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公开(公告)号：US20130243746A1
公开(公告)日：2013-09-19
申请号：US13831368
申请日：2013-03-14
申请人： OXYRANE UK LIMITED
发明人： Wouter Vervecken , Kathleen Camilla Telesphore Alida Maria Piens , Jan Robert Ludo Stout , Gwenda Noëlla Pynaert
IPC分类号： C12N9/24
CPC分类号： A61K47/48246 , A61K38/00 , A61K38/43 , A61K38/47 , A61K47/64 , C07K14/65 , C07K2319/70 , C12N9/2408 , C12N9/2451 , C12N9/62 , C12P21/02 , C12P21/06 , C12Y302/01003 , C12Y302/0102
摘要： This document relates to molecular complexes having acid alpha glucosidase activity and at least one modification that results in enhanced ability of the molecular complex to be transported to the interior of a mammalian cell.
摘要翻译： 本文件涉及具有酸性α糖苷酶活性的分子复合物和至少一种导致分子复合物被输送到哺乳动物细胞内部的能力的修饰。
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公开(公告)号：US10011857B2
公开(公告)日：2018-07-03
申请号：US15087201
申请日：2016-03-31
申请人： Oxyrane UK Limited
发明人： Kathleen Camilla Telesphore Alida Maria Piens , Wouter Vervecken , Albena Vergilieva Valevska , Gwenda Noëlla Pynaert
IPC分类号： C12P19/26 , C12P21/00 , A61K38/43 , C12N15/81 , C12N9/10 , C12N9/24 , A61K38/17 , A61K38/16 , A61K38/00
CPC分类号： C12P21/005 , A61K38/00 , A61K38/16 , A61K38/1709 , C12N9/2402 , C12N9/2488 , C12Y302/01 , C12Y302/01024 , Y02P20/52
摘要： The invention provides mannosidases capable of uncapping mannose-1-phospho-6-mannose moieties and demannosylating phosphorylated N-glycans, methods of using such mannosidases, glycoproteins produced using the methods, as well as methods of facilitating mammalian cellular uptake of glycoproteins.
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公开(公告)号：US09249399B2
公开(公告)日：2016-02-02
申请号：US13831368
申请日：2013-03-14
申请人： Oxyrane UK Limited
发明人： Wouter Vervecken , Kathleen Camilla Telesphore Alida Maria Piens , Jan Robert Ludo Stout , Gwenda Noëlla Pynaert
IPC分类号： C12N9/26 , C12P21/02 , C12P21/06 , C07K19/00 , C07K14/65 , C12N9/62 , A61K38/43 , A61K38/47 , C12N9/44 , A61K38/46 , A61K38/00
CPC分类号： A61K47/48246 , A61K38/00 , A61K38/43 , A61K38/47 , A61K47/64 , C07K14/65 , C07K2319/70 , C12N9/2408 , C12N9/2451 , C12N9/62 , C12P21/02 , C12P21/06 , C12Y302/01003 , C12Y302/0102
摘要： This document relates to molecular complexes having acid alpha glucosidase activity and at least one modification that results in enhanced ability of the molecular complex to be transported to the interior of a mammalian cell.
摘要翻译： 本文件涉及具有酸性α糖苷酶活性的分子复合物和至少一种导致分子复合物被输送到哺乳动物细胞内部的能力的修饰。
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公开(公告)号：US10648044B2
公开(公告)日：2020-05-12
申请号：US14981123
申请日：2015-12-28
申请人： Oxyrane UK Limited
发明人： Wouter Vervecken , Kathleen Camilla Telesphore Alida Maria Piens , Jan Robert Ludo Stout , Gwenda Noëlla Pynaert
IPC分类号： C12N9/24 , C12N9/26 , C12N1/15 , C12N15/55 , C12P21/06 , C12P21/02 , A61K38/47 , C12N9/62 , A61K38/43 , C12N9/44 , A61K47/64 , C07K14/65 , A61K38/00
摘要： This document relates to molecular complexes having acid alpha glucosidase activity and at least one modification that results in enhanced ability of the molecular complex to be transported to the interior of a mammalian cell.
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公开(公告)号：US20160251693A1
公开(公告)日：2016-09-01
申请号：US15087201
申请日：2016-03-31
申请人： Oxyrane UK Limited
发明人： Kathleen Camilla Telesphore Alida Maria Piens , Wouter Vervecken , Albena Vergilieva Valevska , Gwenda Noëlla Pynaert
CPC分类号： C12P21/005 , A61K38/00 , A61K38/16 , A61K38/1709 , C12N9/2402 , C12N9/2488 , C12Y302/01 , C12Y302/01024 , Y02P20/52
摘要： The invention provides mannosidases capable of uncapping mannose-1-phospho-6-mannose moieties and demannosylating phosphorylated N-glycans, methods of using such mannosidases, glycoproteins produced using the methods, as well as methods of facilitating mammalian cellular uptake of glycoproteins.
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