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    Antibody, composite, detection device and method using same
    3.
    发明授权
    Antibody, composite, detection device and method using same 有权

    公开(公告)号：US11292830B2

    公开(公告)日：2022-04-05

    申请号：US16742036

    申请日：2020-01-14

    Applicant: Panasonic Intellectual Property Management Co., Ltd.

    Inventor： Emina Ikeuchi

    IPC: C07K16/10 ,  G01N33/543 ,  G01N33/569 ,  G01N21/75

    Abstract: The present invention is an antibody including an amino acid sequence, wherein the amino acid sequence includes, in an N- to C-direction, the following structural domains: N-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4-C wherein FR denotes a framework region amino acid sequence and CDR denotes a complementary determining region amino acid sequence; the CDR1 includes an amino acid sequence represented by GFTFSNY (SEQ ID NO: 1); the CDR2 includes an amino acid sequence represented by NSGGTG (SEQ ID NO: 2); and the CDR3 includes an amino acid sequence represented by RVDGRVLSTIVVSYDY (SEQ ID NO: 3). The antibody is capable of binding to an intranuclear protein of an influenza virus.

    Antibody, composite, detection device and method using same
    5.
    发明授权
    Antibody, composite, detection device and method using same 有权

    公开(公告)号：US10883991B2

    公开(公告)日：2021-01-05

    申请号：US16431769

    申请日：2019-06-05

    Applicant: Panasonic Intellectual Property Management Co., Ltd.

    Inventor： Emina Ikeuchi

    IPC: G01N33/569 ,  C07K16/10 ,  G01N1/00

    Abstract: The present invention is an antibody including an amino acid sequence, wherein the amino acid sequence includes, in an N- to C-direction, the following structural domains: N-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4-C wherein FR denotes a framework region amino acid sequence and CDR denotes a complementary determining region amino acid sequence; the CDR1 includes an amino acid sequence represented by SEQ ID NO: 1; the CDR2 includes an amino acid sequence represented by SEQ ID NO: 2; and the CDR3 includes an amino acid sequence represented by SEQ ID NO: 3. The antibody is capable of binding to an intranuclear protein of an influenza virus.

    Composite comprising antibody capable of binding to intranuclear protein of influenza virus
    6.
    发明授权
    Composite comprising antibody capable of binding to intranuclear protein of influenza virus 有权

    公开(公告)号：US10280212B2

    公开(公告)日：2019-05-07

    申请号：US15970597

    申请日：2018-05-03

    Applicant: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.

    Inventor： Emina Ikeuchi

    IPC: C12N15/70 ,  C07K16/10 ,  A61K47/68 ,  G01N33/569

    Abstract: The present invention provides a composite comprising a novel antibody and at least one selected from the group consisting of a solid phase support and a labeled substance. The antibody consists of the amino acid sequence represented by SEQ ID NO: 08, and is capable of binding to an intranuclear protein of an influenza virus type A. The influenza virus type A is at least one selected from the group consisting of H1N1, H2N2, H3N2, and H7N9. The antibody is bound to the at least one selected from the group consisting of the solid phase support and the labeled substance. The present invention also provides a detection device and a detection method using the composite.

    Detection device and detection method
    8.
    发明授权
    Detection device and detection method 有权

    公开(公告)号：US11768155B2

    公开(公告)日：2023-09-26

    申请号：US16747021

    申请日：2020-01-20

    Applicant: Panasonic Intellectual Property Management Co., Ltd.

    Inventor： Hiroto Yanagawa ,  Masahiko Shioi ,  Kazuaki Nishio ,  Emina Ikeuchi

    IPC: G01N21/64 ,  G01N33/543 ,  G01N33/68

    CPC classification number: G01N21/648 ,  G01N33/54373 ,  G01N33/6857 ,  G01N2021/6441

    Abstract: The present disclosure provides a detection device capable of detecting a low concentration of an analyte with high sensitivity. The detection apparatus according to the present disclosure comprises a metal microstructure on which a first VHH antibody having a property of binding specifically to the analyte is immobilized and which generate surface plasmon by being irradiated with excitation light, an inlet through which a second VHH antibody and a sample that may contain an analyte are introduced, wherein the second VHH antibody has a property of binding specifically to the analyte and is labeled with a fluorescent substance, a light source for irradiating the metal microstructure to which the second VHH antibody and the sample have been introduced with the excitation light, and a detection unit for detecting the analyte on the basis of fluorescence generated from the fluorescent substance by the irradiation of the excitation light.

    VHH antibody
    9.
    发明授权
    VHH antibody 有权

    公开(公告)号：US10941192B2

    公开(公告)日：2021-03-09

    申请号：US16372506

    申请日：2019-04-02

    Applicant: Panasonic Intellectual Property Management Co., Ltd.

    Inventor： Emina Ikeuchi ,  Jin Muraoka

    IPC: C07K16/06 ,  C12N15/85

    Abstract: Provided is a VHH antibody including an amino acid sequence in which at least one selected from the group consisting of glycine in position 36, arginine in position 50, and glycine in position 78, on the basis of IMGT numbering, of the amino acid sequence represented by SEQ ID NO: 1 is substituted with another amino acid. The VHH antibody according to the present disclosure is thermostable.

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