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公开(公告)号：US20060140918A1
公开(公告)日：2006-06-29
申请号：US11360180
申请日：2006-02-23
申请人： Patrick Tresco , Roy Biran , Mark Noble
发明人： Patrick Tresco , Roy Biran , Mark Noble
CPC分类号： C12M25/14 , A61K35/12 , C12M21/08 , C12N5/0068 , C12N5/0618 , C12N2501/13 , C12N2502/08 , C12N2502/99 , C12N2533/10 , C12N2533/30 , C12N2533/32 , C12N2533/50 , C12N2533/52 , C12N2535/10
摘要： The present invention relates to a device and corresponding methods for its use, in the propagation of tissue. The device comprises a bioartificial composite comprised of a substrate having at least one surface capable of the reception and growth promoting retention of a cellular preparation, and a first layer of adherent cells disposed on said surface. The first layer is prepared from the cellular preparation, and the cells comprising the first layer have cytoskeletal elements aligned uniformly, so that the bioartificial composite acts as a template to accept a second layer of cells upon the first layer, said second layer comprising an organized layer oriented in the direction of said first layer, wherein said substrate has at least one surface defined by a critical surface curvature and/or topography. The device may be implanted for the promotion of tissue regrowth, or may be used to develop tissue on an ex vivo basis, for implantation or for experimentation.
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2.发明申请公开(公告)号：US20100316691A2
公开(公告)日：2010-12-16
申请号：US12523383
申请日：2008-01-22
申请人： Patrick Kiser , Patrick Tresco , Mark Mitchnick , Kavita Gupta , Hyder Aliyar
发明人： Patrick Kiser , Patrick Tresco , Mark Mitchnick , Kavita Gupta , Hyder Aliyar
CPC分类号： A61F6/08 , A61K9/0036 , C08G18/4244 , C08G18/4277 , C08G18/428 , C08G18/771 , C08G2230/00
摘要： The present disclosure relates to biodegradable intravaginal rings for the delivery of therapeutic or prophylactic agent, inter alia, antiviral agents. The present disclosure further relates to biodegradable polyurethanes which will allow therapeutic/prophylactic agents to be released in a controlled manner that will not degrade when in use, but will degrade upon disposal.
摘要翻译： 本公开涉及用于递送治疗性或预防剂（尤其是抗病毒剂）的可生物降解的阴道内环。 本公开还涉及可生物降解的聚氨酯，其将使得治疗/预防剂以受控的方式释放，在使用时不会降解，但在处置时会降解。
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公开(公告)号：US20100166826A1
公开(公告)日：2010-07-01
申请号：US12523383
申请日：2008-01-22
申请人： Patrick F. Kiser , Patrick Tresco , Mark Mitchnick , Kavita Gupta , Hyder Aliyar
发明人： Patrick F. Kiser , Patrick Tresco , Mark Mitchnick , Kavita Gupta , Hyder Aliyar
CPC分类号： A61F6/08 , A61K9/0036 , C08G18/4244 , C08G18/4277 , C08G18/428 , C08G18/771 , C08G2230/00
摘要： The present disclosure relates to biodegradable intravaginal rings for the delivery of therapeutic or prophylactic agent, inter alia, antiviral agents. The present disclosure further relates to biodegradable polyurethanes which will allow therapeutic/prophylactic agents to be released in a controlled manner that will not degrade when in use, but will degrade upon disposal.
摘要翻译： 本公开涉及用于递送治疗性或预防剂（尤其是抗病毒剂）的可生物降解的阴道内环。 本公开还涉及可生物降解的聚氨酯，其将使得治疗/预防剂以受控的方式释放，在使用时不会降解，但在处置时会降解。
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公开(公告)号：US20050209556A1
公开(公告)日：2005-09-22
申请号：US10804818
申请日：2004-03-19
申请人： Patrick Tresco , Mayank Patel
发明人： Patrick Tresco , Mayank Patel
CPC分类号： A61M31/002 , A61M39/0208
摘要： A device and method are described for the delivery of cells, tissues, enzymes and/or pharmacological agents for the treatment or prevention of diseases, disorders or deficiencies. The device is placed intravascularly and includes a chamber that houses living cells delimited by a membrane on either side that physically separates the cells from the blood stream and the central lumen of the catheter. The device can be inserted over a guidewire and permits flushing and reloading of the central lumen with viability supporting factors that sustain the cells in the outer chamber for long indwelling times without removing it from the body. In addition, the central lumen can be used to deliver therapeutic substances or withdraw blood. The new intravascular catheter can be used for the treatment or prevention of a variety of diseases and disorders, that may use the implantation of living cells, tissues, enzymes or pharmacological agents or for use, for example, for non-therapeutic purposes that may involve sustained intravascular release of biological factors as, for example, in stimulating growth of farm animals to augment the production of meat.
摘要翻译： 描述了用于递送用于治疗或预防疾病，病症或缺陷的细胞，组织，酶和/或药理学试剂的装置和方法。 该装置被血管内放置，并且包括容纳活细胞的室，所述活细胞由任一侧上的膜分隔，所述细胞将细胞与血流和导管的中心腔物理分离。 该装置可以插入导丝上，并允许中央管腔的冲洗和重新加载具有维持细胞在外室中长时间驻留时间的活力支撑因素，而不会从体内移除。 此外，中央腔可用于递送治疗物质或抽血。 新的血管内导管可以用于治疗或预防各种疾病和病症，其可以使用活细胞，组织，酶或药理学剂的植入，或用于例如可能涉及的非治疗目的 持续的生物因子的血管内释放，例如刺激农场动物的生长以增加肉的生产。
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5.发明申请公开(公告)号：US20080140185A1
公开(公告)日：2008-06-12
申请号：US11578321
申请日：2005-04-15
申请人： Patrick F. Kiser , Patrick Tresco
发明人： Patrick F. Kiser , Patrick Tresco
CPC分类号： C08G18/771 , C08G18/10 , C08G18/428 , C08G18/4887 , C08G2230/00 , C08G18/4833
摘要： The compositions disclosed herein include biodegradable elastomers that provide a material for. medical purposes. They may further provide a drug delivery system for the treatment of a wide variety of medical conditions. In particular, the compositions provide biodegradable elastomers composed of a pre-polymeric block, a degradable sequence and a bis-functional linker. The usefulness of the present invention is that it provides a biodegradable elastomer for use with medical devices.
摘要翻译： 本文公开的组合物包括提供材料的可生物降解的弹性体。 医疗用途。 他们可以进一步提供用于治疗各种各样的医疗条件的药物递送系统。 特别地，组合物提供由预聚合嵌段，可降解序列和双官能连接体组成的可生物降解的弹性体。 本发明的有用性是提供用于医疗装置的可生物降解的弹性体。
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公开(公告)号：US20050125848A1
公开(公告)日：2005-06-09
申请号：US11036004
申请日：2005-01-14
IPC分类号： A61K35/12 , C12N5/0797 , A01K67/033 , C12N5/08 , A01K67/00
CPC分类号： A61K35/54 , A61K35/12 , C12N5/0623
摘要： A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing A2B5, NG2 and eNCAM is provided. In addition, methods for transplanting these cells into an animal are provided. Animals models transplanted with these human neuroepithelial precursor cells and methods for monitoring survival, proliferation, differentiation and migration of the cells in the animal model via detection of human specific markers are also provided.
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