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公开(公告)号：US20130098780A1
公开(公告)日：2013-04-25
申请号：US13576561
申请日：2011-01-28
IPC分类号： G01N27/416
CPC分类号： G01N27/4163 , G01N27/4145 , G01N33/4836
摘要： A sensor system comprising a substrate and integrated onto the substrate an array (7) of sensor elements (1), each sensor element comprising one or more inductors (3), one or more electrochemical sensors (4), and one or more optical sensors (2). The system further comprising a controller configured in use to separately address each of the sensor elements (1) to drive the respective inductors and receive outputs of the respective sensors.
摘要翻译： 一种传感器系统，包括基板并将传感器元件（1）的阵列（7）集成到所述基板上，每个传感器元件包括一个或多个电感器（3），一个或多个电化学传感器（4）和一个或多个光学传感器 （2）。 所述系统还包括控制器，其被配置为用于单独地寻址每个所述传感器元件（1）以驱动相应的电感器并接收各个传感器的输出。
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公开(公告)号：US09656020B2
公开(公告)日：2017-05-23
申请号：US13377358
申请日：2010-06-09
CPC分类号： A61M5/1723 , A61M2005/14208 , G06F19/00 , G06F19/3468
摘要： According to a first aspect of the present invention there is provided a controller for controlling a glucagon pump. The controller comprises an input 8 for receiving an input signal indicative of a measured blood glucose concentration, an output 9 for providing a pulsed glucagon pump drive signal, each pulse being arranged to cause a glucagon pump to deliver a volume of glucagon, and a processing unit 10 for setting the pulse frequency of the pump drive signal in dependence upon the input signal, such that when the input signal indicates that the measured blood glucose concentration is above a threshold concentration the pulse frequency is zero and when the input signal indicates that the measured blood glucose concentration is below the threshold concentration the pulse frequency is increased as the measured blood glucose concentration decreases.
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公开(公告)号：US09283323B2
公开(公告)日：2016-03-15
申请号：US13570525
申请日：2012-08-09
CPC分类号： A61M5/1723 , A61M5/142 , A61M2005/14208 , A61M2005/1726 , A61M2205/52 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： The present invention relates to a controller unit and methods for controlling an insulin pump. The controller unit includes a user input that receives a gain factor. The gain factor has been calculated based on historical data in relation to a patient. The controller unit includes a measurement input for receiving data representative of a measured blood glucose level for the patient. Processing logic of the controller unit is configured to apply the measured blood glucose level to a pancreatic beta-cell insulin secretion computational model to predict an insulin output level, apply the gain factor to the predicted insulin output level to determine a patient insulin deficiency level, and calculate a control signal for controlling the insulin output level of the insulin pump based on the patient insulin deficiency level. Methods are provided for optimizing the gain factor based on the historical data in relation to the patient.
摘要翻译： 本发明涉及一种用于控制胰岛素泵的控制器单元和方法。 控制器单元包括接收增益因子的用户输入。 增益因子是根据与患者相关的历史数据计算的。 控制器单元包括测量输入，用于接收表示患者的测量血糖水平的数据。 控制器单元的处理逻辑被配置为将测量的血糖水平应用于胰腺β细胞胰岛素分泌计算模型以预测胰岛素输出水平，将增益因子应用于预测的胰岛素输出水平以确定患者胰岛素缺乏水平， 并且基于患者胰岛素缺乏水平计算用于控制胰岛素泵的胰岛素输出水平的控制信号。 提供了基于与患者相关的历史数据来优化增益因子的方法。
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公开(公告)号：US20120232519A1
公开(公告)日：2012-09-13
申请号：US13377358
申请日：2010-06-09
IPC分类号： A61M5/168
CPC分类号： A61M5/1723 , A61M2005/14208 , G06F19/00 , G06F19/3468
摘要： According to a first aspect of the present invention there is provided a controller for controlling a glucagon pump. The controller comprises an input 8 for receiving an input signal indicative of a measured blood glucose concentration, an output 9 for providing a pulsed glucagon pump drive signal, each pulse being arranged to cause a glucagon pump to deliver a volume of glucagon, and a processing unit 10 for setting the pulse frequency of the pump drive signal in dependence upon the input signal, such that when the input signal indicates that the measured blood glucose concentration is above a threshold concentration the pulse frequency is zero and when the input signal indicates that the measured blood glucose concentration is below the threshold concentration the pulse frequency is increased as the measured blood glucose concentration decreases.
摘要翻译： 根据本发明的第一方面，提供了一种用于控制胰高血糖素泵的控制器。 控制器包括用于接收指示测量的血糖浓度的输入信号的输入8，用于提供脉冲胰高血糖素泵驱动信号的输出9，每个脉冲被布置成使胰高血糖素泵输送一定量的胰高血糖素，以及处理 单元10，用于根据输入信号设置泵驱动信号的脉冲频率，使得当输入信号指示所测量的血糖浓度高于阈值浓度时，脉冲频率为零，并且当输入信号指示 测量血糖浓度低于阈值浓度，脉搏频率随着测量血糖浓度的降低而增加。
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公开(公告)号：US09683260B2
公开(公告)日：2017-06-20
申请号：US13881986
申请日：2011-10-28
申请人： Pantelis Georgiou , Sam Reed , Yan Liu , Christofer Toumazou , Chung-Pei Ou
发明人： Pantelis Georgiou , Sam Reed , Yan Liu , Christofer Toumazou , Chung-Pei Ou
CPC分类号： C12Q1/6874 , C12Q1/6825 , C12Q1/6858 , G01N27/4145 , G01N27/44 , C12Q2533/101 , C12Q2565/301 , C12Q2565/607 , C12Q2565/501
摘要： An apparatus with a transducer having a first output signal and arranged to receive an electrical input. The transducer switches the first output signal between an ON and OFF state. The apparatus has a chemical sensing surface coupled to the transducer arranged to receive a chemical input. A signal generator oscillates one or more of said inputs to vary the switching point of the transducer. The oscillating input may be the chemical input and/or the electrical input. The output signal may be a pulse whose period ON or OFF is determined by the oscillating input modulated by the chemical input.
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公开(公告)号：US20130252828A1
公开(公告)日：2013-09-26
申请号：US13881986
申请日：2011-10-28
申请人： Pantelis Georgiou , Sam Reed , Yan Liu , Christofer Toumazou , Chung-Pei Ou
发明人： Pantelis Georgiou , Sam Reed , Yan Liu , Christofer Toumazou , Chung-Pei Ou
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6825 , C12Q1/6858 , G01N27/4145 , G01N27/44 , C12Q2533/101 , C12Q2565/301 , C12Q2565/607 , C12Q2565/501
摘要： An apparatus with a transducer having a first output signal and arranged to receive an electrical input. The transducer switches the first output signal between an ON and OFF state. The apparatus has a chemical sensing surface coupled to the transducer arranged to receive a chemical input. A signal generator oscillates one or more of said inputs to vary the switching point of the transducer. The oscillating input may be the chemical input and/or the electrical input. The output signal may be a pulse whose period ON or OFF is determined by the oscillating input modulated by the chemical input.
摘要翻译： 一种具有换能器的装置，具有第一输出信号并被布置成接收电输入。 传感器在ON和OFF状态之间切换第一个输出信号。 该装置具有耦合到换能器的化学感测表面，其布置成接收化学输入。 信号发生器振荡一个或多个所述输入以改变换能器的切换点。 振荡输入可以是化学输入和/或电输入。 输出信号可以是其周期ON或OFF由通过化学输入调制的振荡输入确定的脉冲。
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