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公开(公告)号：US20090238768A1
公开(公告)日：2009-09-24
申请号：US12095218
申请日：2006-12-01
申请人： Oskar Axelsson , Haukur Johannesson , Andreas Meijer , Andreas Olsson , Tim Stahlberg , Mikkel Thaning , Duncan Wynn , Anders Brathe
发明人： Oskar Axelsson , Haukur Johannesson , Andreas Meijer , Andreas Olsson , Tim Stahlberg , Mikkel Thaning , Duncan Wynn , Anders Brathe
CPC分类号： C07D403/12 , C07D257/02
摘要： The present invention relates to novel compounds of formula (I) and (II), compositions comprising compounds of formula (II) and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and MR spectroscopy (MRS).
摘要翻译： 本发明涉及式（I）和（II）的新型化合物，包含式（II）化合物的组合物及其作为磁共振（MR）成像（MRI）和MR光谱学（MRS）中的造影剂的用途。
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公开(公告)号：US08633337B2
公开(公告)日：2014-01-21
申请号：US13696960
申请日：2011-05-13
申请人： Anders Brathe , Andreas Olsson , Mikkel Thaning , Steffen Bugge
发明人： Anders Brathe , Andreas Olsson , Mikkel Thaning , Steffen Bugge
IPC分类号： C07C277/08 , B01J19/00
CPC分类号： C07C319/14 , C07B59/001 , C07B2200/05 , C07C319/20 , C07C319/24 , C07C323/44
摘要： The present invention provides a method for the preparation of a radiolabeled guanidine derivative, in particular wherein the radiolabeled guanidine derivative is a positron emission tomography (PET) tracer. Certain intermediates useful in said method are also provided, as well as means for carrying out said method in an automated fashion. The method of the invention provides advantages over known methods for the preparation of radiolabeled guanidine derivatives.
摘要翻译： 本发明提供了一种制备放射性标记的胍衍生物的方法，特别是其中放射性标记的胍衍生物是正电子发射断层摄影（PET）示踪剂。 还提供了可用于所述方法的某些中间体，以及用于以自动方式实施所述方法的装置。 本发明的方法提供了优于制备放射性标记的胍衍生物的已知方法的优点。
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公开(公告)号：US08124806B2
公开(公告)日：2012-02-28
申请号：US12279100
申请日：2007-02-14
IPC分类号： C07C233/65 , A61K49/00
CPC分类号： C07C237/46 , A61K49/0433 , A61K49/0438
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety containing amide functions allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地，含碘化合物是含有含有酰胺官能团的脂族中心部分的化合物，其允许与其结合的三个碘化苯基的排列。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。
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公开(公告)号：US20090053142A1
公开(公告)日：2009-02-26
申请号：US12279100
申请日：2007-02-14
IPC分类号： A61K49/04 , C07C237/30
CPC分类号： C07C237/46 , A61K49/0433 , A61K49/0438
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety containing amide functions allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地，含碘化合物是含有含有酰胺官能团的脂族中心部分的化合物，其允许与其结合的三个碘化苯基的排列。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。
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公开(公告)号：US20130060064A1
公开(公告)日：2013-03-07
申请号：US13696960
申请日：2011-05-13
申请人： Anders Brathe , Andreas Olsson , Mikkel Thaning , Steffen Bugge
发明人： Anders Brathe , Andreas Olsson , Mikkel Thaning , Steffen Bugge
IPC分类号： C07C277/08 , B01J19/00
CPC分类号： C07C319/14 , C07B59/001 , C07B2200/05 , C07C319/20 , C07C319/24 , C07C323/44
摘要： The present invention provides a method for the preparation of a radiolabeled guanidine derivative, in particular wherein the radiolabeled guanidine derivative is a positron emission tomography (PET) tracer. Certain intermediates useful in said method are also provided, as well as means for carrying out said method in an automated fashion. The method of the invention provides advantages over known methods for the preparation of radiolabeled guanidine derivatives.
摘要翻译： 本发明提供了一种制备放射性标记的胍衍生物的方法，特别是其中放射性标记的胍衍生物是正电子发射断层摄影（PET）示踪剂。 还提供了可用于所述方法的某些中间体，以及用于以自动方式实施所述方法的装置。 本发明的方法提供了优于制备放射性标记的胍衍生物的已知方法的优点。
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6.发明授权Methods and devices configured for dissolving hyperpolarised solid material with a solvent within a cryostat for NMR analyses 有权配置用于将超极化固体物质溶解在低温恒温器内用于NMR分析的方法和装置公开(公告)号：US07372274B2
公开(公告)日：2008-05-13
申请号：US10415968
申请日：2001-11-02
申请人： Jan Henrik Ardenkjaer-Larsen , Oskar H. E. Axelsson , Klaes Koppel Golman , Georg Hansson , Haukur Johannesson , Rolf Servin , Mikkel Thaning , Lennart Hansson
发明人： Jan Henrik Ardenkjaer-Larsen , Oskar H. E. Axelsson , Klaes Koppel Golman , Georg Hansson , Haukur Johannesson , Rolf Servin , Mikkel Thaning , Lennart Hansson
CPC分类号： G01R33/282 , G01N1/44 , G01R33/307 , G01R33/5601 , G01R33/62
摘要： The present invention relates to devices and method for dissolving solid polarised material while retaining a high level of polarisation. In an embodiment of the present invention a material is polarised in a strong magnetic field in a cryostat 2 and then brought into solution while still inside the cryostat 2.
摘要翻译： 本发明涉及用于溶解固体极化材料同时保持高水平偏振的装置和方法。 在本发明的一个实施例中，材料在低温恒温器2中的强磁场中极化，然后在仍然在低温恒温器2内部的同时进入溶液中。
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公开(公告)号：US5314903A
公开(公告)日：1994-05-24
申请号：US978131
申请日：1992-11-18
申请人： Oskar Axelsson , Mikkel Thaning , Peter Moldt
发明人： Oskar Axelsson , Mikkel Thaning , Peter Moldt
IPC分类号： A61K31/415 , A61K31/4184 , A61P3/00 , A61P3/14 , A61P9/10 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , C07D235/30
CPC分类号： C07D235/30
摘要： The present invention discloses compounds of the formula ##STR1## wherein R' and R" independently of each other are hydrogen or alkyl, or R' and R" together form a 3 to 6 membered alkylene chain;n is 1 or 2;R.sup.1 is phenyl which may be substituted one or more times with halogen, CF.sub.3, alkoxy, alkyl, or amino; andR.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently of each other are hydrogen, halogen, amino, CF.sub.3, alkyl or alkoxy; or a pharmaceutically-acceptable addition salt thereof.The compounds are useful as pharmaceuticals, for example, in the treatment of ischemia, anoxia, migraine and psychosis.
摘要翻译： 本发明公开了式“IMAGE”的化合物，其中R'和R“彼此独立地是氢或烷基，或者R'和R”一起形成3至6元亚烷基链; n为1或2; R 1是可以被卤素，CF 3，烷氧基，烷基或氨基取代一次或多次的苯基; R 4，R 5，R 6和R 7彼此独立地是氢，卤素，氨基，CF 3，烷基或烷氧基; 或其药学上可接受的加成盐。 这些化合物可用作药物，例如用于治疗缺血，缺氧，偏头痛和精神病。
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公开(公告)号：US20070148096A1
公开(公告)日：2007-06-28
申请号：US11610517
申请日：2006-12-14
IPC分类号： A61K49/04 , C07C237/20
CPC分类号： C07C237/46 , A61K49/0433
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing a benzene scaffolding moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地，含碘化合物是含有苯支架部分的化合物，其允许排列与其结合的三个碘化苯基。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。
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9.发明申请Contrast Agents and Diagnostic Compositions Based on Iodine-Containing Cyanuric Acid Derivatives 审中-公开基于含碘的氰尿酸衍生物的对比剂和诊断组合物公开(公告)号：US20080267884A1
公开(公告)日：2008-10-30
申请号：US12092871
申请日：2005-11-10
申请人： Oskar Axelsson , Mikkel Thaning
发明人： Oskar Axelsson , Mikkel Thaning
IPC分类号： C07D251/34 , A61K49/04
CPC分类号： C07D251/34 , A61K49/0438
摘要： The present invention relates to a class of compounds of Formula (I) and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing a cyanuric acid scaffolding moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类式（I）的化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地说，含碘化合物是含有氰尿酸支架部分的化合物，其允许与其结合的三个碘化苯基的排列。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。
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公开(公告)号：US07485753B2
公开(公告)日：2009-02-03
申请号：US11565673
申请日：2006-12-01
IPC分类号： C07C233/58 , A61K49/04 , A61K31/16
CPC分类号： C07C237/46 , A61K49/0433 , C07C2601/02
摘要： The present invention relates to iodine containing compounds containing a central cyclopropane scaffolding moiety allowing for the arrangement of three iodinated phenyl groups bound thereto.The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译： 本发明涉及含有中心环丙烷支架部分的含碘化合物，其允许与其结合的三个碘化苯基的排列。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。
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