Hjertman ,  Marie-Louise Gustavsson ,  Jacob Kaluski ,  Gustav Levander ,  Olle Ljungquist ,  Anders Strom ,  Jonas Virding

    IPC分类号： A61M5/315 ,  A61M5/142 ,  A61M5/24 ,  A61M5/31 ,  A61M5/00

    CPC分类号： A61M5/31548 ,  A61M5/31578 ,  A61M5/24 ,  A61M5/31525 ,  A61M5/3155 ,  A61M5/31595

    摘要： A liquid preparation of a pharmaceutically active agent having a defined composation is repeatedly dosed from a multi-dose container having a defined volume. The amount dosed is selected as 1/N of the volume of the multi-dose container, N being an integer having a value of 2 or higher.A device for dosing a liquid preparation comprises a holder (1) for a multi-dose container (2), which has a movable rear wall (5) acting as a piston for expelling the liquid preparation (6) from the container, and a piston rod (7), which is provided with releasable blocking means (11, 14, 19, 22), such that the movement of the piston rod is limited to a preset length (35) corresponding to an expelled volume of 1/N of the volume of said multi-dose container, N being an integer having a value of 2 or higher.A preferred embodiment of the device is as an injection device for repeated parenteral injections from an injection cartridge.

    摘要翻译： PCT No.PCT / SE92 / 00654 Sec。 371日期：1994年9月26日 102（e）日期1994年9月26日PCT提交1992年9月23日PCT公布。 公开号WO93 / 08854 日期1993年5月13日具有确定的组合物的药物活性剂的液体制剂从具有确定体积的多剂量容器重复给药。 选定剂量为多剂量容器体积的1 / N，N为2以上的整数。 一种用于计量液体制剂的装置包括用于多剂量容器（2）的保持器（1），其具有用作将液体制剂（6）从容器排出的活塞的活动后壁（5），以及 活塞杆（7）设置有可释放的阻塞装置（11,14,19,22），使得活塞杆的移动被限制到对应于1 / N的排出体积的预设长度（35） 所述多剂量容器的体积，N为2以上的整数。 该装置的优选实施例是用于从注射筒重复胃肠外注射的注射装置。

    Method and device for injection
    2.
    发明授权
    Method and device for injection 失效
    注射方法和装置

    公开(公告)号：US4968299A

    公开(公告)日：1990-11-06

    申请号：US212647

    申请日：1988-06-28

    申请人： Bo Ahlstrand ,  Ebba Florin-Robertsson ,  Linda Fryklund ,  Birger Hjertman ,  Anders Strom

    发明人： Bo Ahlstrand ,  Ebba Florin-Robertsson ,  Linda Fryklund ,  Birger Hjertman ,  Anders Strom

    IPC分类号： A61M5/24 ,  A61M5/315

    CPC分类号： A61M5/31525 ,  A61M5/2448 ,  A61M5/3155 ,  A61M5/31578

    摘要： A dual-chamber cylinder ampoule is used for the mixture of a sensitive, solid medicament, with liquid which is caused to flow calmly through the medicament in order to avoid any shaking and mechanical influence. The mixing is preferably carried out at a pressure above atmospheric.An injection device for the preparation of an injection solution and a following injection of such solution includes first and second tubular members for enclosing and holding a dual-chamber cylinder ampoule, in which the dry medicament is kept separated from the liquid. When the two tubular members are being screwed together the liquid is calmly and gently mixed with the dry medicament and dissolves it, and the resulted solution can thereafter be injected by means of the dosage and administration mechanism, provided in one tubular member, through a needle arranged at the front end of the other tubular member.

    Growth promoting polypeptides and preparation method
    3.
    发明授权
    Growth promoting polypeptides and preparation method 失效
    生长促进多肽及其制备方法

    公开(公告)号：US4054557A

    公开(公告)日：1977-10-18

    申请号：US470040

    申请日：1974-05-15

    申请人： Hans Uno Sievertsson ,  Linda Fryklund ,  Knut Oivind Uthne

    发明人： Hans Uno Sievertsson ,  Linda Fryklund ,  Knut Oivind Uthne

    IPC分类号： A61K38/00 ,  C07K14/475 ,  C08H1/00

    CPC分类号： C07K14/475 ,  A61K38/00 ,  Y10S530/831

    摘要： The application discloses (A) a growth-promoting polypeptide having molecular weight from about 5,000 to about 7,000 chromatographic mobility under electrophoresis from about 0.25 to about 0.37 relative to lysine at pH 5 and from about 0.17 to about 0.43 relative to aspartic acid at pH 7.5, terminal amino acid at its amino end being asparagine or aspartic acid, and respective amounts of aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, leucine, tyrosine, phenylalanine, lysine, arginine, trypophan, and cysteine or carboxymethyl cysteine, and also a couple of instances also methionine, isoleucine and histidine; and (B) the derivation of the polypeptides from blood serum or plasma or a plasma fraction by combined steps of (a) homogenizing the starting material in water, (b) admixing a solution of hydrochloric acid in ethanol thereby splitting the polypeptide from its carrier proteins and precipitating them, (c) adjusting the pH to 8.4 to provide a precipitate, (d) separating it, (e) adjusting the pH of the liquid residue to 3, (f) admixing a water-insoluble strongly acidic cation exchange matrix of sulfopropyl-oxygen-linked-substitued dextran cross-linked with epichlorhydrin at pH 3, (g) separating the gel matrix from the liquid, (h) eluting the polypeptide-containing material from the matrix with (x) ammonium acetate at pH 10 or (y) 0.75M ammonium bicarbonate; and (i) precipitating the polypeptide by admixing acetone.

    摘要翻译： 本申请公开了（A）相对于PH7.5的天冬氨酸，相对于pH5的赖氨酸和约0.17-约0.43的分子量约为5,000至约7000的色谱迁移率，生物促进多肽的电泳从约0.25至约0.37 氨基末端氨基酸为天冬酰胺或天冬氨酸，各自的天冬氨酸，苏氨酸，丝氨酸，谷氨酸，脯氨酸，甘氨酸，丙氨酸，缬氨酸，亮氨酸，酪氨酸，苯丙氨酸，赖氨酸，精氨酸，trypophan和半胱氨酸 或羧甲基半胱氨酸，还有一些情况，例如甲硫氨酸，异亮氨酸和组氨酸; 和（B）通过以下步骤的组合步骤（a）在水中均化原料，（b）将盐酸在乙醇中的溶液混合，从而将多肽从其载体中分离出来，从血清或血浆或血浆级分衍生多肽 蛋白质并沉淀，（c）将pH调节至8.4以提供沉淀物，（d）将其分离，（e）将液体残余物的pH调节至3，（f）混合不溶于水的强酸性阳离子交换基质 （g）将凝胶基质与液体分离，（h）用pH为10的（x）乙酸铵从基质中洗脱含有多肽的物质， 或（y）0.75M碳酸氢铵; 和（i）通过混合丙酮沉淀多肽。