公开(公告)号：US20170067012A1

公开(公告)日：2017-03-09

申请号：US15249285

申请日：2016-08-26

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sei Kwang HAHN ,  Yun seop KIM ,  Won Ho KONG ,  Hyemin KIM

IPC: C12N5/00 ,  C08B37/08

CPC classification number: C12N5/0006 ,  C08B37/0072

Abstract: Provided are a hyaluronic acid derivative for liver-targeting delivery via intravenous injection of cells and a preparation method thereof. More particularly, provided are a preparation method of a hyaluronic acid derivative capable of modifying the surface of cells and also having biocompatibility, biodegradability, and liver-targeting deliver property, and use of the hyaluronic acid derivative prepared thereby as a liver-targeting cell delivery system.

Abstract translation: 提供通过静脉内注射细胞用于肝靶向递送的透明质酸衍生物及其制备方法。 更具体地，提供了能够改变细胞表面并且还具有生物相容性，生物可降解性和肝靶向递送性的透明质酸衍生物的制备方法，以及由此制备的透明质酸衍生物作为肝靶向细胞递送的用途 系统。

公开(公告)号：US20150297749A1

公开(公告)日：2015-10-22

申请号：US14430945

申请日：2013-10-02

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sei Kwang HAHN ,  Won Ho KONG ,  Kitae PARK

IPC: A61K47/48 ,  A61K51/04 ,  C12N15/113 ,  A61K51/12

CPC classification number: A61K51/0493 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/1275 ,  A61K49/1839 ,  A61K51/1251 ,  C12N15/111 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2320/30 ,  C12N2320/32

Abstract: This disclosure relates to a low density lipoprotein-like cationic solid lipid nanoparticle targeting liver cells including parenchyma cells and non-parenchyma cells, a composition for liver target delivery, a composition for diagnosis and/or treatment of liver disease comprising the same, and a method for liver targeting of an active ingredient.

Abstract translation: 本公开内容涉及靶向肝细胞的低密度脂蛋白样阳离子固体脂质纳米颗粒，包括实质细胞和非实质细胞，用于肝靶标递送的组合物，用于诊断和/或治疗肝病的组合物，其包含该组合物，以及 肝脏靶向活性成分的方法。