-
公开(公告)号：US4803224A
公开(公告)日：1989-02-07
申请号：US857878
申请日：1986-05-01
申请人： Osamu Tenmyo , Hiroaki Ohkuma , Masataka Konishi
发明人： Osamu Tenmyo , Hiroaki Ohkuma , Masataka Konishi
IPC分类号： C08G69/26 , C12P13/02 , C07C103/50 , A61K31/195
摘要： There is disclosed an antibiotic complex designated as BU-2231 V which is produced by fermentation of a BU-2231-producing strain of Streptoalloteichus hindustanus, ATCC 31158. Complex BU-2231 V is recovered and purified from the fermentation broth by use of ion exchange chromatography techniques. Structural analysis shows that the complex is a mixture of components which are .gamma.-homopolymers of D-.alpha.,.gamma.-diaminobutyric acid having an average molecular weight of from about 5,100 to about 5,200. BU-2231 V has been found to be effective to inhibit growth of various Gram-positive and Gram-negative bacteria and of the herpes simplex virus.
摘要翻译： 公开了一种称为BU-2231V的抗生素复合物，其通过发酵产生的BU-2231产生的Streptoalloteichus hindustanus，ATCC 31158的菌株产生。通过使用离子交换从发酵液中回收并纯化复合物BU-2231V 色谱技术。 结构分析表明，该复合物是组分的混合物，其是平均分子量为约5100至约5200的D-α，γ-二氨基丁酸的γ-均聚物。 已经发现BU-2231V有效抑制各种革兰氏阳性和革兰氏阴性菌和单纯疱疹病毒的生长。
-
公开(公告)号：US5098708A
公开(公告)日：1992-03-24
申请号：US546463
申请日：1990-07-06
IPC分类号： C12P1/06
CPC分类号： C12P1/06 , Y10S435/822 , Y10S435/826
摘要： Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.
摘要翻译： 公开了通过新型微生物Amycolatopsis orientalis ATCC-53884的BU-3889V生产菌株的发酵生产抗病毒抗生素复合物BU-3889V及其生物活性成分A1，A2，A3，D1，D2和D3。 通过使用离子交换色谱技术分离复合物BU-3889V并将组分分离。 生物活性成分的特征在于其物理化学性质。 已经发现这些产品有效地抑制包括单纯疱疹病毒，人类免疫缺陷病毒（HIV）和流感病毒在内的病毒。
-
公开(公告)号：US4314028A
公开(公告)日：1982-02-02
申请号：US109427
申请日：1980-01-03
CPC分类号： C07H15/26 , Y10S435/822
摘要： Addition of certain amine precursor compounds to the culture medium during fermentation of a tallysomycin-producing strain of Streptoalloteichus hindustanus results in production of new tallysomycin derivatives having advantageous antimicrobial and antitumor properties.
摘要翻译： 在培养的产丝菌霉素生产菌株Streptoalloteichus hindustanus的发酵期间向培养基中加入某些胺前体化合物导致产生具有有利的抗微生物和抗肿瘤性质的新的菌丝霉素衍生物。
-
公开(公告)号：US5124150A
公开(公告)日：1992-06-23
申请号：US624029
申请日：1991-03-11
IPC分类号： C12P1/06
CPC分类号： C12P1/06 , Y10S435/822
摘要： Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.
摘要翻译： 公开了通过新型微生物Amycolatopsis orientalis ATCC-53884的BU-3889V生产菌株的发酵生产抗病毒抗生素复合物BU-3889V及其生物活性成分A1，A2，A3，D1，D2和D3。 通过使用离子交换色谱技术分离复合物BU-3889V并将组分分离。 生物活性成分的特征在于其物理化学性质。 已经发现这些产品有效地抑制包括单纯疱疹病毒，人类免疫缺陷病毒（HIV）和流感病毒在内的病毒。
-
公开(公告)号：US4246400A
公开(公告)日：1981-01-20
申请号：US57528
申请日：1979-07-13
IPC分类号： C07H15/26 , A61K31/70 , A61K31/7028 , A61P31/04 , A61P35/00 , C07K9/00 , C12P19/58 , C12R1/01 , A61K31/71 , C07H15/22
CPC分类号： C07K9/003 , Y10S514/883
摘要： Addition of certain amine precursor compounds to the culture medium during fermentation of a tallysomycin-producing strain of Streptoalloteichus hindustanus results in production of new tallysomycin derivatives having advantageous antimicrobial and antitumor properties.
摘要翻译： 在培养的产丝菌霉素生产菌株Streptoalloteichus hindustanus的发酵期间向培养基中加入某些胺前体化合物导致产生具有有利的抗微生物和抗肿瘤性质的新的菌丝霉素衍生物。
-
公开(公告)号：US5286649A
公开(公告)日：1994-02-15
申请号：US819543
申请日：1992-01-10
CPC分类号： C12P1/06 , Y10S435/822
摘要： Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.
摘要翻译： 公开了通过新型微生物Amycolatopsis orientalis ATCC-53884的BU-3889V生产菌株的发酵生产抗病毒抗生素复合物BU-3889V及其生物活性成分A1，A2，A3，D1，D2和D3。 通过使用离子交换色谱技术分离复合物BU-3889V并将组分分离。 生物活性成分的特征在于其物理化学性质。 已经发现这些产品有效地抑制包括单纯疱疹病毒，人类免疫缺陷病毒（HIV）和流感病毒在内的病毒。
-
公开(公告)号：US4708872A
公开(公告)日：1987-11-24
申请号：US812699
申请日：1985-12-23
摘要： A novel antibiotic complex designated herein as BBM-1675 complex is produced by fermentation of certain novel strains of Actinomadura verrucosospora. The complex may be separated into two major components, BBM-1675 A.sub.1 and A.sub.2, and four minor components, BBM-1675 A.sub.3, A.sub.4, B.sub.1 and B.sub.2, and such components exhibit both antimicrobial activity and antitumor activity.
摘要翻译： 本文命名为BBM-1675复合物的新型抗生素复合物是通过发酵某些新型的放线菌属（Actinomadura verrucosospora）菌株产生的。 复合物可以分为BBM-1675A1和A2两个主要组分，以及四个次要组分BBM-1675 A3，A4，B1和B2，并且这些组分表现出抗微生物活性和抗肿瘤活性。
-
公开(公告)号：US5116845A
公开(公告)日：1992-05-26
申请号：US519067
申请日：1990-05-04
CPC分类号： A61K31/44 , C12P17/188
摘要： The novel antitumor antibiotic designated herein as BU-3420T is produced by fermentation of Micromonospora chersina strain M956-1 (ATCC 53710). BU-3420T and its triacetate derivative possess antibacterial and antifungal activity and also inhibit the growth of mammalian tumors such as P388 leukemia in mice.
摘要翻译： 本文命名为BU-3420T的新型抗肿瘤抗生素是通过发酵黑麦草细菌菌株M956-1（ATCC 53710）产生的。 BU-3420T及其三醋酸酯衍生物具有抗菌和抗真菌活性，并且还抑制小鼠中哺乳动物肿瘤如P388白血病的生长。
-
公开(公告)号：US4916065A
公开(公告)日：1990-04-10
申请号：US208330
申请日：1988-06-10
IPC分类号： C12P17/02 , A61K31/435 , A61P35/00 , C07D491/08 , C12N1/20 , C12P17/18 , C12R1/29
CPC分类号： C07D491/08 , C12P17/18 , C12R1/29 , Y10S435/867
摘要： The novel antitumor antibiotic designated herein as BU-3420T is produced by fermentation of Micromonospora chersina strain M956-1 (ATCC 53710). BU-3420T and its triacetate derivative possess antibacterial and antifungal activity and also inhibit the growth of mammalian tumors such as P388 leukemia in mice.
-
公开(公告)号：US5036008A
公开(公告)日：1991-07-30
申请号：US507543
申请日：1990-04-11
申请人： Hiroaki Ohkuma , Koji Tomita , Masataka Konishi , Hideo Kamei
发明人： Hiroaki Ohkuma , Koji Tomita , Masataka Konishi , Hideo Kamei
IPC分类号： C07D309/32
CPC分类号： C07D309/32
摘要： The present invention relates to the antitumor antibiotic compound BU-3285T and its preparation. The compound is obtained by culturing a new strain of Chainia rosea and demonstrates both antitumor and antifungal activity. It also relates to the desulfated derivative of BU-3285T which is obtained by treatment of BU-3285T with sulfatase enzyme. BU-3285T desulfate possesses antitumor activity.
摘要翻译： 本发明涉及抗肿瘤抗生素化合物BU-3285T及其制备方法。 该化合物通过培养一种新的连翘蔷薇菌株获得，并且具有抗肿瘤和抗真菌活性。 它还涉及通过用硫酸酯酶处理BU-3285T获得的BU-3285T的脱硫衍生物。 BU-3285T硫酸盐具有抗肿瘤活性。
-
-
-
-
-
-
-
-
-
搜索结果
66 条记录 (耗时 0.019 秒)
