公开(公告)号：US4775731A

公开(公告)日：1988-10-04

申请号：US844710

申请日：1986-03-27

申请人： Otto Wichterle ,  Jiri Trekoval ,  Jiri Vacik ,  Jiri Michalek

发明人： Otto Wichterle ,  Jiri Trekoval ,  Jiri Vacik ,  Jiri Michalek

IPC分类号： G02C7/04 ,  C08F20/00 ,  C08F20/26 ,  C08F20/52 ,  C08F26/00 ,  C08F26/10 ,  C08F220/00 ,  C08F220/04 ,  C08F220/06 ,  C08F220/28 ,  C08F220/40 ,  C08F220/56 ,  C08F226/10 ,  C08F265/00 ,  C08F265/06 ,  G02B1/04

CPC分类号： C08F265/06 ,  C08F220/40 ,  G02B1/043

摘要： Hydrophilic three dimensional polymers, the prevailing mass of which is formed by structural units corresponding to monomers miscible with water at any ratio, and the method for their production, wherein one weight part of the monomers miscible with water is copolymerized, by the effect of free-radical initiators, with 0.01 to 1 weight part of a polyfunctional unsaturated oligomer, which is prepared with an average degree of polymerization x=3 to x=100 by the anionic polymerization of allyl methacrylate, with the contingent addition of methacrylonitrile or methacrylic esters of univalent saturated alcohols containing 1 to 4 carbon atoms or methacrylic esters of monohydroxy compounds containing at least one etheric oxygen atom in the chain, or where 0.7 to 1 weight part of monomers miscible with water is copolymerized with 0.01 to 0.3 weight parts of hydrophobic monomers of the alkyl methacrylate or acrylate type in the presence of an oligomeric crosslinking agent with at least two olefinic double bonds added in the amount of 0.01 to 0.1 weight parts, advantageously up to 0.05 weight parts, by the effect of free-radical initiators.

摘要翻译： 亲水性三维聚合物，其主要质量由对应于与任何比例的水混溶的单体的结构单元及其生产方法形成，其中一个重量份的可与水混溶的单体通过游离的方式共聚合 - 通过甲基丙烯酸烯丙酯的阴离子聚合制备具有平均聚合度x = 3至x = 100的多官能不饱和低聚物的0.01至1重量份，或偶然加入甲基丙烯腈或甲基丙烯酸酯 含有1至4个碳原子的单价饱和醇或在链中含有至少一个醚性氧原子的单羟基化合物的甲基丙烯酸酯，或其中0.7至1重量份与水混溶的单体与0.01至0.3重量份的疏水单体共聚 在具有至少两个烯烃的低聚交联剂的存在下，甲基丙烯酸烷基酯或丙烯酸酯类型 通过自由基引发剂的作用，添加量为0.01至0.1重量份，有利地高达0.05重量份的双键双键。

公开(公告)号：US4604440A

公开(公告)日：1986-08-05

申请号：US718957

申请日：1985-04-02

申请人： Otto Wichterle ,  Jiri Trekoval ,  Jiri Vacik ,  Jiri Michalek

发明人： Otto Wichterle ,  Jiri Trekoval ,  Jiri Vacik ,  Jiri Michalek

IPC分类号： G02C7/04 ,  C08F20/00 ,  C08F20/26 ,  C08F20/52 ,  C08F26/00 ,  C08F26/10 ,  C08F220/00 ,  C08F220/04 ,  C08F220/06 ,  C08F220/28 ,  C08F220/40 ,  C08F220/56 ,  C08F226/10 ,  C08F265/00 ,  C08F265/06 ,  G02B1/04

CPC分类号： C08F265/06 ,  C08F220/40 ,  G02B1/043

摘要： Hydrophilic three dimensional polymers, the prevailing mass of which is formed by structural units corresponding to monomers miscible with water at any ratio, and the method for their production, wherein one weight part of the monomers miscible with water is copolymerized, by the effect of free-radical initiators, with 0.01 to 1 weight part of a polyfunctional unsaturated oligomer, which is prepared with an average degree of polymerization x=3 to x=100 by the anionic polymerization of allyl methacrylate, with the contingent addition of methacrylonitrile or methacrylic esters of univalent saturated alcohols containing 1 to 4 carbon atoms or methacrylic esters of monohydroxy compounds containing at least one etheric oxygen atom in the chain, or where 0.7 to 1 weight part of monomers miscible with water is copolymerized with 0.01 to 0.3 weight parts of hydrophobic monomers of the alkyl methacrylate or acrylate type in the presence of an oligomeric crosslinking agent with at least two olefinic double bonds added in the amount of 0.01 to 0.1 weight parts, advantageously up to 0.05 weight parts, by the effect of free-radical initiators.

公开(公告)号：US08444408B2

公开(公告)日：2013-05-21

申请号：US11721075

申请日：2005-12-09

申请人： Jiri Michalek ,  Jiri Vacik

发明人： Jiri Michalek ,  Jiri Vacik

IPC分类号： B29C41/04

CPC分类号： B29C41/04 ,  B29D11/023

摘要： The invention is related to a method of the manufacture of an implantable lens from a liquid polymer precursor in an open mold, during which the liquid polymer precursor in metered into the open mold in a such measured amount, that comes into contact with a functional shaping inner surface of the open mold, which is located under a peripheral circular sharp edge of the stationary open mold or which reaches up to this peripheral circular sharp edge, at which point the open mold, which contains the liquid polymer precursor, is rotated around it's vertical axis at a speed, at which the edge of the surface of the liquid polymer precursor reaches the peripheral circular sharp edge of the open mold, after which the liquid polymer precursor is exposed to conditions, under which it transforms itself into a state of a clear solid polymer by polymerization and/or cross-linking, until such time, at which the stated transition is attained, and then the implantable intraocular lens is removed from the open mold. The invention also includes the open mold used for the implementation of the stated method and the lens produced in this way.

摘要翻译： 本发明涉及一种从开放模具中的液体聚合物前体制造可植入透镜的方法，其中将液体聚合物前体以如此测量的量计量到开放模具中，其与功能成型接触 打开的模具的内表面位于固定开放模具的周边圆形锋利边缘下方，或者到达该周边圆形锋利边缘，此时包含液体聚合物前体的开放模具围绕其旋转 垂直轴以液体聚合物前体的表面的边缘到达开放模具的周边圆形锋利边缘的速度，之后液体聚合物前体暴露于其中将其自身转变为 通过聚合和/或交联清除固体聚合物，直到达到所述转变的时间，然后将可植入人工晶状体从 开模。 本发明还包括用于实施所述方法的开模和以这种方式制造的透镜。

公开(公告)号：US20110093067A1

公开(公告)日：2011-04-21

申请号：US12980701

申请日：2010-12-29

申请人： Jiri Michalek ,  Jiri Vacik

发明人： Jiri Michalek ,  Jiri Vacik

IPC分类号： A61F2/16 ,  B29D11/00

CPC分类号： B29C41/04 ,  B29D11/023

摘要： A method of manufacturing an implantable lens from liquid polymer precursor in an open mold includes metering the liquid into the mold in a measured amount that comes into contact with a functional shaping inner surface of the mold located under a peripheral circular sharp edge of the stationary mold or which reaches up to this peripheral circular sharp edge, at which point the open mold is rotated around it's vertical axis at a speed at which the edge of the surface of the liquid polymer precursor reaches the peripheral circular sharp edge of the open mold, after which the liquid polymer precursor is exposed to conditions under which it transforms itself into a state of a clear solid polymer by polymerization and/or cross-linking, until the transition is attained, and then the implantable intraocular lens is removed from the mold.

摘要翻译： 在开放模具中从液态聚合物前体制造可植入透镜的方法包括将液体计量到与模具的功能成形内表面接触的测量量中，所述功能成型内表面位于固定模具的周边圆形锋利边缘下方 或者达到该周边圆形锋利边缘，此时开放模具以其液体聚合物前体的表面的边缘到达开放模具的周边圆形锋利边缘的速度绕其垂直轴线旋转，之后 其中液体聚合物前体暴露于通过聚合和/或交联将其自身转化成透明固体聚合物状态的条件，直到达到转变，然后从模具中除去可植入的眼内透镜。

公开(公告)号：US08409481B2

公开(公告)日：2013-04-02

申请号：US12980701

申请日：2010-12-29

申请人： Jiri Michalek ,  Jiri Vacik

发明人： Jiri Michalek ,  Jiri Vacik

IPC分类号： B29C41/04

CPC分类号： B29C41/04 ,  B29D11/023

摘要： A method of manufacturing an implantable lens from liquid polymer precursor in an open mold includes metering the liquid into the mold in a measured amount that comes into contact with a functional shaping inner surface of the mold located under a peripheral circular sharp edge of the stationary mold or which reaches up to this peripheral circular sharp edge, at which point the open mold is rotated around it's vertical axis at a speed at which the edge of the surface of the liquid polymer precursor reaches the peripheral circular sharp edge of the open mold, after which the liquid polymer precursor is exposed to conditions under which it transforms itself into a state of a clear solid polymer by polymerization and/or cross-linking, until the transition is attained, and then the implantable intraocular lens is removed from the mold.

摘要翻译： 在开放模具中从液态聚合物前体制造可植入透镜的方法包括将液体计量到与模具的功能成形内表面接触的测量量中，所述功能成型内表面位于固定模具的周边圆形锋利边缘下方 或者达到该周边圆形锋利边缘，此时开放模具以其液体聚合物前体的表面的边缘到达开放模具的周边圆形锋利边缘的速度绕其垂直轴线旋转，之后 其中液体聚合物前体暴露于通过聚合和/或交联将其自身转化成透明固体聚合物状态的条件，直到达到转变，然后从模具中除去可植入的眼内透镜。

公开(公告)号：US20090224415A1

公开(公告)日：2009-09-10

申请号：US11721075

申请日：2005-12-09

申请人： Jiri Michalek ,  Jiri Vacik

发明人： Jiri Michalek ,  Jiri Vacik

IPC分类号： B29D11/00

CPC分类号： B29C41/04 ,  B29D11/023

摘要： The invention is related to a method of the manufacture of an implantable lens from a liquid polymer precursor in an open mold, during which the liquid polymer precursor in metered into the open mold in a such measured amount, that comes into contact with a functional shaping inner surface of the open mold, which is located under a peripheral circular sharp edge of the stationary open mold or which reaches up to this peripheral circular sharp edge, at which point the open mold, which contains the liquid polymer precursor, is rotated around it's vertical axis at a speed, at which the edge of the surface of the liquid polymer precursor reaches the peripheral circular sharp edge of the open mold, after which the liquid polymer precursor is exposed to conditions, under which it transforms itself into a state of a clear solid polymer by polymerization and/or cross-linking, until such time, at which the stated transition is attained, and then the implantable intraocular lens is removed from the open mold. The invention also includes the open mold used for the implementation of the stated method and the lens produced in this way.

摘要翻译： 本发明涉及一种从开放模具中的液体聚合物前体制造可植入透镜的方法，其中将液体聚合物前体以如此测量的量计量到开放模具中，其与功能成型接触 打开的模具的内表面位于固定开放模具的周边圆形锋利边缘下方，或者到达该周边圆形锋利边缘，此时包含液体聚合物前体的开放模具围绕其旋转 垂直轴以液体聚合物前体的表面的边缘到达开放模具的周边圆形锋利边缘的速度，之后液体聚合物前体暴露于其中将其自身转变为 通过聚合和/或交联清除固体聚合物，直到达到所述转变的时间，然后将可植入人工晶状体从 开模。 本发明还包括用于实施所述方法的开模和以这种方式制造的透镜。

公开(公告)号：US4916197A

公开(公告)日：1990-04-10

申请号：US376697

申请日：1989-07-07

申请人： Jiri Vacik ,  Jana Kudelkova

发明人： Jiri Vacik ,  Jana Kudelkova

IPC分类号： C08F220/28 ,  C08F226/10 ,  G02B1/04

CPC分类号： G02B1/043 ,  C08F220/28 ,  C08F226/10

摘要： The solution pertains to a hydrophilic copolymer suitable in particular for contact and intraocular lenses and medical applications and to a method for its production.The solution consists in a hydrophilic copolymer which can be prepared by copolymerization of 5 to 95 wt.-% 1-vinyl-2-pyrrolidone with 95 to 5 wt.-% alkylene glycol acetate methacrylates or acrylates of the general formula I ##STR1## where R is the group CH.sub.2 .dbd.CH-- or CH.sub.2 .dbd.C(CH.sub.3)-- and n means an integer 1 to 3, in the presence of 0.01 to 50 wt.-% of a crosslinking agent under the conditions of radical copolymerization in the presence of radical initiators.

摘要翻译： 该解决方案涉及适合于特别用于接触和眼内透镜和医疗应用的亲水共聚物及其生产方法。 该溶液包含亲水性共聚物，其可以通过使5-95重量％的1-乙烯基-2-吡咯烷酮与95-5重量％的亚烷基二醇乙酸酯甲基丙烯酸酯或通式Ⅰ的丙烯酸酯共聚合来制备 （I）其中R是基团CH 2 = CH-或CH 2 = C（CH 3） - ，并且n表示1至3的整数，在自由基共聚的条件下，在0.01至50重量％的交联剂存在下 在激进的发起者的存在下。

公开(公告)号：US3997660A

公开(公告)日：1976-12-14

申请号：US464033

申请日：1974-04-25

申请人： Jinrich Kopecek ,  Jiri Vacik ,  Ladislav Sprincl

发明人： Jinrich Kopecek ,  Jiri Vacik ,  Ladislav Sprincl

IPC分类号： C08F20/54 ,  C08G18/62 ,  C08L33/00 ,  C08L33/14 ,  A61K31/74 ,  A61K9/70 ,  A61K31/78

CPC分类号： C08L33/00 ,  C08F20/54 ,  C08G18/6266 ,  C08G18/6283 ,  C08L33/14 ,  Y10S424/13

摘要： Soluble, hydrophilic polymers suitable for medical use and as blood plasma substitutes comprising low molecular weight polymer derived from at least one monomer of an acrylamide type material or a mono-ester of an acrylic type acid and a glycol which is condensed with bifunctional compounds to form a condensation polymer having increased molecular weight and enzymatically cleavable cross-links. The hydrophilic polymer is produced by polymerizing the acrylamide type material or mono-ester mentioned above to form a low molecular weight polymer which is then condensed with a bifunctional compound to form a high molecular weight condensation polymer having enzymatically cleavable cross-links.

摘要翻译： 适用于医疗用途的可溶性亲水性聚合物和作为血浆替代物的低分子量聚合物，其包含至少一种丙烯酰胺型材料的单体或丙烯酸类和乙二醇的单酯，其与双官能化合物缩合形成 具有增加的分子量和可酶切割交联的缩聚物。 亲水性聚合物通过聚合上述丙烯酰胺型材料或单酯来形成低分子量聚合物，然后与双官能化合物缩合形成具有可酶切割交联的高分子量缩合聚合物。

公开(公告)号：US4956432A

公开(公告)日：1990-09-11

申请号：US362763

申请日：1989-06-07

申请人： Jiri Vacik ,  Blahoslav Obereigner ,  Dana Souckova

发明人： Jiri Vacik ,  Blahoslav Obereigner ,  Dana Souckova

IPC分类号： G02C7/04 ,  C08F2/00 ,  C08F2/02 ,  C08F2/46 ,  C08F2/48 ,  C08F4/40 ,  C08F20/26 ,  C08F20/52 ,  C08F20/60 ,  C08F220/26 ,  C08F220/58 ,  C08F220/60 ,  G02B1/04

CPC分类号： C08F20/60 ,  G02B1/043

摘要： The solution concerns hydrophilic transparent crosslinked copolymers and a method for their production.A substance of the solution is the hydrophilic copolymer which can be prepared by the radical copolymerization of monomers with the general formula I, where R is hydrogen or methyl, alone or in their mutual combinations or by copolymerization of the monomers with general formula I and the monomers with general formula II, where R.sup.1 means hydrogen or methyl and X is a group OCH.sub.2 CH.sub.2 OH, OCH.sub.2 CH(OH)CH.sub.3, OCH.sub.2 CH(OH)CH.sub.2 OH, (OCH.sub.2 CH.sub.2).sub.3 OH, (OCH.sub.2 CH.sub.2).sub.2 OH, alkoxyl from OCH.sub.3 to OC.sub.16 H.sub.33, NH.sub.2, NHCH.sub.2 (OH)CH.sub.3, N(C.sub.2 H.sub.5).sub.2, and NH-tert-C.sub.4 H.sub.9, whereas the content of monomers of the general formula I and II amounts to 40 to 99.99 wt.-% of the entire mixture, where at least 5 wt.-% form the monomers of general formula I, with 0.01 to 60 wt.-% of a crosslinking agent, related to the entire monomer mixture, which has at least two olefinic double bonds, in the presence of radical initiators. ##STR1##

公开(公告)号：US3954966A

公开(公告)日：1976-05-04

申请号：US453082

申请日：1974-03-20

申请人： Drahoslav Lim ,  Ladislav Sprincl ,  Jindrich Kopecek ,  Jiri Vacik

发明人： Drahoslav Lim ,  Ladislav Sprincl ,  Jindrich Kopecek ,  Jiri Vacik

IPC分类号： A61K9/00 ,  A61K31/78

CPC分类号： A61K9/0026 ,  A61K31/78

摘要： Surgical infusion solutions, useful particularly as blood plasma substitutes, comprising physiological solution of polymers or copolymers formed from ethyleneglycol acrylates and methacrylates, acrylamide, methacrylamide and acrylamides and methacrylamides substituted on the nitrogen atom with either one or two lower alkyl radicals and/or one or two hydroxyalkyl or dihydroxyalkyl radicals containing 1 to 6 carbon atoms and mixtures of these polymeric materials dissolved in a physiological solvent therefor. The polymerization or copolymerization is carried out by solution polymerization methods and the polymeric material is precipitated by mixing it in a suitable non-solvent therefor, but which is miscible with the polymerization solvent.

摘要翻译： 包括由乙二醇丙烯酸酯和甲基丙烯酸酯，丙烯酰胺，甲基丙烯酰胺和丙烯酰胺形成的聚合物或共聚物的生理溶液和在氮原子上被一个或两个低级烷基取代的丙烯酰胺和甲基丙烯酰胺的生物溶液，和/或一种或多种 含有1至6个碳原子的两个羟烷基或二羟基烷基和这些聚合物材料的混合物溶于其生理溶剂中。 聚合或共聚是通过溶液聚合法进行的，聚合物通过将其混合在合适的非溶剂中而与聚合溶剂混溶而沉淀。