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公开(公告)号：US4803224A
公开(公告)日：1989-02-07
申请号：US857878
申请日：1986-05-01
申请人： Osamu Tenmyo , Hiroaki Ohkuma , Masataka Konishi
发明人： Osamu Tenmyo , Hiroaki Ohkuma , Masataka Konishi
IPC分类号： C08G69/26 , C12P13/02 , C07C103/50 , A61K31/195
摘要： There is disclosed an antibiotic complex designated as BU-2231 V which is produced by fermentation of a BU-2231-producing strain of Streptoalloteichus hindustanus, ATCC 31158. Complex BU-2231 V is recovered and purified from the fermentation broth by use of ion exchange chromatography techniques. Structural analysis shows that the complex is a mixture of components which are .gamma.-homopolymers of D-.alpha.,.gamma.-diaminobutyric acid having an average molecular weight of from about 5,100 to about 5,200. BU-2231 V has been found to be effective to inhibit growth of various Gram-positive and Gram-negative bacteria and of the herpes simplex virus.
摘要翻译： 公开了一种称为BU-2231V的抗生素复合物，其通过发酵产生的BU-2231产生的Streptoalloteichus hindustanus，ATCC 31158的菌株产生。通过使用离子交换从发酵液中回收并纯化复合物BU-2231V 色谱技术。 结构分析表明，该复合物是组分的混合物，其是平均分子量为约5100至约5200的D-α，γ-二氨基丁酸的γ-均聚物。 已经发现BU-2231V有效抑制各种革兰氏阳性和革兰氏阴性菌和单纯疱疹病毒的生长。
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公开(公告)号：US5286649A
公开(公告)日：1994-02-15
申请号：US819543
申请日：1992-01-10
CPC分类号： C12P1/06 , Y10S435/822
摘要： Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.
摘要翻译： 公开了通过新型微生物Amycolatopsis orientalis ATCC-53884的BU-3889V生产菌株的发酵生产抗病毒抗生素复合物BU-3889V及其生物活性成分A1，A2，A3，D1，D2和D3。 通过使用离子交换色谱技术分离复合物BU-3889V并将组分分离。 生物活性成分的特征在于其物理化学性质。 已经发现这些产品有效地抑制包括单纯疱疹病毒，人类免疫缺陷病毒（HIV）和流感病毒在内的病毒。
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公开(公告)号：US5098708A
公开(公告)日：1992-03-24
申请号：US546463
申请日：1990-07-06
IPC分类号： C12P1/06
CPC分类号： C12P1/06 , Y10S435/822 , Y10S435/826
摘要： Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.
摘要翻译： 公开了通过新型微生物Amycolatopsis orientalis ATCC-53884的BU-3889V生产菌株的发酵生产抗病毒抗生素复合物BU-3889V及其生物活性成分A1，A2，A3，D1，D2和D3。 通过使用离子交换色谱技术分离复合物BU-3889V并将组分分离。 生物活性成分的特征在于其物理化学性质。 已经发现这些产品有效地抑制包括单纯疱疹病毒，人类免疫缺陷病毒（HIV）和流感病毒在内的病毒。
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公开(公告)号：US4314028A
公开(公告)日：1982-02-02
申请号：US109427
申请日：1980-01-03
CPC分类号： C07H15/26 , Y10S435/822
摘要： Addition of certain amine precursor compounds to the culture medium during fermentation of a tallysomycin-producing strain of Streptoalloteichus hindustanus results in production of new tallysomycin derivatives having advantageous antimicrobial and antitumor properties.
摘要翻译： 在培养的产丝菌霉素生产菌株Streptoalloteichus hindustanus的发酵期间向培养基中加入某些胺前体化合物导致产生具有有利的抗微生物和抗肿瘤性质的新的菌丝霉素衍生物。
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公开(公告)号：US5124150A
公开(公告)日：1992-06-23
申请号：US624029
申请日：1991-03-11
IPC分类号： C12P1/06
CPC分类号： C12P1/06 , Y10S435/822
摘要： Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.
摘要翻译： 公开了通过新型微生物Amycolatopsis orientalis ATCC-53884的BU-3889V生产菌株的发酵生产抗病毒抗生素复合物BU-3889V及其生物活性成分A1，A2，A3，D1，D2和D3。 通过使用离子交换色谱技术分离复合物BU-3889V并将组分分离。 生物活性成分的特征在于其物理化学性质。 已经发现这些产品有效地抑制包括单纯疱疹病毒，人类免疫缺陷病毒（HIV）和流感病毒在内的病毒。
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公开(公告)号：US4246400A
公开(公告)日：1981-01-20
申请号：US57528
申请日：1979-07-13
IPC分类号： C07H15/26 , A61K31/70 , A61K31/7028 , A61P31/04 , A61P35/00 , C07K9/00 , C12P19/58 , C12R1/01 , A61K31/71 , C07H15/22
CPC分类号： C07K9/003 , Y10S514/883
摘要： Addition of certain amine precursor compounds to the culture medium during fermentation of a tallysomycin-producing strain of Streptoalloteichus hindustanus results in production of new tallysomycin derivatives having advantageous antimicrobial and antitumor properties.
摘要翻译： 在培养的产丝菌霉素生产菌株Streptoalloteichus hindustanus的发酵期间向培养基中加入某些胺前体化合物导致产生具有有利的抗微生物和抗肿瘤性质的新的菌丝霉素衍生物。
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公开(公告)号：US5256548A
公开(公告)日：1993-10-26
申请号：US874775
申请日：1992-04-27
申请人： Masahisa Oka , Koji Tomita , Osamu Tenmyo , Nobuaki Naruse
发明人： Masahisa Oka , Koji Tomita , Osamu Tenmyo , Nobuaki Naruse
CPC分类号： C12R1/03 , C07K7/06 , Y10S435/825
摘要： There is provided a new antiviral antibiotic designated herein as BU-4344V which is produced by fermentation of a BU-4344V-producing strain of a new microorganism, Actinomadura parvosata subsp. kistnae ATCC No. 55076. Antibiotic BU-4344V is recovered and purified from the fermentation broth by use of extraction, chromatography, and crystallization techniques. BU-4344V has been found to have some antibacterial activity and inhibits the growth of viruses, including influenza virus type A.
摘要翻译： 提供了本文命名为BU-4344V的新的抗病毒抗生素，其通过发酵新生微生物（Actinomadura parvosata subsp。）的BU-4344V生产菌株而产生。 kistnae ATCC No.50576.通过使用提取，色谱和结晶技术从发酵液中回收和纯化抗生素BU-4344V。 已经发现BU-4344V具有一些抗菌活性并抑制病毒的生长，包括A型流感病毒。
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公开(公告)号：US5466450A
公开(公告)日：1995-11-14
申请号：US95435
申请日：1993-07-20
IPC分类号： A61K31/70 , A61K31/7028 , A61P31/12 , A61P31/22 , C07G11/00 , C07H15/26 , C07H19/01 , C12P1/06 , C12P19/58 , C12R1/01 , A61K35/00
CPC分类号： C07H19/01 , C07H15/26 , Y10S435/822
摘要： A novel antibiotic complex designated BU-4224V produced by fermentation of Kibdelosporangium albatum sp. nov. Strain R761-7. The complex may be separated chromatographically into bioactive components designated BU-4224V A, B.sub.1, B.sub.2, and C. The components BU-4224V B.sub.1 and B.sub.2 display both antiviral and antimicrobial activity, while component BU-4224V A has antimicrobial activity and component BU-4224V C has antiviral activity.
摘要翻译： 一种名为BU-4224V的新型抗生素复合物，由Kibdelosporangium albatum sp。 nov。 菌株R761-7。 复合物可以色谱分离成生物活性成分为BU-4224V A，B1，B2和C.组分BU-4224V B1和B2显示抗病毒和抗微生物活性，而组分BU-4224V A具有抗微生物活性和组分BU- 4224V C具有抗病毒活性。
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9.发明授权Compound produced by a strain of microtetraspora having antibacterial and neuritogenic activity 失效由具有抗菌和神经生长活性的微型菌株产生的化合物
公开(公告)号：US5266588A
公开(公告)日：1993-11-30
申请号：US951976
申请日：1992-09-25
申请人： Soichiro Toda , Takashi Tsuno , Satoshi Yamamoto , Toshifumi Hasegawa , Osamu Tenmyo , Mary P. Rosser
发明人： Soichiro Toda , Takashi Tsuno , Satoshi Yamamoto , Toshifumi Hasegawa , Osamu Tenmyo , Mary P. Rosser
IPC分类号： A61K31/40 , C07D405/12
CPC分类号： C07D405/12 , A61K31/40
摘要： Disclosed is a novel compound, designated BU-4514N, which is produced by cultivation of a novel strain of Microtetraspora, designated species T689-92. The novel compound possesses antibacterial and neuritogenic properties.
摘要翻译： 公开了一种命名为BU-4514N的新化合物，它是通过培养一种新型微型菌株（Microtetraspora），命名为T689-92的菌株产生的。 该新化合物具有抗菌和神经发生特性。
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公开(公告)号：US5256646A
公开(公告)日：1993-10-26
申请号：US559864
申请日：1990-07-27
IPC分类号： A61K31/70 , A61K31/7028 , A61P31/12 , A61P31/22 , C07G11/00 , C07H15/26 , C07H19/01 , C12P1/06 , C12P19/58 , C12R1/01 , A61K31/71 , C07H3/00
CPC分类号： C07H19/01 , C07H15/26 , Y10S435/822
摘要： A novel antibiotic complex designated BU-4224V produced by fermentation of Kibdelosporangium albatum sp. nov. Strain R761-7. The complex may be separated chromatographically into bioactive components designated BU-4224V A, B.sub.1, B.sub.2, and C. The components BU-4224V B.sub.1 and B.sub.2 display both antiviral and antimicrobial activity, while component BU-4224V A has antimicrobial activity and component BU-4224V C has antiviral activity.
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