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公开(公告)号：US09636316B2
公开(公告)日：2017-05-02
申请号：US14861169
申请日：2015-09-22
申请人： PHARNEXT
IPC分类号： A61K31/255 , A61K31/205 , A61K31/19 , A61K31/197 , A61K31/445 , A61K45/06 , A61K31/185 , A61K31/13 , A61K31/27 , A61K31/55 , A61K31/195 , A61K31/325
CPC分类号： A61K31/4045 , A61K9/0053 , A61K31/13 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/27 , A61K31/325 , A61K31/445 , A61K31/55 , A61K45/06 , A61K2300/00
摘要： The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on baclofen and acamprosate combination.
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2.发明授权公开(公告)号：US09144558B2
公开(公告)日：2015-09-29
申请号：US14479614
申请日：2014-09-08
申请人： PHARNEXT
IPC分类号： A61K31/255 , A61K31/205 , A61K31/19 , A61K31/197 , A61K31/445 , A61K45/06 , A61K31/185 , A61K31/13 , A61K31/27 , A61K31/55
CPC分类号： A61K31/4045 , A61K9/0053 , A61K31/13 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/27 , A61K31/325 , A61K31/445 , A61K31/55 , A61K45/06 , A61K2300/00
摘要： The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on baclofen and acamprosate combination.
摘要翻译： 本发明涉及用于治疗与谷氨酸兴奋毒性相关的神经障碍和淀粉样蛋白的组合和方法。 毒性。 更具体地说，本发明涉及阿尔茨海默病，阿尔茨海默氏病相关疾病，肌萎缩性侧索硬化，多发性硬化，帕金森病，亨廷顿病，神经性疼痛，酒精神经病，酒精中毒或酒精戒断或脊髓损伤的新型组合疗法 对巴氯芬和acrosrosate组合。
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3.发明授权公开(公告)号：US08865769B2
公开(公告)日：2014-10-21
申请号：US13691981
申请日：2012-12-03
申请人： PHARNEXT
IPC分类号： A61K31/185 , A61K31/205 , A61K31/13 , A61K31/445 , A61K31/42 , A61K31/44 , A61K31/195 , A61K31/138 , A61K31/164 , A61K31/197 , A61K45/06 , A61K31/137 , A61K31/64 , A61K31/145
CPC分类号： A61K31/44 , A61K9/2004 , A61K31/137 , A61K31/138 , A61K31/145 , A61K31/164 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/42 , A61K31/428 , A61K31/445 , A61K31/64 , A61K45/06 , A61K2300/00
摘要： The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorder, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on Baclofen and Acamprosate combination.
摘要翻译： 本发明涉及用于治疗与谷氨酸兴奋毒性相关的神经障碍和淀粉样蛋白的组合和方法。 毒性。 更具体地说，本发明涉及多发性硬化症，阿尔茨海默氏病，阿尔茨海默病相关病症，肌萎缩性侧索硬化症，帕金森病，亨廷顿病，神经性疼痛，酒精神经病，酒精中毒或酒精戒断或脊髓损伤的新型组合疗法 在巴氯芬和Acamprosate组合。
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公开(公告)号：US10434109B2
公开(公告)日：2019-10-08
申请号：US16025461
申请日：2018-07-02
申请人： PHARNEXT
IPC分类号： A61K31/137 , A61K31/155 , A61K31/64 , A61K31/185 , A61K31/44 , A61K45/06 , A61K31/585 , A61K31/138 , A61K31/197 , A61K31/28 , A61K31/42 , A61K31/423 , A61K31/445 , A61K31/4709 , A61K31/48 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/50 , A61K31/167 , A61K31/4164
摘要： The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorders, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.
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公开(公告)号：US09867837B2
公开(公告)日：2018-01-16
申请号：US14014650
申请日：2013-08-30
申请人： PHARNEXT
IPC分类号： A61K31/44 , A61K31/64 , A61K31/137 , A61K31/185 , A61K31/195 , A61K31/135 , A61K31/585 , A61K31/138 , A61K31/197 , A61K31/28 , A61K31/42 , A61K31/423 , A61K31/445 , A61K31/4709 , A61K31/48 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/50 , A61K45/06 , A61K31/155 , A61K31/167 , A61K31/4164
CPC分类号： A61K31/585 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/167 , A61K31/185 , A61K31/197 , A61K31/28 , A61K31/4164 , A61K31/42 , A61K31/423 , A61K31/44 , A61K31/445 , A61K31/4709 , A61K31/48 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/50 , A61K31/64 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorders, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.
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公开(公告)号：US08741886B2
公开(公告)日：2014-06-03
申请号：US13706907
申请日：2012-12-06
申请人： Pharnext
IPC分类号： A61K31/255 , A01N41/02 , A61K31/205 , A01N37/30 , A61K31/19 , A01N37/10
CPC分类号： A61K31/44 , A61K9/2004 , A61K31/137 , A61K31/138 , A61K31/145 , A61K31/164 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/42 , A61K31/428 , A61K31/445 , A61K31/64 , A61K45/06 , A61K2300/00
摘要： The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorder, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on Baclofen and Acamprosate combination.
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公开(公告)号：US20180338988A1
公开(公告)日：2018-11-29
申请号：US16025461
申请日：2018-07-02
申请人： PHARNEXT
IPC分类号： A61K31/585 , A61K45/06 , A61K31/137 , A61K31/64 , A61K31/50 , A61K31/4985 , A61K31/496 , A61K31/495 , A61K31/48 , A61K31/4709 , A61K31/445 , A61K31/44 , A61K31/423 , A61K31/42 , A61K31/4164 , A61K31/28 , A61K31/197 , A61K31/185 , A61K31/167 , A61K31/155 , A61K31/138
CPC分类号： A61K31/585 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/167 , A61K31/185 , A61K31/197 , A61K31/28 , A61K31/4164 , A61K31/42 , A61K31/423 , A61K31/44 , A61K31/445 , A61K31/4709 , A61K31/48 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/50 , A61K31/64 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorders, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.
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公开(公告)号：US09931326B2
公开(公告)日：2018-04-03
申请号：US14914666
申请日：2014-09-01
申请人： PHARNEXT
IPC分类号： A61K31/444 , A61K31/137 , A61K31/185 , A61K31/197 , A61K31/64 , A61K31/155 , A61K45/06 , A61K31/44 , A61K31/138 , A61K31/48 , A61K31/585 , A61K31/635
CPC分类号： A61K31/44 , A61K31/137 , A61K31/138 , A61K31/185 , A61K31/197 , A61K31/48 , A61K31/585 , A61K31/635 , A61K31/64 , A61K2300/00
摘要： The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of multiple sclerosis, Alzheimer's disease, Alzheimer's disease-related disorders, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.
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