利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.013 秒)

    Crystal structure of cytochrome P450 3A4 and uses thereof
    1.
    发明申请
    Crystal structure of cytochrome P450 3A4 and uses thereof 审中-公开
    细胞色素P450 3A4的晶体结构及其用途

    公开(公告)号：US20070179716A1

    公开(公告)日：2007-08-02

    申请号：US11588430

    申请日：2006-10-27

    申请人： Pamela Williams ,  Dijana Vinkovic ,  Harren Jhoti

    发明人： Pamela Williams ,  Dijana Vinkovic ,  Harren Jhoti

    IPC分类号： G06F19/00

    CPC分类号： G01N33/68 ,  C12Q1/26 ,  G01N2333/90245

    摘要： The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Tables 1-4. The structure may be used in to model the interaction of compounds such as pharmaceuticals with this protein, and to determine the structure of related cytochrome P450 molecules.

    摘要翻译： 本发明提供细胞色素P450 3A4蛋白分子的晶体结构。 结构如表1-4所示。 该结构可用于模拟化合物如药物与该蛋白质的相互作用，并确定相关细胞色素P450分子的结构。

    Travel pillow
    3.
    发明授权
    Travel pillow 失效
    旅行枕头

    公开(公告)号：US07441292B2

    公开(公告)日：2008-10-28

    申请号：US11747805

    申请日：2007-05-11

    申请人： Pamela Williams ,  Darrio H. Williams

    发明人： Pamela Williams ,  Darrio H. Williams

    IPC分类号： A47G9/10

    CPC分类号： A45F4/02 ,  A45F2004/026 ,  A47C7/021 ,  B60N2/882

    摘要： A pillow for coupling to a surface. The pillow includes: a first cushion; a first cover enclosing the first cushion; a second cover enclosing the first cover, the second cover including: a first end, having a first corner; a second end, disposed opposite the first end, having a second corner; and a first aperture disposed near the first corner; wherein the first aperture is large enough to permit ingress and egress of the first cushion therethrough; and an elongated band member, coupled to the first end and the second end, respectively, thereby forming an opening between the elongated band member and the second cover. The pillow further includes: a loop member, coupled to the second end; a carrying strap member coupled to the first corner and the second corner, respectively; a pair of D-rings, each D-ring coupled to the first corner and the second corner, respectively; and a slide fastener.

    摘要翻译： 用于耦合到表面的枕头。 枕头包括：第一个垫子; 封闭第一垫子的第一盖子; 封闭第一盖的第二盖，第二盖包括：具有第一角的第一端; 第二端与第一端相对设置，具有第二角; 以及设置在第一角附近的第一孔; 其中所述第一孔足够大以允许所述第一垫通过其入口和出口; 以及分别耦合到第一端和第二端的细长带构件，从而在细长带构件和第二盖之间形成开口。 所述枕头还包括：联接到所述第二端的环构件; 分别连接到第一角和第二角的承载构件; 一对D形环，每个D形环分别耦合到第一角和第二角; 和拉链。

    Travel pillow
    5.
    发明授权
    Travel pillow 失效
    旅行枕头

    公开(公告)号：US07444697B2

    公开(公告)日：2008-11-04

    申请号：US11383158

    申请日：2006-05-12

    申请人： Pamela Williams ,  Darrio H Williams

    发明人： Pamela Williams ,  Darrio H Williams

    IPC分类号： A47K7/02

    CPC分类号： A45F4/02 ,  A45F2004/026 ,  A47C7/021 ,  B60N2/882

    摘要： A pillow for coupling to a surface. The pillow includes: a first cushion of soft resilient material; a first cover enclosing the cushion; a second cover enclosing the first cover, the second cover including an edge portion having a first aperture disposed therethrough; and a suction cup assembly coupled to the first cover and disposed through the first aperture. The suction cup assembly includes: a suction cup; a release tab coupled to an edge of the suction cup; a neck; a nub coupled to the neck and having a larger dimension than a radius of the neck; a second cushion of soft resilient material disposed about the neck and between the first cover and the nub; and a rigid annular member disposed about the neck and between the second cushion and the nub, wherein the second cushion extends radially beyond the rigid annular member.

    摘要翻译： 用于耦合到表面的枕头。 枕头包括：柔软弹性材料的第一缓冲垫; 封闭衬垫的第一盖; 封闭所述第一盖的第二盖，所述第二盖包括具有穿过其设置的第一孔的边缘部分; 以及联接到第一盖并且设置成穿过第一孔的吸盘组件。 吸盘组件包括：吸盘; 耦合到所述吸盘的边缘的释放片; 一个脖子 连接到颈部并且具有比颈部半径更大的尺寸的纽扣; 软弹性材料的第二缓冲垫，围绕颈部设置，并且位于第一盖和凸起之间; 以及刚性环形构件，其围绕所述颈部并且在所述第二衬垫和所述凸块之间设置，其中所述第二衬垫径向延伸超过所述刚性环形构件。

    Travel Pillow
    6.
    发明申请
    Travel Pillow 失效
    旅行枕头

    公开(公告)号：US20070261171A1

    公开(公告)日：2007-11-15

    申请号：US11747805

    申请日：2007-05-11

    申请人： Pamela Williams ,  Darrio H. Williams

    发明人： Pamela Williams ,  Darrio H. Williams

    IPC分类号： A47G9/10

    CPC分类号： A45F4/02 ,  A45F2004/026 ,  A47C7/021 ,  B60N2/882

    摘要： A pillow for coupling to a surface. The pillow includes: a first cushion; a first cover enclosing the first cushion; a second cover enclosing the first cover, the second cover including: a first end, having a first corner; a second end, disposed opposite the first end, having a second corner; and a first aperture disposed near the first corner; wherein the first aperture is large enough to permit ingress and egress of the first cushion therethrough; and an elongated band member, coupled to the first end and the second end, respectively, thereby forming an opening between the elongated band member and the second cover. The pillow further includes: a loop member, coupled to the second end; a carrying strap member coupled to the first corner and the second corner, respectively; a pair of D-rings, each D-ring coupled to the first corner and the second corner, respectively; and a slide fastener.

    摘要翻译： 用于连接到表面的枕头。 枕头包括：第一个垫子; 封闭第一垫子的第一盖子; 封闭第一盖的第二盖，第二盖包括：具有第一角的第一端; 第二端与第一端相对设置，具有第二角; 以及设置在第一角附近的第一孔; 其中所述第一孔足够大以允许所述第一垫通过其入口和出口; 以及分别耦合到第一端和第二端的细长带构件，从而在细长带构件和第二盖之间形成开口。 所述枕头还包括：联接到所述第二端的环构件; 分别连接到第一角和第二角的承载构件; 一对D形环，每个D形环分别耦合到第一角和第二角; 和拉链。

    Travel Pillow
    9.
    发明申请
    Travel Pillow 失效
    旅行枕头

    公开(公告)号：US20070261172A1

    公开(公告)日：2007-11-15

    申请号：US11383158

    申请日：2006-05-12

    申请人： Pamela Williams ,  Darrio Williams

    发明人： Pamela Williams ,  Darrio Williams

    IPC分类号： A47G9/00

    CPC分类号： A45F4/02 ,  A45F2004/026 ,  A47C7/021 ,  B60N2/882

    摘要： A pillow for coupling to a surface. The pillow includes: a first cushion of soft resilient material; a first cover enclosing the cushion; a second cover enclosing the first cover, the second cover including an edge portion having a first aperture disposed therethrough; and a suction cup assembly coupled to the first cover and disposed through the first aperture. The suction cup assembly includes: a suction cup; a release tab coupled to an edge of the suction cup; a neck; a nub coupled to the neck and having a larger dimension than a radius of the neck; a second cushion of soft resilient material disposed about the neck and between the first cover and the nub; and a rigid annular member disposed about the neck and between the second cushion and the nub, wherein the second cushion extends radially beyond the rigid annular member.

    摘要翻译： 用于连接到表面的枕头。 枕头包括：柔软弹性材料的第一缓冲垫; 封闭衬垫的第一盖; 封闭所述第一盖的第二盖，所述第二盖包括具有穿过其设置的第一孔的边缘部分; 以及联接到第一盖并且设置成穿过第一孔的吸盘组件。 吸盘组件包括：吸盘; 耦合到所述吸盘的边缘的释放片; 一个脖子 连接到颈部并具有比颈部半径更大的尺寸的纽扣; 软弹性材料的第二缓冲垫，围绕颈部设置，并且位于第一盖和凸起之间; 以及刚性环形构件，其围绕所述颈部并且在所述第二衬垫和所述凸块之间设置，其中所述第二衬垫径向延伸超过所述刚性环形构件。

    Methods of purification of cytochrome P450 proteins
    10.
    发明申请
    Methods of purification of cytochrome P450 proteins 审中-公开
    纯化细胞色素P450蛋白的方法

    公开(公告)号：US20060234365A1

    公开(公告)日：2006-10-19

    申请号：US10221036

    申请日：2002-09-09

    申请人： Alison Ward ,  Jose Cosme ,  Pamela Williams ,  Bruce Hamilton ,  Laurent Vuillard

    发明人： Alison Ward ,  Jose Cosme ,  Pamela Williams ,  Bruce Hamilton ,  Laurent Vuillard

    IPC分类号： C12N9/02

    CPC分类号： C12N9/0077 ,  C07K2319/00

    摘要： The invention provides a method for the purification of cytochrome P450 molecules, the method comprising expressing in a host cell culture a cytochrome P450 molecule; recovering said cells from said culture and suspending said cells in a high salt buffer; lysing said cells and removing cell debris to provide a high-salt lysate; adding to said lysate a detergent to provide a high-salt-detergent lysate; and recovering said P450 from said lysate. The method provides yields of P450 proteins suitable for crystallization.

    摘要翻译： 本发明提供了细胞色素P450分子的纯化方法，该方法包括在宿主细胞培养物中表达细胞色素P450分子; 从所述培养物中回收所述细胞并将所述细胞悬浮在高盐缓冲液中; 裂解所述细胞并除去细胞碎片以提供高盐裂解物; 向所述裂解物中加入洗涤剂以提供高盐 - 洗涤剂裂解物; 并从所述裂解物中回收所述P450。 该方法提供适合于结晶的P450蛋白质的产率。