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公开(公告)号：US20110058448A1
公开(公告)日：2011-03-10
申请号：US12991466
申请日：2009-05-07
申请人： Oscar-Werner Reif , Gerhard Greller , Juergen Van Den Boogaard , Karl-Heinz Kompart , Marco Lohrengel
发明人： Oscar-Werner Reif , Gerhard Greller , Juergen Van Den Boogaard , Karl-Heinz Kompart , Marco Lohrengel
IPC分类号： B01F7/16
CPC分类号： B01F7/16 , B01F11/0082 , B01F13/045 , B01F15/00071 , B01F15/00831 , B01F15/0085
摘要： A mixing system has a single-use container (1) with flexible walls and a mixing device. The mixing device has at least one encapsulated drive (5) and a mixer shaft (3). The drive (5) can be disposed of after use together with the mixer shaft (3) and the single-use container (1). The mixing system can be used in biotechnology and the pharmaceutical industry for mixing liquids, dissolving solids or cultivating cells and microorganisms.
摘要翻译： 混合系统具有具有柔性壁的一次性容器（1）和混合装置。 混合装置具有至少一个封装的驱动器（5）和混合器轴（3）。 驱动器（5）可以与混合器轴（3）和一次性容器（1）一起使用后被处理。 混合系统可用于生物技术和制药工业用于混合液体，溶解固体或培养细胞和微生物。
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公开(公告)号：US09669366B2
公开(公告)日：2017-06-06
申请号：US12991466
申请日：2009-05-07
申请人： Oscar-Werner Reif , Gerhard Greller , Juergen Van Den Boogaard , Karl-Heinz Kompart , Marco Lohrengel
发明人： Oscar-Werner Reif , Gerhard Greller , Juergen Van Den Boogaard , Karl-Heinz Kompart , Marco Lohrengel
CPC分类号： B01F7/16 , B01F11/0082 , B01F13/045 , B01F15/00071 , B01F15/00831 , B01F15/0085
摘要： A mixing system has a single-use container (1) with flexible walls and a mixing device. The mixing device has at least one encapsulated drive (5) and a mixer shaft (3). The drive (5) can be disposed of after use together with the mixer shaft (3) and the single-use container (1). The mixing system can be used in biotechnology and the pharmaceutical industry for mixing liquids, dissolving solids or cultivating cells and microorganisms.
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公开(公告)号：US20110058447A1
公开(公告)日：2011-03-10
申请号：US12991461
申请日：2009-05-07
申请人： Oscar-Werner Reif , Gerhard Greller , Juergen Van Den Boogaard , Sven Luehmann , Marco Lohrengel
发明人： Oscar-Werner Reif , Gerhard Greller , Juergen Van Den Boogaard , Sven Luehmann , Marco Lohrengel
IPC分类号： B01F7/16
CPC分类号： C12M23/14 , B01F7/1695 , B01F13/0827 , B01F13/0836 , B01F15/00071 , B01F15/00831 , B01F15/0085 , B01F2015/00084 , B01F2215/0032 , B01F2215/0073 , C12M27/02
摘要： A mixing system has a container with flexible walls (1), a fluid-tight drive space (6) and a mixing device. The container with flexible walls (1) has at least one head plate (5). The fluid-tight drive space (6) is outside of the container interior (2), and is enclosed by the head plate (5) and a cap (7) attached to the head plate (5). The mixing device has a stirrer shaft (3), onto which stirrer elements (4, 4′) are attached. The stirrer shaft (3) is guided from the container interior (2) through an opening in the head plate (5) and the section of the stirrer shaft (3) in the drive space (6) is guided by bearings (9, 10). A seal (8) is fit into the opening of the head plate, and encloses the stirrer shaft (3) and seals the container interior (2) from the drive space (6).
摘要翻译： 混合系统具有容器，该容器具有柔性壁（1），流体密封的驱动空间（6）和混合装置。 具有柔性壁（1）的容器具有至少一个头板（5）。 流体密封的驱动空间（6）位于容器内部（2）的外部，并由头板（5）和盖（7）封闭，盖帽（7）附接到头板（5）。 混合装置具有搅拌器轴（3），搅拌器元件（4,4'）安装在搅拌轴上。 搅拌器轴（3）从容器内部（2）通过头板（5）中的开口引导，并且驱动空间（6）中的搅拌器轴（3）的部分由轴承（9,10 ）。 密封件（8）装配在头板的开口中，并包围搅拌器轴（3）并将容器内部（2）与驱动空间（6）密封。
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公开(公告)号：US09045722B2
公开(公告)日：2015-06-02
申请号：US12991461
申请日：2009-05-07
申请人： Oscar-Werner Reif , Gerhard Greller , Juergen Van Den Boogaard , Sven Luehmann , Marco Lohrengel
发明人： Oscar-Werner Reif , Gerhard Greller , Juergen Van Den Boogaard , Sven Luehmann , Marco Lohrengel
CPC分类号： C12M23/14 , B01F7/1695 , B01F13/0827 , B01F13/0836 , B01F15/00071 , B01F15/00831 , B01F15/0085 , B01F2015/00084 , B01F2215/0032 , B01F2215/0073 , C12M27/02
摘要： A mixing system has a container with flexible walls (1), a fluid-tight drive space (6) and a mixing device. The container with flexible walls (1) has at least one head plate (5). The fluid-tight drive space (6) is outside of the container interior (2), and is enclosed by the head plate (5) and a cap (7) attached to the head plate (5). The mixing device has a stirrer shaft (3), onto which stirrer elements (4, 4′) are attached. The stirrer shaft (3) is guided from the container interior (2) through an opening in the head plate (5) and the section of the stirrer shaft (3) in the drive space (6) is guided by bearings (9, 10). A seal (8) is fit into the opening of the head plate, and encloses the stirrer shaft (3) and seals the container interior (2) from the drive space (6).
摘要翻译： 混合系统具有容器，该容器具有柔性壁（1），流体密封的驱动空间（6）和混合装置。 具有柔性壁（1）的容器具有至少一个头板（5）。 流体密封的驱动空间（6）位于容器内部（2）的外部，并由头板（5）和盖（7）封闭，盖帽（7）附接到头板（5）。 混合装置具有搅拌器轴（3），搅拌器元件（4,4'）安装在搅拌轴上。 搅拌器轴（3）从容器内部（2）通过头板（5）中的开口引导，并且驱动空间（6）中的搅拌器轴（3）的部分由轴承（9,10 ）。 密封件（8）装配在头板的开口中，并包围搅拌器轴（3）并将容器内部（2）与驱动空间（6）密封。
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公开(公告)号：US09255244B2
公开(公告)日：2016-02-09
申请号：US12867647
申请日：2009-02-12
CPC分类号： C12M27/02 , B01F7/1695 , B01F15/00831 , B01F15/0085 , C12M23/26 , C12M37/04 , F16C33/76
摘要： A bioreactor (1) having a container (2), a shaft housing (3) for guiding a shaft (5) through a wall (7), a stirrer (6) connected to the shaft (5) in the interior (9) of the container (2), and a drive (4) arranged outside the container (2) and connectable to the shaft (5). The shaft (5) is mounted in the shaft housing (3) via at least one ball bearing (23) and is sealed in relation to the shaft housing (3) by at least one seal (11, 20). The seal (11, 20) is configured as a radial shaft seal (28) having two sealing lips (30, 31) that are arranged one behind the other in the longitudinal direction of the shaft (5) and are able to run on the shaft (5) without lubricant.
摘要翻译： 具有容器（2）的生物反应器（1），用于通过壁（7）引导轴（5）的轴壳体（3），与内部（9）中的轴（5）连接的搅拌器（6） 和位于所述容器（2）的外部并且可连接到所述轴（5）的驱动器（4）。 轴（5）经由至少一个滚珠轴承（23）安装在轴壳体（3）中，并通过至少一个密封件（11,20）相对于轴壳体（3）密封。 密封件（11,20）被构造为具有两个密封唇（30,31）的径向轴密封件（28），所述密封唇缘（30,31）沿轴（5）的纵向方向一个接一个地布置，并且能够在 轴（5）无润滑剂。
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公开(公告)号：US20110003374A1
公开(公告)日：2011-01-06
申请号：US12867647
申请日：2009-02-12
IPC分类号： C12M1/02
CPC分类号： C12M27/02 , B01F7/1695 , B01F15/00831 , B01F15/0085 , C12M23/26 , C12M37/04 , F16C33/76
摘要： A bioreactor (1) having a container (2), a shaft housing (3) for guiding a shaft (5) through a wall (7), a stirrer (6) connected to the shaft (5) in the interior (9) of the container (2), and a drive (4) arranged outside the container (2) and connectable to the shaft (5). The shaft (5) is mounted in the shaft housing (3) via at least one ball bearing (23) and is sealed in relation to the shaft housing (3) by at least one seal (11, 20). The seal (11, 20) is configured as a radial shaft seal (28) having two sealing lips (30, 31) that are arranged one behind the other in the longitudinal direction of the shaft (5) and are able to run on the shaft (5) without lubricant.
摘要翻译： 具有容器（2）的生物反应器（1），用于通过壁（7）引导轴（5）的轴壳体（3），与内部（9）中的轴（5）连接的搅拌器（6） 和位于所述容器（2）的外部并且可连接到所述轴（5）的驱动器（4）。 轴（5）经由至少一个滚珠轴承（23）安装在轴壳体（3）中，并通过至少一个密封件（11,20）相对于轴壳体（3）密封。 密封件（11,20）被构造为具有两个密封唇（30,31）的径向轴密封件（28），所述密封唇缘（30,31）沿轴（5）的纵向方向一个接一个地布置，并且能够在 轴（5）无润滑剂。
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公开(公告)号：US10322388B2
公开(公告)日：2019-06-18
申请号：US12226082
申请日：2007-04-12
摘要： Container system with one container (1) with a flexible partition, in particular a disposable container, that can be inserted into a carrying container that supports its lateral container partition (10) and in which liquid medium (8) that has been poured in can be mixed, with the carrying container (4) featuring at least one baffle (15, 15′, 15″, 15′″) on the internal support partition (11) that forms the lateral container partition.
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公开(公告)号：US08342737B2
公开(公告)日：2013-01-01
申请号：US12226297
申请日：2007-04-24
申请人： Gerhard Greller , Oscar-Werner Reif
发明人： Gerhard Greller , Oscar-Werner Reif
CPC分类号： B01F11/0082 , B01F3/04262 , B01F11/0091 , B01F15/00071 , B01F15/0085 , B01F2215/0073 , C12M23/28 , C12M27/16 , C12M27/22
摘要： A vibrational mixer (1), in particular a single-path mixer for use in single-path bioreactors (4) with flexible walls, consisting of a mixer shaft (2) that can be set into longitudinal motions by a drive (8), with at least one mixing element (3), wherein at least one channel (13) is arranged in the mixer shaft with an opening to an interior reactor space (6).
摘要翻译： 振动混合器（1），特别是用于具有柔性壁的单路生物反应器（4）的单路混合器，由混合器轴（2）组成，该混合器轴可由驱动器（8）设置成纵向运动， 至少一个混合元件（3），其中至少一个通道（13）布置在混合器轴中，开口通向内部反应器空间（6）。
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公开(公告)号：US20110229963A1
公开(公告)日：2011-09-22
申请号：US13129700
申请日：2009-10-19
CPC分类号： B01F7/00058 , B01F15/00707 , B01F15/00831 , B01F15/0085 , C12M27/02
摘要： A stirrer for a bioreactor has first and second opposed mountings fastened to the inner surfaces of opposite walls of the bioreactor and disposed along a common rotational axis. A first arm has an end connected to the first mounting for rotation about the rotational axis and for pivoting about a first pivot axis that is transverse to the rotational axis. A second arm has an end connected to the second mounting for rotation about the rotational axis and for pivoting about a second pivot axis that is transverse to the rotational axis. Ends of the arms are coupled for pivoting about at least one additional pivot axis that is transverse to the rotational axis.
摘要翻译： 用于生物反应器的搅拌器具有固定到生物反应器的相对壁的内表面并沿着公共旋转轴线设置的第一和第二相对的安装件。 第一臂具有连接到第一安装件的端部，用于围绕旋转轴线旋转并围绕横向于旋转轴线的第一枢转轴线枢转。 第二臂具有连接到第二安装件的端部，用于围绕旋转轴线旋转并且围绕横向于旋转轴线的第二枢转轴线枢转。 臂的端部被联接以围绕横向于旋转轴线的至少一个附加枢转轴线枢转。
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10.发明授权Container having flexible walls with connecting piece for mixer shaft and coupling piece for drive device fixed magnetically to opposite inner and outer surfaces of container wall 有权容器具有柔性壁，其具有用于混合器轴的连接件和用于驱动装置的联接件，磁力固定到容器壁的相对的内表面和外表面公开(公告)号：US09095828B2
公开(公告)日：2015-08-04
申请号：US11717357
申请日：2007-03-13
CPC分类号： B01F13/0827 , B01F11/0082 , B01F11/0091 , B01F13/0863 , B01F15/0085 , B01F2215/0032
摘要： A container has flexible walls defining an interior. A mixer is arranged in the interior of the container and includes a mixer shaft with opposite first and second ends. A mixing element is mounted to the first end of the mixer shaft. The second end of the mixer shaft is fixed magnetically to a coupling piece disposed on the exterior of the flexible wall of the container. The coupling piece is connected operatively to a force introducing device that generates movement of the mixer.
摘要翻译： 容器具有限定内部的柔性壁。 混合器布置在容器的内部，并包括具有相对的第一和第二端的混合器轴。 混合元件安装到混合器轴的第一端。 混合器轴的第二端固定地固定在设置在容器的柔性壁的外部上的联接件上。 联接件可操作地连接到产生混合器运动的力导入装置。
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