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公开(公告)号：US11730859B2
公开(公告)日：2023-08-22
申请号：US17021130
申请日：2020-09-15
Inventor： Dong-Woo Cho , Jae Yun Kim , Jae Yeon Lee
CPC classification number: A61L27/3683 , A61L27/38 , A61L27/52 , A61L27/54 , A61L2300/254
Abstract: The method for decellularization of kidney tissue according to the present invention, the decellularized material produced through the method, and a bioink comprising the decellularized material have the effect of maximizing the effect of kidney treatment by maximizing the content of components specialized for kidney treatment such as the collecting duct and renal tubule of the kidney.
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公开(公告)号：US11925726B2
公开(公告)日：2024-03-12
申请号：US17126449
申请日：2020-12-18
Applicant: POSTECH Research and Business Development Foundation , THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION
Inventor： Dong-Woo Cho , Wonil Han , Narendra K. Singh , Yong Kyun Kim , Sun Ah Nam
CPC classification number: A61L27/3839 , A61F2/022 , A61L27/3641 , A61L27/3683 , A61L27/3886 , C12N5/0685 , C12N5/0686 , C12N5/069 , C12N5/0697
Abstract: The present disclosure is related to a perfusable-type bio-dual proximal tubule cell construct and a producing method thereof capable of applying an in vitro artificial organ model configured to include a first bioink comprising a decellularized substance derived from a mammalian kidney tissue and human umbilical vascular endothelial cells (HUVECs) and a second bioink comprising the decellularized substance and renal proximal tubular epithelial cells (RPTECs), wherein the first bioink and the second bioink are coaxial and printed in tubular constructs having different inner diameters.
According to the present disclosure, it is possible to use the renal proximal tubule-on-a-chip as a bioreactor capable of observing a biological drug reaction similar to a real drug by perfusing various drugs to the renal proximal tubule-on-a-chip.
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