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公开(公告)号：US20180172974A1
公开(公告)日：2018-06-21
申请号：US15897335
申请日：2018-02-15
申请人： Paris Sciences Et Lettres - Quartier Latin , Centre National de la Recherche Scientifique (CNRS) , Universite Pierre Et Marie Curie (Paris 6) , Universite Paris Diderot Paris 7
IPC分类号： G02B21/36 , H04N5/225 , G02B21/24 , G02B21/18 , G02B21/10 , G02B21/08 , G06T7/70 , G02B21/00 , G02B5/04 , G02B5/00 , G01B11/00 , C12Q1/6816 , G02B21/02
CPC分类号： G02B21/365 , C12Q1/6816 , G01B11/002 , G02B5/005 , G02B5/04 , G02B21/0032 , G02B21/0052 , G02B21/02 , G02B21/086 , G02B21/10 , G02B21/18 , G02B21/241 , G02B21/361 , G06T7/70 , H04N5/2256
摘要： The invention relates to an optical device for measuring the position of an object along a first axis, the object being subjected to light radiations emitted by a light source. The optical device comprises: an imaging system comprising an objective for collecting light radiations diffused by the object, the imaging system having an optical axis extending parallel to the first axis; a transmission mask having at least a first aperture and a second aperture, the first aperture and second aperture being spaced from each other along a second axis, perpendicular to the first axis, the transmission mask being arranged so as to let a first part of the radiations and a second part of the radiations which are diffused by the object pass through the first aperture and the second aperture respectively, while blocking a part of the radiations emitted by the light source which is not diffused by the object; and a detector adapted for generating an image including a first spot and a second spot representative of the first part and second part of the radiations impacting the detector plane, wherein variation of the position of the object relative to the object plane of the imaging system along the first axis causes variation of a position of the first spot and of the second spot relative to each other along the second axis.
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公开(公告)号：US09933609B2
公开(公告)日：2018-04-03
申请号：US15381320
申请日：2016-12-16
申请人： Paris Sciences Et Lettres—Quartier Latin , Centre National de la Recherche Scientifique (CNRS) , Universite Pierre Et Marie Curie (Paris 6) , Universite Paris Diderot Paris 7
IPC分类号： G02B21/36 , G06T7/70 , G02B5/00 , G02B5/04 , G02B21/02 , G02B21/08 , G02B21/18 , G02B21/24 , H04N5/225 , C12Q1/68 , G01B11/00 , G02B21/00 , G02B21/10
CPC分类号： G02B21/365 , C12Q1/6816 , G01B11/002 , G02B5/005 , G02B5/04 , G02B21/0032 , G02B21/0052 , G02B21/02 , G02B21/086 , G02B21/10 , G02B21/18 , G02B21/241 , G02B21/361 , G06T7/70 , H04N5/2256
摘要： The invention relates to an optical device for measuring the position of an object along a first axis, the object being subjected to light radiations emitted by a light source. The optical device comprises: an imaging system comprising an objective for collecting light radiations diffused by the object, the imaging system having an optical axis extending parallel to the first axis; a transmission mask having at least a first aperture and a second aperture, the first aperture and second aperture being spaced from each other along a second axis, perpendicular to the first axis, the transmission mask being arranged so as to let a first part of the radiations and a second part of the radiations which are diffused by the object pass through the first aperture and the second aperture respectively, while blocking a part of the radiations emitted by the light source which is not diffused by the object; and a detector adapted for generating an image including a first spot and a second spot representative of the first part and second part of the radiations impacting the detector plane, wherein variation of the position of the object relative to the object plane of the imaging system along the first axis causes variation of a position of the first spot and of the second spot relative to each other along the second axis.
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公开(公告)号：US20180361378A1
公开(公告)日：2018-12-20
申请号：US15571679
申请日：2016-05-06
申请人： Paris Sciences Et Lettres - Quartier Latin , Centre National de la Recherche Scientifique(CNRS) , Universite Pierre Et Marie Curie(Paris 6) , Universite Paris Diderot Paris 7
发明人： Vincent Croquette , David Bensimon , Jimmy Ouellet , Jean-François Allemand , Charles Andre , Gordon Hamilton
IPC分类号： B01L3/00 , G01N27/327 , C12Q1/6825
摘要： The invention proposes a device for analyzing nucleic acid molecules (M), comprising: —a bead (20), on which one molecule can be anchored at one end, —a surface (520), on which the molecule can be anchored at the other end, —an actuator (30), adapted to cause the bead to move relative to said surface in one direction, —a sensor (50), adapted to measure a distance between the bead and the surface, the device further comprising a well (11), having an axis (X-X) extending along the direction of motion of the bead and a bottom (110) formed by said surface, said well being filled with electrically conductive solution (40), and receiving the bead, the sensor being adapted to measure an impedance of the well, depending on a distance between the bead and the surface, to determine, the distance between the bead and the surface.
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公开(公告)号：US20170176735A1
公开(公告)日：2017-06-22
申请号：US15381320
申请日：2016-12-16
申请人： Paris Sciences Et Lettres - Quartier Latin , Centre National de la Recherche Scientifique (CNRS) , Universite Pierre Et Marie Curie (Paris 6) , Universite Paris Diderot Paris 7
IPC分类号： G02B21/36 , H04N5/225 , G02B5/00 , G02B5/04 , G02B21/02 , G02B21/18 , G02B21/24 , G06T7/70 , G02B21/08
CPC分类号： G02B21/365 , C12Q1/6816 , G01B11/002 , G02B5/005 , G02B5/04 , G02B21/0032 , G02B21/0052 , G02B21/02 , G02B21/086 , G02B21/10 , G02B21/18 , G02B21/241 , G02B21/361 , G06T7/70 , H04N5/2256
摘要： The invention relates to an optical device for measuring the position of an object along a first axis, the object being subjected to light radiations emitted by a light source. The optical device comprises: an imaging system comprising an objective for collecting light radiations diffused by the object, the imaging system having an optical axis extending parallel to the first axis; a transmission mask having at least a first aperture and a second aperture, the first aperture and second aperture being spaced from each other along a second axis, perpendicular to the first axis, the transmission mask being arranged so as to let a first part of the radiations and a second part of the radiations which are diffused by the object pass through the first aperture and the second aperture respectively, while blocking a part of the radiations emitted by the light source which is not diffused by the object; and a detector adapted for generating an image including a first spot and a second spot representative of the first part and second part of the radiations impacting the detector plane, wherein variation of the position of the object relative to the object plane of the imaging system along the first axis causes variation of a position of the first spot and of the second spot relative to each other along the second axis.
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公开(公告)号：US20210178384A1
公开(公告)日：2021-06-17
申请号：US17186954
申请日：2021-02-26
申请人： Paris Sciences Et Lettres - Quartier Latin , Centre National de la Recherche Scientifique (CNRS) , Universite Paris Diderot Paris 7 , Sorbonne Universite
发明人： Vincent Croquette , David Bensimon , Jimmy Ouellet , Jean-François Allemand , Charles Andre , Gordon Hamilton
IPC分类号： B01L3/00 , C12Q1/6825 , G01N27/327
摘要： The invention proposes a device for analyzing nucleic acid molecules (M), comprising: —a bead (20), on which one molecule can be anchored at one end, —a surface (520), on which the molecule can be anchored at the other end, —an actuator (30), adapted to cause the bead to move relative to said surface in one direction, —a sensor (50), adapted to measure a distance between the bead and the surface, the device further comprising a well (11), having an axis (X-X) extending along the direction of motion of the bead and a bottom (110) formed by said surface, said well being filled with electrically conductive solution (40), and receiving the bead, the sensor being adapted to measure an impedance of the well, depending on a distance between the bead and the surface, to determine, the distance between the bead and the surface.
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公开(公告)号：US10933416B2
公开(公告)日：2021-03-02
申请号：US15571679
申请日：2016-05-06
申请人： Paris Sciences Et Lettres—Quartier Latin , Centre National de la Recherche Scientifique (CNRS) , Universite Paris Diderot Paris 7 , Sorbonne Universite
发明人： Vincent Croquette , David Bensimon , Jimmy Ouellet , Jean-François Allemand , Charles Andre , Gordon Hamilton
IPC分类号： C12Q1/68 , B01L3/00 , C12Q1/6825 , G01N27/327 , G01N27/07
摘要： The invention proposes a device for analyzing nucleic acid molecules (M), comprising: —a bead (20), on which one molecule can be anchored at one end, —a surface (520), on which the molecule can be anchored at the other end, —an actuator (30), adapted to cause the bead to move relative to said surface in one direction, —a sensor (50), adapted to measure a distance between the bead and the surface, the device further comprising a well (11), having an axis (X-X) extending along the direction of motion of the bead and a bottom (110) formed by said surface, said well being filled with electrically conductive solution (40), and receiving the bead, the sensor being adapted to measure an impedance of the well, depending on a distance between the bead and the surface, to determine, the distance between the bead and the surface.
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公开(公告)号：US10209505B2
公开(公告)日：2019-02-19
申请号：US15897335
申请日：2018-02-15
申请人： Paris Sciences Et Lettres—Quartier Latin , Centre National de la Recherche Scientifique (CNRS) , Sorbonne Universite , Universite Paris Diderot Paris 7
IPC分类号： G02B21/36 , G06T7/70 , G02B5/00 , G02B5/04 , G02B21/02 , G02B21/08 , G02B21/18 , G02B21/24 , H04N5/225 , C12Q1/6816 , G01B11/00 , G02B21/00 , G02B21/10
摘要： The invention relates to an optical device for measuring the position of an object along a first axis, the object being subjected to light radiations emitted by a light source. The optical device comprises: an imaging system comprising an objective for collecting light radiations diffused by the object, the imaging system having an optical axis extending parallel to the first axis; a transmission mask having at least a first aperture and a second aperture, the first aperture and second aperture being spaced from each other along a second axis, perpendicular to the first axis, the transmission mask being arranged so as to let a first part of the radiations and a second part of the radiations which are diffused by the object pass through the first aperture and the second aperture respectively, while blocking a part of the radiations emitted by the light source which is not diffused by the object; and a detector adapted for generating an image including a first spot and a second spot representative of the first part and second part of the radiations impacting the detector plane, wherein variation of the position of the object relative to the object plane of the imaging system along the first axis causes variation of a position of the first spot and of the second spot relative to each other along the second axis.
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