公开(公告)号：US20170067012A1

公开(公告)日：2017-03-09

申请号：US15249285

申请日：2016-08-26

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sei Kwang HAHN ,  Yun seop KIM ,  Won Ho KONG ,  Hyemin KIM

IPC: C12N5/00 ,  C08B37/08

CPC classification number: C12N5/0006 ,  C08B37/0072

Abstract: Provided are a hyaluronic acid derivative for liver-targeting delivery via intravenous injection of cells and a preparation method thereof. More particularly, provided are a preparation method of a hyaluronic acid derivative capable of modifying the surface of cells and also having biocompatibility, biodegradability, and liver-targeting deliver property, and use of the hyaluronic acid derivative prepared thereby as a liver-targeting cell delivery system.

Abstract translation: 提供通过静脉内注射细胞用于肝靶向递送的透明质酸衍生物及其制备方法。 更具体地，提供了能够改变细胞表面并且还具有生物相容性，生物可降解性和肝靶向递送性的透明质酸衍生物的制备方法，以及由此制备的透明质酸衍生物作为肝靶向细胞递送的用途 系统。

公开(公告)号：US20160174885A1

公开(公告)日：2016-06-23

申请号：US14855727

申请日：2015-09-16

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sei Kwang HAHN ,  Dohee KEUM ,  Ho Sang JUNG ,  Hyemin KIM ,  Myeong Hwan SHIN

IPC: A61B5/145 ,  A61B5/1473

CPC classification number: A61B5/14542 ,  A61B5/14528 ,  A61B5/1473 ,  A61B2562/028

Abstract: The present invention relates to a microneedle, a sensor for detecting nitrogen monoxide, including the microneedle, a medical apparatus including the microneedle, and a manufacturing method thereof. The microneedle of the present invention may detect whether nitrogen monoxide is present or not by using electrochemical principles. Further, a change in concentration of nitrogen monoxide may be sensed in real time. The effects of detecting nitrogen monoxide may be used to diagnose cancer and forecast the size and growth degree of a tumor.

Abstract translation: 本发明涉及一种微针，包括微针检测一氧化氮的传感器，包括该微针的医疗装置及其制造方法。 本发明的微针可以通过使用电化学原理来检测是否存在一氧化氮。 此外，可以实时检测一氧化氮浓度的变化。 检测一氧化氮的效果可用于诊断癌症并预测肿瘤的大小和生长程度。