摘要:
The invention relates to a method of magnetic imaging (MR) of a living sample comprising the steps of hyperpolarizing a hyperpolarizable gas ex-vivo and transferring the nuclear polarization from the hyperpolarized gas to the nuclei of an MR imaging agent, that is not hyperpolarizable, that is exposed to a uniform magnetic field and that is introduced in contact to the hyperpolarizable gas, separating the hyperpolarizable gas from the MR imaging agent, administering the MR imaging agent to the living sample, exciting NMR transitions in the nuclei of the imaging agent and detecting an NMR signal thereof.
摘要:
The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body. The method comprises the step of ex vivo polarization of a high T1 agent. The polarizing agent is optionally separated from the high T1 agent before the high T1 agent is administered to the sample.
摘要:
This invention provides a method of MR investigation of a sample, the method comprising: (i) placing in a uniform magnetic field a composition comprising an OMRI contrast agent and an MR imaging agent containing nuclei (MR imaging nuclei) capable of emitting magnetic resonance signals (e.g. the primary magnetic field B0) and capable of exhibiting a T1 relaxation time of 6 s or more (at 37° C. in D2O in a field of 7T); (ii) exposing the composition to a first radiation of a frequency selected to excite electron spin transitions in the OMRI contrast agent; (iii) optionally but preferably separating the whole, substantially the whole, or a portion of said OMRI contrast agent from said MR imaging agent; (iv) administering said MR imaging agent to said sample, (v) exposing the sample to a second radiation of a frequency selected to excite nuclear spin transitions; (vi) detecting magnetic resonance signals from the sample; and (vii) optionally, generating an image or dynamic flow data from the detected signals.
摘要:
This invention relates to a method of electron spin resonance enhanced magnetic resonance imaging which relies on ex vivo dynamic nuclear polarisation of an MR imaging agent.
摘要:
The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula I ##STR1## (wherein n is 0 or 1, and where n is 1 each C.sub.6 R.sub.5 moeity may be the same or different; each group R is a hydrogen atom, an iodine atom or a hydrophilic moiety M or M.sub.1, two or three non-adjacent R groups in each C.sub.6 R.sub.5 moiety being iodine and at least one, and preferably two or three, R groups in each C.sub.6 R.sub.5 moiety being M or M.sub.1 moieties; X denotes a bond or a group providing a 1 to 7 atom chain linking two C.sub.6 R.sub.5 moieties or, where n is 0, X denotes a group R; each M independently is a non-ionic hydrophilic moiety; and each M.sub.1 independently represents a C.sub.1-4 alkyl group substituted by at least one hydroxyl group and optionally linked to the phenyl ring via a carbonyl, sulphone or sulphoxide group, at least one R group being an M.sub.1 moiety; with the proviso that where n is zero either at least one M.sub.1 group other than a hydroxymethyl or 1,2-dihydroxyethyl group is present or then if one hydroxymethyl or 1,2-dihydroxyethyl M.sub.1 group is present at least one nitrogen-attached or hydroxylated-C.sub.3-4 alkyl moiety-containing M group is also present) and isomers thereof.
摘要翻译:本发明提供了可用作式I的X射线对比剂的低粘度碘化芳基化合物(其中n为0或1,并且其中n为1,每个C 6 R 5的摩尔可以相同或不同;每个基团R为氢原子 ,碘原子或亲水部分M或M1,每个C 6 R 5部分中两个或三个不相邻的R基团是碘,并且每个C 6 R 5部分中至少一个,优选两个或三个R基团是M或M1部分; X 表示提供连接两个C 6 R 5部分的1至7个原子链的键或基团,或其中n为0,X表示基团R;每个M独立地为非离子亲水部分;并且每个M 1独立地表示C 1-4烷基 至少一个被至少一个羟基取代并且任选地通过羰基,砜或亚砜基团与苯环连接的基团,至少一个R基团是M1部分;条件是其中n为0,或者至少一个除了 存在羟甲基或1,2-二羟乙基, 甲基或1,2-二羟乙基M1基团存在,还存在至少一个含氮连接或羟基化的含C3-4烷基部分的M基团)及其异构体。
摘要:
The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula C6R6 wherein three non-adjacent R groups are iodine and the remaining R groups are non-ionic, hydrophilic moieties, said compound being water soluble at 20° C. to a concentration of at least 350 mgl/ml and which in aqueous solution at 20° C. at a concentration of 350 mgl/ml has a viscosity no greater than 13.8 mPas.
摘要:
The invention provides iodinated bis phenyl compounds, useful as X-ray contrast agents, of formula (I) (wherein each C.sub.6 R.sub.5 moiety may be the same or different; each denotes a hydrogen or iodine atom or a group M, two or three non-adjacent R groups on each C.sub.6 R.sub.5 moiety denoting iodine atoms and one, two or three R groups on each C.sub.6 R.sub.5 moiety denoting M groups; X denotes a group providing a 1, 2 or 3 atom chain linking the two C.sub.6 R.sub.5 groups, preferably where X is or contains in the bridging chain a carbonyloxy group each C.sub.6 R.sub.5 group being a triodophenyl group or a group in which each R is other than hydrogen; and each M is independently a non-ionic hydrophilic moiety, M preferably being a non-ionic hydrophilic moiety comprising a monohydroxy- or polyhydroxy-alkyl group) and isomers, especially stereoisomers and rotamers, thereof. ##STR1##
摘要翻译:PCT No.PCT / GB95 / 02264 Sec。 371日期:1997年6月27日 102(e)日期1997年6月27日PCT提交1995年9月22日PCT公布。 公开号WO96 / 09285 日期:1996年3月28日本发明提供了可用作式(I)的X射线造影剂的碘化双苯基化合物(其中每个C 6 R 5部分可以相同或不同;各自表示氢或碘原子或基团M, 每个C6R5部分上两个或三个不相邻的R基团,表示碘原子,每个C6R5部分上含有一个,两个或三个R基团,表示M基团; X表示提供连接两个C 6 R 5基团的1,2或3个原子链的基团, 优选其中X是桥连环中或在桥连环中含有碳氧基,每个C 6 R 5基团是三苯基或每个R不是氢的基团;每个M独立地是非离子亲水部分,M优选是非离子亲水部分, 包含单羟基或多羟基 - 烷基的离子亲水部分)和异构体,特别是立体异构体和旋转异构体。
摘要:
The present invention relates to the use of persistent free radicals, in particular persistent free radicals having a carbon-based .pi.-bonded electronic system available for delocalization of the unpaired electrons as image enhancing agents in magnetic resonance imaging (MRI), in particular electron spin resonance enhanced magnetic resonance imaging (ESREMRI). The invention also relates to contrast media containing such radicals and to the use of such radicals and their non-radical precursors in the manufacture of MRI and ESREMRI contrast media.