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公开(公告)号：US08343988B2
公开(公告)日：2013-01-01
申请号：US12372785
申请日：2009-02-18
申请人： Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Sven Franciscus Anna Van Brandt , Bruno Roux , Peter Ten Holte , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Alexey Borisovich Dyatkin
发明人： Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Sven Franciscus Anna Van Brandt , Bruno Roux , Peter Ten Holte , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Alexey Borisovich Dyatkin
IPC分类号： A01N43/54 , A61K31/505 , C07D401/00
CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48
摘要： This invention comprises the novel compounds of formula (I) wherein n, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括其中n，t，R 1，R 2，R 3，R 4，L，Q，X，Y，Z并具有定义的具有组蛋白脱乙酰酶抑制酶活性的式（I）化合物。 其制剂，含有它们的组合物及其作为药物的用途。
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2.发明授权公开(公告)号：US08119650B2
公开(公告)日：2012-02-21
申请号：US12160140
申请日：2007-01-16
IPC分类号： C07D401/14 , A61K31/4439
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，X和Y具有定义含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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3.发明申请AZA-BICYCLOHEXYL SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE 有权AZA-BICYCLOHEXYL取代的吲哚基氨基酸衍生物作为HISTONE DEACETYLASE的新型抑制剂公开(公告)号：US20110015218A1
公开(公告)日：2011-01-20
申请号：US12934894
申请日：2009-03-26
IPC分类号： A61K31/506 , C07D403/14 , A61P35/00
CPC分类号： C07D403/14 , C07D401/14 , C07D405/14
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, A and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，R4，A和X具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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4.发明申请公开(公告)号：US20100234353A1
公开(公告)日：2010-09-16
申请号：US12724273
申请日：2010-03-15
申请人： Kristof Van Emelen , Leo Jacobus Jozef Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van Heusden
发明人： Kristof Van Emelen , Leo Jacobus Jozef Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van Heusden
IPC分类号： A61K31/55 , C07D211/98 , A61K31/4468 , C07D239/32 , A61K31/506 , C07D401/14 , A61K31/496 , C07D401/04 , C07D413/14 , A61K31/5377 , A61P35/00
CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48
摘要： This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括其中n，m，t，R 1，R 2，R 3，R 4，R 5，L，Q，X，Y，Z并具有定义的含有组蛋白脱乙酰酶抑制酶活性的式（I） 其制剂，含有它们的组合物及其作为药物的用途。
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5.发明授权公开(公告)号：US07767679B2
公开(公告)日：2010-08-03
申请号：US10507159
申请日：2003-03-11
申请人： Kristof Van Emelen , Leo Jacobus Jozef Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van heusden
发明人： Kristof Van Emelen , Leo Jacobus Jozef Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van heusden
IPC分类号： A61K31/506 , C07D403/04
CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48
摘要： This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括其中n，m，t，R 1，R 2，R 3，R 4，R 5，L，Q，X，Y，Z并具有定义的含有组蛋白脱乙酰酶抑制酶活性的式（I） 其制剂，含有它们的组合物及其作为药物的用途。
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公开(公告)号：US08592441B2
公开(公告)日：2013-11-26
申请号：US13447636
申请日：2012-04-16
申请人： Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
发明人： Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
IPC分类号： C07D401/14 , C07D409/14 , A61K31/506
CPC分类号： A61K31/506 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
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7.发明申请SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE 有权取代的吲哚基氨基酸衍生物作为HISTONE脱乙酰基酶的新型抑制剂公开(公告)号：US20120220615A1
公开(公告)日：2012-08-30
申请号：US13447636
申请日：2012-04-16
申请人： Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
发明人： Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
IPC分类号： C07D401/14 , A61P35/04 , C07D491/04 , A61K31/506
CPC分类号： A61K31/506 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，X和Y具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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8.发明授权公开(公告)号：US08163733B2
公开(公告)日：2012-04-24
申请号：US12724273
申请日：2010-03-15
申请人： Kristof Van Emelen , Leo Jacobus Jozef Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van Heusden
发明人： Kristof Van Emelen , Leo Jacobus Jozef Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van Heusden
IPC分类号： A61K31/55 , A61K31/4468 , A61K31/506 , A61K31/496
CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48
摘要： This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括其中n，m，t，R 1，R 2，R 3，R 4，R 5，L，Q，X，Y，Z并具有定义的含有组蛋白脱乙酰酶抑制酶活性的式（I） 其制剂，含有它们的组合物及其作为药物的用途。
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9.发明授权Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase 有权取代的吲哚基 - 烷基 - 氨基衍生物作为组蛋白脱乙酰酶的抑制剂公开(公告)号：US07834025B2
公开(公告)日：2010-11-16
申请号：US12160221
申请日：2007-01-16
IPC分类号： A61K31/506 , C07D401/14
CPC分类号： C07D401/14
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, R5, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括具有组蛋白脱乙酰酶抑制酶活性的式（I）的新化合物，其中R 1，R 2，R 3，R 4，R 5，X和Y具有定义的含义; 其制剂，含有它们的组合物及其作为药物的用途。
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10.发明授权Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase 有权取代的吲哚基烷基氨基衍生物作为组蛋白脱乙酰酶的新型抑制剂公开(公告)号：US08524728B2
公开(公告)日：2013-09-03
申请号：US13027793
申请日：2011-02-15
申请人： Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
发明人： Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
IPC分类号： A61K31/506 , C07D401/14
CPC分类号： A61K31/506 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，X和Y具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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