公开(公告)号：US20050172344A1

公开(公告)日：2005-08-04

申请号：US10980922

申请日：2004-11-03

申请人： Ottavio Arancio ,  Paul Mathews ,  Stephen Schmidt ,  Ralph Nixon ,  Fortunato Battaglia ,  Fabrizio Trinchese ,  Shumin Liu

发明人： Ottavio Arancio ,  Paul Mathews ,  Stephen Schmidt ,  Ralph Nixon ,  Fortunato Battaglia ,  Fabrizio Trinchese ,  Shumin Liu

IPC分类号： A01K67/027 ,  C12N5/06 ,  G01N33/50 ,  G01N33/68

CPC分类号： G01N33/502 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0312 ,  G01N33/5008 ,  G01N33/5014 ,  G01N33/5058 ,  G01N33/6896

摘要： The present invention describes a dissociated cell culture system comprising cells of the hippocampus, one of the brain areas affected by Alzheimer's Disease (AD) or amyloid beta-related diseases. This culture system comprises hippocampal neuronal and glial cells from animal models of AD, particularly, but not limited to, double transgenic mice expressing both the human APP mutation (K670N:M671L) (mAPP), and the human PS1 mutation (M146L) (mPS1), and serves as a powerful tool for the screening and testing of compounds and substances, e.g., drugs, for their ability to affect, treat, or prevent AD or β-amyloid-related diseases. The effects of a test substance on the cells in this culture system can be quantitatively assessed to determine if the test substance affects the cells biochemically and/or electrophysiologically, and/or optically, and/or immunocytochemically. The present in vitro culture system is advantageous for AD drug screening, because it is rapid and efficient. By contrast, even in the fastest animal model of AD, pathology does not start before the end of the second month. If such in vivo animal models are used, it is necessary to wait at least the two month time duration or longer to test for drug efficacy for AD treatment or prevention. At the same time the present invention provides a tool for production of amyloid-beta that can be used for electrophysiological, behavioral, and toxicological studies.

摘要翻译： 本发明描述了解离的细胞培养系统，其包括海马细胞，受阿尔茨海默病（AD）或淀粉样蛋白β相关疾病影响的脑区之一。 该培养系统包括来自AD的动物模型的海马神经元和神经胶质细胞，特别但不限于表达人APP突变（K670N：M671L）（mAPP）和人PS1突变（M146L）（mP1）的双转基因小鼠 ），并且用作筛选和测试化合物和物质（例如药物）对其影响，治疗或预防AD或β-淀粉样蛋白相关疾病的能力的有力工具。 可以定量评估测试物质对该培养系统中细胞的影响，以确定测试物质是否通过生物化学和/或电生理学和/或光学和/或免疫细胞化学方法影响细胞。 目前的体外培养体系对于AD药物筛选是有利的，因为它是快速和有效的。 相比之下，即使在AD的最快动物模型中，病理学也不会在第二个月之前开始。 如果使用这样的体内动物模型，则需要等待至少两个月的持续时间或更长时间来测试AD治疗或预防的药物功效。 同时，本发明提供了可用于电生理，行为和毒理学研究的淀粉样蛋白-β生产工具。

公开(公告)号：US20160047488A1

公开(公告)日：2016-02-18

申请号：US14751827

申请日：2015-06-26

申请人： Stephen Schmidt ,  Kenneth Douglas Neal

发明人： Stephen Schmidt ,  Kenneth Douglas Neal

IPC分类号： F16K43/00 ,  F16K3/02 ,  F16K3/04

CPC分类号： F16K3/0272

摘要： A gate valve is provided with a flapper mechanism that is disposed in the main body of the valve and automatically works to seal and isolate the main body of the valve from a bonnet. The bonnet is isolated without any manual function or operation. When the flapper valve is in a closed position, the bonnet, gate and gate actuating mechanism can be removed from the gate valve body without isolating the gate valve. This enables the bonnet and associated components to be repaired or replaced while water or fluid under pressure continues to flow through the main body of the gate valve.

摘要翻译： 闸阀设置有挡板机构，其设置在阀的主体中并且自动地工作以将阀的主体与发动机罩密封和隔离。 发动机罩是隔离的，没有任何手动功能或操作。 当挡板阀处于关闭位置时，阀盖，闸门和闸门致动机构可以从闸阀阀体上拆下，而不需要隔离闸阀。 这使得能够在水或压力下的液体继续流过闸阀的主体时修理或更换发动机罩和相关部件。

公开(公告)号：US20110196844A1

公开(公告)日：2011-08-11

申请号：US12983375

申请日：2011-01-03

申请人： Vrishal Kulkarni ,  Stephen Schmidt ,  Craig W. Stanfill ,  Ephraim Meriwether Vishniac

发明人： Vrishal Kulkarni ,  Stephen Schmidt ,  Craig W. Stanfill ,  Ephraim Meriwether Vishniac

IPC分类号： G06F17/30

CPC分类号： G06F17/30312 ,  G06F17/30321 ,  G06F17/30418

摘要： Managing data includes: receiving at least one group of individually accessible data units over an input device or port, each data unit identified by a key value, with key values of the received data units being sorted such that the key value identifying a given first data unit that is received before a given second data unit occurs earlier in a sort order than the key value identifying the given second data unit; and processing the data units for storage in a data storage system. The processing includes: storing a plurality of blocks of data, each of one or more of the blocks being generated by combining a plurality of the data units; providing an index that includes an entry for each of the blocks, wherein one or more of the entries enable location, based on a provided key value, of a block that includes data units corresponding to a range of key values that includes the provided key value; and generating one or more screening data structures associated with the stored blocks for determining a possibility that a data unit that includes a given key value was included in the group of individually accessible data units.

摘要翻译： 管理数据包括：通过输入设备或端口接收至少一组单独可访问的数据单元，每个数据单元通过键值标识，所接收的数据单元的键值被排序，使得键值识别给定的第一数据 在给定的第二数据单元之前接收的单元以比识别给定的第二数据单元的键值更高的排序顺序发生; 并处理数据单元以存储在数据存储系统中。 该处理包括：存储多个数据块，通过组合多个数据单元来生成一个或多个块中的每一个块; 提供包括每个块的条目的索引，其中所述条目中的一个或多个使得能够基于提供的密钥值来确定包括与包括所提供的密钥值的密钥值的范围相对应的数据单元的块的位置 ; 以及生成与所存储的块相关联的一个或多个筛选数据结构，以确定包括给定键值的数据单元被包括在可单独访问的数据单元组中的可能性。

公开(公告)号：US20070183847A1

公开(公告)日：2007-08-09

申请号：US11552438

申请日：2006-10-24

申请人： Ronald Gordon ,  Stephen Schmidt

发明人： Ronald Gordon ,  Stephen Schmidt

IPC分类号： E04G21/10

CPC分类号： E02F3/841 ,  E02F3/7609

摘要： A sidewalk grader provided for grading a sidewalk base disposed along a curb of an existing road structure. The sidewalk grader comprises a tracking assembly fixable to a vertically adjustable backfill blade of a compact excavator positioned to move forward over an existing road structure to advance the sidewalk grader. The tracking assembly comprises a vertically adjustable tracking means disposed for engagement with the top surface of the curb, to provide a reference point. A grading assembly is mounted to the tracking assembly. The grading assembly comprises a frame, and a grading blade rotatingly mounted to the frame to permit adjustment of slope of the blade. An adjustable link connects the grading blade to the frame to adjustable fix their relative position. The tracking means is vertically adjustable to enable the same to engage with the surface of a curb for reference to enable precise adjustment, control, and positioning of the grading assembly, and for maintaining the desired position of the sidewalk grader in relation to the curb as the sidewalk grader advances along the existing road structure.

公开(公告)号：US20050062430A1

公开(公告)日：2005-03-24

申请号：US10862548

申请日：2004-06-07

申请人： Kurt Schroder ,  Douglas Jackson ,  Stephen Schmidt

发明人： Kurt Schroder ,  Douglas Jackson ,  Stephen Schmidt

IPC分类号： B01J19/08 ,  C01G1/02 ,  G01G1/02 ,  H01J7/46 ,  H03K20060101 ,  H03K3/55 ,  H05B7/22 ,  H05H1/36

CPC分类号： H05H1/36 ,  B01J19/088 ,  B01J2219/0809 ,  B01J2219/0822 ,  B01J2219/0875 ,  B01J2219/0894 ,  H03K3/55

摘要： A nanopowder synthesis system having an autofuser device which obviates the need for external power switches, and which accommodates repeated discharges (of the order of 107) between ablating electrodes of precursor material at a high repetition rate (≧1 Hz).

摘要翻译： 一种具有自动定影器装置的纳米粉末合成系统，其消除了对外部功率开关的需要，并且以高重复率（> = 1Hz）容纳前体材料的烧蚀电极之间的重复放电（约为10 <7>的量级）。

公开(公告)号：US08489553B2

公开(公告)日：2013-07-16

申请号：US13540125

申请日：2012-07-02

申请人： Vrishal Kulkarni ,  Stephen Schmidt ,  Craig W. Stanfill ,  Ephraim Meriwether Vishniac

发明人： Vrishal Kulkarni ,  Stephen Schmidt ,  Craig W. Stanfill ,  Ephraim Meriwether Vishniac

IPC分类号： G06F17/30

CPC分类号： G06F17/30312 ,  G06F17/30321 ,  G06F17/30418

摘要： Managing data by: receiving a group of individually accessible data units, each data unit identified by a key value, with key values determined such that the key value identifying a first data unit received before a second data unit occurs earlier in a sort order than the key value identifying the second data unit; and processing the data units for storage in a data storage system. The processing includes: storing blocks of data, the blocks being generated by combining a plurality of the data units; providing an index with entries that enable location, based on a provided key value, of a block that includes a data unit corresponding to the provided key value; and generating one or more screening data structures associated with the blocks for determining, based on a given key value, whether to search the stored blocks for a data unit corresponding to the given key value.

公开(公告)号：US08214331B2

公开(公告)日：2012-07-03

申请号：US12983375

申请日：2011-01-03

申请人： Vrishal Kulkarni ,  Stephen Schmidt ,  Craig W. Stanfill ,  Ephraim Meriwether Vishniac

发明人： Vrishal Kulkarni ,  Stephen Schmidt ,  Craig W. Stanfill ,  Ephraim Meriwether Vishniac

IPC分类号： G06F17/30

CPC分类号： G06F17/30312 ,  G06F17/30321 ,  G06F17/30418

摘要： Managing data includes: receiving at least one group of individually accessible data units over an input device or port, each data unit identified by a key value, with key values of the received data units being sorted such that the key value identifying a given first data unit that is received before a given second data unit occurs earlier in a sort order than the key value identifying the given second data unit; and processing the data units for storage in a data storage system. The processing includes: storing a plurality of blocks of data, each of one or more of the blocks being generated by combining a plurality of the data units; providing an index that includes an entry for each of the blocks, wherein one or more of the entries enable location, based on a provided key value, of a block that includes data units corresponding to a range of key values that includes the provided key value; and generating one or more screening data structures associated with the stored blocks for determining a possibility that a data unit that includes a given key value was included in the group of individually accessible data units.

摘要翻译： 管理数据包括：通过输入设备或端口接收至少一组单独可访问的数据单元，每个数据单元通过键值标识，所接收的数据单元的键值被排序，使得键值识别给定的第一数据 在给定的第二数据单元之前接收的单元以比识别给定的第二数据单元的键值更高的排序顺序发生; 并处理数据单元以存储在数据存储系统中。 该处理包括：存储多个数据块，通过组合多个数据单元来生成一个或多个块中的每一个块; 提供包括每个块的条目的索引，其中所述条目中的一个或多个使得能够基于提供的密钥值来确定包括与包括所提供的密钥值的密钥值的范围相对应的数据单元的块的位置 ; 以及生成与所存储的块相关联的一个或多个筛选数据结构，以确定包括给定键值的数据单元被包括在可单独访问的数据单元组中的可能性。

公开(公告)号：US20110307897A1

公开(公告)日：2011-12-15

申请号：US13161010

申请日：2011-06-15

申请人： Matthew Darcy Atterbury ,  H. Mark Bromley ,  Wayne Mesard ,  Arkadi Popov ,  Stephen Schmidt ,  Craig W. Stanfill ,  Joseph Skeffington Wholey, III

发明人： Matthew Darcy Atterbury ,  H. Mark Bromley ,  Wayne Mesard ,  Arkadi Popov ,  Stephen Schmidt ,  Craig W. Stanfill ,  Joseph Skeffington Wholey, III

IPC分类号： G06F9/46

CPC分类号： G06F9/44521 ,  G06F9/44536 ,  G06F9/4494

摘要： Processing data includes: receiving units of work that each include one or more work elements, and processing a first unit of work using a first compiled dataflow graph (160) loaded into a data processing system (100) in response to receiving the first unit of work. The processing includes: analysis to determine a characteristic of the first unit of work; identifying one or more compiled dataflow graphs from graphs stored in a data storage system (107) that include at least some that were compiled for processing a unit of work having the determined characteristic; loading one of the identified compiled dataflow graphs into the data processing system (100) as the first compiled dataflow graph (160); and generating one or more output work elements from at least one work element in the first unit of work.

摘要翻译： 处理数据包括：接收工作单元，每个工作单元包括一个或多个工作元件，以及响应于接收到第一单元的第一单元来处理加载到数据处理系统（100）中的第一编译数据流图（160）来处理第一工作单元 工作。 处理包括：分析确定第一工作单元的特征; 从存储在数据存储系统（107）中的图形中识别一个或多个编译数据流图，所述图形包括至少一些被编译用于处理具有所确定的特征的工作单元的编译数据流图; 将所识别的编译数据流图中的一个加载到数据处理系统（100）中作为第一编译数据流图（160）; 以及从所述第一工作单元中的至少一个工作元件生成一个或多个输出工作元件。

公开(公告)号：US20070033840A1

公开(公告)日：2007-02-15

申请号：US11581181

申请日：2006-10-13

申请人： Stephen Schmidt

发明人： Stephen Schmidt

IPC分类号： E04G21/10

CPC分类号： E02F3/841 ,  E02F3/7609

摘要： A sidewalk grader provided for grading a sidewalk base disposed along a curb of an existing road structure. The sidewalk grader comprises a tracking assembly fixable to a vertically adjustable backfill blade of a compact excavator positioned to move forward over an existing road structure to advance the sidewalk grader. The tracking assembly comprises a vertically adjustable tracking means disposed for engagement with the top surface of the curb, to provide a reference point. A grading assembly is mounted to the tracking assembly. The grading assembly comprises a frame, and a grading blade rotatingly mounted to the frame to permit adjustment of slope of the blade. An adjustable link connects the grading blade to the frame to adjustable fix their relative position. The tracking means is vertically adjustable to enable the same to engage with the surface of a curb for reference to enable precise adjustment, control, and positioning of the grading assembly, and for maintaining the desired position of the sidewalk grader in relation to the curb as the sidewalk grader advances along the existing road structure.

摘要翻译： 一个人行道分级机，用于分级沿现有道路结构的路边设置的人行道基座。 人行道分级机包括可定位成紧凑型挖掘机的可垂直调节的回填叶片的跟踪组件，定位成在现有道路结构上向前移动以推进人行道分级机。 跟踪组件包括设置成与路缘石的顶表面接合的可垂直调节的跟踪装置，以提供参考点。 分级组件安装到跟踪组件。 分级组件包括框架和旋转地安装到框架上以允许调节叶片的斜率的分级叶片。 可调节的连接将分级叶片连接到框架以可调整地固定其相对位置。 跟踪装置是可垂直调节的，以使其能够与路缘石的表面接合以供参考，以使得能够精确地调整，控制和定位分级组件，并且用于将侧路平层机相对于路缘石的期望位置保持为 人行道平铺机沿着现有的道路结构前进。

公开(公告)号：US20060072277A1

公开(公告)日：2006-04-06

申请号：US10955166

申请日：2004-09-30

申请人： Stephen Schmidt ,  Steven McCool

发明人： Stephen Schmidt ,  Steven McCool

IPC分类号： H02H9/06

CPC分类号： H05K9/0064 ,  H02G3/0437

摘要： A power and signal distribution system is adaptable to existing building areas and provides a shielded, low resistance and low inductance grounding structure. The distribution system comprises two or more electrically conductive enclosed channels; one for lower current signals and power distribution and one for high current signals and power distribution. The enclosed channels are electrically coupled and are configured as crosses or spokes with branches extending substantially over the length and width of the building area. The earth ground for the building has a direct connection to one of the enclosures. The ground of each device in the building area is directly connected to the enclosed channels by a low impedance connection. Cables are routed through the enclosures and extended to the devices. The walls of the enclosed channels have a thickness that is greater than the skin depth of a predetermined low frequency.