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公开(公告)号：US08450559B2
公开(公告)日：2013-05-28
申请号：US12934685
申请日：2009-03-27
申请人： Orlando Borrás Hidalgo , Roxana Caridad Portieles Álvarez , Merardo Pujol Ferrer , Gil Alberto Enriquez Obregón , Ernesto Manuel González Ramos , Camilo Ayra Pardo , Carlos Guillermo Borroto Nordelo
发明人： Orlando Borrás Hidalgo , Roxana Caridad Portieles Álvarez , Merardo Pujol Ferrer , Gil Alberto Enriquez Obregón , Ernesto Manuel González Ramos , Camilo Ayra Pardo , Carlos Guillermo Borroto Nordelo
CPC分类号： A01N37/18 , C07K14/415 , C12N15/8279 , C12N15/8282
摘要： The present invention reveals a nucleic acid sequence from Nicotiana megalosiphon encoding for an anti-pathogenic protein. The invention comprises the use of this nucleic acid molecule in transgenic plants of agricultural interest to confer resistance to pathogens. The invention also includes a bioproduct that comprises this anti-pathogenic protein to control plant pathogen agents.
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公开(公告)号：US20110124581A1
公开(公告)日：2011-05-26
申请号：US12934685
申请日：2009-03-27
申请人： Orlando Borrás Hidalgo , Roxana Caridad Portieles Álvarez , Merardo Pujol Ferrer , Gil Alberto Enriquez Obregón , Ernesto Manuel González Ramos , Camilo Ayra Pardo , Carlos Guillermo Borroto Nordelo
发明人： Orlando Borrás Hidalgo , Roxana Caridad Portieles Álvarez , Merardo Pujol Ferrer , Gil Alberto Enriquez Obregón , Ernesto Manuel González Ramos , Camilo Ayra Pardo , Carlos Guillermo Borroto Nordelo
CPC分类号： A01N37/18 , C07K14/415 , C12N15/8279 , C12N15/8282
摘要： The present invention reveals a nucleic acid sequence from Nicotiana megalosiphon encoding for an anti-pathogenic protein. The invention comprises the use of this nucleic acid molecule in transgenic plants of agricultural interest to confer resistance to pathogens. The invention also includes a bioproduct that comprises this anti-pathogenic protein to control plant pathogen agents.
摘要翻译： 本发明揭示了编码抗病原性蛋白质的烟草巨乳的核酸序列。 本发明包括在农业感兴趣的转基因植物中使用该核酸分子来赋予对病原体的抗性。 本发明还包括一种生物产物，其包含该抗病原性蛋白质以控制植物病原体。
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公开(公告)号：US10104889B2
公开(公告)日：2018-10-23
申请号：US14001344
申请日：2012-02-27
申请人： Orlando Borrás Hidalgo , Eduardo Canales López , Merardo Pujol Ferrer , Carlos Guillermo Borroto Nordelo , Yamilet Coll García
发明人： Orlando Borrás Hidalgo , Eduardo Canales López , Merardo Pujol Ferrer , Carlos Guillermo Borroto Nordelo , Yamilet Coll García
摘要： The present invention describes a method for the stimulation of the natural defense and the induction of resistance to diseases in plants by simultaneous activation of genes related to the route of the salicylic acid, the jasmonic acid/ethylene and the hypersensitive response. The invention also includes the use of brassinosteroids for the preventive and curative treatment against plant diseases caused by pathogens. In addition, includes a method for the prevention and treatment of the Huanglongbing disease in citrus.
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公开(公告)号：US20140171326A1
公开(公告)日：2014-06-19
申请号：US14001344
申请日：2012-02-27
申请人： Orlando Borras Hidalgo , Eduardo Canales López , Merardo Pujol Ferrer , Carlos Guillermo Borroto Nordelo , Yamilet Coll Garcia
发明人： Orlando Borras Hidalgo , Eduardo Canales López , Merardo Pujol Ferrer , Carlos Guillermo Borroto Nordelo , Yamilet Coll Garcia
IPC分类号： A01N43/22
摘要： The present invention describes a method for the stimulation of the natural defense and the induction of resistance to diseases in plants by simultaneous activation of genes related to the route of the salicylic acid, the jasmonic acid/ethylene and the hypersensitive response. The invention also includes the use of brassinosteroids for the preventive and curative treatment against plant diseases caused by pathogens. In addition, includes a method for the prevention and treatment of the Huanglongbing disease in citrus.
摘要翻译： 本发明描述了通过同时激活与水杨酸，茉莉酸/乙烯和过敏反应的途径有关的基因来刺激自然防御和对植物疾病抗性的诱导的方法。 本发明还包括使用油菜素类固醇来预防和治疗由病原体引起的植物疾病。 另外还包括一种预防和治疗柑橘黄龙病的方法。
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公开(公告)号：US20090304633A1
公开(公告)日：2009-12-10
申请号：US12280055
申请日：2007-02-28
申请人： Jorge Roberto Toledo Alonso , Oliberto Sánchez Ramos , Maritza Isidra Barrera Valle , Nancy Elena Figueroa Baile , Yanet Prieto Carratala , Maria Pilar Rodriguez Molto , Maria Teresa Frias Lepoureau , Carlos Guillermo Borroto Nordelo
发明人： Jorge Roberto Toledo Alonso , Oliberto Sánchez Ramos , Maritza Isidra Barrera Valle , Nancy Elena Figueroa Baile , Yanet Prieto Carratala , Maria Pilar Rodriguez Molto , Maria Teresa Frias Lepoureau , Carlos Guillermo Borroto Nordelo
CPC分类号： C07K14/005 , A01K2267/01 , A61K39/12 , A61K2039/55 , A61K2039/552 , A61K2039/55566 , A61K2039/57 , A61K2039/6031 , C07K14/70575 , C07K16/1081 , C07K2317/76 , C07K2319/21 , C07K2319/74 , C12N2710/10343 , C12N2770/24322 , C12N2770/24334
摘要： The current invention describes chimeric vaccine antigens against the virus that causes the Classic Swine Fever (CSFV). Such vaccine antigens are based on viral subunits coupled to proteins able to stimulate cellular and humoral immune system. Chimeric antigens can be produced in expression systems that guarantee a correct tertiary structure folding of the chimeric molecules, which constitute the essence of the current invention. The vaccine formulations containing such chimeric antigens induce an early and potent immune response on vaccinated pigs and confer full protection against CSFV. Moreover, the resultant vaccine formulations prevent the viral transmission from sows to their offspring. The chimeric antigens, as well as the resultant vaccine formulations, can be applied in animal health as vaccines for preventive use in swine.
摘要翻译： 本发明描述了针对导致经典猪瘟（CSFV）的病毒的嵌合疫苗抗原。 这种疫苗抗原基于与能够刺激细胞和体液免疫系统的蛋白质偶联的病毒亚基。 嵌合抗原可以在保证构成本发明精华的嵌合分子的正确三级结构折叠的表达系统中产生。 含有这种嵌合抗原的疫苗制剂在接种疫苗的猪上诱导早期有效的免疫应答并赋予对CSFV的完全保护。 此外，所得疫苗制剂防止病毒从母猪传播到其后代。 嵌合抗原以及得到的疫苗制剂可以作为预防用于猪的疫苗用于动物健康。
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公开(公告)号：US08409562B2
公开(公告)日：2013-04-02
申请号：US12280055
申请日：2007-02-28
申请人： Jorge Roberto Toledo Alonso , Oliberto Sánchez Ramos , Maritza Isidra Barrera Valle , Nancy Elena Figueroa Baile , Yanet Prieto Carratala , Maria Pilar Rodriguez Molto , Maria Teresa Frias Lepoureau , Carlos Guillermo Borroto Nordelo
发明人： Jorge Roberto Toledo Alonso , Oliberto Sánchez Ramos , Maritza Isidra Barrera Valle , Nancy Elena Figueroa Baile , Yanet Prieto Carratala , Maria Pilar Rodriguez Molto , Maria Teresa Frias Lepoureau , Carlos Guillermo Borroto Nordelo
CPC分类号： C07K14/005 , A01K2267/01 , A61K39/12 , A61K2039/55 , A61K2039/552 , A61K2039/55566 , A61K2039/57 , A61K2039/6031 , C07K14/70575 , C07K16/1081 , C07K2317/76 , C07K2319/21 , C07K2319/74 , C12N2710/10343 , C12N2770/24322 , C12N2770/24334
摘要： The current invention describes chimeric vaccine antigens against the virus that causes the Classic Swine Fever (CSFV). Such vaccine antigens are based on viral subunits coupled to proteins able to stimulate cellular and humoral immune system. Chimeric antigens can be produced in expression systems that guarantee a correct tertiary structure folding of the chimeric molecules, which constitute the essence of the current invention. The vaccine formulations containing such chimeric antigens induce an early and potent immune response on vaccinated pigs and confer full protection against CSFV. Moreover, the resultant vaccine formulations prevent the viral transmission from sows to their offspring. The chimeric antigens, as well as the resultant vaccine formulations, can be applied in animal health as vaccines for preventive use in swine.
摘要翻译： 本发明描述了针对导致经典猪瘟（CSFV）的病毒的嵌合疫苗抗原。 这种疫苗抗原基于与能够刺激细胞和体液免疫系统的蛋白质偶联的病毒亚基。 嵌合抗原可以在保证构成本发明精华的嵌合分子的正确三级结构折叠的表达系统中产生。 含有这种嵌合抗原的疫苗制剂在接种疫苗的猪上诱导早期有效的免疫应答并赋予对CSFV的完全保护。 此外，所得疫苗制剂防止病毒从母猪传播到其后代。 嵌合抗原以及得到的疫苗制剂可以作为预防用于猪的疫苗用于动物健康。
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7.发明申请公开(公告)号：US20090324644A1
公开(公告)日：2009-12-31
申请号：US12280568
申请日：2007-02-28
申请人： Oliberto Sanchez Ramos , Jorge Roberto Toledo Alonso , Damarys Diaz Archer , Nancy Elena Figueroa Baile , Maria Pilar Rodriguez Molto , Carlos Guillermo Borroto Nordelo
发明人： Oliberto Sanchez Ramos , Jorge Roberto Toledo Alonso , Damarys Diaz Archer , Nancy Elena Figueroa Baile , Maria Pilar Rodriguez Molto , Carlos Guillermo Borroto Nordelo
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K39/385 , A61K2039/55505 , A61K2039/55566 , A61K2039/605 , A61K2039/64 , C07K14/005 , C07K14/705 , C07K2319/32 , C07K2319/735 , C07K2319/74 , C12N2760/16122 , C12N2760/16134
摘要： The present invention describes chimeric vaccine antigens against the avian influenza virus (AIV). Said vaccine antigens are based on viral subunits that are coupled to protein molecules that stimulate not only the cellular but also the humoral immune system. The chimeric antigens may be produced in expression systems that guarantee correct three-dimensional folding of the chimeric molecules that constitute the basis of the present invention. The vaccine compositions that contain said chimeric antigens induce a potent, early immune response both in birds and in vaccinated mammals, stimulating high haemagglutinin-inhibiting antibody titres and a potent specific cellular response against the viral antigen. The chimeric antigens, and also the resulting vaccine compositions, are applicable to the field of human and animal health as vaccines for preventive use.
摘要翻译： 本发明描述针对禽流感病毒（AIV）的嵌合疫苗抗原。 所述疫苗抗原基于与蛋白质分子偶联的病毒亚基，其不仅刺激细胞而且刺激体液免疫系统。 嵌合抗原可以在保证构成本发明基础的嵌合分子的正确三维折叠的表达系统中产生。 含有所述嵌合抗原的疫苗组合物在鸟类和接种的哺乳动物中诱导有效的早期免疫应答，刺激高血凝素抑制性抗体滴度和针对病毒抗原的有效特异性细胞应答。 嵌合抗原以及所得的疫苗组合物可用于人和动物健康领域作为用于预防用途的疫苗。
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公开(公告)号：US20100300166A1
公开(公告)日：2010-12-02
申请号：US12598084
申请日：2008-04-29
申请人： Jesús Mena Campos , Eulogio Pimentel Vázquez , Marieta Marín Bruzos , Armando Tomás Hernández García , Ileana Sánchez Ortiz , Yamilka Ramírez Núñez , Sonia González Blanco , Marianela García Siverio , Carlos Guillermo Borroto Nordelo
发明人： Jesús Mena Campos , Eulogio Pimentel Vázquez , Marieta Marín Bruzos , Armando Tomás Hernández García , Ileana Sánchez Ortiz , Yamilka Ramírez Núñez , Sonia González Blanco , Marianela García Siverio , Carlos Guillermo Borroto Nordelo
IPC分类号： C05F11/08
摘要： A composition to stimulate the development and growth of plants that comprises at least a Tsukamurella paurometabola strain, biofertilizing agent that optimize the assimilation of the organic matter by plants, favoring the intake of nitrogen and phosphorus by the plant. Said agent is able of increasing the growth and development of the plants after the application of this biofertilizer directly to the soil or in a natural or artificial substrate, with organic matter, or after its application in any type of soil or substrate with an organic complement
摘要翻译： 一种刺激植物发育和生长的组合物，其至少包含一种能够优化植物有机物同化的生物增肥剂，有利于植物摄取氮和磷。 所述试剂能够在将该生物肥料直接施用于土壤或天然或人造基质与有机物质之后或在其用于任何类型的土壤或基质中的有机补体之后增加植物的生长和发育
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