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公开(公告)号：US20090186878A1
公开(公告)日：2009-07-23
申请号：US12162631
申请日：2007-01-26
申请人： Patrick Morris , Faustinus Yeboah , James McAlpine , Maxime Ranger , Emmanuelle Roux , Michael Harvey
发明人： Patrick Morris , Faustinus Yeboah , James McAlpine , Maxime Ranger , Emmanuelle Roux , Michael Harvey
IPC分类号： A61K31/55 , C07D243/38
CPC分类号： C07D243/38
摘要： The present invention relates to crystalline forms of ECO-4601 and the processes for providing them. The invention further relates to pharmaceutical compositions comprising the crystalline forms and to methods of use of the crystalline forms as pharmaceuticals.
摘要翻译： 本发明涉及ECO-4601的结晶形式及其提供方法。 本发明还涉及包含结晶形式的药物组合物和使用结晶形式作为药物的方法。
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2.发明申请Phosphate prodrugs of a farnesyl dibenzodiazepinone, processes for their production and their use as pharmaceuticals 失效法呢基二苯并二氮杂酮的磷酸酯前药，其制备方法及其作为药物的用途公开(公告)号：US20070078112A1
公开(公告)日：2007-04-05
申请号：US11527581
申请日：2006-09-27
申请人： Mustapha Aouidate , James McAlpine , Faustinus Yeboah , Ashraf Ibrahim , Arjun Banskota , Maxime Ranger , Gregory White
发明人： Mustapha Aouidate , James McAlpine , Faustinus Yeboah , Ashraf Ibrahim , Arjun Banskota , Maxime Ranger , Gregory White
IPC分类号： A61K31/551 , C07D243/10
CPC分类号： C07D243/10 , C07F9/5535
摘要： This invention relates to phosphate prodrugs of a farnesylated dibenzodiazepinone, to processes of their manufacture, to pharmaceutical compositions comprising the prodrugs, and to their use in the treatment of neoplasms.
摘要翻译： 本发明涉及法呢基化二苯并二氮杂酮的磷酸酯前药，其制备方法，包含前药的药物组合物及其在治疗赘生物中的用途。
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3.发明授权Phosphate prodrugs of a farnesyl dibenzodiazepinone, processes for their production and their use as pharmaceuticals 失效法呢基二苯并二氮杂酮的磷酸酯前药，其制备方法及其作为药物的用途公开(公告)号：US07384935B2
公开(公告)日：2008-06-10
申请号：US11527581
申请日：2006-09-27
申请人： Mustapha Aouidate , James B. McAlpine , Faustinus Yeboah , Ashraf Ibrahim , Arjun H. Banskota , Maxime Ranger , Gregory L. White
发明人： Mustapha Aouidate , James B. McAlpine , Faustinus Yeboah , Ashraf Ibrahim , Arjun H. Banskota , Maxime Ranger , Gregory L. White
IPC分类号： C07D243/10 , A61K31/551 , A61P35/00
CPC分类号： C07D243/10 , C07F9/5535
摘要： This invention relates to phosphate prodrugs of a farnesylated dibenzodiazepinone, to processes of their manufacture, to pharmaceutical compositions comprising the prodrugs, and to their use in the treatment of neoplasms.
摘要翻译： 本发明涉及法呢基化二苯并二氮杂酮的磷酸酯前药，其制备方法，包含前药的药物组合物及其在治疗赘生物中的用途。
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公开(公告)号：US20060276436A1
公开(公告)日：2006-12-07
申请号：US11443186
申请日：2006-05-31
申请人： Maxime Ranger , Emmanuelle Roux
发明人： Maxime Ranger , Emmanuelle Roux
IPC分类号： A61K31/675 , A61K31/551
CPC分类号： A61K31/5513 , A61K31/551 , A61K31/675
摘要： The invention relates to pharmaceutical formulations comprising a farnesyl dibenzodiazepinone compound, or an analog, or a pharmaceutically acceptable salt or prodrug thereof, and a pharmaceutically acceptable surfactant and having improved chemical and biological properties. Such a formulation is a ready-to-use solution suitable for parenteral or non-parenteral administration or a bulk formulation for ex tempore preparation. The present invention also relates to therapeutic methods using the formulations, and methods for their preparation.
摘要翻译： 本发明涉及包含法呢基二苯并二氮杂酮化合物或其类似物或其药学上可接受的盐或前药以及药学上可接受的表面活性剂并且具有改善的化学和生物学性质的药物制剂。 这种制剂是适用于肠胃外或非肠胃外给药的即用型溶液或用于临时制备的本体制剂。 本发明还涉及使用该制剂的治疗方法及其制备方法。
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5.发明申请Process for the preparation of amphiphilic poly(n-vinyl-2-pyrrolidone) block copolymers 审中-公开制备两亲聚（N-乙烯基-2-吡咯烷酮）嵌段共聚物的方法公开(公告)号：US20080027205A1
公开(公告)日：2008-01-31
申请号：US11834422
申请日：2007-08-06
申请人： Laibin Luo , David Lessard , Sandra Gori , Maxime Ranger , Yuan Wang , Julie Lafreniere , Jean-Francois Meunier , Genevieve Bibeau , Frederic Lebrun , Lu Liu
发明人： Laibin Luo , David Lessard , Sandra Gori , Maxime Ranger , Yuan Wang , Julie Lafreniere , Jean-Francois Meunier , Genevieve Bibeau , Frederic Lebrun , Lu Liu
IPC分类号： C08G6/00
CPC分类号： C08G63/00 , C08F293/005 , C08F297/00 , C08F297/02 , C08L53/00 , C08L2666/02
摘要： The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.
摘要翻译： 本发明提供了制备两亲聚（N-乙烯基-2-吡咯烷酮），（PVP） - 嵌段 - 聚酯共聚物和由PVP作为一个单元组成的其它二嵌段和三嵌段共聚物的两步聚合方法。 本发明的嵌段共聚物可用作药物递送的载体。
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公开(公告)号：US20070110709A1
公开(公告)日：2007-05-17
申请号：US11558543
申请日：2006-11-10
IPC分类号： A61K48/00 , A61K38/17 , A61K31/787
CPC分类号： C08L71/02 , A61K9/1075 , A61K31/198 , A61K31/216 , A61K31/277 , A61K31/282 , C08F293/005 , C08G83/008 , C08L51/003 , C08L53/00 , C08L2666/24 , C08L2666/02
摘要： The present invention is directed toward water-soluble supramolecular self-assemblies and a process for their preparation via micellization of polyelectrolytes through the use of hydrophobic monomeric units. In this invention the polyelectrolyte segment ultimately forms the core of the supramolecular assembly whereas the shell consists of uncharged hydrophilic polymers or oligomers. It has been determined that the inclusion of the hydrophobic co-monomers to the polyelectrolyte segment forming the micelle core leads to a structure of enhanced stability.
摘要翻译： 本发明涉及水溶性超分子自组装及其通过使用疏水性单体单元通过聚电解质的胶束化制备的方法。 在本发明中，聚电解质段最终形成超分子组装的核心，而壳由不带电的亲水聚合物或低聚物组成。 已经确定，将疏水性共聚单体包含在形成胶束芯的聚电解质区段中导致稳定性提高的结构。
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公开(公告)号：US07763604B2
公开(公告)日：2010-07-27
申请号：US11434154
申请日：2006-05-16
IPC分类号： A61K31/5513 , A61P35/00
CPC分类号： A61K31/551
摘要： This invention relates to methods of inhibiting growth and/or proliferation of a neoplastic cell, and methods of treating neoplasms by administration of the farnesylated dibenzodiazepinone compound of Formula I via continuous intravenous infusion. The invention includes pharmaceutical compositions comprising the compound of Formula I:
摘要翻译： 本发明涉及抑制肿瘤细胞生长和/或增殖的方法，以及通过连续静脉输注给予式I的法呢基化二苯并二氮杂酮化合物来治疗肿瘤的方法。 本发明包括药物组合物，其包含式I化合物：
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公开(公告)号：US20060270662A1
公开(公告)日：2006-11-30
申请号：US11434154
申请日：2006-05-16
IPC分类号： A61K31/551
CPC分类号： A61K31/551
摘要： This invention relates to methods of inhibiting growth and/or proliferation of a neoplastic cell, and methods of treating neoplasms by administration of the farnesylated dibenzodiazepinone compound of Formula I via continuous intravenous infusion. The invention includes pharmaceutical compositions comprising the compound of Formula I:
摘要翻译： 本发明涉及抑制肿瘤细胞生长和/或增殖的方法，以及通过连续静脉输注给予式I的法呢基化二苯并二氮杂酮化合物来治疗肿瘤的方法。 本发明包括药物组合物，其包含式I化合物：
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9.发明授权Process for the preparation of amphiphilic poly (N-vinyl-2-pyrrolidone) block copolymers 有权制备两亲聚（N-乙烯基-2-吡咯烷酮）嵌段共聚物的方法公开(公告)号：US07262253B2
公开(公告)日：2007-08-28
申请号：US10727083
申请日：2003-12-02
申请人： Laibin Luo , David Lessard , Sandra Gori , Maxime Ranger , Yuan Wang , Julie Lafreniere , Jean-Francois Meunier , Genevieve Bibeau , Frederic Lebrun , Lu Wei Liu
发明人： Laibin Luo , David Lessard , Sandra Gori , Maxime Ranger , Yuan Wang , Julie Lafreniere , Jean-Francois Meunier , Genevieve Bibeau , Frederic Lebrun , Lu Wei Liu
IPC分类号： C08F126/10 , C08F226/10
CPC分类号： C08G63/00 , C08F293/005 , C08F297/00 , C08F297/02 , C08L53/00 , C08L2666/02
摘要： The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.
摘要翻译： 本发明提供了制备两亲聚（N-乙烯基-2-吡咯烷酮），（PVP） - 嵌段 - 聚酯共聚物和由PVP作为一个单元组成的其它二嵌段和三嵌段共聚物的两步聚合方法。 本发明的嵌段共聚物可用作药物递送的载体。
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10.发明申请Process for the preparation of amphiphilic poly (N-vinyl-2-pyrrolidone) block copolymers 有权制备两亲聚（N-乙烯基-2-吡咯烷酮）嵌段共聚物的方法公开(公告)号：US20050119404A1
公开(公告)日：2005-06-02
申请号：US10727083
申请日：2003-12-02
申请人： Laibin Luo , David Lessard , Sandra Gori , Maxime Ranger , Yuan Wang , Julie Lafreniere , Jean-Francois Meunier , Genevieve Bibeau , Frederic Lebrun , Lu Liu
发明人： Laibin Luo , David Lessard , Sandra Gori , Maxime Ranger , Yuan Wang , Julie Lafreniere , Jean-Francois Meunier , Genevieve Bibeau , Frederic Lebrun , Lu Liu
IPC分类号： C08F26/10 , C08F265/04 , C08F293/00 , C08F297/00 , C08F297/02 , C08K5/05 , C08L53/00
CPC分类号： C08G63/00 , C08F293/005 , C08F297/00 , C08F297/02 , C08L53/00 , C08L2666/02
摘要： The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.
摘要翻译： 本发明提供了制备两亲聚（N-乙烯基-2-吡咯烷酮），（PVP） - 嵌段 - 聚酯共聚物和由PVP作为一个单元组成的其它二嵌段和三嵌段共聚物的两步聚合方法。 本发明的嵌段共聚物可用作药物递送的载体。
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