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公开(公告)号：US5314903A
公开(公告)日：1994-05-24
申请号：US978131
申请日：1992-11-18
申请人： Oskar Axelsson , Mikkel Thaning , Peter Moldt
发明人： Oskar Axelsson , Mikkel Thaning , Peter Moldt
IPC分类号： A61K31/415 , A61K31/4184 , A61P3/00 , A61P3/14 , A61P9/10 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , C07D235/30
CPC分类号： C07D235/30
摘要： The present invention discloses compounds of the formula ##STR1## wherein R' and R" independently of each other are hydrogen or alkyl, or R' and R" together form a 3 to 6 membered alkylene chain;n is 1 or 2;R.sup.1 is phenyl which may be substituted one or more times with halogen, CF.sub.3, alkoxy, alkyl, or amino; andR.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently of each other are hydrogen, halogen, amino, CF.sub.3, alkyl or alkoxy; or a pharmaceutically-acceptable addition salt thereof.The compounds are useful as pharmaceuticals, for example, in the treatment of ischemia, anoxia, migraine and psychosis.
摘要翻译： 本发明公开了式“IMAGE”的化合物，其中R'和R“彼此独立地是氢或烷基，或者R'和R”一起形成3至6元亚烷基链; n为1或2; R 1是可以被卤素，CF 3，烷氧基，烷基或氨基取代一次或多次的苯基; R 4，R 5，R 6和R 7彼此独立地是氢，卤素，氨基，CF 3，烷基或烷氧基; 或其药学上可接受的加成盐。 这些化合物可用作药物，例如用于治疗缺血，缺氧，偏头痛和精神病。
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公开(公告)号：US5210091A
公开(公告)日：1993-05-11
申请号：US888036
申请日：1992-05-22
申请人： Oskar Axelsson , Mikkel Thaning , Peter Moldt
发明人： Oskar Axelsson , Mikkel Thaning , Peter Moldt
IPC分类号： C07D235/30
CPC分类号： C07D235/30
摘要： The application discloses benzimidazole derivatives, pharmaceutical preparations comprised the compounds, their preparation and use in the treatment of disorders of the Central Nervous System such as ischemia, migraine, epilepsia, psychosis, Parkinsonism and depression.
摘要翻译： 该申请公开了苯并咪唑衍生物，药物制剂包括化合物，其制备和用于治疗中枢神经系统疾病如缺血，偏头痛，癫痫，精神病，帕金森综合征和抑郁症。
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公开(公告)号：US08124806B2
公开(公告)日：2012-02-28
申请号：US12279100
申请日：2007-02-14
IPC分类号： C07C233/65 , A61K49/00
CPC分类号： C07C237/46 , A61K49/0433 , A61K49/0438
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety containing amide functions allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地，含碘化合物是含有含有酰胺官能团的脂族中心部分的化合物，其允许与其结合的三个碘化苯基的排列。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。
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公开(公告)号：US20090053142A1
公开(公告)日：2009-02-26
申请号：US12279100
申请日：2007-02-14
IPC分类号： A61K49/04 , C07C237/30
CPC分类号： C07C237/46 , A61K49/0433 , A61K49/0438
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety containing amide functions allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地，含碘化合物是含有含有酰胺官能团的脂族中心部分的化合物，其允许与其结合的三个碘化苯基的排列。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。
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公开(公告)号：US07485753B2
公开(公告)日：2009-02-03
申请号：US11565673
申请日：2006-12-01
IPC分类号： C07C233/58 , A61K49/04 , A61K31/16
CPC分类号： C07C237/46 , A61K49/0433 , C07C2601/02
摘要： The present invention relates to iodine containing compounds containing a central cyclopropane scaffolding moiety allowing for the arrangement of three iodinated phenyl groups bound thereto.The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译： 本发明涉及含有中心环丙烷支架部分的含碘化合物，其允许与其结合的三个碘化苯基的排列。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。
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公开(公告)号：US20080199402A1
公开(公告)日：2008-08-21
申请号：US11565673
申请日：2006-12-01
IPC分类号： A61K49/04 , C07C237/00 , A61K49/00
CPC分类号： C07C237/46 , A61K49/0433 , C07C2601/02
摘要： The present invention relates to iodine containing compounds containing a central cyclopropane scaffolding moiety allowing for the arrangement of three iodinated phenyl groups bound thereto.The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译： 本发明涉及含有中心环丙烷支架部分的含碘化合物，其允许与其结合的三个碘化苯基的排列。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。
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7.发明申请Contrast Agents and Diagnostic Compositions Based on Iodine-Containing Cyanuric Acid Derivatives 审中-公开基于含碘的氰尿酸衍生物的对比剂和诊断组合物公开(公告)号：US20080267884A1
公开(公告)日：2008-10-30
申请号：US12092871
申请日：2005-11-10
申请人： Oskar Axelsson , Mikkel Thaning
发明人： Oskar Axelsson , Mikkel Thaning
IPC分类号： C07D251/34 , A61K49/04
CPC分类号： C07D251/34 , A61K49/0438
摘要： The present invention relates to a class of compounds of Formula (I) and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing a cyanuric acid scaffolding moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类式（I）的化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地说，含碘化合物是含有氰尿酸支架部分的化合物，其允许与其结合的三个碘化苯基的排列。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。
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公开(公告)号：US20090238768A1
公开(公告)日：2009-09-24
申请号：US12095218
申请日：2006-12-01
申请人： Oskar Axelsson , Haukur Johannesson , Andreas Meijer , Andreas Olsson , Tim Stahlberg , Mikkel Thaning , Duncan Wynn , Anders Brathe
发明人： Oskar Axelsson , Haukur Johannesson , Andreas Meijer , Andreas Olsson , Tim Stahlberg , Mikkel Thaning , Duncan Wynn , Anders Brathe
CPC分类号： C07D403/12 , C07D257/02
摘要： The present invention relates to novel compounds of formula (I) and (II), compositions comprising compounds of formula (II) and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and MR spectroscopy (MRS).
摘要翻译： 本发明涉及式（I）和（II）的新型化合物，包含式（II）化合物的组合物及其作为磁共振（MR）成像（MRI）和MR光谱学（MRS）中的造影剂的用途。
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公开(公告)号：US20070148096A1
公开(公告)日：2007-06-28
申请号：US11610517
申请日：2006-12-14
IPC分类号： A61K49/04 , C07C237/20
CPC分类号： C07C237/46 , A61K49/0433
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing a benzene scaffolding moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地，含碘化合物是含有苯支架部分的化合物，其允许排列与其结合的三个碘化苯基。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。
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公开(公告)号：US06180649B2
公开(公告)日：2001-01-30
申请号：US09171530
申请日：1998-11-19
申请人： Peter Moldt , Bjarne Hugo Dahl , Jorgen Drejer , Oskar Axelsson
发明人： Peter Moldt , Bjarne Hugo Dahl , Jorgen Drejer , Oskar Axelsson
IPC分类号： A61K31445
CPC分类号： C07D401/04
摘要： The present invention discloses compounds of the formula wherein the dotted bonds are optional extra bonds allowing any tautomeric isomers compatible with substituents X and R3; R3 is non-existing, hydrogen, or alkyl; X is O, S, imino, alkoxy, alkylthio, or amino; R1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, acyl, acylalkyl, alkoxyalkyl, dialkoxyalkyl, or phenylalkyl which may be substituted with alkyl, halogen, amino, nitro or cyano; and R4, R5, R6 and R7 independently of each other are hydrogen; halogen; amino; nitro; CN; CF3; COOH; COO-alkyl; alkyl; acyl; alkoxy; —(CH2)n,—OH wherein n is 0, 1, 2, or 3; —(CH2)m—O-alkyl wherein m is 0, 1,2, or 3; —(CH2)p—O-acyl wherein p is 0, 1,2, or 3; or a pharmaceutically acceptable addition salt thereof. The compounds are useful as pharmaceuticals, for example, in the treatment of traumatic lesions of peripheral nerves, the medulla, and/or the spinal cord, cerebral ischaemic neuronal damage, neuropathy and especially peripheral neuropathy, dementia, Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, or any other neurodegenerative disease.
摘要翻译： 本发明公开了以下结构的化合物：虚线键是任选的额外键，允许与取代基X和R 3相容的任何互变异构体; R3不存在，氢或烷基; X是O，S，亚氨基，烷氧基，烷硫基或 氨基; R 1是氢，烷基，烯基，炔基，环烷基，环烷基烷基，酰基，酰基烷基，烷氧基烷基，二烷氧基烷基或可被烷基，卤素，氨基，硝基或氰基取代的苯基烷基; 和R 4，R 5，R 6和R 7彼此独立地是氢; 卤素; 氨基; 硝基; CN; CF3; COOH; COO-烷基; 烷基; 酰基; 烷氧基 - （CH 2）n，-OH，其中n为0,1,2或3; - （CH 2）m -O-烷基，其中m为0,1,2或3; - （CH 2）p -O-酰基，其中p为0,1,2或3;或其药学上可接受的加成盐。 该化合物可用作药物，例如用于治疗周围神经，髓质和/或脊髓的创伤性损伤，脑缺血性神经元损伤，神经病变，特别是周围神经病变，痴呆，阿尔茨海默病，亨廷顿病，帕金森病 疾病，肌萎缩性侧索硬化或任何其他神经变性疾病。
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