-
公开(公告)号：US11986489B2
公开(公告)日：2024-05-21
申请号：US17167428
申请日：2021-02-04
发明人： James Galloway , Tamara Byk-Tennenbaum , Erez Ilan , Lior Weissman , Sivan Doron , Eve Montia
IPC分类号： A61K31/717 , A61K31/704 , A61L15/28 , A61L15/44 , A61L24/00 , A61L24/08
CPC分类号： A61K31/717 , A61K31/704 , A61L15/28 , A61L15/44 , A61L24/0015 , A61L24/0042 , A61L24/08 , A61L2400/04 , A61K31/704 , A61K2300/00 , A61L15/28 , C08L1/04 , A61L24/08 , C08L1/04 , A61K31/717 , A61K2300/00
摘要： The present invention is directed to methods of enhancing toxicity of a glycolytic dependent compound towards a cancerous tissue and/or organ in a subject, the method being comprised of targeting the glycolytic dependent compound to the cancerous tissue and/or organ by placing oxidized regenerated cellulose (ORC) and/or oxidized cellulose (OC) in direct connection with the cancerous tissue and/or organ, and administering the glycolytic dependent compound to the subject by a systemic route.
-
公开(公告)号：US10716548B2
公开(公告)日：2020-07-21
申请号：US15366230
申请日：2016-12-01
发明人： Yair Pilpel , Sivan Doron , Yuri Zherdev , Lior Erez , Ashley DeAnglis
摘要： The invention relates to syringes for storing and mixing components.
-
公开(公告)号：US10555991B2
公开(公告)日：2020-02-11
申请号：US15629392
申请日：2017-06-21
发明人： Yair Pilpel , Ashley Deanglis , Yuri Zherdev , Sivan Doron , Anne Gorman , Israel Nur
IPC分类号： A61K38/36 , A61L24/10 , A61K38/48 , A61K38/17 , A61K31/194 , A61K31/198 , A61K33/14 , A61L24/00
摘要： Provided herein is a single component sealant formulation (e.g. in a liquid form), methods for its preparation, and use. The formulation includes fibrinogen; vitamin K-dependent clotting zymogens comprising at least Factor II (FII) and Factor X (FX).
-
公开(公告)号：US09814765B2
公开(公告)日：2017-11-14
申请号：US14560089
申请日：2014-12-04
发明人： Yair Pilpel , Ashley Deanglis , Yuri Zherdev , Sivan Doron , Anne Gorman , Israel Nur
IPC分类号： A61K38/48 , A61K38/36 , A61K31/194 , A61K31/198 , A61K38/17 , A61K33/14 , A61L24/00 , A61L24/10
CPC分类号： A61K38/4846 , A61K31/194 , A61K31/198 , A61K33/14 , A61K38/1767 , A61K38/36 , A61K38/363 , A61K38/4833 , A61L24/0015 , A61L24/106 , A61L2300/254 , A61L2300/418 , C12Y304/21005 , C12Y304/21006 , C12Y304/21021 , C12Y304/21022
摘要： Provided herein is a single component sealant formulation (e.g. in a liquid form), methods for its preparation, and use. The formulation includes fibrinogen; vitamin K-dependent clotting zymogens comprising at least Factor II (FII) and Factor X (FX).
-
公开(公告)号：US11246579B2
公开(公告)日：2022-02-15
申请号：US16910698
申请日：2020-06-24
发明人： Yair Pilpel , Sivan Doron , Yuri Zherdev , Lior Erez , Ashley DeAnglis
摘要： The invention relates to syringes for storing and mixing components.
-
公开(公告)号：US11229688B2
公开(公告)日：2022-01-25
申请号：US16166510
申请日：2018-10-22
发明人： Yair Pilpel , Sivan Doron , Yuri Zherdev , Tamara Byk-Tennenbaum
IPC分类号： A61K38/48 , C12N9/74 , C12N15/115 , A61K38/36 , A61K47/26 , A61M5/19 , C12N15/113 , G01N33/53
摘要： The present invention is directed to compounds, methods for stabilizing thrombin activity with a thrombin binding oligonucleotide and to stabilized thrombin. The thrombin binding oligonucleotide is capable of inhibiting thrombin activity whereby the inhibition can be reversed with an antisense oligonucleotide.
-
公开(公告)号：US10435681B2
公开(公告)日：2019-10-08
申请号：US16144262
申请日：2018-09-27
发明人： Nadav Orr , Yair Pilpel , Sivan Doron
摘要： The present invention is directed to compounds useful in stabilizing thrombin activity, thrombin compositions comprising the compounds, methods of using the compounds and methods of identifying compounds capable of stabilizing thrombin activity. The compounds are preferably isolated peptides comprising or interacting with the gamma loop of thrombin.
-
8.发明申请DEVICE AND METHOD FOR PREPARING AND ADMINISTERING ONE-COMPONENT FIBRIN SEALANT 审中-公开用于制备和管理单组分纤维素密封剂的装置和方法公开(公告)号：US20150272562A1
公开(公告)日：2015-10-01
申请号：US14668341
申请日：2015-03-25
发明人： Ashley DeAnglis , Yair Pilpel , Yuri Zherdev , Sivan Doron , Lior Erez
CPC分类号： A61B17/00491 , A61K38/36 , A61K38/363 , A61K38/4833 , A61L24/106 , A61M3/005 , A61M2202/045 , C12Y304/21005
摘要： Provided herein are systems for preparing and delivering fibrin sealant to a surface and methods of use thereof. In one embodiment, the system comprises: a. a quantity of a liquid mixture disposed within a container, the mixture comprising: I. fibrin or II. fibrinogen and Factor II; and b. a resin bed disposed within a vessel, the vessel capable of being in fluid communication with the container, wherein when in fluid communication, passage of the mixture through the vessel results in modification of the concentration of small molecules inhibitor(s) and/or inducer(s) within the mixture, favoring fibrin clot formation.
摘要翻译： 本文提供了用于制备和递送纤维蛋白密封剂到表面的系统及其使用方法。 在一个实施例中，系统包括：a。 一定量的液体混合物置于容器内，该混合物包括：I.血纤蛋白或II。 纤维蛋白原和因子II; 和b。 设置在容器内的树脂床，容器能够与容器流体连通，其中当流体连通时，混合物通过容器导致改变小分子抑制剂和/或诱导剂的浓度 在混合物中，有利于血纤维蛋白凝块的形成。
-
公开(公告)号：US20150118213A1
公开(公告)日：2015-04-30
申请号：US14519552
申请日：2014-10-21
发明人： Nadav Orr , Yair Pilpel , Sivan Doron
CPC分类号： C12N9/6429 , A61K38/43 , C07K7/00 , C12Q1/56 , C12Y304/21005 , G01N2500/04
摘要： The present invention is directed to compounds useful in stabilizing thrombin activity, thrombin compositions comprising the compounds, methods of using the compounds and methods of identifying compounds capable of stabilizing thrombin activity. The compounds are preferably isolated peptides comprising or interacting with the gamma loop of thrombin.
摘要翻译： 本发明涉及可用于稳定凝血酶活性的化合物，包含该化合物的凝血酶组合物，使用该化合物的方法和鉴定能够稳定凝血酶活性的化合物的方法。 所述化合物优选是分离的肽，其包含或与凝血酶的γ环相互作用。
-
公开(公告)号：US20220088156A1
公开(公告)日：2022-03-24
申请号：US17548196
申请日：2021-12-10
发明人： Yair Pilpel , Sivan Doron , Yuri Zherdev , Tamara Byk-Tennenbaum
IPC分类号： A61K38/48 , C12N9/74 , C12N15/115 , A61K38/36 , A61K47/26 , A61M5/19 , C12N15/113 , G01N33/53
摘要： The present invention is directed to compounds, methods for stabilizing thrombin activity with a thrombin binding oligonucleotide and to stabilized thrombin. The thrombin binding oligonucleotide is capable of inhibiting thrombin activity whereby the inhibition can be reversed with an antisense oligonucleotide.
-
-
-
-
-
-
-
-
-
搜索结果
26 条记录 (耗时 0.026 秒)
