公开(公告)号：US20230159762A1

公开(公告)日：2023-05-25

申请号：US18076700

申请日：2022-12-07

申请人： PERKINELMER HEALTH SCIENCES, INC.

发明人： Nara Narayanan ,  Kevin Groves ,  Guojie Ho

IPC分类号： C09B23/16 ,  A61P35/00 ,  C07D403/14 ,  C07D409/08 ,  C07D209/90 ,  C07D403/08 ,  C07D401/08 ,  C07D333/74 ,  A61K49/00 ,  A61K51/04 ,  C07D209/92 ,  C07D333/50 ,  C09B1/00 ,  G01N33/58

CPC分类号： C09B23/16 ,  A61P35/00 ,  C07D403/14 ,  C07D409/08 ,  C07D209/90 ,  C07D403/08 ,  C07D401/08 ,  C07D333/74 ,  A61K49/0052 ,  A61K49/0058 ,  A61K51/0431 ,  A61K51/0434 ,  A61K51/0446 ,  A61K51/0497 ,  C07D209/92 ,  C07D333/50 ,  C09B1/002 ,  C09B1/005 ,  C09B23/166 ,  G01N33/582

摘要： This disclosure provides a family of compounds that absorb and fluoresce in the short wave infrared region (SWIR, optionally 1000 nm to 1300 nm), including hydrophilic compounds that exhibit absorption and emission spectral profiles in aqueous solutions substantially similar to those observed in organic solvents such as methanol or DMSO. The compounds can be chemically linked to biomolecules including proteins, nucleic acids, and therapeutic small molecules. The compounds are useful for imaging in a variety of medical, biological and diagnostic applications, including SWIR in vivo imaging of regions of interest within a mammal.

公开(公告)号：US11549017B2

公开(公告)日：2023-01-10

申请号：US16124639

申请日：2018-09-07

申请人： PERKINELMER HEALTH SCIENCES, INC.

发明人： Nara Narayanan ,  Kevin Groves ,  Guojie Ho

IPC分类号： A61K51/00 ,  A61M36/14 ,  C09B23/16 ,  A61P35/00 ,  C07D403/14 ,  C07D409/08 ,  C07D209/90 ,  C07D403/08 ,  C07D401/08 ,  C07D333/74 ,  A61K49/00 ,  A61K51/04 ,  C07D209/92 ,  C07D333/50 ,  C09B1/00 ,  G01N33/58

摘要： This disclosure provides a family of compounds that absorb and fluoresce in the short wave infrared region (SWIR, optionally 1000 nm to 1300 nm), including hydrophilic compounds that exhibit absorption and emission spectral profiles in aqueous solutions substantially similar to those observed in organic solvents such as methanol or DMSO. The compounds can be chemically linked to biomolecules including proteins, nucleic acids, and therapeutic small molecules. The compounds are useful for imaging in a variety of medical, biological and diagnostic applications, including SWIR in vivo imaging of regions of interest within a mammal.

公开(公告)号：US20190100654A1

公开(公告)日：2019-04-04

申请号：US16124639

申请日：2018-09-07

申请人： PERKINELMER HEALTH SCIENCES, INC.

发明人： Nara Narayanan ,  Kevin Groves ,  Guojie Ho

IPC分类号： C09B23/16 ,  A61K49/00 ,  G01N33/58 ,  A61K51/04 ,  C07D209/92 ,  C07D333/50 ,  C09B1/00

摘要： This disclosure provides a family of compounds that absorb and fluoresce in the short wave infrared region (SWIR, optionally 1000 nm to 1300 nm), including hydrophilic compounds that exhibit absorption and emission spectral profiles in aqueous solutions substantially similar to those observed in organic solvents such as methanol or DMSO. The compounds can be chemically linked to biomolecules including proteins, nucleic acids, and therapeutic small molecules. The compounds are useful for imaging in a variety of medical, biological and diagnostic applications, including SWIR in vivo imaging of regions of interest within a mammal.