-
公开(公告)号：US06451810B1
公开(公告)日：2002-09-17
申请号：US09589580
申请日：2000-06-07
申请人： Patrick L. Coleman , Stephen L. Crooks , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
发明人： Patrick L. Coleman , Stephen L. Crooks , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
IPC分类号： A01N4342
CPC分类号： C07D471/04 , A61K31/4745
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译： 在1位含有酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。
-
公开(公告)号：US20090023722A1
公开(公告)日：2009-01-22
申请号：US12165014
申请日：2008-06-30
申请人： Patrick L. Coleman , Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
发明人： Patrick L. Coleman , Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
IPC分类号： A61K31/5377 , A61K31/437 , A61K31/496 , A61P35/00 , A61P31/12
CPC分类号： C07D471/04 , A61K31/4745
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译： 在1位含有酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。
-
公开(公告)号：US07393859B2
公开(公告)日：2008-07-01
申请号：US10848893
申请日：2004-05-19
申请人： Patrick L. Coleman , Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
发明人： Patrick L. Coleman , Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
IPC分类号： A61K31/437 , C07D471/02
CPC分类号： C07D471/04 , A61K31/4745
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译： 在1位含有酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。
-
公开(公告)号：US06756382B2
公开(公告)日：2004-06-29
申请号：US10027218
申请日：2001-12-21
申请人： Patrick L. Coleman , Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
发明人： Patrick L. Coleman , Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
IPC分类号： A61K3144
CPC分类号： C07D471/04 , A61K31/4745
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
-
公开(公告)号：US07678918B2
公开(公告)日：2010-03-16
申请号：US11999602
申请日：2007-12-06
申请人： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
发明人： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
IPC分类号： C07D411/02
CPC分类号： C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
摘要： Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.
摘要翻译： 咪唑并吡啶和四氢咪唑并吡啶化合物诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。 该化合物显示抗病毒和抗肿瘤性质。 公开了制备可用于制备化合物的化合物和中间体的方法。
-
公开(公告)号：US06949646B2
公开(公告)日：2005-09-27
申请号：US11004674
申请日：2004-12-03
申请人： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
发明人： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
IPC分类号： A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/4745 , A61K31/522 , A61P7/00 , A61P17/00 , A61P29/00 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07D213/00 , C07D233/00 , C07D257/00 , C07D401/04 , C07D471/04 , C07D471/14 , C07D471/22 , C07D519/00
CPC分类号： C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
摘要： Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
摘要翻译： 咪唑并吡啶和四氢咪唑并吡啶化合物诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。 该化合物显示抗病毒和抗肿瘤性质。 还公开了制备可用于制备化合物的化合物和中间体的方法。
-
公开(公告)号：US06888000B2
公开(公告)日：2005-05-03
申请号：US10734306
申请日：2003-12-12
申请人： Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
发明人： Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
IPC分类号： A61K31/4745 , A61K31/541 , A61P37/02 , C07D417/14 , C07D471/02 , C07D471/04
CPC分类号： A61K31/4745 , C07D471/04 , Y02A50/409
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide or sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
-
公开(公告)号：US06800624B2
公开(公告)日：2004-10-05
申请号：US10027272
申请日：2001-12-21
IPC分类号： A61K314745
CPC分类号： A61K9/0063 , A61K9/006 , A61K31/4745 , A61K45/06 , C07D471/04 , Y02A50/409 , A61K2300/00
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide or sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译： 在1位含有磺酰胺或磺酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫反应调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。
-
公开(公告)号：US06331539B1
公开(公告)日：2001-12-18
申请号：US09589216
申请日：2000-06-07
IPC分类号： A61K314745
CPC分类号： A61K9/0063 , A61K9/006 , A61K31/4745 , A61K45/06 , C07D471/04 , Y02A50/409 , A61K2300/00
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide or sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译： 在1位含有磺酰胺或磺酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫反应调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。
-
公开(公告)号：US06797716B2
公开(公告)日：2004-09-28
申请号：US10406181
申请日：2003-04-03
申请人： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
发明人： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
IPC分类号： A61K31437
CPC分类号： C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
摘要： Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
-
-
-
-
-
-
-
-
-
搜索结果
84 条记录 (耗时 0.052 秒)
