公开(公告)号：US20050177196A1

公开(公告)日：2005-08-11

申请号：US11050611

申请日：2005-02-03

申请人： Orhan Soykan ,  Timothy Robinson ,  Walter Olson ,  Vinod Sharma ,  Amy Dearking

发明人： Orhan Soykan ,  Timothy Robinson ,  Walter Olson ,  Vinod Sharma ,  Amy Dearking

IPC分类号： A61B5/00 ,  G01N33/68 ,  G06F19/00 ,  A61N1/362

CPC分类号： G01N33/6893 ,  G01N2800/326 ,  Y10T436/13

摘要： In general, the invention is directed to systems and techniques for assessing a risk of ventricular tachyarrhythmia in a patient by measuring one or more biochemical markers that reflect the health of a patient. Typically, the patient submits a sample, such as a blood sample, which is tested for one or more biomarkers. Based upon the results of the tests, the patient's risk of ventricular tachyarrhythmia may be assessed. When the patient is found to be at risk, the patient may receive an implantable medical device or drug therapy to address the risk.

摘要翻译： 通常，本发明涉及通过测量反映患者健康的一种或多种生物化学标记来评估患者的心室性快速性心律失常风险的系统和技术。 通常，患者提交样品，例如血液样品，其被测试一种或多种生物标志物。 根据测试结果，可以评估患者的心室性心律失常风险。 当患者被发现处于危险中时，患者可能会接受可植入的医疗设备或药物治疗来解决风险。

公开(公告)号：US20050266576A1

公开(公告)日：2005-12-01

申请号：US11157549

申请日：2005-06-21

申请人： Orhan Soykan ,  Amy Dearking ,  Timothy Robinson ,  Walter Olson ,  Vinod Sharma

发明人： Orhan Soykan ,  Amy Dearking ,  Timothy Robinson ,  Walter Olson ,  Vinod Sharma

IPC分类号： G01N33/68 ,  G06F19/00 ,  G01N33/00

CPC分类号： G01N33/6893 ,  G01N2800/326

摘要： The invention is a method for identifying proteins associated with sudden cardiac death (SCD) and for assessing a patient's risk of SCD by determining the amount of one or more SCD-associated proteins in the patient. Typically, the patient submits a sample, such as a blood sample, which is tested for one or more SCD-associated proteins. Based upon the results of the tests, the patient's risk of SCD may be assessed.

摘要翻译： 本发明是鉴定与心脏猝死相关的蛋白质（SCD）的方法，并且通过确定患者中一种或多种与SCD相关的蛋白质的量来评估患者的SCD风险。 通常，患者提交样品，例如血液样品，其被测试一种或多种与SCD相关的蛋白质。 根据测试结果，可以评估患者SCD的风险。

公开(公告)号：US20060088503A1

公开(公告)日：2006-04-27

申请号：US11249948

申请日：2005-10-13

申请人： Vinod Sharma ,  Orhan Soykan ,  Maura Donovan ,  Walter Olson

发明人： Vinod Sharma ,  Orhan Soykan ,  Maura Donovan ,  Walter Olson

IPC分类号： A01N63/00

CPC分类号： A61L27/3873 ,  A61K9/0024 ,  A61K38/00 ,  A61K48/005 ,  A61L27/227 ,  A61L27/3834 ,  C07K14/705

摘要： A method for decreasing risk of ventricular tachycardia following myocardial infarction increases cell-to-cell coupling and/or excitability in the border zone of an infarcted region of myocardial tissue. Enhanced conduction to treat the border zone is carried out by genetically modifying myocytes in the border zone to form more gap junctions and/or sodium channels and/or calcium channels. Alternatively, enhanced conduction is carried out by incorporating cells into the border zone that form gap junctions with the myocytes and/or form sodium channels and/or form calcium channels.

摘要翻译： 降低心肌梗死后室性心动过速风险的方法增加了心肌组织梗塞区域边界区的细胞间电偶耦合和/或兴奋性。 通过在边界区域中遗传修饰肌细胞以形成更多的间隙连接和/或钠通道和/或钙通道来进行治疗边界区域的增强传导。 或者，通过将细胞并入到与肌细胞形成间隙连接和/或形成钠通道和/或形成钙通道的边界区域中来进行增强的传导。

公开(公告)号：US20070021375A1

公开(公告)日：2007-01-25

申请号：US11536426

申请日：2006-09-28

申请人： Vinod Sharma ,  Walter Olson

发明人： Vinod Sharma ,  Walter Olson

IPC分类号： A61K48/00 ,  C07H21/04

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K38/177

摘要： Disclosed are compositions, methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of cells of targeted regions of the cardiac conduction system. In particular, a bio-pacemaker composition is delivered to cardiac cells to increase the intrinsic pacemaking rate of the cells, wherein the bio-pacemaker composition increases expression of a channel or subunit thereof that produces funny current and a T-type Ca2+ channel or subunit thereof, and expresses one or more molecules that suppresses the expression of the wild type potassium channel.

摘要翻译： 公开了用于预防或治疗心脏功能障碍的组合物，方法和系统，特别是心脏起搏功能障碍，通过心脏传导系统的靶向区域的细胞的遗传修饰。 特别地，将生物起搏器组合物递送到心脏细胞以增加细胞的内在起搏速率，其中生物起搏器组合物增加产生滑稽电流的通道或其亚基的表达，并且T型Ca 2 + 通道或其亚单位，并表达抑制野生型钾通道表达的一种或多种分子。

公开(公告)号：US20070116874A1

公开(公告)日：2007-05-24

申请号：US11284611

申请日：2005-11-22

申请人： Walter Olson

发明人： Walter Olson

IPC分类号： C23C16/00

CPC分类号： C23C8/04 ,  C23C10/04 ,  C23C10/06 ,  F01D5/18 ,  F01D5/28 ,  F05D2230/313 ,  F05D2300/121

摘要： A method for coating internal surfaces of a turbine engine component comprises flowing an aluminide containing gas into passages in the turbine engine component so as to coat the internal surfaces formed by the passages, allowing the aluminide containing gas to flow through the passages and out openings in external surfaces of the turbine engine component, and flowing a volume of a gas selected from the group consisting of argon, hydrogen, and mixtures thereof over the external surfaces to minimize any build-up of an aluminide coating on the external surfaces.

摘要翻译： 一种用于涂覆涡轮发动机部件的内表面的方法包括将含铝化物的气体流入涡轮发动机部件中的通道，以便涂覆由通道形成的内表面，允许含铝化物的气体流过通道，并将出口 涡轮发动机部件的外表面，并且将一批体积的选自氩，氢及其混合物的气体流过外表面，以最小化铝表面在外表面上的积聚。

公开(公告)号：US20070239215A1

公开(公告)日：2007-10-11

申请号：US11394477

申请日：2006-03-31

申请人： Sourav Bhunia ,  Walter Olson ,  Can Cinbis

发明人： Sourav Bhunia ,  Walter Olson ,  Can Cinbis

IPC分类号： A61N1/00

CPC分类号： A61B5/14542 ,  A61B5/1459 ,  A61N1/3621 ,  A61N1/36557 ,  A61N1/3956

摘要： A medical device identifies a hemodynamically unstable arrhythmia based upon optical hemodynamic sensor signals. The optical hemodynamic sensor includes a light source for transmitting light corresponding to first and second wavelengths through a blood perfused tissue of a patient and a light detector for generating optical signals corresponding to an intensity of the detected light at the first and second wavelengths. At a low motion period for the patient, optical signals are obtained from the optical hemodynamic sensor and are analyzed to determine a baseline motion level for the patient. Subsequent signals obtained from the optical hemodynamic sensor are compared to the baseline motion levels, with only those signals corresponding to periods where motion does not exceed the baseline level of motion being further analyzed to determine if they are consistent with a hemodynamically unstable arrhythmia.

摘要翻译： 医疗设备基于光学血液动力学传感器信号识别血液动力学不稳定的心律失常。 光学血液动力学传感器包括用于通过患者的血液灌注组织透射与第一和第二波长相对应的光的光源，以及用于产生与第一和第二波长的检测光的强度对应的光信号的光检测器。 在患者的低运动周期中，从光学血液动力学传感器获得光学信号，并且被分析以确定患者的基线运动水平。 将从光学血液动力学传感器获得的后续信号与基线运动水平进行比较，只有那些对应于运动未超过基线运动水平的周期的信号进行进一步分析，以确定它们是否与血液动力学不稳定的心律失常一致。

公开(公告)号：US20060122649A1

公开(公告)日：2006-06-08

申请号：US11004498

申请日：2004-12-03

申请人： Raja Ghanem ,  Walter Olson

发明人： Raja Ghanem ,  Walter Olson

IPC分类号： A61N1/36

CPC分类号： A61N1/05 ,  A61N1/362

摘要： A cardiac pacemaker and method of its use. The pacemaker is provided with a pacing electrode array configured for location at a left anterior portion of a patient's thorax between the patients third and sixth ribs, outside the patient's thoracic cavity. The pacing electrode array includes multiple pacing electrodes and preferably includes one or more steering electrodes for configuring the electrical field produced by delivery of pacing pulses to avoid unwanted nerve and muscle stimulation while allowing cardiac stimulation. The electrode array may be located subcutaneously, submuscularly or on the patient's skin.

公开(公告)号：US20060247688A1

公开(公告)日：2006-11-02

申请号：US11116577

申请日：2005-04-28

申请人： Walter Olson ,  King Moy ,  Joey Nakayama ,  Gary Prokop ,  Gary Stilwell

发明人： Walter Olson ,  King Moy ,  Joey Nakayama ,  Gary Prokop ,  Gary Stilwell

IPC分类号： A61N1/39

CPC分类号： A61N1/3968 ,  A61N1/0504 ,  A61N1/375 ,  A61N1/3756

摘要： SubQ ICDs are disclosed that are entirely implantable subcutaneously with minimal surgical intrusion into the body of the patient and provide distributed cardioversion-defibrillation sense and stimulation electrodes for delivery of cardioversion-defibrillation shock and pacing therapies across the heart when necessary. Configurations include one hermetically sealed housing with 1 or, optionally, 2 subcutaneous sensing and cardioversion-defibrillation therapy delivery leads or alternatively, 2 hermetically sealed housings interconnected by a power/signal cable. The housings are generally dynamically configurable to adjust to varying rib structure and associated articulation of the thoracic cavity and muscles. Further the housings may optionally be flexibly adjusted for ease of implant and patient comfort.

摘要翻译： 公开了SubQ ICD，其完全可植入皮下，以最小的手术侵入患者身体，并提供分布式心脏复律除颤感和刺激电极，用于在需要时在整个心脏中递送心脏复律除颤电击和起搏治疗。 配置包括一个密封的外壳，具有1个或任选地2个皮下感测和心脏复律除颤治疗输送引线，或者备选地，通过电源/信号电缆互连的2个气密密封外壳。 这些外壳通常是可动态配置的，以适应胸部结构和胸腔和肌肉关联的变化。 此外，为了便于植入和患者舒适，还可以灵活地调整这些外壳。

公开(公告)号：US20060216415A1

公开(公告)日：2006-09-28

申请号：US11089989

申请日：2005-03-24

申请人： Walter Olson ,  Mathew Gartland

发明人： Walter Olson ,  Mathew Gartland

IPC分类号： B05D7/22 ,  C23C16/00

CPC分类号： C23C16/12 ,  C23C16/045 ,  C23C16/45591

摘要： A manifold for use in a process for coating different sized passages in a workpiece is provided. The manifold has an internal chamber, an inlet for receiving a flow of a coating gas, and a flow diverter within the internal chamber for separating the flow of coating gas into a first flow sufficient to coat a full length of surfaces of a first internal passage set having a first cross section dimension and a second flow sufficient to coat a full length of surfaces of a second internal passage set having a second cross section dimension smaller than the first cross section dimension.

摘要翻译： 提供了用于在工件中涂覆不同尺寸通道的方法中的歧管。 歧管具有内部室，用于接收涂覆气体流的入口和内部室内的分流器，用于将涂覆气体流分离成足以涂覆第一内部通道的全长表面的第一流动 其具有第一横截面尺寸和足以涂覆具有小于第一横截面尺寸的第二横截面尺寸的第二内部通道组的全长表面的第二流动。

公开(公告)号：US20050049647A1

公开(公告)日：2005-03-03

申请号：US10652839

申请日：2003-08-29

申请人： Walter Olson

发明人： Walter Olson

IPC分类号： A61N1/372 ,  A61N1/375

CPC分类号： A61N1/37211 ,  A61N1/37247 ,  A61N1/375

摘要： An externally actuable, hermetically sealed switch is incorporated with an implantable medical device (IMD). A patient applies pressure against the tissue over the IMD and actuates the switch. The actuation of the switch causes the IMD to take predetermined actions, such as recording data, inhibiting therapy, initiating therapy, increasing therapy, requesting information, initiating a communications session, or performing a status check. Thus, the patient is able to interact with the IMD without requiring an external device such as a programmer, patient activator or magnet.

摘要翻译： 外部可致动的密封开关与可植入医疗装置（IMD）结合。 患者对IMD上的组织施加压力并致动开关。 开关的启动使得IMD采取预定的动作，例如记录数据，抑制治疗，开始治疗，增加治疗，请求信息，发起通信会话或执行状态检查。 因此，患者能够与IMD交互，而不需要外部设备，例如程序员，患者激活器或磁体。